DocuSign incident on November 6, 2026: We are investigating an issue affecting Docusign Connect integrations in the IL4 environment. Started 6:25 PM UTC, resolved ongoing (● 5m). Affected: eSignature (USFED).

Homeostatic macrophages maintain tissue health and resolve inflammation. Upon sustained exposure to type II cytokine IL4, transcription factors STAT6, KLF4, EGR2 and a ligand-regulated nuclear recepto...

UFO whistleblowers beg Trump for immunity so they can reveal 'alien secrets'

Mitochondrial phosphatase PGAM5 negatively regulates IL-4-induced anti-inflammatory responses and metabolic reprogramming of macrophages by controlling JAK

Respiratory syncytial virus (RSV) poses a considerable health burden to pediatric and elderly populations, but vaccine development is hindered by the risk of enhanced respiratory disease (ERD) and limitations of current animal models.MethodsSyrian hamsters of different ages were intranasally inoculated with RSV to establish an age-stratified model. Additionally, old hamsters were immunized with heat-inactivated RSV (HI-RSV) for ERD research. Disease pathogenesis was assessed through symptom monitoring, viral load quantification, histopathological examination, and transcriptomic analysis.ResultsRSV infection induced coughing-like symptoms in adult and old hamsters. Neonates exhibited significant growth retardation, the most pronounced viral replication and delayed viral clearance, and prolonged bronchiolitis-like lung injury. HI-RSV vaccination in old hamsters resulted in classic ERD, characterized by enhanced lung pathology, eosinophil infiltration, and mucus overproduction. Further transcriptomic profiling revealed upregulation of pathways related to Th1/Th2 cell differentiation, with marked increases in Th2 cytokines (Il4, Il5, and Il13) and associated transcription factors (Jak3, GATA binding protein 3, and Runt-related transcription factor 3), mechanistically linking Th2-biased immunity to ERD.ConclusionsOur findings confirm the relevance of using Syrian hamsters to study age-dependent RSV pathogenesis and to evaluate the safety of RSV vaccines, particularly with regard to the risk of ERD associated with Th2-biased immune responses.

Nick is desperate, holed up in a cheap hotel, suffering from an ulcer and convinced that a local mob boss wants him killed. Desperate and terrified, he calls Mikey, his friend since childhood and a fe...

The connectivity cloud giant recently achieved FedRAMP High certification and GovRAMP Moderate authorization.

Dead FloydGarcia's Chicago, Chicago, IL4/30/26Help on the Way > Slipknot! > Take it Back > Bertha Fat Old Sun It Hurts me Too Money...

Mr. Blotto4/10/2001 - Tipsey Tuesday Waterloo TavernChicago, IL4 Piece Acoustic - Paul Bolger, Mike Bolger, Mark Hague, Marty Connelly Set 1: They Love Each...