REVIEW | FREE TO READ THIS MONTH! 🧪
@clemmensenc.bsky.social et al
Incretin-based therapeutics for the treatment of neurodegenerative diseases
@clemmensenc.bsky.social et al
Incretin-based therapeutics for the treatment of neurodegenerative diseases
Incretin-based therapeutics for the treatment of neurodegenerative diseases - Nature Metabolism
This Review summarizes preclinical and clinical evidence highlighting the potential of incretin-based drugs as treatments of neurodegenerative diseases, such as Alzheimer’s disease or Parkinson’s disease.
bit.ly
August 23, 2025 at 6:18 PM
REVIEW | FREE TO READ THIS MONTH! 🧪
@clemmensenc.bsky.social et al
Incretin-based therapeutics for the treatment of neurodegenerative diseases
@clemmensenc.bsky.social et al
Incretin-based therapeutics for the treatment of neurodegenerative diseases
#Throwback 🧪
REVIEW | Incretin-based therapeutics for the treatment of neurodegenerative diseases
@clemmensenc.bsky.social et al
REVIEW | Incretin-based therapeutics for the treatment of neurodegenerative diseases
@clemmensenc.bsky.social et al
Incretin-based therapeutics for the treatment of neurodegenerative diseases - Nature Metabolism
This Review summarizes preclinical and clinical evidence highlighting the potential of incretin-based drugs as treatments of neurodegenerative diseases, such as Alzheimer’s disease or Parkinson’s disease.
bit.ly
November 29, 2025 at 7:01 PM
#Throwback 🧪
REVIEW | Incretin-based therapeutics for the treatment of neurodegenerative diseases
@clemmensenc.bsky.social et al
REVIEW | Incretin-based therapeutics for the treatment of neurodegenerative diseases
@clemmensenc.bsky.social et al
#Throwback 🧪
REVIEW | Incretin-based therapeutics for the treatment of neurodegenerative diseases
@clemmensenc.bsky.social et al
REVIEW | Incretin-based therapeutics for the treatment of neurodegenerative diseases
@clemmensenc.bsky.social et al
Incretin-based therapeutics for the treatment of neurodegenerative diseases - Nature Metabolism
This Review summarizes preclinical and clinical evidence highlighting the potential of incretin-based drugs as treatments of neurodegenerative diseases, such as Alzheimer’s disease or Parkinson’s disease.
bit.ly
October 18, 2025 at 7:01 PM
#Throwback 🧪
REVIEW | Incretin-based therapeutics for the treatment of neurodegenerative diseases
@clemmensenc.bsky.social et al
REVIEW | Incretin-based therapeutics for the treatment of neurodegenerative diseases
@clemmensenc.bsky.social et al
Our latest review, led by @anikavear.bsky.social with Michael Heneka, explores the emerging role of incretin-based therapies in neurodegenerative disease treatment www.nature.com/articles/s42...
Incretin-based therapeutics for the treatment of neurodegenerative diseases - Nature Metabolism
This Review summarizes preclinical and clinical evidence highlighting the potential of incretin-based drugs as treatments of neurodegenerative diseases, such as Alzheimer’s disease or Parkinson’s dise...
www.nature.com
April 14, 2025 at 9:19 AM
Our latest review, led by @anikavear.bsky.social with Michael Heneka, explores the emerging role of incretin-based therapies in neurodegenerative disease treatment www.nature.com/articles/s42...
⚠️ Das Risiko sinkt um 50 %
Zumindest laut eines Reviews in Nature Metabolism: Semaglutid senkte das Alzheimer-Risiko bei Diabetiker:innen deutlich. Weitere klinische Studien laufen. 🧪
🔗 www.nature.com/artic...
Zumindest laut eines Reviews in Nature Metabolism: Semaglutid senkte das Alzheimer-Risiko bei Diabetiker:innen deutlich. Weitere klinische Studien laufen. 🧪
🔗 www.nature.com/artic...
Incretin-based therapeutics for the treatment of neurodegenerative diseases
Nature Metabolism - This Review summarizes preclinical and clinical evidence highlighting the potential of incretin-based drugs as treatments of neurodegenerative diseases, such as...
www.nature.com
May 5, 2025 at 8:04 AM
⚠️ Das Risiko sinkt um 50 %
Zumindest laut eines Reviews in Nature Metabolism: Semaglutid senkte das Alzheimer-Risiko bei Diabetiker:innen deutlich. Weitere klinische Studien laufen. 🧪
🔗 www.nature.com/artic...
Zumindest laut eines Reviews in Nature Metabolism: Semaglutid senkte das Alzheimer-Risiko bei Diabetiker:innen deutlich. Weitere klinische Studien laufen. 🧪
🔗 www.nature.com/artic...
REVIEW | FREE TO READ THIS WEEK! 🧪
@clemmensenc.bsky.social et al
Incretin-based therapeutics for the treatment of neurodegenerative diseases
@clemmensenc.bsky.social et al
Incretin-based therapeutics for the treatment of neurodegenerative diseases
Incretin-based therapeutics for the treatment of neurodegenerative diseases - Nature Metabolism
This Review summarizes preclinical and clinical evidence highlighting the potential of incretin-based drugs as treatments of neurodegenerative diseases, such as Alzheimer’s disease or Parkinson’s disease.
bit.ly
August 27, 2025 at 6:17 PM
REVIEW | FREE TO READ THIS WEEK! 🧪
@clemmensenc.bsky.social et al
Incretin-based therapeutics for the treatment of neurodegenerative diseases
@clemmensenc.bsky.social et al
Incretin-based therapeutics for the treatment of neurodegenerative diseases
#Throwback 🧪
REVIEW | Incretin-based therapeutics for the treatment of neurodegenerative diseases
@clemmensenc.bsky.social et al
REVIEW | Incretin-based therapeutics for the treatment of neurodegenerative diseases
@clemmensenc.bsky.social et al
Incretin-based therapeutics for the treatment of neurodegenerative diseases - Nature Metabolism
This Review summarizes preclinical and clinical evidence highlighting the potential of incretin-based drugs as treatments of neurodegenerative diseases, such as Alzheimer’s disease or Parkinson’s disease.
dlvr.it
January 17, 2026 at 7:02 PM
#Throwback 🧪
REVIEW | Incretin-based therapeutics for the treatment of neurodegenerative diseases
@clemmensenc.bsky.social et al
REVIEW | Incretin-based therapeutics for the treatment of neurodegenerative diseases
@clemmensenc.bsky.social et al
Nature research paper: Prohormone cleavage prediction uncovers a non-incretin anti-obesity peptide
https://go.nature.com/3FljeNK
https://go.nature.com/3FljeNK
Prohormone cleavage prediction uncovers a non-incretin anti-obesity peptide - Nature
Computational drug discovery is used to identify a 12-mer peptide derived from BRINP2 with potent anti-obesity effects that are independent of leptin, glucagon-like peptide 1 receptor and melanocortin 4 receptor.
go.nature.com
March 7, 2025 at 9:20 AM
Nature research paper: Prohormone cleavage prediction uncovers a non-incretin anti-obesity peptide
https://go.nature.com/3FljeNK
https://go.nature.com/3FljeNK
🩳 TL;DR: Die Entdeckung von GLP-1 war keine lineare Erfolgsgeschichte, sondern das Ergebnis vieler kleiner Schritte.
📝 Einfache, gut durchdachte Experimente und Studien legten den Grundstein für eine neue Klasse hochwirksamer Medikamente.
🔗 www.nature.com/artic... 🧪
🏁
8/8
📝 Einfache, gut durchdachte Experimente und Studien legten den Grundstein für eine neue Klasse hochwirksamer Medikamente.
🔗 www.nature.com/artic... 🧪
🏁
8/8
Gut instincts — the origins of the incretin effect
Nature Reviews Endocrinology - Gut instincts — the origins of the incretin effect
www.nature.com
May 19, 2025 at 7:30 PM
🩳 TL;DR: Die Entdeckung von GLP-1 war keine lineare Erfolgsgeschichte, sondern das Ergebnis vieler kleiner Schritte.
📝 Einfache, gut durchdachte Experimente und Studien legten den Grundstein für eine neue Klasse hochwirksamer Medikamente.
🔗 www.nature.com/artic... 🧪
🏁
8/8
📝 Einfache, gut durchdachte Experimente und Studien legten den Grundstein für eine neue Klasse hochwirksamer Medikamente.
🔗 www.nature.com/artic... 🧪
🏁
8/8
Follow @rnflex.bsky.social and the-incretins.beehiiv.com for GLP-1 and GIP knowledge. To answer your question, Retatrutide is going to blow the competition out of the water.
Home | The Incretin Space
A collection of collated data on incretin drug developments, including new drugs, new treatments and the future of incretin in medicine
the-incretins.beehiiv.com
June 7, 2026 at 9:19 PM
Follow @rnflex.bsky.social and the-incretins.beehiiv.com for GLP-1 and GIP knowledge. To answer your question, Retatrutide is going to blow the competition out of the water.
#Throwback 🧪
REVIEW | Incretin-based therapeutics for the treatment of neurodegenerative diseases
@clemmensenc.bsky.social et al
REVIEW | Incretin-based therapeutics for the treatment of neurodegenerative diseases
@clemmensenc.bsky.social et al
Incretin-based therapeutics for the treatment of neurodegenerative diseases - Nature Metabolism
This Review summarizes preclinical and clinical evidence highlighting the potential of incretin-based drugs as treatments of neurodegenerative diseases, such as Alzheimer’s disease or Parkinson’s disease.
dlvr.it
August 8, 2026 at 5:11 PM
#Throwback 🧪
REVIEW | Incretin-based therapeutics for the treatment of neurodegenerative diseases
@clemmensenc.bsky.social et al
REVIEW | Incretin-based therapeutics for the treatment of neurodegenerative diseases
@clemmensenc.bsky.social et al
So exciting! #SUMMIT trial, the first #HFpEF trial of incretin therapy with HF clinical outcomes as prespecified primary outcome. And #tirzepatide reduced CV death or worsening HF by significant 38%! Improvement in KCCQ quality of life by 7 pts, wt loss 12%, hsCRP reduction by 35%! #AHA24 #CardioSky
November 16, 2024 at 3:19 PM
So exciting! #SUMMIT trial, the first #HFpEF trial of incretin therapy with HF clinical outcomes as prespecified primary outcome. And #tirzepatide reduced CV death or worsening HF by significant 38%! Improvement in KCCQ quality of life by 7 pts, wt loss 12%, hsCRP reduction by 35%! #AHA24 #CardioSky
Orforglipron is being tested in a dedicated trial for #Hypertension Will the results change how we approach BP management? www.ahajournals.org/doi/10.1161/...
Incretin-Based Therapies: A Paradigm Shift in Blood Pressure Management? | Hypertension
In the management of hypertension, only limited advances have been made over the past
decades. Recent studies highlight the potential of next-generation incretin-based
therapeutics, such as GLP-1 RAs ...
www.ahajournals.org
May 27, 2025 at 10:27 AM
Orforglipron is being tested in a dedicated trial for #Hypertension Will the results change how we approach BP management? www.ahajournals.org/doi/10.1161/...
The incretin-bone axis: molecular mechanisms and clinical implications. A Muscarà et al. Front Endocrinol 5 Oct 2026 shorturl.at/kdROy ...fine update ...effects of GIP and GLP-1
October 7, 2026 at 6:46 AM
The incretin-bone axis: molecular mechanisms and clinical implications. A Muscarà et al. Front Endocrinol 5 Oct 2026 shorturl.at/kdROy ...fine update ...effects of GIP and GLP-1
Incretin hormones—GLP-1 and GIP—act as a critical link connecting digestion, metabolism, and cardiovascular function, supporting physiological adaptations to nutrient intake.
www.thelancet.com/journals/lan...
www.thelancet.com/journals/lan...
December 14, 2025 at 6:47 AM
Incretin hormones—GLP-1 and GIP—act as a critical link connecting digestion, metabolism, and cardiovascular function, supporting physiological adaptations to nutrient intake.
www.thelancet.com/journals/lan...
www.thelancet.com/journals/lan...
MEGA PDF on Incretin therapies by the one and only @drkevinfernando.bsky.social
Very topical at the moment for CRM world
#PharmSky #Medsky #GPsky #CRM #CardioSky
img.medscapestatic.com/vim/live/pro...
Very topical at the moment for CRM world
#PharmSky #Medsky #GPsky #CRM #CardioSky
img.medscapestatic.com/vim/live/pro...
November 19, 2024 at 7:03 PM
MEGA PDF on Incretin therapies by the one and only @drkevinfernando.bsky.social
Very topical at the moment for CRM world
#PharmSky #Medsky #GPsky #CRM #CardioSky
img.medscapestatic.com/vim/live/pro...
Very topical at the moment for CRM world
#PharmSky #Medsky #GPsky #CRM #CardioSky
img.medscapestatic.com/vim/live/pro...
REVIEW | FREE TO READ THIS MONTH! 🧪
@clemmensenc.bsky.social et al
Incretin-based therapeutics for the treatment of neurodegenerative diseases
@clemmensenc.bsky.social et al
Incretin-based therapeutics for the treatment of neurodegenerative diseases
Incretin-based therapeutics for the treatment of neurodegenerative diseases - Nature Metabolism
This Review summarizes preclinical and clinical evidence highlighting the potential of incretin-based drugs as treatments of neurodegenerative diseases, such as Alzheimer’s disease or Parkinson’s disease.
bit.ly
August 20, 2025 at 6:17 PM
REVIEW | FREE TO READ THIS MONTH! 🧪
@clemmensenc.bsky.social et al
Incretin-based therapeutics for the treatment of neurodegenerative diseases
@clemmensenc.bsky.social et al
Incretin-based therapeutics for the treatment of neurodegenerative diseases
🚨 NEW DOC Updates #podcast
You know how GLP-1s impact diabetes & weight loss. But what about coronary disease treatment? Liver disease? Heart failure? In this special ep, we explores the latest in incretin biology.
👂Listen: diabetesjournals.org/journals/pages/podcasts_incretin_biology
You know how GLP-1s impact diabetes & weight loss. But what about coronary disease treatment? Liver disease? Heart failure? In this special ep, we explores the latest in incretin biology.
👂Listen: diabetesjournals.org/journals/pages/podcasts_incretin_biology
October 6, 2026 at 2:18 PM
🚨 NEW DOC Updates #podcast
You know how GLP-1s impact diabetes & weight loss. But what about coronary disease treatment? Liver disease? Heart failure? In this special ep, we explores the latest in incretin biology.
👂Listen: diabetesjournals.org/journals/pages/podcasts_incretin_biology
You know how GLP-1s impact diabetes & weight loss. But what about coronary disease treatment? Liver disease? Heart failure? In this special ep, we explores the latest in incretin biology.
👂Listen: diabetesjournals.org/journals/pages/podcasts_incretin_biology
#Throwback 🧪
REVIEW | Incretin-based therapeutics for the treatment of neurodegenerative diseases
@clemmensenc.bsky.social et al
REVIEW | Incretin-based therapeutics for the treatment of neurodegenerative diseases
@clemmensenc.bsky.social et al
Incretin-based therapeutics for the treatment of neurodegenerative diseases - Nature Metabolism
This Review summarizes preclinical and clinical evidence highlighting the potential of incretin-based drugs as treatments of neurodegenerative diseases, such as Alzheimer’s disease or Parkinson’s disease.
dlvr.it
March 15, 2026 at 6:02 PM
#Throwback 🧪
REVIEW | Incretin-based therapeutics for the treatment of neurodegenerative diseases
@clemmensenc.bsky.social et al
REVIEW | Incretin-based therapeutics for the treatment of neurodegenerative diseases
@clemmensenc.bsky.social et al
#Throwback 🧪
REVIEW | Incretin-based therapeutics for the treatment of neurodegenerative diseases
@clemmensenc.bsky.social et al
REVIEW | Incretin-based therapeutics for the treatment of neurodegenerative diseases
@clemmensenc.bsky.social et al
Incretin-based therapeutics for the treatment of neurodegenerative diseases - Nature Metabolism
This Review summarizes preclinical and clinical evidence highlighting the potential of incretin-based drugs as treatments of neurodegenerative diseases, such as Alzheimer’s disease or Parkinson’s disease.
dlvr.it
May 19, 2026 at 6:01 PM
#Throwback 🧪
REVIEW | Incretin-based therapeutics for the treatment of neurodegenerative diseases
@clemmensenc.bsky.social et al
REVIEW | Incretin-based therapeutics for the treatment of neurodegenerative diseases
@clemmensenc.bsky.social et al
And of course I'll keep writing for my blog. My next post on insulin sensitivity is almost done!
Home | The Incretin Space
A collection of collated data on incretin drug developments, including new drugs, new treatments and the future of incretin in medicine
the-incretins.beehiiv.com
September 9, 2026 at 9:13 PM
And of course I'll keep writing for my blog. My next post on insulin sensitivity is almost done!
Very proud of @laurenjonesucl.bsky.social and Ella Cross for giving excellent oral and poster presentations at the European Incretin Study Group meeting in Porto, and both winning prizes for them too!
September 5, 2026 at 6:01 PM
Very proud of @laurenjonesucl.bsky.social and Ella Cross for giving excellent oral and poster presentations at the European Incretin Study Group meeting in Porto, and both winning prizes for them too!
Yick Cheung Au Yeung tells us about incretin mimetics and fluid homeostasis #NeuroendoCelebrate2026
September 3, 2026 at 11:21 AM
Yick Cheung Au Yeung tells us about incretin mimetics and fluid homeostasis #NeuroendoCelebrate2026
GLP-1 receptor agonists are increasingly used to treat type 2 diabetes and obesity, and trials have shown reductions in cardiovascular risk and slowing of kidney failure. Adverse events are mostly gastrointestinal. Read the full review: nej.md/4sUFlys
@tuftsmedschool.bsky.social
@tuftsmedschool.bsky.social
April 1, 2026 at 10:01 PM
GLP-1 receptor agonists are increasingly used to treat type 2 diabetes and obesity, and trials have shown reductions in cardiovascular risk and slowing of kidney failure. Adverse events are mostly gastrointestinal. Read the full review: nej.md/4sUFlys
@tuftsmedschool.bsky.social
@tuftsmedschool.bsky.social
💡 JAMA Insights: #GLP1 receptor agonists and dual incretin agents support weight loss with minimal lifestyle counseling, but diet and activity advice remain necessary for safety and long-term success in #Obesity care.
ja.ma/3Rpe1e1
ja.ma/3Rpe1e1
May 24, 2026 at 1:00 PM
💡 JAMA Insights: #GLP1 receptor agonists and dual incretin agents support weight loss with minimal lifestyle counseling, but diet and activity advice remain necessary for safety and long-term success in #Obesity care.
ja.ma/3Rpe1e1
ja.ma/3Rpe1e1