Anthropic says its biology lab has already found something big
Anthropic says its biology lab has already found something big
But maybe the biggest reveal is that Anthropic has not let Claude run lose in its biology lab. Humans are still, so far, in the loop.
techcrunch.com
September 23, 2026 at 10:19 PM
Anthropic says its biology lab has already found something big
Anthropic says its biology lab has already found something big
The AI giant announced that this lab has already made what it believes is a big discovery: a new enzyme “system” that has certain properties reminiscent of CRISPR,”
The AI giant announced that this lab has already made what it believes is a big discovery: a new enzyme “system” that has certain properties reminiscent of CRISPR,”
Anthropic says its biology lab has already found something big | TechCrunch
But maybe the biggest reveal is that Anthropic has not let Claude run loose in its biology lab. Humans are still, so far, in the loop.
techcrunch.com
September 24, 2026 at 3:19 PM
Anthropic says its biology lab has already found something big
The AI giant announced that this lab has already made what it believes is a big discovery: a new enzyme “system” that has certain properties reminiscent of CRISPR,”
The AI giant announced that this lab has already made what it believes is a big discovery: a new enzyme “system” that has certain properties reminiscent of CRISPR,”
Photos from the #HandsOff protest and march in the downtown Chicago Loop! It was insanely packed. Panoramic shot and other favorites. 3/X
April 5, 2025 at 11:16 PM
Photos from the #HandsOff protest and march in the downtown Chicago Loop! It was insanely packed. Panoramic shot and other favorites. 3/X
Finding one mutation that improves a protein is hard. Finding five that work together is exponentially harder.
Today in @science.org, Hsu and Konermann labs present MULTI-evolve, a lab-in-the-loop framework that does it in just one machine learning-guided round.
Today in @science.org, Hsu and Konermann labs present MULTI-evolve, a lab-in-the-loop framework that does it in just one machine learning-guided round.
February 19, 2026 at 7:51 PM
Finding one mutation that improves a protein is hard. Finding five that work together is exponentially harder.
Today in @science.org, Hsu and Konermann labs present MULTI-evolve, a lab-in-the-loop framework that does it in just one machine learning-guided round.
Today in @science.org, Hsu and Konermann labs present MULTI-evolve, a lab-in-the-loop framework that does it in just one machine learning-guided round.
The Thinking Machines Lab founder and former CTO of OpenAI tells WIRED she isn’t interested in automating people out of jobs. Instead, she’s building AI that can collaborate. www.wired.com/story/mira-m...
Mira Murati Wants Her AI to ‘Keep Humans in the Loop’
The Thinking Machines Lab founder and former CTO of OpenAI tells WIRED she isn’t interested in automating people out of jobs. Instead, she’s building AI that can collaborate.
www.wired.com
May 15, 2026 at 9:06 AM
The Thinking Machines Lab founder and former CTO of OpenAI tells WIRED she isn’t interested in automating people out of jobs. Instead, she’s building AI that can collaborate. www.wired.com/story/mira-m...
recycling this classic from my twt
July 24, 2025 at 3:12 PM
recycling this classic from my twt
Prescient has preprinted their lab-in-the-loop workflow for antibody design, which discusses how candidate antibodies discovered in transgenic mice are iteratively improved using multi-parameter optimization and active learning
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Lab-in-the-loop therapeutic antibody design with deep learning
Therapeutic antibody design is a complex multi-property optimization problem that traditionally relies on expensive search through sequence space. Here, we introduce "Lab-in-the-loop," a paradigm shif...
www.biorxiv.org
February 25, 2025 at 6:29 AM
Prescient has preprinted their lab-in-the-loop workflow for antibody design, which discusses how candidate antibodies discovered in transgenic mice are iteratively improved using multi-parameter optimization and active learning
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
This work just out in Science Advances by Tom Sexton’s lab (to which Mariano Barbieri from our lab contributed modeling data) is a thorough demonstration of how extrusion- and transcription-centric interactions are predominantly antagonistic. Must read!
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Transcription processes compete with loop extrusion to homogenize promoter and enhancer dynamics
Gene promoters and enhancers share the same constrained mobilities during transcription, opposing cohesin-mediated loop extrusion.
www.science.org
December 14, 2024 at 9:23 AM
This work just out in Science Advances by Tom Sexton’s lab (to which Mariano Barbieri from our lab contributed modeling data) is a thorough demonstration of how extrusion- and transcription-centric interactions are predominantly antagonistic. Must read!
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
#Bugtorweek Day 5
Dragonfly 💡 Intellect
Innovation - Community - Lab
Did you know?: Dragonflies connect their bodies into a loop when mating, sometimes forming the shape of a heart.
Dragonfly 💡 Intellect
Innovation - Community - Lab
Did you know?: Dragonflies connect their bodies into a loop when mating, sometimes forming the shape of a heart.
June 26, 2026 at 3:13 PM
#Bugtorweek Day 5
Dragonfly 💡 Intellect
Innovation - Community - Lab
Did you know?: Dragonflies connect their bodies into a loop when mating, sometimes forming the shape of a heart.
Dragonfly 💡 Intellect
Innovation - Community - Lab
Did you know?: Dragonflies connect their bodies into a loop when mating, sometimes forming the shape of a heart.
Between the Ears: A Circular History of the Loop in binaural ambisonic mix!
Produced, edited and sound design by GSA visiting tutor Angus McIntyre, Ambisonic mix by MDes Sound for the Moving Image lead Ronan Breslin & mixed in our ambisonic sound lab in Glasgow.
www.bbc.co.uk/sounds/play/...
Produced, edited and sound design by GSA visiting tutor Angus McIntyre, Ambisonic mix by MDes Sound for the Moving Image lead Ronan Breslin & mixed in our ambisonic sound lab in Glasgow.
www.bbc.co.uk/sounds/play/...
Between the Ears - A Circular History of the Loop - BBC Sounds
An immersive exploration into the history of the music loop.
www.bbc.co.uk
September 23, 2026 at 1:35 PM
Between the Ears: A Circular History of the Loop in binaural ambisonic mix!
Produced, edited and sound design by GSA visiting tutor Angus McIntyre, Ambisonic mix by MDes Sound for the Moving Image lead Ronan Breslin & mixed in our ambisonic sound lab in Glasgow.
www.bbc.co.uk/sounds/play/...
Produced, edited and sound design by GSA visiting tutor Angus McIntyre, Ambisonic mix by MDes Sound for the Moving Image lead Ronan Breslin & mixed in our ambisonic sound lab in Glasgow.
www.bbc.co.uk/sounds/play/...
The original sin of software development
July 31, 2026 at 6:05 AM
The original sin of software development
(1/n) Excited to present the latest work from the de Wit lab, where we identify and characterise loop extrusion-mediated fountains in mammalian genomes using acute depletion of 3D genome regulators: doi.org/10.1093/nar/.... A Bluetorial🧵:
Extrusion fountains are restricted by WAPL-dependent cohesin release and CTCF barriers
Abstract. Interphase chromosomes are mainly shaped by loop extrusion and compartmentalisation mechanisms. However, their temporal component and cause-effec
doi.org
July 1, 2025 at 6:34 AM
(1/n) Excited to present the latest work from the de Wit lab, where we identify and characterise loop extrusion-mediated fountains in mammalian genomes using acute depletion of 3D genome regulators: doi.org/10.1093/nar/.... A Bluetorial🧵:
Thrilled to share a new important study from the lab, published today in @nature.com, showing how cohesin mediates efficient replication fork plasticity and stress response, using its loop extrusion activity to promote 3D contacts on replicating DNA:
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Cohesin reshapes replication fork contacts to aid fork slowing and reversal - Nature
Cohesin-mediated loop extrusion limits sister-fork coupling and tethers nearby replication forks under replication stress, promoting fork reversal and slowing fork progression to safeguard genome...
www.nature.com
September 16, 2026 at 4:04 PM
Thrilled to share a new important study from the lab, published today in @nature.com, showing how cohesin mediates efficient replication fork plasticity and stress response, using its loop extrusion activity to promote 3D contacts on replicating DNA:
www.nature.com/articles/s41...
www.nature.com/articles/s41...
We’ve wasted years on this. Instead of having a real discussion about how we failed with COVID, we’ve been stuck in a death loop of humoring right wing hysteria over the lab, over school closures, over lockdowns.
1.2 million Americans died. These fuckers tried to claim they weren’t in real time!
1.2 million Americans died. These fuckers tried to claim they weren’t in real time!
May 14, 2025 at 1:50 PM
We’ve wasted years on this. Instead of having a real discussion about how we failed with COVID, we’ve been stuck in a death loop of humoring right wing hysteria over the lab, over school closures, over lockdowns.
1.2 million Americans died. These fuckers tried to claim they weren’t in real time!
1.2 million Americans died. These fuckers tried to claim they weren’t in real time!
Extraction shooters are the video game equivalent of The Purge, which means they're designed in a lab to be the most toxic genre imaginable but I can't deny a certain satisfaction in the gameplay loop.
March 1, 2026 at 12:04 PM
Extraction shooters are the video game equivalent of The Purge, which means they're designed in a lab to be the most toxic genre imaginable but I can't deny a certain satisfaction in the gameplay loop.
Hey. I made a game for the #GMTKJam!
It's called Loop Lab. it's a point-and-click adventure game where you're stuck in a time loop in a laboratory.
Go play it and vote on it.
————————————————————
itch.io/jam/gmtk-202...
————————————————————
#itchio #IndieDev #SoloDev #GameJam #GameDev
It's called Loop Lab. it's a point-and-click adventure game where you're stuck in a time loop in a laboratory.
Go play it and vote on it.
————————————————————
itch.io/jam/gmtk-202...
————————————————————
#itchio #IndieDev #SoloDev #GameJam #GameDev
Loop Lab by testzero for GMTK Game Jam 2025
Made for GMTK Game Jam 2025
itch.io
August 3, 2025 at 2:54 PM
Just in case some are not in the loop, there is still zero, that means none, zero direct evidence of anything related to a lab leak.
There are lots of allegations about how it *must* have happened, but zero actual evidence.
This is one reason they keep yelling so loud about it.
There are lots of allegations about how it *must* have happened, but zero actual evidence.
This is one reason they keep yelling so loud about it.
June 5, 2024 at 2:16 PM
Just in case some are not in the loop, there is still zero, that means none, zero direct evidence of anything related to a lab leak.
There are lots of allegations about how it *must* have happened, but zero actual evidence.
This is one reason they keep yelling so loud about it.
There are lots of allegations about how it *must* have happened, but zero actual evidence.
This is one reason they keep yelling so loud about it.
New preprint from the lab !! Loop extrusion may provide mechanical robustness to chromatin. Great work by Hossein Salari. @cnrs.fr @lbmcinlyon.bsky.social
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Loop extrusion provides mechanical robustness to chromatin
Chromosomes are complex biopolymers folded into dynamic loops via a loop extrusion process and may experience various mechanical forces in vivo . We develop a force-dependent model of chromatin loop e...
www.biorxiv.org
September 29, 2025 at 1:24 PM
New preprint from the lab !! Loop extrusion may provide mechanical robustness to chromatin. Great work by Hossein Salari. @cnrs.fr @lbmcinlyon.bsky.social
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Neuroscientist Patricia Goldman-Rakic would have been 89 years old today. Her work in the 1970s showed us on a molecular level how working memory functions through loop firing and local suppression. Sadly, she passed away in 2003 at just 66 years old.
tinyurl.com/5n7evkh6
#WomenInSTEM #NeuroSky 🧠
tinyurl.com/5n7evkh6
#WomenInSTEM #NeuroSky 🧠
Making Working Memory Work: The Multidisciplinary Neuroscience of Patricia Goldman-Rakic
You’re a monkey, and somebody in a white lab coat has shown you a location where a delicious, ever-so-nummy, bit of banana has been placed, and then obscured your visual field. It is up to you, my goo...
tinyurl.com
April 22, 2026 at 2:03 PM
Neuroscientist Patricia Goldman-Rakic would have been 89 years old today. Her work in the 1970s showed us on a molecular level how working memory functions through loop firing and local suppression. Sadly, she passed away in 2003 at just 66 years old.
tinyurl.com/5n7evkh6
#WomenInSTEM #NeuroSky 🧠
tinyurl.com/5n7evkh6
#WomenInSTEM #NeuroSky 🧠
New from our lab in @narjournal.bsky.social:
We dissect the folding dynamics of a fundamental element of RNA secondary structure—a stem-loop—at single-molecule and microsecond resolution.
doi.org/10.1093/nar/... 1/5
We dissect the folding dynamics of a fundamental element of RNA secondary structure—a stem-loop—at single-molecule and microsecond resolution.
doi.org/10.1093/nar/... 1/5
July 31, 2025 at 2:27 AM
New from our lab in @narjournal.bsky.social:
We dissect the folding dynamics of a fundamental element of RNA secondary structure—a stem-loop—at single-molecule and microsecond resolution.
doi.org/10.1093/nar/... 1/5
We dissect the folding dynamics of a fundamental element of RNA secondary structure—a stem-loop—at single-molecule and microsecond resolution.
doi.org/10.1093/nar/... 1/5
Congratulations to @andibrunner.bsky.social
and the team, and many thanks to the lab of Jan-Michael Peters for support!
We found that the interphase and mitotic chromatin loop organization have more in common than previously thought:
In both stages big loops are built first, small ones second
and the team, and many thanks to the lab of Jan-Michael Peters for support!
We found that the interphase and mitotic chromatin loop organization have more in common than previously thought:
In both stages big loops are built first, small ones second
@andibrunner.bsky.social et al. @ellenberglab.bsky.social show that interphase organization into Cohesin-driven loops occurs in a sequential and hierarchical manner - just like the mitotic organization by Condensins. https://buff.ly/426gIEu
@wanluzhang.bsky.social
@wanluzhang.bsky.social
January 9, 2025 at 9:57 PM
Congratulations to @andibrunner.bsky.social
and the team, and many thanks to the lab of Jan-Michael Peters for support!
We found that the interphase and mitotic chromatin loop organization have more in common than previously thought:
In both stages big loops are built first, small ones second
and the team, and many thanks to the lab of Jan-Michael Peters for support!
We found that the interphase and mitotic chromatin loop organization have more in common than previously thought:
In both stages big loops are built first, small ones second
We @prescientdesign.bsky.social Genentech pre-printed our "Lab-in-the-loop for therapeutic antibody design." We built a general ML system to accelerate molecule design for challenging, therapeutically relevant targets.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
www.biorxiv.org
February 26, 2025 at 9:15 PM
We @prescientdesign.bsky.social Genentech pre-printed our "Lab-in-the-loop for therapeutic antibody design." We built a general ML system to accelerate molecule design for challenging, therapeutically relevant targets.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Food scraps and mushrooms: the closed-loop garden behind the world’s first community-powered sauna
Food scraps and mushrooms: the closed-loop garden behind the world’s first community-powered sauna
R-Urban Poplar in London is a ‘living lab’ where locals can experiment with ways of taking charge of their food supply
www.theguardian.com
July 17, 2026 at 1:28 AM
Food scraps and mushrooms: the closed-loop garden behind the world’s first community-powered sauna
I know we are not supposed to say nice things about LLMs here, but one use case we have found to be excellent is for human-in-the-loop code review. We write a lot of code in our lab and LLMs have caught a few bugs that flew under the radar. Not a replacement for human review, but useful nonetheless.
August 29, 2025 at 4:59 AM
I know we are not supposed to say nice things about LLMs here, but one use case we have found to be excellent is for human-in-the-loop code review. We write a lot of code in our lab and LLMs have caught a few bugs that flew under the radar. Not a replacement for human review, but useful nonetheless.
somebody at UChicago is feeding preprints to LLMs without authors' consent, in a research study
they have the gall to suggest to authors they've opted-in that they volunteer to evaluate the LLMs' suggestions regarding their own work.
lol, lmao even. here is the invite and my reply
they have the gall to suggest to authors they've opted-in that they volunteer to evaluate the LLMs' suggestions regarding their own work.
lol, lmao even. here is the invite and my reply
January 5, 2026 at 10:55 PM
somebody at UChicago is feeding preprints to LLMs without authors' consent, in a research study
they have the gall to suggest to authors they've opted-in that they volunteer to evaluate the LLMs' suggestions regarding their own work.
lol, lmao even. here is the invite and my reply
they have the gall to suggest to authors they've opted-in that they volunteer to evaluate the LLMs' suggestions regarding their own work.
lol, lmao even. here is the invite and my reply