Across 711K biobank participants, loss-of-function variants had longer QT intervals and more LQTS diagnoses. Dominant-negative variants also showed greater enrichment in LQTS cases than haploinsufficient variants, linking molecular mechanism to disease risk.
October 21, 2026 at 6:00 PM
Across 711K biobank participants, loss-of-function variants had longer QT intervals and more LQTS diagnoses. Dominant-negative variants also showed greater enrichment in LQTS cases than haploinsufficient variants, linking molecular mechanism to disease risk.
Long QT syndrome is a life-threatening cardiac arrhythmia for which current therapies don’t correct the molecular defect
Alfred L. George, Jr. & team now identify the first trafficking corrector for KCNQ1 mutations that cause LQTS: doi.org/10.1172/jci....
Alfred L. George, Jr. & team now identify the first trafficking corrector for KCNQ1 mutations that cause LQTS: doi.org/10.1172/jci....
March 17, 2026 at 11:01 AM
Long QT syndrome is a life-threatening cardiac arrhythmia for which current therapies don’t correct the molecular defect
Alfred L. George, Jr. & team now identify the first trafficking corrector for KCNQ1 mutations that cause LQTS: doi.org/10.1172/jci....
Alfred L. George, Jr. & team now identify the first trafficking corrector for KCNQ1 mutations that cause LQTS: doi.org/10.1172/jci....
By Bryan May of Queen: www.youtube.com/watch?v=LqTS...
Ford - Advert - Everything We Do (Is Driven by You) - (1991)
YouTube video by ROVR
www.youtube.com
June 21, 2026 at 11:30 AM
By Bryan May of Queen: www.youtube.com/watch?v=LqTS...
くそがきしゃかいか見学
music.youtube.com/watch?v=LqTs...
music.youtube.com/watch?v=LqTs...
Mot Mot Mot - GameApp「SHOW BY ROCK!! Fes A Live」
YouTube video by Criticrista - Topic
music.youtube.com
July 22, 2026 at 9:23 PM
くそがきしゃかいか見学
music.youtube.com/watch?v=LqTs...
music.youtube.com/watch?v=LqTs...
宇佐美がいいやつ(ちゃんと返事をこまめに返してくれる)でレオスと笹が意気投合してるの良かったしリゼ様が一生かわいそおもろい
www.youtube.com/watch?v=lQTs...
www.youtube.com/watch?v=lQTs...
にじさんじ甲子園2025 ドラフト会議【 #にじ甲2025 】
YouTube video by にじさんじ
www.youtube.com
June 15, 2025 at 12:43 PM
宇佐美がいいやつ(ちゃんと返事をこまめに返してくれる)でレオスと笹が意気投合してるの良かったしリゼ様が一生かわいそおもろい
www.youtube.com/watch?v=lQTs...
www.youtube.com/watch?v=lQTs...
New publication: SGK1-inhibition restores cardiac repolarization in LQT2 rabbits and LQT3 mice by reducing late sodium current. Congratulations to the authors!
pubmed.ncbi.nlm.nih.gov/41991141/
#CVRCBern @odeninglab.bsky.social
pubmed.ncbi.nlm.nih.gov/41991141/
#CVRCBern @odeninglab.bsky.social
SGK1-inhibition restores cardiac repolarization in LQT2 rabbits and LQT3 mice by reducing late sodium current - PubMed
Current management does not fully prevent arrhythmias in long QT syndrome (LQTS), underscoring a need for novel therapies. Here, we investigated potential beneficial effects of serum/glucocorticoid-re...
pubmed.ncbi.nlm.nih.gov
June 25, 2026 at 5:10 AM
New publication: SGK1-inhibition restores cardiac repolarization in LQT2 rabbits and LQT3 mice by reducing late sodium current. Congratulations to the authors!
pubmed.ncbi.nlm.nih.gov/41991141/
#CVRCBern @odeninglab.bsky.social
pubmed.ncbi.nlm.nih.gov/41991141/
#CVRCBern @odeninglab.bsky.social
New publication: Beneficial action potential duration–shortening effects, but deleterious negative inotropism of IKs-activator docosahexaenoyl glycine in long QT syndrome type 2. Congratulations to the authors!
pubmed.ncbi.nlm.nih.gov/40794559/
#CVRCBern
pubmed.ncbi.nlm.nih.gov/40794559/
#CVRCBern
Beneficial action potential duration-shortening effects, but deleterious negative inotropism of IKs-activator docosahexaenoyl glycine in long QT syndrome type 2 - PubMed
DHA-gly-induced IKs enhancement shows promising results in shortening APD/QT in LQT2 rabbits, while having no effect on LQT1 (impaired IKs). However, its adverse effect on cardiac contractility, even in LQT1, makes it unsuitable to treat LQTS patients. Our study highlights the importance of consider …
pubmed.ncbi.nlm.nih.gov
November 5, 2025 at 12:42 PM
New publication: Beneficial action potential duration–shortening effects, but deleterious negative inotropism of IKs-activator docosahexaenoyl glycine in long QT syndrome type 2. Congratulations to the authors!
pubmed.ncbi.nlm.nih.gov/40794559/
#CVRCBern
pubmed.ncbi.nlm.nih.gov/40794559/
#CVRCBern
Interested in pursuing a PhD in cellular cardiac electrophysiology in the beautiful City of Bern? There are two open PhD student positions on #precision #mechanism-based therapies in #LQTS.
April 10, 2025 at 11:33 AM
Interested in pursuing a PhD in cellular cardiac electrophysiology in the beautiful City of Bern? There are two open PhD student positions on #precision #mechanism-based therapies in #LQTS.
📰 #neuropsychiatrie
Management challenges in delirium in genetically confirmed long QT syndrome: a case report and discussion.
#Delirium #qtc #psychiatry
link.springer.com/article/10.1...
Management challenges in delirium in genetically confirmed long QT syndrome: a case report and discussion.
#Delirium #qtc #psychiatry
link.springer.com/article/10.1...
Management challenges in delirium in genetically confirmed long QT syndrome: a case report and discussion - neuropsychiatrie
Background Treating delirium in adolescents with congenital long QT syndrome (LQTS) demands agents that do not aggravate ventricular repolarisation. Case summary A 15-year-old girl with genetically co...
link.springer.com
January 24, 2026 at 4:29 AM
📰 #neuropsychiatrie
Management challenges in delirium in genetically confirmed long QT syndrome: a case report and discussion.
#Delirium #qtc #psychiatry
link.springer.com/article/10.1...
Management challenges in delirium in genetically confirmed long QT syndrome: a case report and discussion.
#Delirium #qtc #psychiatry
link.springer.com/article/10.1...
his comprehensive analysis not only advances understanding of KCNQ1 variant pathogenicity but also highlights the urgent need for better predictive tools and mechanism-based therapies to improve outcomes for patients with LQT1.
#Cardiology #LQTS #CellBiology
#Cardiology #LQTS #CellBiology
February 20, 2025 at 2:49 PM
his comprehensive analysis not only advances understanding of KCNQ1 variant pathogenicity but also highlights the urgent need for better predictive tools and mechanism-based therapies to improve outcomes for patients with LQT1.
#Cardiology #LQTS #CellBiology
#Cardiology #LQTS #CellBiology
Med. student Anna Leppänen from @uniuef.bsky.social wanted to do a review on the effectiveness of ECG screening for prolonged QTc in neonates. Ilari Kuitunen and I helped a bit. Read the results here www.heartrhythmjournal.com/article/S154...
Consequences of electrocardiography screening for prolonged QTc in neonates – A systematic review
An ongoing discussion has been the effectiveness of neonatal ECG screening for long
QT syndrome (LQTS).
www.heartrhythmjournal.com
March 4, 2025 at 5:22 PM
Med. student Anna Leppänen from @uniuef.bsky.social wanted to do a review on the effectiveness of ECG screening for prolonged QTc in neonates. Ilari Kuitunen and I helped a bit. Read the results here www.heartrhythmjournal.com/article/S154...
November 17, 2024 at 9:56 PM
Ikustea, entzutea, informazioa eta lengoaia prozesatzea edo gure bihotzak taupada etengabeak egitea, besteak beste, organismoko zelulen arteko komunikazio-gaitasunaren ondorio da.
zientziakaiera.eus/2025/03/06/b...
zientziakaiera.eus/2025/03/06/b...
Bihotzeko QT luzearen sindromea, hERG kanaleko mutazioek sortutako kanalopatia - Zientzia Kaiera
QT luzearen sindromeak (ingelesezko sigletan, LQTS) bi motatakoak izan daitezke: hartutakoa eta sortzetikoa.
zientziakaiera.eus
March 6, 2025 at 7:37 PM
Ikustea, entzutea, informazioa eta lengoaia prozesatzea edo gure bihotzak taupada etengabeak egitea, besteak beste, organismoko zelulen arteko komunikazio-gaitasunaren ondorio da.
zientziakaiera.eus/2025/03/06/b...
zientziakaiera.eus/2025/03/06/b...
Finally, we can take advantage of the generative aspects of the VAE by averaging neighbor traits and decode this to predict candidate trait/disease gene. Essentially, transferring information from related traits. We explore this in mode detail for heart rhythm disorder - Long QT Syndrome (LQTS).
January 29, 2026 at 8:12 AM
Finally, we can take advantage of the generative aspects of the VAE by averaging neighbor traits and decode this to predict candidate trait/disease gene. Essentially, transferring information from related traits. We explore this in mode detail for heart rhythm disorder - Long QT Syndrome (LQTS).
I now feel the need for this. Apologies. www.youtube.com/watch?v=LqTS...
Ford - Advert - Everything We Do (Is Driven by You) - (1991)
YouTube video by ROVR
www.youtube.com
June 30, 2026 at 10:51 AM
I now feel the need for this. Apologies. www.youtube.com/watch?v=LqTS...
Uzun QT sendromu (Long QT Syndrome - LQTS), kalp ritminde görülen anormal bir elektriksel aktivite ile karakterize edilen nadir fakat potansiyel olarak ölümcül bir kardiyovasküler bozukluktur.
www.aligurtuna.com/uzun-qt-send...
www.aligurtuna.com/uzun-qt-send...
Uzun QT sendromu (Long QT Syndrome - LQTS)
Uzun QT sendromu (Long QT Syndrome - LQTS) - Kalp ve Damar Sağlığı (Kardiyoloji) hakkında kapsamlı, güvenilir sağlık bilgisi ve tedavi rehberi için tıklayın!
www.aligurtuna.com
October 2, 2024 at 10:23 AM
Uzun QT sendromu (Long QT Syndrome - LQTS), kalp ritminde görülen anormal bir elektriksel aktivite ile karakterize edilen nadir fakat potansiyel olarak ölümcül bir kardiyovasküler bozukluktur.
www.aligurtuna.com/uzun-qt-send...
www.aligurtuna.com/uzun-qt-send...
I have LQTS Type 1... My Dad did (likely what killed his Dad) my brother has it, all 4 of my boys inherited it... thankfully ours is pretty controllable with knowledge, medication and awareness to make lifestyle changes or activity decisions.
#lqts #longqtsyndrome #longqt #mymutation #canibeanxmen
#lqts #longqtsyndrome #longqt #mymutation #canibeanxmen
February 24, 2025 at 3:41 AM
I have LQTS Type 1... My Dad did (likely what killed his Dad) my brother has it, all 4 of my boys inherited it... thankfully ours is pretty controllable with knowledge, medication and awareness to make lifestyle changes or activity decisions.
#lqts #longqtsyndrome #longqt #mymutation #canibeanxmen
#lqts #longqtsyndrome #longqt #mymutation #canibeanxmen
Fresh #lilyandfoxnails tonight… Crazy Love. It is Heart Month so I wear hearts for #longqtsyndrome #lqts I have Type 1. #heartmonth #hearthealthmonth #nails #nailsnailsnails #nailwraps #selfcare @lilyandfox
February 14, 2025 at 3:34 AM
Fresh #lilyandfoxnails tonight… Crazy Love. It is Heart Month so I wear hearts for #longqtsyndrome #lqts I have Type 1. #heartmonth #hearthealthmonth #nails #nailsnailsnails #nailwraps #selfcare @lilyandfox
Heart Health Month...
I have LongQTSyndrome Type 1
#hearthealthmonth #lqts #lomngqtsydrome #getchecked #heart #hearthealth
I have LongQTSyndrome Type 1
#hearthealthmonth #lqts #lomngqtsydrome #getchecked #heart #hearthealth
February 9, 2025 at 11:10 PM
Heart Health Month...
I have LongQTSyndrome Type 1
#hearthealthmonth #lqts #lomngqtsydrome #getchecked #heart #hearthealth
I have LongQTSyndrome Type 1
#hearthealthmonth #lqts #lomngqtsydrome #getchecked #heart #hearthealth
Fresh #lilyandfoxnails tonight… I’ll Be Yours. It is Heart Month so I wear hearts for #longqtsyndrome #lqts I have Type 1. #heartmonth #hearthealthmonth #nails #nailsnailsnails #nailwraps #selfcare #lilyandfox
February 2, 2025 at 7:44 AM
Fresh #lilyandfoxnails tonight… I’ll Be Yours. It is Heart Month so I wear hearts for #longqtsyndrome #lqts I have Type 1. #heartmonth #hearthealthmonth #nails #nailsnailsnails #nailwraps #selfcare #lilyandfox