#Ischemia-reperfusion
LightNews LightNews
chemosensors.bsky.social
A great Chemical Science
by Jihong Liu "A multifunctional “three-in-one” fluorescent theranostic system for hepatic ischemia–reperfusion injury" doi.org/10.1039/D4SC...
A multifunctional “three-in-one” fluorescent theranostic system for hepatic ischemia–reperfusion injury
Hepatic ischemia–reperfusion injury (HIRI) is the main cause of postoperative liver dysfunction and liver failure. Traditional separation of HIRI diagnosis and therapy confers several disadvantages, i...
doi.org
November 18, 2024 at 2:59 PM
swilua.bsky.social
pubmed.ncbi.nlm.nih.gov/37181854/
Effect of crocin on experimental gastrocnemius muscle ischemia/reperfusion injury in rat - PubMed
Ischemia-reperfusion (IR) injury to the lower extremities causes damage to various tissues, notably the limbs. Because research in recent years have demonstrated that saffron and its components are useful in ischemic strokes, the goal of this study was to see whether Crocin (Cr), one of the active c …
pubmed.ncbi.nlm.nih.gov
March 20, 2026 at 8:55 PM
dribavet.bsky.social
Hier übrigens mal die ellenlange skills-and-expertise-Liste von Herrn Kleinschnitz. Quelle: ResearchGate

LongCovid sehe ich hier nicht.

PS: Der Nobelpreisträger, mit dem ich drei Papers veröffentlichte, sagte immer:
„Wer sich in mehr als 20 Themen als Experte darstellt, ist unseriös!“
Skills and expertise von Christoph Kleinschnitz: Reactive Oxygen Species • Neuroprotection • Free Radicals • Ischemia-Reperfusion Injury • Neurodegeneration • Free Radical Scavengers • Experimental Stroke • Neurology • Stroke • Cerebral Ischemia • Multiple Sclerosis • Neurological Diseases • Neurological Disorders • Clinical Neurology • Neurodegenerative Diseases • Stroke Imaging • Adult Neurology • Neurologic Examination • Neuroimaging • Blood Brain Barrier • Stroke Thrombolysis • Traumatic Brain Injury • Cerebrovascular Circulation • Neuroinflammation • Brain Diseases • Neurophysiology • Neuroradiology • Neurosurgery • Neuroimmunology • Movement Disorders • Demyelinating Diseases • Inflammatory Diseases • CNS Demyelinating Autoimmune Diseases • Transcranial Ultrasonography • Neuromuscular Disorders • Brain Ischemia
November 23, 2025 at 5:00 PM
tom-riffel.bsky.social
first result of our 18 color imaging of immune populations in lungs following is ischemia+reperfusion injury 🤩
first result of our 18 color imaging of immune populations in lungs following is ischemia+reperfusion injury 🤩
November 20, 2024 at 11:31 PM
chillslincoln79.bsky.social
Severe ischemia-reperfusion injury induces epigenetic inactivation of LHX1 in kidney progenitor cells after kidney transplantation.👩‍🔬🥼👨‍🔬🧪 #KidneyDisease #Transplant #NephSeq #Epigenetics #Ischemia

👇👇

www.amjtransplant.org/article/S160...
Severe ischemia-reperfusion injury induces epigenetic inactivation of LHX1 in kidney progenitor cells after kidney transplantation
Severe ischemia-reperfusion injury (IRI) causes acute and chronic kidney allograft damage. As therapeutic interventions to reduce damage are limited yet, research on how to promote kidney repair has g...
www.amjtransplant.org
November 23, 2024 at 10:08 AM
haoyin.bsky.social
A 5-day protocol to generate hiPSC 3D Vascular Organoid😎
ETV2▶️Endothelial Cell
NKX3.1▶️Mural Cell

👉Perfusable, arteriovenous network in vivo
👉⏫Reperfusion in mouse diabetic limb ischemia
👉⏫transplanted islet performance

@meleromartinlab.bsky.social #CellStemCell 2025
www.cell.com/cell-stem-ce...
December 14, 2025 at 12:53 PM
swilua.bsky.social
OK BUT WAIT

I STARTED MY AMARO ADVENTURE BECAUSE OF A SAFFRON AMARO AND HOW IT SEEMED TO HELP ME WALK BETTER
pubmed.ncbi.nlm.nih.gov Abstract v L Full text links Abstract Ischemia-reperfusion (IR) injury to the lower extremities cause damage to various tissues, notably the limbs. (Highlighted) Because research in recent years have demonstrated that saffron and its components are useful in ischemic strokes (end highlighted), the goal of this study was to see whether Crocin (Cr), one of the active constituents in saffron, could protect the gastrocnemius muscle from IR injury. A total number of 32 Sprague-Dawley rats were randomized into four groups randomly: control, Cr, IR, and IR + Cr. Xylazine and ketamine were used to anesthetize all of the rats. The left lower limbs of the other two groups were subjected to 2 hr of ischemia and 2 hr of reperfusion with tourniquet, with the exception of the control and Cr groups. Tumor necrosis factor alfa (TNF-a), interleukin 6 (IL-6), IL-1B, total antioxidant status (TAS) and total oxidant status (TOS) levels were assessed in the blood as well as muscle IL-6, IL1B, SOD1-2, catalase (CAT) and glutathione peroxidase (GPx) expression. According to the IR group,
March 20, 2026 at 8:55 PM
aliciakowaltowski.bsky.social
gist.science/paper/bio/10...
Caloric Restriction Promotes Ischemia/Reperfusion Cardioprotection Through Increased Mitochondrial Na+/Ca2+ Exchange — Plain-Language Explanation
The human heart is a tireless pump, but it is also a machine that can be damaged by its own restart. When a blockage cuts off blood flow to the heart, the…
gist.science
September 28, 2026 at 9:18 AM
novaforgelabs.bsky.social
New in peptide research: "BPC 157 in Rodent Ischemia-Reperfusion Injury: A Critical Review of Preclinical Evidence" (International journal of molecular sciences)
https://pubmed.ncbi.nlm.nih.gov/42794771/
#peptides #research
September 28, 2026 at 11:00 PM
biorxivpreprint.bsky.social
Sirt5 preserves cardiac function in ischemia-reperfusion injury by inhibiting ANT2 lactylation https://www.biorxiv.org/content/10.1101/2024.11.25.625148v1
Sirt5 preserves cardiac function in ischemia-reperfusion injury by inhibiting ANT2 lactylation https://www.biorxiv.org/content/10.1101/2024.11.25.625148v1
Myocardial ischemia-reperfusion (IR) injury is the most common type of heart disease. IR-disrupted m
www.biorxiv.org
November 26, 2024 at 4:00 PM
garrettfogo.bsky.social
Happy to share a large part of my PhD work that is now published in Autophagy!

www.tandfonline.com/doi/full/10....
Mitochondrial dynamics and quality control regulate proteostasis in neuronal ischemia-reperfusion
Mitochondrial damage and dysfunction are hallmarks of neuronal injury during cerebral ischemia-reperfusion (I/R). Critical mitochondrial functions including energy production and cell signaling are...
www.tandfonline.com
March 17, 2025 at 1:27 PM
biorxivpreprint.bsky.social
Spatial metabolomics reveals persistent localized niche-specific metabolic failure in kidneys following ischemia-reperfusion injury https://www.biorxiv.org/content/10.1101/2025.05.27.656326v1
June 1, 2025 at 7:45 PM
biorxivpreprint.bsky.social
Orally Delivered Milk-Derived Nanovesicles Loaded with Connexin 43 Peptides forTargeted Cardiac Ischemia-Reperfusion Therapy https://www.biorxiv.org/content/10.1101/2025.01.01.630994v1
January 2, 2025 at 6:46 PM
biomedicines.bsky.social
🫁 Could Maresin1 help protect transplanted lungs? This study found that Maresin1 reduced lung ischemia-reperfusion injury in a model by suppressing ferroptosis through PKA-Hippo-YAP signaling.
www.mdpi.com/2227-9059/13...
September 28, 2026 at 8:23 AM
biomedicines.bsky.social
New Study in Biomedicines!🚀 This study explored early vs. delayed meloxicam treatments in renal ischemia–reperfusion injury, highlighting key cell death pathways and ERK1/2 phosphorylation
www.mdpi.com/2227-9059/14...
September 28, 2026 at 8:23 AM
labwaggoner.bsky.social
ILC1 protect liver transplants from ischemia-reperfusion injury via IFN-γ
doi.org/10.1016/j.aj...
December 31, 2024 at 2:51 PM
natmetabolism.nature.com
Pentose phosphate pathway-derived NADPH facilitates physiological hypertrophy and alleviates ischemia–reperfusion injury in the heart
Nature Metabolism, Published online: 08 September 2026; doi:10.1038/s42255-026-01587-9NADPH derived from the pentose phosphate pathway is shown to mediate exercise-induced physiological cardiac hypertrophy and protect against damage caused by ischaemia–reperfusion injury.
dlvr.it
September 15, 2026 at 9:38 AM
kristleifur.bsky.social
HA-fa KÓ-schíí! Mjeeg gokkt KÓ-schíí.

Með öðrum orðum: Gera eins og litli Daði segir. Hafa kósí. Mjög gott kósí.

Breyta myrkri í stjörnur og kulda í heitan pott. Beita markvissum tæknilegum aðgerðum til að valda oxýtósínseytingu—kúri og söng—af því oxýtósín er bólgueyðandi.
Oxytocin ameliorates ischemia/reperfusion-induced injury by inhibiting mast cell degranulation and inflammation in the rat heart
Oxytocin (OT) has shown a cardioprotective effect on myocardial ischemia/reperfusion injury (MIRI). This study aimed to investigate whether the cardio…
www.sciencedirect.com
October 1, 2024 at 7:55 AM
ljwalport.bsky.social
🚨Looking to recruit a postdoc chemist/chemical biologist to join an exciting translational collaboration. Funded by Kidney Research UK we aim to develop new peptide-based therapeutics to alleviate innate immune complications in transplanted kidneys through preventing ischemia-reperfusion injury.🚨
December 17, 2024 at 4:10 PM
apatgiri.bsky.social
IMM protein ANT2 lactylation!!!

Sirt5 preserves cardiac function in ischemia-reperfusion injury by inhibiting ANT2 lactylation
November 26, 2024 at 4:17 PM
joycevaladares.bsky.social
Excited to share that at the annual MRC MBU symposium I was awarded best poster prize for my PhD project on Succinate Metabolism in Cardiac Ischemia/ Reperfusion Injury! Thanks to my lab, collaborators, and my PI Mike Murphy. @mitoredox.bsky.social
October 20, 2025 at 1:58 PM
2therescue.bsky.social
Bears parallels to weaning of cardiopulmonary bypass after resuscitation of the heart following ischemia-reperfusion damage. Some things take time.
June 10, 2025 at 5:38 AM
haoyin.bsky.social
Fibrillar collagen probe CNA35-Cy7 i.v. to monitor mouse kidney #Fibrosis (ischemia-reperfusion injury)

Can it be used for other organs in vivo?😄

#KidneyInt 2020
www.sciencedirect.com/science/arti...
May 8, 2024 at 3:52 AM
labwaggoner.bsky.social
CD94-targeted depletion reduces NK cells and attenuates mouse kidney ischemia-reperfusion injury and subsequent acute lung injury
www.sciencedirect.com/science/arti...
September 9, 2026 at 3:13 PM
csem.ch
Mitochondria transplantation holds promise for ischemia-reperfusion injury (>3M patients/yr).

cellvie + @csem.ch built an automated, standardized process—GMP-compliant + ready for CDMO transfer.

Phase I prep underway.

🔬 Thoughts from the #biotech / #celltherapy community?
📖 bit.ly/4mL5E7u
CSEM and cellvie bring mitochondria treatment one step closer to the clinic
cellvie and CSEM develop automated manufacturing for mitochondrial therapy, aiming to advance treatment of ischemia-reperfusion injury and benefit over 3 million patients annually.
bit.ly
September 3, 2025 at 7:47 AM