GABA receptor #ionchannel cryo…
January 23, 2025 at 10:37 AM
GABA receptor #ionchannel cryo…
Tetrameric #ionchannel with confused ion
December 6, 2025 at 11:20 AM
Tetrameric #ionchannel with confused ion
#ionchannel legend…
Latest in our Research News: JGP study from Liu and Bezanilla (https://buff.ly/3DjcXl1) reveals that a sodium channel mutant blocks fast inactivation downstream of inactivation particle binding, diverting the channel into an alternative open state. https://buff.ly/4gj0hJv
December 19, 2024 at 7:48 AM
#ionchannel legend…
Excited to share our preprint about volume regulated ion channels here! We solved structures of heteromeric LRRC8A:D channels and show how they are gated closed by pore-blocking lipids. Led by @antonylurie.bsky.social + David Kern
#IonChannel #cryoem
www.biorxiv.org/content/10.1...
#IonChannel #cryoem
www.biorxiv.org/content/10.1...
November 27, 2024 at 8:43 PM
Excited to share our preprint about volume regulated ion channels here! We solved structures of heteromeric LRRC8A:D channels and show how they are gated closed by pore-blocking lipids. Led by @antonylurie.bsky.social + David Kern
#IonChannel #cryoem
www.biorxiv.org/content/10.1...
#IonChannel #cryoem
www.biorxiv.org/content/10.1...
May be a bit premature, but here is the Starter Pack I am trying to populate for #IonChannel research. Ping me and I’ll add you obviously! (Or to be removed)
go.bsky.app/6taxHfx
@jgenphysiol.bsky.social @auditorynerves.bsky.social @plesslab.bsky.social @rainbowlabuol.bsky.social
go.bsky.app/6taxHfx
@jgenphysiol.bsky.social @auditorynerves.bsky.social @plesslab.bsky.social @rainbowlabuol.bsky.social
November 19, 2024 at 2:26 PM
May be a bit premature, but here is the Starter Pack I am trying to populate for #IonChannel research. Ping me and I’ll add you obviously! (Or to be removed)
go.bsky.app/6taxHfx
@jgenphysiol.bsky.social @auditorynerves.bsky.social @plesslab.bsky.social @rainbowlabuol.bsky.social
go.bsky.app/6taxHfx
@jgenphysiol.bsky.social @auditorynerves.bsky.social @plesslab.bsky.social @rainbowlabuol.bsky.social
Happy to share our new review on the structural pharmacology of TRP channels!
Check out the supplementary table, which includes a list of all ligands, corresponding PDBs of complexes with TRP channels, and reported affinity values.
www.sciencedirect.com/science/arti... #ionchannel #TRPchannel (1/5)
Check out the supplementary table, which includes a list of all ligands, corresponding PDBs of complexes with TRP channels, and reported affinity values.
www.sciencedirect.com/science/arti... #ionchannel #TRPchannel (1/5)
December 1, 2024 at 3:00 AM
Happy to share our new review on the structural pharmacology of TRP channels!
Check out the supplementary table, which includes a list of all ligands, corresponding PDBs of complexes with TRP channels, and reported affinity values.
www.sciencedirect.com/science/arti... #ionchannel #TRPchannel (1/5)
Check out the supplementary table, which includes a list of all ligands, corresponding PDBs of complexes with TRP channels, and reported affinity values.
www.sciencedirect.com/science/arti... #ionchannel #TRPchannel (1/5)
New preprint: We demonstrate how to apply FEP-based ligand efficacy modeling to ion channels.
#CompChem 💻:⚗️ #Science 🧪 #DrugDiscovery #IonChannel #FEP
doi.org/10.64898/202...
#CompChem 💻:⚗️ #Science 🧪 #DrugDiscovery #IonChannel #FEP
doi.org/10.64898/202...
September 25, 2026 at 1:55 AM
New preprint: We demonstrate how to apply FEP-based ligand efficacy modeling to ion channels.
#CompChem 💻:⚗️ #Science 🧪 #DrugDiscovery #IonChannel #FEP
doi.org/10.64898/202...
#CompChem 💻:⚗️ #Science 🧪 #DrugDiscovery #IonChannel #FEP
doi.org/10.64898/202...
🧵 I’m excited to share our latest preprint! We studied 252 SCN5A variants found in patients with Brugada Syndrome by automated patch clamp. [1/7]
March 20, 2025 at 1:59 AM
New: @elainetao.bsky.social and @corrylab.bsky.social investigate the binding of sodium channel inhibitors to the Naᵥ1.5 pore using simulations, revealing promiscuous, polyspecific binding at the fenestrations and central cavity. https://buff.ly/40rLqHb
January 8, 2025 at 7:15 PM
Thank you @amglazer.bsky.social for the exciting opportunity to collaborate! Since then, we've provided functional evidence supporting the VUS reclassification in children with abnormal sodium #ionchannel function at Sydney Children’s Hospital.
📝 Excited to share our latest work, now out at European Heart Journal! We studied 252 SCN5A variants previously found in patients with Brugada Syndrome, an inherited arrhythmia disorder linked to sudden cardiac death. [1/4]
November 21, 2025 at 12:14 AM
Thank you @amglazer.bsky.social for the exciting opportunity to collaborate! Since then, we've provided functional evidence supporting the VUS reclassification in children with abnormal sodium #ionchannel function at Sydney Children’s Hospital.
Distinct properties and activation of hexameric and heptameric Pannexin 1 #ionchannel concatemers | Journal of General Physiology https://buff.ly/4iKt3UN
December 22, 2024 at 11:39 AM
Distinct properties and activation of hexameric and heptameric Pannexin 1 #ionchannel concatemers | Journal of General Physiology https://buff.ly/4iKt3UN
📣 📣 📣 Optically Guided Tension Clamp 📣 📣 📣
Now out: Michael Sindoni developed a new system that uses machine learning & closed-loop control to clamp membrane tension with high precision. Study your favorite force-gated ion channel!
#IonChannel #Biophysics
Read more: www.cell.com/biophysj/ful...
Now out: Michael Sindoni developed a new system that uses machine learning & closed-loop control to clamp membrane tension with high precision. Study your favorite force-gated ion channel!
#IonChannel #Biophysics
Read more: www.cell.com/biophysj/ful...
March 31, 2025 at 1:24 PM
📣 📣 📣 Optically Guided Tension Clamp 📣 📣 📣
Now out: Michael Sindoni developed a new system that uses machine learning & closed-loop control to clamp membrane tension with high precision. Study your favorite force-gated ion channel!
#IonChannel #Biophysics
Read more: www.cell.com/biophysj/ful...
Now out: Michael Sindoni developed a new system that uses machine learning & closed-loop control to clamp membrane tension with high precision. Study your favorite force-gated ion channel!
#IonChannel #Biophysics
Read more: www.cell.com/biophysj/ful...
Calmodulin regulates TRPV5 #ionchannel intracellular trafficking and plasma membrane abundance - Zuidscherwoude - The Journal of Physiology
#openaccess https://buff.ly/3VgZzUq
#openaccess https://buff.ly/3VgZzUq
December 3, 2024 at 11:39 AM
Calmodulin regulates TRPV5 #ionchannel intracellular trafficking and plasma membrane abundance - Zuidscherwoude - The Journal of Physiology
#openaccess https://buff.ly/3VgZzUq
#openaccess https://buff.ly/3VgZzUq
After a safe, even if long, travel to SF yesterday, I am so looking forward to peeking into new discoveries, forging a positive future, reconnecting with brilliant minds, and making new friends.
If you are at #BPS2026, come say hello, and make my day 🥰!!
#science 🧪 #biophysics #ionchannel #bps2026
If you are at #BPS2026, come say hello, and make my day 🥰!!
#science 🧪 #biophysics #ionchannel #bps2026
February 20, 2026 at 1:21 PM
After a safe, even if long, travel to SF yesterday, I am so looking forward to peeking into new discoveries, forging a positive future, reconnecting with brilliant minds, and making new friends.
If you are at #BPS2026, come say hello, and make my day 🥰!!
#science 🧪 #biophysics #ionchannel #bps2026
If you are at #BPS2026, come say hello, and make my day 🥰!!
#science 🧪 #biophysics #ionchannel #bps2026
Get your #Ionchannel abstracts in!
Late abstract submission is still open for #bps2025! Join your community in Los Angeles and get important feedback on your research! www.biophysics.org/2025meeting/...
The Biophysical Society > Meetings & Events > Annual Meeting > 2025 Annual Meeting > Abstracts
www.biophysics.org
December 16, 2024 at 7:57 PM
Get your #Ionchannel abstracts in!
We are currently advertising our AI #ionchannel modelling PhD Studentship. Fully funded (sadly only for UK based students). Please repost or mention to any potential victims hmmmm, *applicants* you know?
www.findaphd.com/phds/project...
Richardbj.bsky.social
www.findaphd.com/phds/project...
Richardbj.bsky.social
December 29, 2024 at 11:31 AM
We are currently advertising our AI #ionchannel modelling PhD Studentship. Fully funded (sadly only for UK based students). Please repost or mention to any potential victims hmmmm, *applicants* you know?
www.findaphd.com/phds/project...
Richardbj.bsky.social
www.findaphd.com/phds/project...
Richardbj.bsky.social
Our January issue is here ✨ https://buff.ly/3DFIr4N The cover shows agonist-induced #ionchannel opening of human NMDA receptors assayed using single channel outside-out patches to detect varied activation delays and failures. From Miaomiao He & @lwollmuth.bsky.social (https://buff.ly/3W6IQ6J).
January 6, 2025 at 3:04 PM
Our January issue is here ✨ https://buff.ly/3DFIr4N The cover shows agonist-induced #ionchannel opening of human NMDA receptors assayed using single channel outside-out patches to detect varied activation delays and failures. From Miaomiao He & @lwollmuth.bsky.social (https://buff.ly/3W6IQ6J).
@dablab.bsky.social team discovered that an #ionchannel - TRPC3 - drives the myogenic response in transitional #pericytes but not smooth muscle cells, making it a target to rescue abnormal #cerebrovascular flow in #neurodegeneration.
#neuroskyence #scicomm
#MedSky 🧪
www.science.org/doi/10.1126/...
#neuroskyence #scicomm
#MedSky 🧪
www.science.org/doi/10.1126/...
Increased luminal pressure in brain capillaries drives TRPC3-dependent depolarization and constriction of transitional pericytes
Blood flow into the cerebral microvasculature is regulated by TRPC3-dependent constriction of transitional pericytes.
www.science.org
April 30, 2025 at 2:52 AM
@dablab.bsky.social team discovered that an #ionchannel - TRPC3 - drives the myogenic response in transitional #pericytes but not smooth muscle cells, making it a target to rescue abnormal #cerebrovascular flow in #neurodegeneration.
#neuroskyence #scicomm
#MedSky 🧪
www.science.org/doi/10.1126/...
#neuroskyence #scicomm
#MedSky 🧪
www.science.org/doi/10.1126/...
Direct visualization of electric-field-stimulated ion conduction in a potassium #ionchannel - Cell https://buff.ly/3WfbsLe
January 12, 2025 at 11:39 AM
Direct visualization of electric-field-stimulated ion conduction in a potassium #ionchannel - Cell https://buff.ly/3WfbsLe
Nav1.7 structure and severe pain: join our next worldwide sodium channel seminar on March 25th by Goragot Wisedchaisri (Seattle, US) on the “Structural basis for severe pain caused by mutations in Nav1.7”
www.sodiumchannelseminars.org for link and infos. See you there!
#ionchannel #WSCS
www.sodiumchannelseminars.org for link and infos. See you there!
#ionchannel #WSCS
March 17, 2025 at 7:25 AM
Nav1.7 structure and severe pain: join our next worldwide sodium channel seminar on March 25th by Goragot Wisedchaisri (Seattle, US) on the “Structural basis for severe pain caused by mutations in Nav1.7”
www.sodiumchannelseminars.org for link and infos. See you there!
#ionchannel #WSCS
www.sodiumchannelseminars.org for link and infos. See you there!
#ionchannel #WSCS
How could simulations elucidate Nav1.5 #ionchannel blockers mechanism? | Journal of General Physiology | Rockefeller University Press https://buff.ly/4gTs9Em
January 13, 2025 at 6:28 PM
How could simulations elucidate Nav1.5 #ionchannel blockers mechanism? | Journal of General Physiology | Rockefeller University Press https://buff.ly/4gTs9Em
Mechanism of conductance control and neurosteroid binding in NMDA #IonChannel receptors | Nature
Sorry it is paywalled…. But look at the beautiful channels 🥲
www.nature.com/articles/s41...
Sorry it is paywalled…. But look at the beautiful channels 🥲
www.nature.com/articles/s41...
November 6, 2025 at 9:08 AM
Mechanism of conductance control and neurosteroid binding in NMDA #IonChannel receptors | Nature
Sorry it is paywalled…. But look at the beautiful channels 🥲
www.nature.com/articles/s41...
Sorry it is paywalled…. But look at the beautiful channels 🥲
www.nature.com/articles/s41...
The background sodium leak #ionchannel NALCN is a major controlling factor in pituitary cell excitability - Belal - The Journal of Physiology
https://physoc.onlinelibrary.wiley.com/doi/10.1113/JP284036?af=R
https://physoc.onlinelibrary.wiley.com/doi/10.1113/JP284036?af=R
December 4, 2024 at 11:39 AM
The background sodium leak #ionchannel NALCN is a major controlling factor in pituitary cell excitability - Belal - The Journal of Physiology
https://physoc.onlinelibrary.wiley.com/doi/10.1113/JP284036?af=R
https://physoc.onlinelibrary.wiley.com/doi/10.1113/JP284036?af=R
Identification of KCNE6, a new member of the KCNE family of potassium #ionchannel auxiliary subunits - PMC https://buff.ly/4gTfdxL
December 29, 2024 at 11:39 AM
Identification of KCNE6, a new member of the KCNE family of potassium #ionchannel auxiliary subunits - PMC https://buff.ly/4gTfdxL
A sodium #ionchannel mutant removes fast inactivation with the inactivation particle bound | Journal of General Physiology | Rockefeller University Press https://buff.ly/3OvarKD
November 30, 2024 at 11:39 AM
A sodium #ionchannel mutant removes fast inactivation with the inactivation particle bound | Journal of General Physiology | Rockefeller University Press https://buff.ly/3OvarKD