Isoniazid, ein Antibiotikum gegen Tuberkulose fällt bis April aus. Erst mal. Da hilft auch keine KI.
February 13, 2026 at 5:21 PM
Isoniazid, ein Antibiotikum gegen Tuberkulose fällt bis April aus. Erst mal. Da hilft auch keine KI.
The banana flavor relx pod tastes like the liquid form of isoniazid 😭😭😭
December 15, 2024 at 5:52 AM
The banana flavor relx pod tastes like the liquid form of isoniazid 😭😭😭
2/ Standard TB treatment takes at least 6 months of multiple antibiotics. The first-line drugs are:
•Isoniazid (INH)
•Rifampin (RIF)
•Pyrazinamide (PZA)
•Ethambutol (EMB)
Miss doses or stop early? The bacteria can mutate and become drug-resistant.
•Isoniazid (INH)
•Rifampin (RIF)
•Pyrazinamide (PZA)
•Ethambutol (EMB)
Miss doses or stop early? The bacteria can mutate and become drug-resistant.
February 6, 2025 at 5:16 AM
2/ Standard TB treatment takes at least 6 months of multiple antibiotics. The first-line drugs are:
•Isoniazid (INH)
•Rifampin (RIF)
•Pyrazinamide (PZA)
•Ethambutol (EMB)
Miss doses or stop early? The bacteria can mutate and become drug-resistant.
•Isoniazid (INH)
•Rifampin (RIF)
•Pyrazinamide (PZA)
•Ethambutol (EMB)
Miss doses or stop early? The bacteria can mutate and become drug-resistant.
The Impact of Isoniazid Preventive Therapy on Tuberculosis Infection and Disease Progression
✅ Just Accepted
🔗 https://bit.ly/4xLuh8Z
✅ Just Accepted
🔗 https://bit.ly/4xLuh8Z
August 19, 2026 at 1:45 AM
The Impact of Isoniazid Preventive Therapy on Tuberculosis Infection and Disease Progression
✅ Just Accepted
🔗 https://bit.ly/4xLuh8Z
✅ Just Accepted
🔗 https://bit.ly/4xLuh8Z
HEPATOTOXICITY AMONG PEOPLE LIVING WITH HIV AND RECEIVING ISONIAZID PREVENTIVE THERAPY IN PREGNANCY AND POSTPARTUM: THE ROLE OF ANTIRETROVIRAL REGIMEN AND PHARMACOGENETICS
✅ Just Accepted
#IDSky
✅ Just Accepted
#IDSky
Hepatotoxicity Among People Living with HIV and Receiving Isoniazid Preventive Therapy in Pregnancy and Postpartum: The Role of Antiretroviral Regimen and Pharmacogenetics
TB APPRISE (IMPAACT P1078), a Phase IV randomized, multi-country non-inferiority trial assessing the safety of 28 weeks of isoniazid preventive therapy (IPT) initiated during pregnancy (immediate IPT) versus deferring to week 12 postpartum (deferred IPT) in people living with HIV on antiretroviral therapy, showed higher than expected hepatotoxicity. We investigated the potential roles of antiretrovirals, isoniazid, pharmacogenetics and other factors.
doi.org
April 19, 2025 at 6:58 PM
HEPATOTOXICITY AMONG PEOPLE LIVING WITH HIV AND RECEIVING ISONIAZID PREVENTIVE THERAPY IN PREGNANCY AND POSTPARTUM: THE ROLE OF ANTIRETROVIRAL REGIMEN AND PHARMACOGENETICS
✅ Just Accepted
#IDSky
✅ Just Accepted
#IDSky
Isoniazid effectively reduces intestinal and systemic inflammation in a Crohn's disease model by limiting harmful microbial expansion.
by Stephens M, Keane K (...) von der Weid PY et 3 al. in J Crohns Colitis #MedSky
📖 read the article:
by Stephens M, Keane K (...) von der Weid PY et 3 al. in J Crohns Colitis #MedSky
📖 read the article:
Uncovering the therapeutic potential of anti-tuberculoid agent Isoniazid in a model of microbial-driven Crohn’s Disease
AbstractAims. TNFα has long stood as a hallmark feature of both inflammatory bowel disease (IBD) and arthritis with its therapeutic potential demonstrated
academic.oup.com
March 4, 2025 at 4:32 AM
Isoniazid effectively reduces intestinal and systemic inflammation in a Crohn's disease model by limiting harmful microbial expansion.
by Stephens M, Keane K (...) von der Weid PY et 3 al. in J Crohns Colitis #MedSky
📖 read the article:
by Stephens M, Keane K (...) von der Weid PY et 3 al. in J Crohns Colitis #MedSky
📖 read the article:
Three Months of Weekly Rifapentine and Isoniazid Versus Four Months of Daily Rifampicin for Tuberculosis Infection: A Randomized Controlled Trial
✅ Just Accepted
🔗 https://bit.ly/4o11Yje
✅ Just Accepted
🔗 https://bit.ly/4o11Yje
June 3, 2026 at 2:14 AM
Three Months of Weekly Rifapentine and Isoniazid Versus Four Months of Daily Rifampicin for Tuberculosis Infection: A Randomized Controlled Trial
✅ Just Accepted
🔗 https://bit.ly/4o11Yje
✅ Just Accepted
🔗 https://bit.ly/4o11Yje
Wait INH stands for isoniazid?
July 17, 2025 at 1:17 PM
Wait INH stands for isoniazid?
My father was one of the scientists who discovered Isoniazid in the 50s to treat TB. It’s a tragedy to see TB rise again in the US
January 28, 2025 at 3:45 AM
My father was one of the scientists who discovered Isoniazid in the 50s to treat TB. It’s a tragedy to see TB rise again in the US
New review article
Molecular diagnostic tests for isoniazid-resistant #tuberculosis: a scoping review
www.thelancet.com/journals/lan...
#IDSky #ClinMicro #TBSky #TB #AMR #OpenAccess #OA
Molecular diagnostic tests for isoniazid-resistant #tuberculosis: a scoping review
www.thelancet.com/journals/lan...
#IDSky #ClinMicro #TBSky #TB #AMR #OpenAccess #OA
March 20, 2026 at 1:42 PM
New review article
Molecular diagnostic tests for isoniazid-resistant #tuberculosis: a scoping review
www.thelancet.com/journals/lan...
#IDSky #ClinMicro #TBSky #TB #AMR #OpenAccess #OA
Molecular diagnostic tests for isoniazid-resistant #tuberculosis: a scoping review
www.thelancet.com/journals/lan...
#IDSky #ClinMicro #TBSky #TB #AMR #OpenAccess #OA
There is already a massive access issue for certain Tuberculosis medications (currently isoniazid, previously moxifloxacin) in the US that is being exacerbated by imported ingredient pricing.
This is almost certainly going to make that worse.
This is almost certainly going to make that worse.
I dunno but it should probably be a bigger deal that the White House announced it wants to slap a 100% tariff on drug imports at the same time it is eliminating Medicare drug subsidies. And we’re talking about critical life-saving drugs like insulin, blood thinners, antibiotics, and heart meds.
July 29, 2026 at 5:03 PM
There is already a massive access issue for certain Tuberculosis medications (currently isoniazid, previously moxifloxacin) in the US that is being exacerbated by imported ingredient pricing.
This is almost certainly going to make that worse.
This is almost certainly going to make that worse.
🔎 “Effectiveness of Isoniazid Preventive Treatment among Contacts of Multidrug-Resistant #Tuberculosis: A Systematic Review and Individual-Participant Meta-Analysis”
Open Access UCL Research: The Effectiveness of Isoniazid Preventive Treatment among Contacts of Multidrug-Resistant Tuberculosis: A Systematic Review and Individual-Participant Meta-Analysis discovery.ucl.ac.uk/id/eprint/10...
The Effectiveness of Isoniazid Preventive Treatment among Contacts of Multidrug-Resistant Tuberculosis: A Systematic Review and Individual-Participant Meta-Analysis
-
UCL Discover...
UCL Discovery is UCL's open access repository, showcasing and providing access to UCL research outputs from all UCL disciplines.
discovery.ucl.ac.uk
September 22, 2026 at 11:08 AM
🔎 “Effectiveness of Isoniazid Preventive Treatment among Contacts of Multidrug-Resistant #Tuberculosis: A Systematic Review and Individual-Participant Meta-Analysis”
Congratulations Professor Gwen Knight @gmknght.bsky.social, co-Director of @lshtmamrcentre.bsky.social and MRC Fellow, on promotion to Professor @lshtm.bsky.social - very richly deserved!
Read Gwen's latest work on AMR surveillance and modelling 🧫👩💻🌍
doi.org/10.1371/jour...
doi.org/10.1371/jour...
Read Gwen's latest work on AMR surveillance and modelling 🧫👩💻🌍
doi.org/10.1371/jour...
doi.org/10.1371/jour...
Mathematical models of drug-resistant tuberculosis lack bacterial heterogeneity: A systematic review
Author summary The emergence of drug-resistant tuberculosis (DR-TB), where the causative bacterium Mycobacterium tuberculosis is resistant to key antibiotics such as rifampicin and isoniazid, poses a ...
doi.org
December 11, 2024 at 7:36 AM
Congratulations Professor Gwen Knight @gmknght.bsky.social, co-Director of @lshtmamrcentre.bsky.social and MRC Fellow, on promotion to Professor @lshtm.bsky.social - very richly deserved!
Read Gwen's latest work on AMR surveillance and modelling 🧫👩💻🌍
doi.org/10.1371/jour...
doi.org/10.1371/jour...
Read Gwen's latest work on AMR surveillance and modelling 🧫👩💻🌍
doi.org/10.1371/jour...
doi.org/10.1371/jour...
47Y/M
Hypertension
Reformed smoker
Recurrent hemoptysis
Weight loss
Imaging report attached
MGIT Mycobacterium asiaticum in BAL specimen
RIF R
ISONIAZID R
ETHAMBUTOL R
MACROLIDE S
AMIKACIN S
LINEZOLID S
Please share your experience or advice on management
NTM PD MOTT
Hypertension
Reformed smoker
Recurrent hemoptysis
Weight loss
Imaging report attached
MGIT Mycobacterium asiaticum in BAL specimen
RIF R
ISONIAZID R
ETHAMBUTOL R
MACROLIDE S
AMIKACIN S
LINEZOLID S
Please share your experience or advice on management
NTM PD MOTT
November 16, 2024 at 10:04 AM
47Y/M
Hypertension
Reformed smoker
Recurrent hemoptysis
Weight loss
Imaging report attached
MGIT Mycobacterium asiaticum in BAL specimen
RIF R
ISONIAZID R
ETHAMBUTOL R
MACROLIDE S
AMIKACIN S
LINEZOLID S
Please share your experience or advice on management
NTM PD MOTT
Hypertension
Reformed smoker
Recurrent hemoptysis
Weight loss
Imaging report attached
MGIT Mycobacterium asiaticum in BAL specimen
RIF R
ISONIAZID R
ETHAMBUTOL R
MACROLIDE S
AMIKACIN S
LINEZOLID S
Please share your experience or advice on management
NTM PD MOTT
We see patterns of seasonal infections that are within the normal range. We see immunity, good antibody and T cell responses, etc.
In an attempt to stay relevant, the cult keeps cherry-picking data, such as a local outbreak of TB. This happens as reported before
wwwnc.cdc.gov/eid/ar...
4/6
In an attempt to stay relevant, the cult keeps cherry-picking data, such as a local outbreak of TB. This happens as reported before
wwwnc.cdc.gov/eid/ar...
4/6
Response to Isoniazid-Resistant Tuberculosis in Homeless Shelters, Georgia, USA, 2015–2017
Response to Isoniazid-Resistant TB, Georgia
wwwnc.cdc.gov
February 6, 2025 at 11:47 AM
We see patterns of seasonal infections that are within the normal range. We see immunity, good antibody and T cell responses, etc.
In an attempt to stay relevant, the cult keeps cherry-picking data, such as a local outbreak of TB. This happens as reported before
wwwnc.cdc.gov/eid/ar...
4/6
In an attempt to stay relevant, the cult keeps cherry-picking data, such as a local outbreak of TB. This happens as reported before
wwwnc.cdc.gov/eid/ar...
4/6
Discovery of gene functions in #Mycobacterium #tuberculosis has been slow. This study tests a genome-wide barcoded #transposon library across 95 environmental conditions, providing a rich resource of new gene functions, including metabolic & resistance pathways @plosbiology.org 🧪 plos.io/4vG0mz1
April 17, 2026 at 7:55 AM
Discovery of gene functions in #Mycobacterium #tuberculosis has been slow. This study tests a genome-wide barcoded #transposon library across 95 environmental conditions, providing a rich resource of new gene functions, including metabolic & resistance pathways @plosbiology.org 🧪 plos.io/4vG0mz1
Carl Muschenheim was born #OTD in 1905. He won a #LaskerAward in 1955 for establishing the efficacy of isoniazid drugs in the treatment of #tuberculosis. 🧪
#TB
https://ow.ly/euFC50Y8A4k
#TB
https://ow.ly/euFC50Y8A4k
February 4, 2026 at 3:40 PM
Carl Muschenheim was born #OTD in 1905. He won a #LaskerAward in 1955 for establishing the efficacy of isoniazid drugs in the treatment of #tuberculosis. 🧪
#TB
https://ow.ly/euFC50Y8A4k
#TB
https://ow.ly/euFC50Y8A4k
#IDSky #HIV #Tuberculosis Our team completed a PK study of adults with advanced HIV taking once-daily dolutegravir and fluconazole alongside 🧬1HP (1-month daily isoniazid + rifapentine) 📊
Once-Daily Dolutegravir–Based Antiretroviral Therapy Among Adults With Advanced HIV Disease Receiving 1 Month of Daily Rifapentine and Isoniazid for Tuberculosis-Preventive Therapy and Fluconazole for...
Among adults treated for HIV-associated cryptococcosis, coadministration of 1-month daily isoniazid/rifapentine (1HP) modestly reduced dolutegravir trough
academic.oup.com
August 18, 2026 at 1:17 PM
#IDSky #HIV #Tuberculosis Our team completed a PK study of adults with advanced HIV taking once-daily dolutegravir and fluconazole alongside 🧬1HP (1-month daily isoniazid + rifapentine) 📊
🫁 Edward Robitzek, a lung expert, won a #LaskerAward in 1955 for establishing the efficacy of isoniazid drugs in the treatment of #tuberculosis. Discover more: http://ow.ly/Nar350CfQCe
#MedSky #SciSky 🧪
#MedSky #SciSky 🧪
March 9, 2026 at 6:05 PM
🫁 Edward Robitzek, a lung expert, won a #LaskerAward in 1955 for establishing the efficacy of isoniazid drugs in the treatment of #tuberculosis. Discover more: http://ow.ly/Nar350CfQCe
#MedSky #SciSky 🧪
#MedSky #SciSky 🧪
Have seen other cases of BCGosis but not prostate abscess
Will treat with isoniazid/rifampicin/ethambutol as M.bovis is intrinsically resistant to pyrazinamide
Will treat with isoniazid/rifampicin/ethambutol as M.bovis is intrinsically resistant to pyrazinamide
November 30, 2024 at 11:46 PM
Have seen other cases of BCGosis but not prostate abscess
Will treat with isoniazid/rifampicin/ethambutol as M.bovis is intrinsically resistant to pyrazinamide
Will treat with isoniazid/rifampicin/ethambutol as M.bovis is intrinsically resistant to pyrazinamide
Can we improve TB preventive therapy (TPT) for those with advanced HIV? 🏥
A new phase-3 trial from @drboulware.bsky.social and colleagues evaluated two strategies for the 1-month 1HP (rifapentine + isoniazid) regimen in patients with cryptococcal meningitis. #IDSky
A new phase-3 trial from @drboulware.bsky.social and colleagues evaluated two strategies for the 1-month 1HP (rifapentine + isoniazid) regimen in patients with cryptococcal meningitis. #IDSky
Inpatient initiation of tuberculosis preventive therapy with 1 month of isoniazid and rifapentine for adults with advanced HIV disease and cryptococcal meningitis (IMPROVE): a non-inferiority, randomi...
1HP initiation before hospital discharge was non-inferior to outpatient initiation
among adults with AHD and cryptococcosis. These data suggest that following exclusion
of active tuberculosis disease,...
www.thelancet.com
February 10, 2026 at 8:28 PM
Can we improve TB preventive therapy (TPT) for those with advanced HIV? 🏥
A new phase-3 trial from @drboulware.bsky.social and colleagues evaluated two strategies for the 1-month 1HP (rifapentine + isoniazid) regimen in patients with cryptococcal meningitis. #IDSky
A new phase-3 trial from @drboulware.bsky.social and colleagues evaluated two strategies for the 1-month 1HP (rifapentine + isoniazid) regimen in patients with cryptococcal meningitis. #IDSky
Ethionamide has been used to treat tuberculosis for decades, but dose-dependent toxic effects have limited its use. In a new trial, alpibectir enabled the ethionamide dose to be reduced by two thirds. Full trial results: nej.md/46PP9Rn
#MedSky #IDSky
#MedSky #IDSky
February 22, 2026 at 6:30 PM
Ethionamide has been used to treat tuberculosis for decades, but dose-dependent toxic effects have limited its use. In a new trial, alpibectir enabled the ethionamide dose to be reduced by two thirds. Full trial results: nej.md/46PP9Rn
#MedSky #IDSky
#MedSky #IDSky
Fixed-Dose Rifapentine–Isoniazid (1HP) for Tuberculosis Preventive Treatment in Chinese Adults: A Prospective Real-World Safety and Pharmacokinetic Study
✅ Just Accepted
🔗 https://bit.ly/4ucANnm
✅ Just Accepted
🔗 https://bit.ly/4ucANnm
May 1, 2026 at 2:16 AM
Fixed-Dose Rifapentine–Isoniazid (1HP) for Tuberculosis Preventive Treatment in Chinese Adults: A Prospective Real-World Safety and Pharmacokinetic Study
✅ Just Accepted
🔗 https://bit.ly/4ucANnm
✅ Just Accepted
🔗 https://bit.ly/4ucANnm
TB is treated with antibiotics. The length of treatment depends on the type of TB.
Active TB-Usually treated with a combination of 3 or more antibiotics for 6–9 months or longer
Latent or Inactive TB-Usually treated with a 6–12 month course of isoniazid
Active TB-Usually treated with a combination of 3 or more antibiotics for 6–9 months or longer
Latent or Inactive TB-Usually treated with a 6–12 month course of isoniazid
January 28, 2025 at 2:07 PM
TB is treated with antibiotics. The length of treatment depends on the type of TB.
Active TB-Usually treated with a combination of 3 or more antibiotics for 6–9 months or longer
Latent or Inactive TB-Usually treated with a 6–12 month course of isoniazid
Active TB-Usually treated with a combination of 3 or more antibiotics for 6–9 months or longer
Latent or Inactive TB-Usually treated with a 6–12 month course of isoniazid
New trial @plosmedicine.org shows that one month of self-administered daily rifapentine and isoniazid (1HP) in people without HIV infection is safe and has high completion rates
journals.plos.org/plosmedicine...
journals.plos.org/plosmedicine...
Acceptability and safety of one versus three months of rifapentine and isoniazid to prevent tuberculosis in people exposed in the household or workplace in Brazil: The Ultra-Curto randomized controlle...
In a multi-center, randomized controlled trial, Betina Durovni and colleagues assess the acceptability and safety of a short-course tuberculosis preventive therapy taken daily or weekly for different ...
journals.plos.org
February 13, 2026 at 11:47 AM
New trial @plosmedicine.org shows that one month of self-administered daily rifapentine and isoniazid (1HP) in people without HIV infection is safe and has high completion rates
journals.plos.org/plosmedicine...
journals.plos.org/plosmedicine...