While eating well slightly lowers inflammation, new research shows it is not enough to reverse the damage caused by frequent alcohol consumption. Moderate and heavy drinking were linked to significant inflammatory spikes, regardless of diet quality.

<p xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="first" dir="auto" id="d20589725e116"> <b>INTRODUCTION:</b> Inflammation is a common pathological condition. On ...

We have previously reported two prodrug designs for the delivery of the potent TLR4 inhibitor TAK-242. Our initial design was used to covalently link TAK-242 to pancreatic islets using a linker to afford sustained delivery of the active drug after transplant. Those drug-eluting islets provided local inhibition of TLR4-linked inflammation and improved islet graft survival. Here, we describe a third family of TAK-242 prodrugs featuring two rate modulating sites, a self-immolative aniline-stabilized methylene spacer bonded directly to the sulfonamide nitrogen, an alcohol tether for bioconjugation, and a β-eliminative aryl-sulfone “trigger”. These prodrugs rapidly release TAK-242 after activation by β-elimination and a rapid subsequent 1,2-elimination, cleanly releasing the drug without detectable intermediates. This manuscript reports the preparation and characterization of a series of methylene-linked TAK-242 prodrugs, evaluating the impact of various modifications on drug release kinetics.

Understand the critical connection between stress and cardiovascular disease, especially for women, according to recent findings.

New research suggests that long-term use of NSAIDs like ibuprofen may lower dementia risk. Could this be the breakthrough we've been waiting for in the fight against neurodegenerative diseases? #DementiaPrevention #InflammationResearch

A new study published in Biopsychosocial Science and Medicine suggests that a father’s psychological resilience may play a significant role in the biological health of his pregnant partner and the duration...

A common gout drug may unexpectedly lower the risk of heart attacks and strokes, according to a major new review A commonly used and affordable medication for gout may help lower the risk of heart attacks...

Standard brain implants use electrodes that penetrate the gray matter to stimulate and record the activity of neurons. These typically need to be put in place via a surgical procedure. To go around that...

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