Arabidopsis WALL-ASSOCIATED KINASES are not required for oligogalacturonide-induced signaling and immunity
Arabidopsis WALL-ASSOCIATED KINASES are not required for oligogalacturonide-induced signaling and immunity
Analysis of Arabidopsis mutants shows that WALL-ASSOCIATED KINASES are dispensable for oligogalacturonide (OG)-induced signaling and immunity, questioning
academic.oup.com
December 12, 2024 at 8:24 PM
Arabidopsis WALL-ASSOCIATED KINASES are not required for oligogalacturonide-induced signaling and immunity
pYtags - our in vivo biosensors for receptor tyrosine kinases - in all their beauty on the cover of Cell Reports! Read more here: www.cell.com/cell-reports...
July 22, 2025 at 8:52 PM
pYtags - our in vivo biosensors for receptor tyrosine kinases - in all their beauty on the cover of Cell Reports! Read more here: www.cell.com/cell-reports...
Excited to share that our work building in vivo biosensors for receptor tyrosine kinases (pYtags!) is now out www.cell.com/cell-reports...
July 1, 2025 at 1:58 PM
Excited to share that our work building in vivo biosensors for receptor tyrosine kinases (pYtags!) is now out www.cell.com/cell-reports...
Now out in Science! Cyclin-dependent kinases (CDKs) are key regulators of the cell cycle. In @vcushing.bsky.social's magnum opus, we use #cryoEM to figure out how the CDK-activating kinase recognises CDKs to fully activate them - a key step in cell cycle control.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Structural basis of T-loop–independent recognition and activation of CDKs by the CDK-activating kinase
Cyclin-dependent kinases (CDKs) are prototypical regulators of the cell cycle. The CDK-activating kinase (CAK) acts as a master regulator of CDK activity by catalyzing the activating phosphorylation o...
www.science.org
October 16, 2025 at 7:17 PM
Now out in Science! Cyclin-dependent kinases (CDKs) are key regulators of the cell cycle. In @vcushing.bsky.social's magnum opus, we use #cryoEM to figure out how the CDK-activating kinase recognises CDKs to fully activate them - a key step in cell cycle control.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Over 50 yrs since the discovery of protein kinases, 80% of human kinases still have ≤20 known substrates, and many are “dark.” I'm EXCITED to announce our new work towards solving this- combining (1) deep learning with (2) proximity proteomics in vivo! ➡️
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
April 28, 2025 at 10:00 PM
Over 50 yrs since the discovery of protein kinases, 80% of human kinases still have ≤20 known substrates, and many are “dark.” I'm EXCITED to announce our new work towards solving this- combining (1) deep learning with (2) proximity proteomics in vivo! ➡️
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
The final version of our study on SERK-BIR module in Marchantia is out.
Congratulations Cate and many thanks to collaborators!
www.sciencedirect.com/science/arti...
Congratulations Cate and many thanks to collaborators!
www.sciencedirect.com/science/arti...
April 17, 2025 at 3:23 PM
The final version of our study on SERK-BIR module in Marchantia is out.
Congratulations Cate and many thanks to collaborators!
www.sciencedirect.com/science/arti...
Congratulations Cate and many thanks to collaborators!
www.sciencedirect.com/science/arti...
Conservation and divergence in the allosteric architectures of five human protein kinases. Excited to share our new preprint by @carlafolgado.bsky.social @tonibeltran.bsky.social @sangerinstitute.bsky.social @crg.eu @ibv-csic.bsky.social
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
Conservation and divergence in the allosteric architectures of five human protein kinases
Protein kinases are central to biological regulation, dysregulated in many diseases, and the targets of a hundred clinically-approved drugs. Structural conservation of kinase active sites makes the de...
www.biorxiv.org
August 9, 2026 at 8:58 AM
Conservation and divergence in the allosteric architectures of five human protein kinases. Excited to share our new preprint by @carlafolgado.bsky.social @tonibeltran.bsky.social @sangerinstitute.bsky.social @crg.eu @ibv-csic.bsky.social
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
@yichangsung.bsky.social gave a great talk on tandem kinases for the UC Davis Plant Path seminar.
February 2, 2026 at 6:03 PM
@yichangsung.bsky.social gave a great talk on tandem kinases for the UC Davis Plant Path seminar.
New preprint 🚨 We systematically measured 17 million phospho-specific dose-response curves (133 kinase inhibitors × 5 cell lines) to decrypt the kinases that shape the human phosphoproteome. We show that drug perturbation potency (not effect size) links kinases to substrates while controlling FDR.
Did you ever come across a phosphosite in your proteomics data for which nothing was known? - I bet so!
We have developed a new strategy termed "potency coherence analysis" that leverages the drug potency dimension in decryptM to decode the kinases that shape the human phosphoproteome.
Read more:
We have developed a new strategy termed "potency coherence analysis" that leverages the drug potency dimension in decryptM to decode the kinases that shape the human phosphoproteome.
Read more:
Chemical proteomics decrypts the kinases that shape the dynamic human phosphoproteome
Mass-spectrometry-based phosphoproteomics enables the analysis of thousands of protein phosphorylation events across the human proteome. However, there is a lack of scalable, hypothesis-free, and stat...
doi.org
November 20, 2025 at 11:59 AM
New preprint 🚨 We systematically measured 17 million phospho-specific dose-response curves (133 kinase inhibitors × 5 cell lines) to decrypt the kinases that shape the human phosphoproteome. We show that drug perturbation potency (not effect size) links kinases to substrates while controlling FDR.
But also - gulp - there's a whole regulatory layer involving phosphorylation of RNA polymerase too (the enzymes that reads and transcribes DNA) by kinase enzymes. And there are seemingly many more of these transcriptional kinases than we thought.
www.cell.com/molecular-ce...
www.cell.com/molecular-ce...
Transcriptional kinases drive gene expression network plasticity
Gene expression in human cells is programatically controlled for normal growth, development,
and responses to the environment. Beyond known cyclin-dependent kinases, other overlooked
kinases and facto...
www.cell.com
September 17, 2026 at 5:02 PM
But also - gulp - there's a whole regulatory layer involving phosphorylation of RNA polymerase too (the enzymes that reads and transcribes DNA) by kinase enzymes. And there are seemingly many more of these transcriptional kinases than we thought.
www.cell.com/molecular-ce...
www.cell.com/molecular-ce...
It’s Isabel Monte @Isabel_MonteG @ZMBP_Tuebingen today @TheSainsburyLab
“Evolution of Receptor Kinases in land plants: from immunity to development”
“Evolution of Receptor Kinases in land plants: from immunity to development”
May 16, 2025 at 1:51 PM
It’s Isabel Monte @Isabel_MonteG @ZMBP_Tuebingen today @TheSainsburyLab
“Evolution of Receptor Kinases in land plants: from immunity to development”
“Evolution of Receptor Kinases in land plants: from immunity to development”
A microscopy-based screen identifies cellular kinases modulating mitochondrial translation
www.cell.com/cell-reports...
www.cell.com/cell-reports...
A microscopy-based screen identifies cellular kinases modulating mitochondrial translation
Mitochondrial DNA encodes 13 OXPHOS subunits, which are synthesized inside the organelle. To address how mitochondrial gene expression integrates into cellular physiology, Yousefi et al. established a fluorescence-based high-throughput screen for mitochondrial translation, combining fluorescent labeling of mitochondrial translation products with siRNA-mediated knockdown. This work identifies kinases affecting mitochondrial translation.
www.cell.com
January 1, 2025 at 6:46 PM
A microscopy-based screen identifies cellular kinases modulating mitochondrial translation
www.cell.com/cell-reports...
www.cell.com/cell-reports...
Genetic Diversity, Predictive Protein Structures, and Interaction Networks of Cysteine-Rich Receptor-Like Kinases in Arabidopsis thaliana | Computational and Structural Biotechnology Journal spj.science.org/doi/10.34133...
Genetic Diversity, Predictive Protein Structures, and Interaction Networks of Cysteine-Rich Receptor-Like Kinases in Arabidopsis thaliana | Computational and Structural Biotechnology Journal
Cysteine-rich receptor-like kinases (CRKs) are a large subfamily of plant receptor-like kinases implicated in immunity and development, yet their ligands, interaction partners, and mechanistic roles r...
spj.science.org
April 8, 2026 at 2:17 PM
Genetic Diversity, Predictive Protein Structures, and Interaction Networks of Cysteine-Rich Receptor-Like Kinases in Arabidopsis thaliana | Computational and Structural Biotechnology Journal spj.science.org/doi/10.34133...
Agree completely. This looks like a variation on good ol' staurosporine, which hits half the kinases known to man. This compound is great news, but surely not because it's some sort of selective inhibitor.
Can't argue with clinical trial results.
But if this compound is acting selectively through GSK3-beta, I'll... be beyond surprised.
pubs.acs.org/doi/10.1021/...
But if this compound is acting selectively through GSK3-beta, I'll... be beyond surprised.
pubs.acs.org/doi/10.1021/...
April 20, 2026 at 2:42 AM
Agree completely. This looks like a variation on good ol' staurosporine, which hits half the kinases known to man. This compound is great news, but surely not because it's some sort of selective inhibitor.
wait, wait, what 😱
Direct targeting and regulation of RNA polymerase II by cell signaling kinases in @science.org
www.science.org/doi/10.1126/...
Direct targeting and regulation of RNA polymerase II by cell signaling kinases in @science.org
www.science.org/doi/10.1126/...
November 7, 2025 at 8:32 AM
wait, wait, what 😱
Direct targeting and regulation of RNA polymerase II by cell signaling kinases in @science.org
www.science.org/doi/10.1126/...
Direct targeting and regulation of RNA polymerase II by cell signaling kinases in @science.org
www.science.org/doi/10.1126/...
And next up we have @yichangsung.bsky.social from @gittacoaker.bsky.social lab talking about tandem kinases … #strompath25
November 26, 2025 at 10:55 PM
And next up we have @yichangsung.bsky.social from @gittacoaker.bsky.social lab talking about tandem kinases … #strompath25
So proud of this work with @rolanddunbrack.bsky.social! Did a lot of new structural bioinformatics of substrate-bound kinases and came up with updated criteria for classifying structures as active. Also made active models of all 437 human catalytic kinases, available here: dunbrack.fccc.edu/kincore
February 23, 2026 at 11:15 PM
So proud of this work with @rolanddunbrack.bsky.social! Did a lot of new structural bioinformatics of substrate-bound kinases and came up with updated criteria for classifying structures as active. Also made active models of all 437 human catalytic kinases, available here: dunbrack.fccc.edu/kincore
Phosphorylation depends both on the sequence and on spatial proximity in vivo between kinases and their substrates.
Both of these factors are accounted for in this preprint
1/2
Both of these factors are accounted for in this preprint
1/2
May 10, 2025 at 1:18 PM
Phosphorylation depends both on the sequence and on spatial proximity in vivo between kinases and their substrates.
Both of these factors are accounted for in this preprint
1/2
Both of these factors are accounted for in this preprint
1/2
#REVIEW 🚨
Brooke Emerling & Co @sbpdiscovery.bsky.social @bemerling.bsky.social summarize the roles of phosphatidylinositol 4-kinases #PI4Ks and phosphatidylinositol phosphate kinases #PIPKs in cancer.
📖 ⬇️
Brooke Emerling & Co @sbpdiscovery.bsky.social @bemerling.bsky.social summarize the roles of phosphatidylinositol 4-kinases #PI4Ks and phosphatidylinositol phosphate kinases #PIPKs in cancer.
📖 ⬇️
Phosphoinositide kinases in cancer: from molecular mechanisms to therapeutic opportunities - Nature Reviews Cancer
In this Review, Emerling and colleagues summarize the roles of phosphatidylinositol 4-kinases (PI4Ks) and phosphatidylinositol phosphate kinases (PIPKs) in cancer. They highlight the altered expression of these kinases in tumours and discuss ongoing efforts in developing therapies targeting these lesser-studied phosphoinositide kinase families.
bit.ly
April 16, 2025 at 1:42 PM
#REVIEW 🚨
Brooke Emerling & Co @sbpdiscovery.bsky.social @bemerling.bsky.social summarize the roles of phosphatidylinositol 4-kinases #PI4Ks and phosphatidylinositol phosphate kinases #PIPKs in cancer.
📖 ⬇️
Brooke Emerling & Co @sbpdiscovery.bsky.social @bemerling.bsky.social summarize the roles of phosphatidylinositol 4-kinases #PI4Ks and phosphatidylinositol phosphate kinases #PIPKs in cancer.
📖 ⬇️
Chemical proteomics decrypts the kinases that shape the dynamic human phosphoproteome https://www.biorxiv.org/content/10.1101/2025.11.18.689017v1
November 18, 2025 at 11:03 PM
Chemical proteomics decrypts the kinases that shape the dynamic human phosphoproteome https://www.biorxiv.org/content/10.1101/2025.11.18.689017v1
✍️ The Pintard Lab ( @ccdlab.bsky.social ) published a new article
📖 @embojournal.org
📃 Molecular basis for the activation of Aurora A and Plk1 kinases during mitotic entry
🔗 link.springer.com/article/10.1...
📖 @embojournal.org
📃 Molecular basis for the activation of Aurora A and Plk1 kinases during mitotic entry
🔗 link.springer.com/article/10.1...
January 30, 2026 at 9:22 AM
✍️ The Pintard Lab ( @ccdlab.bsky.social ) published a new article
📖 @embojournal.org
📃 Molecular basis for the activation of Aurora A and Plk1 kinases during mitotic entry
🔗 link.springer.com/article/10.1...
📖 @embojournal.org
📃 Molecular basis for the activation of Aurora A and Plk1 kinases during mitotic entry
🔗 link.springer.com/article/10.1...
First post 🤠 If you want to discuss about the evolution of receptor kinases signaling pathways in land plants, please pass by my Poster (n° 306) #ICAR2025
June 18, 2025 at 2:04 PM
First post 🤠 If you want to discuss about the evolution of receptor kinases signaling pathways in land plants, please pass by my Poster (n° 306) #ICAR2025
2 papers in @science.org this week uncover wheat tandem kinase function. Working in parallel, the authors of each paper show that two different tandem kinases converge to activate the same NLR!
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
#PlantScience
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
#PlantScience
A wheat tandem kinase activates an NLR to trigger immunity
The role of nucleotide-binding leucine-rich repeat (NLR) receptors in plant immunity is well studied, but the function of a class of tandem kinases (TKs) that confer disease resistance in wheat and ba...
www.science.org
March 30, 2025 at 3:18 PM
2 papers in @science.org this week uncover wheat tandem kinase function. Working in parallel, the authors of each paper show that two different tandem kinases converge to activate the same NLR!
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
#PlantScience
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
#PlantScience