Just finished a marathon JC on an impressive paper just out in @cp-devcell.bsky.social from Antoine Peters' lab. Key (and cool!) takeaway: kdm2a/b matKO leads to extensive oocyte DNA hypermethylation. Embryonic development phenotype suppressed with Dnmt3a matKO www.cell.com/developmenta...
Preventing CpG hypermethylation in oocytes safeguards mouse development
Kawamura et al. show that H3K36me2 removal by the KDM2A and KDM2B histone demethylases
restricts DNMT3A in establishing global DNA methylation in oocytes. Maternal Kdm2a/Kdm2b
knockout embryos die dur...
www.cell.com
September 12, 2025 at 10:20 AM
Just finished a marathon JC on an impressive paper just out in @cp-devcell.bsky.social from Antoine Peters' lab. Key (and cool!) takeaway: kdm2a/b matKO leads to extensive oocyte DNA hypermethylation. Embryonic development phenotype suppressed with Dnmt3a matKO www.cell.com/developmenta...
In a new study, FMI researchers show that two enzymes—KDM2A and KDM2B—act as safeguards in eggs, preventing excessive DNA methylation at gene regions. Without them, abnormal methylation is passed to embryos, repressing genes needed for early development. www.cell.com/developmenta...
Preventing CpG hypermethylation in oocytes safeguards mouse development
Kawamura et al. show that H3K36me2 removal by the KDM2A and KDM2B histone demethylases
restricts DNMT3A in establishing global DNA methylation in oocytes. Maternal Kdm2a/Kdm2b
knockout embryos die dur...
www.cell.com
September 2, 2025 at 3:54 PM
In a new study, FMI researchers show that two enzymes—KDM2A and KDM2B—act as safeguards in eggs, preventing excessive DNA methylation at gene regions. Without them, abnormal methylation is passed to embryos, repressing genes needed for early development. www.cell.com/developmenta...
RESEARCH | Y Wang, H Xie, Q Liu, CY Wang et al. (HUST, CN)
#Kdm2a demethylates #H3K36me2 to mediate fast-to-slow-twitch #myofiber transition and reshape #SkeletalMuscle metabolic flexibility under #metabolic stress conditions
#Kdm2a demethylates #H3K36me2 to mediate fast-to-slow-twitch #myofiber transition and reshape #SkeletalMuscle metabolic flexibility under #metabolic stress conditions
Kdm2a inhibition in skeletal muscle improves metabolic flexibility in obesity - Nature Metabolism
Kdm2a demethylates H3K36me2 to mediate fast-to-slow-twitch myofiber transition and reshape skeletal muscle metabolic flexibility under metabolic stress conditions.
bit.ly
March 22, 2025 at 6:02 PM
RESEARCH | Y Wang, H Xie, Q Liu, CY Wang et al. (HUST, CN)
#Kdm2a demethylates #H3K36me2 to mediate fast-to-slow-twitch #myofiber transition and reshape #SkeletalMuscle metabolic flexibility under #metabolic stress conditions
#Kdm2a demethylates #H3K36me2 to mediate fast-to-slow-twitch #myofiber transition and reshape #SkeletalMuscle metabolic flexibility under #metabolic stress conditions
The histone H3 lysine 36 demethylase KDM2A/FBXL11 controls Polycomb-mediated gene repression and germ cell development in male mice www.nature.com/articles/s4...
July 24, 2025 at 2:15 PM
The histone H3 lysine 36 demethylase KDM2A/FBXL11 controls Polycomb-mediated gene repression and germ cell development in male mice www.nature.com/articles/s4...
Epigenetics Update - The histone H3 lysine 36 demethylase KDM2A/FBXL11 controls Polycomb-mediated gene repression and germ cell development in male mice go.nature.com/4lPspqq
#Epigenetics #KDM2A #GermCells #Polycomb
---
High-resolution insights without cell sorting; epigenometech.com
#Epigenetics #KDM2A #GermCells #Polycomb
---
High-resolution insights without cell sorting; epigenometech.com
August 6, 2025 at 12:33 PM
Epigenetics Update - The histone H3 lysine 36 demethylase KDM2A/FBXL11 controls Polycomb-mediated gene repression and germ cell development in male mice go.nature.com/4lPspqq
#Epigenetics #KDM2A #GermCells #Polycomb
---
High-resolution insights without cell sorting; epigenometech.com
#Epigenetics #KDM2A #GermCells #Polycomb
---
High-resolution insights without cell sorting; epigenometech.com
Just out: Structure and mechanism of inhibition of lysine demethylase 2A (KDM2A) by compound 183c
Structure and mechanism of inhibition of lysine demethylase 2A (KDM2A) by compound 183c
Communications Chemistry, Published online: 27 June 2026; doi:10.1038/s42004-026-02100-9Lysine demethylase 2A (KDM2A) is a critical epigenetic regulator and a promising target for cancers dependent on Alternative Lengthening of Telomeres (ALT). Here, the authors elucidate the mechanism of compound 183c, a potent KDM2A inhibitor, revealing the cofactor 2-oxoglutarate dependent binding to the H3K36me2 substrate pocket, demonstrating its efficacy in selectively inhibiting ALT-positive cancer cell proliferation.
dlvr.it
June 27, 2026 at 8:34 PM
Just out: Structure and mechanism of inhibition of lysine demethylase 2A (KDM2A) by compound 183c
💡A recent study revealed how epigenetic modifications regulate skeletal muscle. Inhibiting Kdm2, a histone 3 demethylase, in the SKM of HFD-fed mice shifts fuel from glucose to lipids, increases slow-twitch fibers, and protects against HFD-induced metabolic disorders.
www.nature.com/articles/s42...
www.nature.com/articles/s42...
Kdm2a inhibition in skeletal muscle improves metabolic flexibility in obesity - Nature Metabolism
Kdm2a demethylates H3K36me2 to mediate fast-to-slow-twitch myofiber transition and reshape skeletal muscle metabolic flexibility under metabolic stress conditions.
www.nature.com
February 4, 2025 at 3:25 PM
💡A recent study revealed how epigenetic modifications regulate skeletal muscle. Inhibiting Kdm2, a histone 3 demethylase, in the SKM of HFD-fed mice shifts fuel from glucose to lipids, increases slow-twitch fibers, and protects against HFD-induced metabolic disorders.
www.nature.com/articles/s42...
www.nature.com/articles/s42...
RESEARCH BRIEFING | Y Wang, H Xie, Q Liu, N Wang, S Zhang, H Yin, W Kong, CY Wang et al. (HUST, CN)
#KDM2A loss in #skeletal #muscle confers flexible protection against #metabolic stress
#KDM2A loss in #skeletal #muscle confers flexible protection against #metabolic stress
Epigenetic modification increases skeletal muscle resilience to metabolic stress - Nature Metabolism
bit.ly
March 23, 2025 at 6:03 PM
RESEARCH BRIEFING | Y Wang, H Xie, Q Liu, N Wang, S Zhang, H Yin, W Kong, CY Wang et al. (HUST, CN)
#KDM2A loss in #skeletal #muscle confers flexible protection against #metabolic stress
#KDM2A loss in #skeletal #muscle confers flexible protection against #metabolic stress
📣 New from Anderson et al!
📄De novo variants in KDM2A cause a syndromic neurodevelopmental disorder
📄De novo variants in KDM2A cause a syndromic neurodevelopmental disorder
De novo variants in KDM2A cause a syndromic neurodevelopmental disorder
De novo variants in KDM2A cause a syndromic neurodevelopmental disorder with a phenotypic
spectrum of mild to severe developmental delay, feeding difficulties, short stature,
microcephaly, and recurre...
www.cell.com
January 2, 2026 at 3:23 PM
📣 New from Anderson et al!
📄De novo variants in KDM2A cause a syndromic neurodevelopmental disorder
📄De novo variants in KDM2A cause a syndromic neurodevelopmental disorder
New #NatMetabolism paper: Kdm2a inhibition in skeletal muscle improves metabolic flexibility in obesity. #MyoBlue tinyurl.com/2nxfhtup
Kdm2a inhibition in skeletal muscle improves metabolic flexibility in obesity - Nature Metabolism
Kdm2a demethylates H3K36me2 to mediate fast-to-slow-twitch myofiber transition and reshape skeletal muscle metabolic flexibility under metabolic stress conditions.
tinyurl.com
January 27, 2025 at 4:50 PM
New #NatMetabolism paper: Kdm2a inhibition in skeletal muscle improves metabolic flexibility in obesity. #MyoBlue tinyurl.com/2nxfhtup
Epigenetics Update - Kdm2a inhibition in skeletal muscle improves metabolic flexibility in obesity bit.ly/3WDgKQN
A Nature Metabolism article supports Kdm2a as a viable target against metabolic stress
#Epigenetics #Metabolism #Stress
---
High-res insight without cell sorting; epigenome.us
A Nature Metabolism article supports Kdm2a as a viable target against metabolic stress
#Epigenetics #Metabolism #Stress
---
High-res insight without cell sorting; epigenome.us
Kdm2a inhibition in skeletal muscle improves metabolic flexibility in obesity - Nature Metabolism
Kdm2a demethylates H3K36me2 to mediate fast-to-slow-twitch myofiber transition and reshape skeletal muscle metabolic flexibility under metabolic stress conditions.
bit.ly
January 29, 2025 at 3:04 PM
Epigenetics Update - Kdm2a inhibition in skeletal muscle improves metabolic flexibility in obesity bit.ly/3WDgKQN
A Nature Metabolism article supports Kdm2a as a viable target against metabolic stress
#Epigenetics #Metabolism #Stress
---
High-res insight without cell sorting; epigenome.us
A Nature Metabolism article supports Kdm2a as a viable target against metabolic stress
#Epigenetics #Metabolism #Stress
---
High-res insight without cell sorting; epigenome.us
Discussed @mrsantos.bsky.social lit review: Preventing CpG hypermethylation in oocytes safeguards mouse development. www.cell.com/developmenta...
Preventing CpG hypermethylation in oocytes safeguards mouse development
Kawamura et al. show that H3K36me2 removal by the KDM2A and KDM2B histone demethylases
restricts DNMT3A in establishing global DNA methylation in oocytes. Maternal Kdm2a/Kdm2b
knockout embryos die dur...
www.cell.com
October 15, 2025 at 2:23 PM
Discussed @mrsantos.bsky.social lit review: Preventing CpG hypermethylation in oocytes safeguards mouse development. www.cell.com/developmenta...
Out now in @natmetabolism.bsky.social
KDM2A loss in skeletal muscle shifts fuel use from glucose to lipids in mice under HFD by increasing the proportion of mitochondria-rich slow-twitch myofibers, which protects mice against metabolic stress.
rdcu.be/d7GbF
KDM2A loss in skeletal muscle shifts fuel use from glucose to lipids in mice under HFD by increasing the proportion of mitochondria-rich slow-twitch myofibers, which protects mice against metabolic stress.
rdcu.be/d7GbF
Kdm2a inhibition in skeletal muscle improves metabolic flexibility in obesity
Nature Metabolism - Kdm2a demethylates H3K36me2 to mediate fast-to-slow-twitch myofiber transition and reshape skeletal muscle metabolic flexibility under metabolic stress conditions.
rdcu.be
January 27, 2025 at 4:20 PM
Out now in @natmetabolism.bsky.social
KDM2A loss in skeletal muscle shifts fuel use from glucose to lipids in mice under HFD by increasing the proportion of mitochondria-rich slow-twitch myofibers, which protects mice against metabolic stress.
rdcu.be/d7GbF
KDM2A loss in skeletal muscle shifts fuel use from glucose to lipids in mice under HFD by increasing the proportion of mitochondria-rich slow-twitch myofibers, which protects mice against metabolic stress.
rdcu.be/d7GbF
Wonderfully in depth study on how DNA methylation is directed in mouse oocytes and the developmental consequences of misguiding methylation activity
www.cell.com/developmenta...
www.cell.com/developmenta...
Preventing CpG hypermethylation in oocytes safeguards mouse development
Kawamura et al. show that H3K36me2 removal by the KDM2A and KDM2B histone demethylases
restricts DNMT3A in establishing global DNA methylation in oocytes. Maternal Kdm2a/Kdm2b
knockout embryos die dur...
www.cell.com
September 5, 2025 at 7:32 AM
Wonderfully in depth study on how DNA methylation is directed in mouse oocytes and the developmental consequences of misguiding methylation activity
www.cell.com/developmenta...
www.cell.com/developmenta...
The authors included RRIDs in their in The American Journal of Human Genetics paper! We value the author's support of reproducibility. #STMpublishing #OpenScience #accelerateopenscience
De novo variants in KDM2A cause a syndromic neurodevelopmental disorder
Read the full paper: De novo variants in KDM2A cause a syndromic neurodevelopmental disorder
doi.org
February 26, 2026 at 7:52 PM
The authors included RRIDs in their in The American Journal of Human Genetics paper! We value the author's support of reproducibility. #STMpublishing #OpenScience #accelerateopenscience
...to partition PGSs and test the same 144 hits for interactions with partitioned scores. We identify 12 interactions, including one between the strongest T2D-associated SNP found to date (at TCF7L2) and the KDM2A TF for HbA1c levels. KDM2A has been found to interact physically with TCF7L2 within...
November 24, 2025 at 5:13 PM
...to partition PGSs and test the same 144 hits for interactions with partitioned scores. We identify 12 interactions, including one between the strongest T2D-associated SNP found to date (at TCF7L2) and the KDM2A TF for HbA1c levels. KDM2A has been found to interact physically with TCF7L2 within...
SBGrid's eLife paper received a citation in July from frank sicheri from @utoronto.ca in @natcomms.nature.com:
Structure and mechanism of inhibition of lysine demethylase 2A (KDM2A) by compound 183c.
Read more here: buff.ly/7caT1d5
#SBGrid #StayConnected
Structure and mechanism of inhibition of lysine demethylase 2A (KDM2A) by compound 183c.
Read more here: buff.ly/7caT1d5
#SBGrid #StayConnected
Structure and mechanism of inhibition of lysine demethylase 2A (KDM2A) by compound 183c - Communications Chemistry
Lysine demethylase 2A (KDM2A) is a critical epigenetic regulator and a promising target for cancers dependent on Alternative Lengthening of Telomeres (ALT). Here, the authors elucidate the mechanism…
www.nature.com
August 31, 2026 at 4:05 PM
SBGrid's eLife paper received a citation in July from frank sicheri from @utoronto.ca in @natcomms.nature.com:
Structure and mechanism of inhibition of lysine demethylase 2A (KDM2A) by compound 183c.
Read more here: buff.ly/7caT1d5
#SBGrid #StayConnected
Structure and mechanism of inhibition of lysine demethylase 2A (KDM2A) by compound 183c.
Read more here: buff.ly/7caT1d5
#SBGrid #StayConnected
RRIDs were included in this Rxiv paper. Thanks for making your methods matter! #methodsmatter #methodsmatter #accelerateopenscience
De novo variants in KDM2A cause a syndromic neurodevelopmental disorder
doi.org
May 21, 2025 at 7:00 AM
RRIDs were included in this Rxiv paper. Thanks for making your methods matter! #methodsmatter #methodsmatter #accelerateopenscience
📢 Out in AJHG:
De novo KDM2A variants cause a syndromic neurodevelopmental disorder. Functional assays and methylation data support this novel gene–disease association.
#RareDisease #NDD #EpiSignature
www.cell.com/ajhg/fulltex...
De novo KDM2A variants cause a syndromic neurodevelopmental disorder. Functional assays and methylation data support this novel gene–disease association.
#RareDisease #NDD #EpiSignature
www.cell.com/ajhg/fulltex...
www.cell.com
January 2, 2026 at 10:30 AM
📢 Out in AJHG:
De novo KDM2A variants cause a syndromic neurodevelopmental disorder. Functional assays and methylation data support this novel gene–disease association.
#RareDisease #NDD #EpiSignature
www.cell.com/ajhg/fulltex...
De novo KDM2A variants cause a syndromic neurodevelopmental disorder. Functional assays and methylation data support this novel gene–disease association.
#RareDisease #NDD #EpiSignature
www.cell.com/ajhg/fulltex...
This research revealed an epigenetic-metabolic circuit wherein CDK13-mediated nuclear pore reprogramming via KDM2A phosphorylation and NUP93 activation drives cholesterol metabolism and metastasis in pancreatic ductal adenocarcinoma (PDAC). Read more: www.sciencedirect.com/science/arti...
September 13, 2026 at 10:04 AM
This research revealed an epigenetic-metabolic circuit wherein CDK13-mediated nuclear pore reprogramming via KDM2A phosphorylation and NUP93 activation drives cholesterol metabolism and metastasis in pancreatic ductal adenocarcinoma (PDAC). Read more: www.sciencedirect.com/science/arti...
The histone H3 lysine 36 demethylase KDM2A/FBXL11 controls Polycomb-mediated gene repression and germ cell development in male mice.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
The histone H3 lysine 36 demethylase KDM2A/FBXL11 controls Polycomb-mediated gene repression and germ cell development in male mice - Nature Communications
Here, the authors show that KDM2A regulates cell cycle progression, modulation of H3K36me2 and H3K27me3 chromatin states and gene repression which are critical for survival of differentiating spermato...
www.nature.com
August 7, 2025 at 7:30 AM
The histone H3 lysine 36 demethylase KDM2A/FBXL11 controls Polycomb-mediated gene repression and germ cell development in male mice.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
De novo variants in KDM2A cause a syndromic neurodevelopmental disorder #RareDisease #Genetics #morbidgene www.cell.com/ajhg/fulltex...
December 29, 2025 at 7:34 PM
De novo variants in KDM2A cause a syndromic neurodevelopmental disorder #RareDisease #Genetics #morbidgene www.cell.com/ajhg/fulltex...
De novo variants in KDM2A cause a syndromic neurodevelopmental disorder
#Drosophila
#Drosophila
De novo variants in KDM2A cause a syndromic neurodevelopmental disorder
#Drosophila
PubMed link
pubmed.ncbi.nlm.nih.gov
December 31, 2025 at 6:23 AM
De novo variants in KDM2A cause a syndromic neurodevelopmental disorder
#Drosophila
#Drosophila
De novo variants in KDM2A cause a syndromic neurodevelopmental disorder
#Drosophila
#Drosophila
De novo variants in <em>KDM2A</em> cause a syndromic neurodevelopmental disorder
#Drosophila
PubMed link
pubmed.ncbi.nlm.nih.gov
April 16, 2025 at 10:23 AM
De novo variants in KDM2A cause a syndromic neurodevelopmental disorder
#Drosophila
#Drosophila