Now in #Science #Immunology: Deshpande, Klose, & al at Charité—Universitätsmedizin Berlin report that #ILC2 resident in #PNS communicate with neurons via #IL13 to maintain #nerve structure & pain thresholds. Mice lacking ILC2 or whose neurons are Il4ra-KO exhibit #hypersensitivity & #gait defects!
Group 2 innate lymphoid cells regulate nociceptive and gait functions of the peripheral nervous system
ILC2-neuron cross-talk contributes to the maintenance of nerve structure and function of the peripheral nervous system.
www.science.org
September 29, 2025 at 9:02 PM
Now in #Science #Immunology: Deshpande, Klose, & al at Charité—Universitätsmedizin Berlin report that #ILC2 resident in #PNS communicate with neurons via #IL13 to maintain #nerve structure & pain thresholds. Mice lacking ILC2 or whose neurons are Il4ra-KO exhibit #hypersensitivity & #gait defects!
And this hyperactivation reshapes chromatin architecture. CUT&RUN and 3C at the IL4RA locus revealed enhanced H3K27ac at distal enhancers and long-range enhancer-promoter contacts (~50kb) that simply don't form during IL10 stimulation. Bypassing feedback rewires 3D genome organisation. 9/10
May 8, 2026 at 3:03 PM
And this hyperactivation reshapes chromatin architecture. CUT&RUN and 3C at the IL4RA locus revealed enhanced H3K27ac at distal enhancers and long-range enhancer-promoter contacts (~50kb) that simply don't form during IL10 stimulation. Bypassing feedback rewires 3D genome organisation. 9/10
Antibody Therapeutics(IF=4.5, Oxford University Press)
🎯🎯GB12-09, a bispecific antibody targeting IL4Rα and IL31Rα for atopic dermatitis therapy
academic.oup.com/abt/article/...
#IL4Ra #IL31Ra #AtopicDermatitis #Antibody
🎯🎯GB12-09, a bispecific antibody targeting IL4Rα and IL31Rα for atopic dermatitis therapy
academic.oup.com/abt/article/...
#IL4Ra #IL31Ra #AtopicDermatitis #Antibody
GB12-09, a bispecific antibody targeting IL4Rα and IL31Rα for atopic dermatitis therapy
Statement of Significance: This research highlighted a novel approach to atopic dermatitis therapy by employing bispecific antibody targeting IL4Rα and IL3
academic.oup.com
February 18, 2026 at 1:27 PM
Antibody Therapeutics(IF=4.5, Oxford University Press)
🎯🎯GB12-09, a bispecific antibody targeting IL4Rα and IL31Rα for atopic dermatitis therapy
academic.oup.com/abt/article/...
#IL4Ra #IL31Ra #AtopicDermatitis #Antibody
🎯🎯GB12-09, a bispecific antibody targeting IL4Rα and IL31Rα for atopic dermatitis therapy
academic.oup.com/abt/article/...
#IL4Ra #IL31Ra #AtopicDermatitis #Antibody