This month we published 2 MANUSCRIPTS in @natureportfolio.bsky.social , nature communication
1. Natalia Pardo discovers the role of nuclear MTHFD2 in centromere stability
2. Espinar and Garcia-Cao reveal the role of nuclear IMPDH2 in the DNA damage response.
Nuclear Metabolism is on 🔥
1. Natalia Pardo discovers the role of nuclear MTHFD2 in centromere stability
2. Espinar and Garcia-Cao reveal the role of nuclear IMPDH2 in the DNA damage response.
Nuclear Metabolism is on 🔥
November 22, 2024 at 5:00 AM
This month we published 2 MANUSCRIPTS in @natureportfolio.bsky.social , nature communication
1. Natalia Pardo discovers the role of nuclear MTHFD2 in centromere stability
2. Espinar and Garcia-Cao reveal the role of nuclear IMPDH2 in the DNA damage response.
Nuclear Metabolism is on 🔥
1. Natalia Pardo discovers the role of nuclear MTHFD2 in centromere stability
2. Espinar and Garcia-Cao reveal the role of nuclear IMPDH2 in the DNA damage response.
Nuclear Metabolism is on 🔥
Simmaron Research, 76 people with ME/CFS.
After 90 days of low-dose rapamycin, fatigue and PEM improved as IMPDH2 activity fell, oxidative purines dropped, and mitochondrial reserve recovered.
No placebo group tempers the result.
link.springer.com/article/10.1...
After 90 days of low-dose rapamycin, fatigue and PEM improved as IMPDH2 activity fell, oxidative purines dropped, and mitochondrial reserve recovered.
No placebo group tempers the result.
link.springer.com/article/10.1...
Association of rapamycin treatment with the modulation of purine metabolism, reduced microglial inflammatory responses, improved mitochondrial energy metabolism, and alleviation of fatigue symptoms in...
Background and rationale In our ongoing phase II observational pilot trial, the compounded formulation of low-dose rapamycin significantly reduced fatigue-related clinical symptoms in ME/CFS subjects....
link.springer.com
July 12, 2026 at 11:36 PM
Simmaron Research, 76 people with ME/CFS.
After 90 days of low-dose rapamycin, fatigue and PEM improved as IMPDH2 activity fell, oxidative purines dropped, and mitochondrial reserve recovered.
No placebo group tempers the result.
link.springer.com/article/10.1...
After 90 days of low-dose rapamycin, fatigue and PEM improved as IMPDH2 activity fell, oxidative purines dropped, and mitochondrial reserve recovered.
No placebo group tempers the result.
link.springer.com/article/10.1...
#Nature Gliocidin is a nicotinamide-mimetic prodrug that targets glioblastoma www.nature.com/articles/s41... Brain-penetrating molecule might offer a route to treat glioblastoma tumours www.nature.com/articles/d41... cryoEM structure of GAD together with IMPDH2 demonstrates its entry.
November 21, 2024 at 12:41 PM
#Nature Gliocidin is a nicotinamide-mimetic prodrug that targets glioblastoma www.nature.com/articles/s41... Brain-penetrating molecule might offer a route to treat glioblastoma tumours www.nature.com/articles/d41... cryoEM structure of GAD together with IMPDH2 demonstrates its entry.
HSPA6 maintains IMPDH2 phosphorylation to regulate GTP synthesis for driving radioresistance of glioblastoma stem cells
HSPA6 maintains IMPDH2 phosphorylation to regulate GTP synthesis for driving radioresistance of glioblastoma stem cells
Yang et al. show that irradiation-induced HSPA6 recruits ROCK2 and maintains tetramer formation of IMPDH2, a key rate-limiting enzyme in purine biosynthesis, which in turn promotes GTP synthesis and reduces DNA damage to drive radioresistance of GSCs. Targeting HSPA6 and IMPDH2 may improve the efficacy of radiotherapy for GBM.
dlvr.it
June 19, 2026 at 11:23 PM
HSPA6 maintains IMPDH2 phosphorylation to regulate GTP synthesis for driving radioresistance of glioblastoma stem cells
Cytosolic EZH2-IMPDH2 complexes regulate melanoma progression and metastasis via GTP
Cytosolic EZH2-IMPDH2 complexes regulate melanoma progression and metastasis via GTP
A cytoplasmic interaction between EZH2 and IMPDH2 drives GTP synthesis to promote cancer progression independently of EZH2’s methyltransferase activity. This newly discovered oncogenic mechanism, observed across multiple cancer types, including melanoma, can be disrupted pharmacologically, highlighting a novel vulnerability for therapeutic targeting.
dlvr.it
July 7, 2026 at 3:19 PM
Cytosolic EZH2-IMPDH2 complexes regulate melanoma progression and metastasis via GTP
An IMPDH2 variant associated with neurodevelopmental disorder disrupts purine biosynthesis and somitogenesis www.biorxiv.org/content/10.1101/2025.05.09.652712v1 #cryoem
May 12, 2025 at 7:10 AM
An IMPDH2 variant associated with neurodevelopmental disorder disrupts purine biosynthesis and somitogenesis www.biorxiv.org/content/10.1101/2025.05.09.652712v1 #cryoem
An IMPDH2 variant associated with neurodevelopmental disorder disrupts purine biosynthesis and somitogenesis https://www.biorxiv.org/content/10.1101/2025.05.09.652712v1
May 11, 2025 at 7:46 AM
An IMPDH2 variant associated with neurodevelopmental disorder disrupts purine biosynthesis and somitogenesis https://www.biorxiv.org/content/10.1101/2025.05.09.652712v1
@roswellpark.bsky.social Team Identifies New Cause of Chemotherapy Resistance in Triple-Negative Breast Cancer #breastcancer #oncology
www.onclive.com/view/roswell...
www.onclive.com/view/roswell...
Roswell Park Team Identifies New Cause of Chemotherapy Resistance in Triple-Negative Breast Cancer
Laboratory research led by Anna Bianchi-Smiraglia, PhD, reveals therapeutic target in metabolic enzyme IMPDH2.
www.onclive.com
January 20, 2025 at 3:16 PM
@roswellpark.bsky.social Team Identifies New Cause of Chemotherapy Resistance in Triple-Negative Breast Cancer #breastcancer #oncology
www.onclive.com/view/roswell...
www.onclive.com/view/roswell...
Look at this amount of work that has gone into the analysis of these beautiful (yes, we are biased) images of rods and rings. Now you can automatically classify these structures which is rather tedious to do manually. 🔬📷🖼️💻📄 bmcbiol.biomedcentral.com/articles/10....
Domain-specific AI segmentation of IMPDH2 rod/ring structures in mouse embryonic stem cells - BMC Biology
Background Inosine monophosphate dehydrogenase 2 (IMPDH2) is an enzyme that catalyses the rate-limiting step of guanine nucleotides. In mouse embryonic stem cells (ESCs), IMPDH2 forms large multi-prot...
bmcbiol.biomedcentral.com
May 13, 2025 at 3:46 PM
Look at this amount of work that has gone into the analysis of these beautiful (yes, we are biased) images of rods and rings. Now you can automatically classify these structures which is rather tedious to do manually. 🔬📷🖼️💻📄 bmcbiol.biomedcentral.com/articles/10....
Our new paper just arrived! Fun collaborative effort led by Sam Ball and Meagan Hennessy to develop an AI tool to segment and classify #IMPDH2 rod-rings in mouse ESCs doi.org/10.1186/s129...
Domain-specific AI segmentation of IMPDH2 rod/ring structures in mouse embryonic stem cells - BMC Biology
Background Inosine monophosphate dehydrogenase 2 (IMPDH2) is an enzyme that catalyses the rate-limiting step of guanine nucleotides. In mouse embryonic stem cells (ESCs), IMPDH2 forms large multi-prot...
doi.org
May 12, 2025 at 7:29 AM
Our new paper just arrived! Fun collaborative effort led by Sam Ball and Meagan Hennessy to develop an AI tool to segment and classify #IMPDH2 rod-rings in mouse ESCs doi.org/10.1186/s129...
They followed up with a second trial:
September 11, 2026 at 7:00 PM
They followed up with a second trial:
The authors included RRIDs in their in Cancer Letters paper! RRIDs improve reproducibility in scientific research. #BetterScience #methodsmatter #OpenScience
tRF-1432 orchestrates RBMS1–IMPDH2 regulatory control to drive purine-dependent chemoresistance in breast cancer
Read the full paper: tRF-1432 orchestrates RBMS1–IMPDH2 regulatory control to drive purine-dependent chemoresistance in breast cancer
doi.org
March 7, 2026 at 8:02 AM
The authors included RRIDs in their in Cancer Letters paper! RRIDs improve reproducibility in scientific research. #BetterScience #methodsmatter #OpenScience
A Novel Allosteric Inhibitor Targeting IMPDH2 at Y233 Overcomes Resistance to Tyrosine Kinase Inhibitors in Lymphoma https://www.biorxiv.org/content/10.1101/2025.08.19.667179v1
August 24, 2025 at 5:48 AM
A Novel Allosteric Inhibitor Targeting IMPDH2 at Y233 Overcomes Resistance to Tyrosine Kinase Inhibitors in Lymphoma https://www.biorxiv.org/content/10.1101/2025.08.19.667179v1
The authors included RRIDs in their in Proceedings of the National Academy of Sciences paper! We value the author's support of reproducibility. #reproducibility #ReproducibleResearch #accelerateopenscience
An IMPDH2 variant associated with neurodevelopmental disorder disrupts purine biosynthesis and somite organization
Read the full paper: An IMPDH2 variant associated with neurodevelopmental disorder disrupts purine biosynthesis and somite organization
doi.org
March 25, 2026 at 7:03 AM
The authors included RRIDs in their in Proceedings of the National Academy of Sciences paper! We value the author's support of reproducibility. #reproducibility #ReproducibleResearch #accelerateopenscience
@proteintech.bsky.social's resource, RRID:AB_2120122, was just reported to be used in the paper. RRIDs improve reproducibility in scientific research. #ReproducibleResearch #BetterScience #OpenResearch
HSPA6 maintains IMPDH2 phosphorylation to regulate GTP synthesis for driving radioresistance of glioblastoma stem cells
Read the full paper: HSPA6 maintains IMPDH2 phosphorylation to regulate GTP synthesis for driving radioresistance of glioblastoma stem cells
doi.org
June 5, 2026 at 7:00 AM
@proteintech.bsky.social's resource, RRID:AB_2120122, was just reported to be used in the paper. RRIDs improve reproducibility in scientific research. #ReproducibleResearch #BetterScience #OpenResearch
Appendage regeneration requires IMPDH2 and creates a sensitized environment for enzyme filament formation https://www.biorxiv.org/content/10.1101/2024.07.29.605679v1
Appendage regeneration requires IMPDH2 and creates a sensitized environment for enzyme filament formation https://www.biorxiv.org/content/10.1101/2024.07.29.605679v1
The regeneration of lost tissue requires biosynthesis of metabolites needed for cell proliferation a
www.biorxiv.org
July 30, 2024 at 4:31 PM
Appendage regeneration requires IMPDH2 and creates a sensitized environment for enzyme filament formation https://www.biorxiv.org/content/10.1101/2024.07.29.605679v1
Che-Chia Hsu et al. show that #IMPA1-derived inositol maintains stemness in castration resistant #ProstateCancer via #IMPDH2 activation. rupress.org/jem/article/...
📘 In Tumor #Metabolism 2025: rupress.org/jem/collecti...
#KSTumorMetab25
📘 In Tumor #Metabolism 2025: rupress.org/jem/collecti...
#KSTumorMetab25
March 14, 2025 at 8:19 PM
Che-Chia Hsu et al. show that #IMPA1-derived inositol maintains stemness in castration resistant #ProstateCancer via #IMPDH2 activation. rupress.org/jem/article/...
📘 In Tumor #Metabolism 2025: rupress.org/jem/collecti...
#KSTumorMetab25
📘 In Tumor #Metabolism 2025: rupress.org/jem/collecti...
#KSTumorMetab25
Che-Chia Hsu, Hui-Kuan Lin et al. show that #IMPA1-derived inositol maintains stemness in castration resistant #ProstateCancer via #IMPDH2 activation. rupress.org/jem/article/...
📘 In our #Immunometabolism 2025 collection: rupress.org/jem/collecti...
📘 In our #Immunometabolism 2025 collection: rupress.org/jem/collecti...
May 6, 2025 at 8:15 AM
Che-Chia Hsu, Hui-Kuan Lin et al. show that #IMPA1-derived inositol maintains stemness in castration resistant #ProstateCancer via #IMPDH2 activation. rupress.org/jem/article/...
📘 In our #Immunometabolism 2025 collection: rupress.org/jem/collecti...
📘 In our #Immunometabolism 2025 collection: rupress.org/jem/collecti...
A paper using RRID:AB_2770784 (from ABclonal) was just published in Cell Reports see "IMPDH2 dephosphorylation under FGFR signaling promotes S-phase progression and tumor growth".Thank you for making your methods matter! #reproducibility #ReproducibleResearch
doi.org
January 5, 2025 at 12:34 PM
A paper using RRID:AB_2770784 (from ABclonal) was just published in Cell Reports see "IMPDH2 dephosphorylation under FGFR signaling promotes S-phase progression and tumor growth".Thank you for making your methods matter! #reproducibility #ReproducibleResearch
A drug to watch for #braincancer? Identified in 2014 by the same lab in #MPNST, the target IMPDH2 has high homology between humans and mice... ergo, the xenograft data might reflect toxicity as well as efficacy; drug may be relevant and worth clinical trials... #btsm aacrjournals.org/cancerres/ar...
November 24, 2024 at 7:33 AM
A drug to watch for #braincancer? Identified in 2014 by the same lab in #MPNST, the target IMPDH2 has high homology between humans and mice... ergo, the xenograft data might reflect toxicity as well as efficacy; drug may be relevant and worth clinical trials... #btsm aacrjournals.org/cancerres/ar...
Selective IMPDH2-targeting drug candidates could help stop cancer from spreading to the brain before tumors form there. The target is not abundant in healthy tissue, suggesting fewer major side effects. doi.org/hb782x
Targeting enzyme could block cancer spread to brain with fewer side effects
A new study has identified a more precise and effective way to prevent cancer from spreading to the brain. The paper, published in the Proceedings of the National Academy of Sciences, details the development of novel drug candidates that target a key enzyme implicated in the spread of lung, breast, skin and other cancers to the brain.
medicalxpress.com
June 19, 2026 at 5:00 PM
Selective IMPDH2-targeting drug candidates could help stop cancer from spreading to the brain before tumors form there. The target is not abundant in healthy tissue, suggesting fewer major side effects. doi.org/hb782x
3/ Importantly, our study suggests that IMPDH2 is essential for the efficient functioning of the DNA damage response, particularly in the context of triple-negative breast cancer cells. Understanding IMPDH2's regulatory role could inform treatment strategies based on PARP1i.
November 22, 2024 at 5:00 AM
3/ Importantly, our study suggests that IMPDH2 is essential for the efficient functioning of the DNA damage response, particularly in the context of triple-negative breast cancer cells. Understanding IMPDH2's regulatory role could inform treatment strategies based on PARP1i.
2/ Our findings demonstrate that nuclear IMPDH2 modulates PARP1 activity, by controlling NAD+ availability.
November 22, 2024 at 5:00 AM
2/ Our findings demonstrate that nuclear IMPDH2 modulates PARP1 activity, by controlling NAD+ availability.
1/ Traditionally known for its role in guanosine synthesis in the cytosol, we showed that IMPDH2 can be found in the nucleus and acts as a regulator of DNA repair.
November 22, 2024 at 5:00 AM
1/ Traditionally known for its role in guanosine synthesis in the cytosol, we showed that IMPDH2 can be found in the nucleus and acts as a regulator of DNA repair.
As for the second: nature.com/articles/s4146…
We revealed a previously unknown role for the enzyme IMPDH2 in the nucleus, shedding light on its involvement in the DNA damage response.
We revealed a previously unknown role for the enzyme IMPDH2 in the nucleus, shedding light on its involvement in the DNA damage response.
https://nature.com/articles/s4146…
November 22, 2024 at 5:00 AM
As for the second: nature.com/articles/s4146…
We revealed a previously unknown role for the enzyme IMPDH2 in the nucleus, shedding light on its involvement in the DNA damage response.
We revealed a previously unknown role for the enzyme IMPDH2 in the nucleus, shedding light on its involvement in the DNA damage response.