Nice paper by the Ansel lab on the regulatory role of IL-31 in type 2 immunity. #Immunosky
“Our data support a model wherein IL-31 activation of IL31RA+ pruritoceptors triggers release of CGRP, which can mediate neurogenic inflammation, inhibit CD4+ T cell proliferation and...production of IL-13.”
“Our data support a model wherein IL-31 activation of IL31RA+ pruritoceptors triggers release of CGRP, which can mediate neurogenic inflammation, inhibit CD4+ T cell proliferation and...production of IL-13.”
Science | AAAS
www.science.org
October 16, 2023 at 8:36 PM
Nice paper by the Ansel lab on the regulatory role of IL-31 in type 2 immunity. #Immunosky
“Our data support a model wherein IL-31 activation of IL31RA+ pruritoceptors triggers release of CGRP, which can mediate neurogenic inflammation, inhibit CD4+ T cell proliferation and...production of IL-13.”
“Our data support a model wherein IL-31 activation of IL31RA+ pruritoceptors triggers release of CGRP, which can mediate neurogenic inflammation, inhibit CD4+ T cell proliferation and...production of IL-13.”
Motivated by a simple question: how can studying pain biology in dogs help dogs, and also improve how we think about pain across species? We profile purified canine sensory neurons revealing conserved pain & itch biology across species, plus meaningful divergence with potential therapeutic relevance
April 20, 2026 at 11:46 AM
Motivated by a simple question: how can studying pain biology in dogs help dogs, and also improve how we think about pain across species? We profile purified canine sensory neurons revealing conserved pain & itch biology across species, plus meaningful divergence with potential therapeutic relevance
Antibody Therapeutics(IF=4.5, Oxford University Press)
🎯🎯GB12-09, a bispecific antibody targeting IL4Rα and IL31Rα for atopic dermatitis therapy
academic.oup.com/abt/article/...
#IL4Ra #IL31Ra #AtopicDermatitis #Antibody
🎯🎯GB12-09, a bispecific antibody targeting IL4Rα and IL31Rα for atopic dermatitis therapy
academic.oup.com/abt/article/...
#IL4Ra #IL31Ra #AtopicDermatitis #Antibody
GB12-09, a bispecific antibody targeting IL4Rα and IL31Rα for atopic dermatitis therapy
Statement of Significance: This research highlighted a novel approach to atopic dermatitis therapy by employing bispecific antibody targeting IL4Rα and IL3
academic.oup.com
February 18, 2026 at 1:27 PM
Antibody Therapeutics(IF=4.5, Oxford University Press)
🎯🎯GB12-09, a bispecific antibody targeting IL4Rα and IL31Rα for atopic dermatitis therapy
academic.oup.com/abt/article/...
#IL4Ra #IL31Ra #AtopicDermatitis #Antibody
🎯🎯GB12-09, a bispecific antibody targeting IL4Rα and IL31Rα for atopic dermatitis therapy
academic.oup.com/abt/article/...
#IL4Ra #IL31Ra #AtopicDermatitis #Antibody