Webinar Nov 10, 9:30 & 18:00 CET: Working with Extremely Large Datasets.
230 GB ZEISS Lightsheet 7 dataset, stitched, deconvolved & rendered in Huygens: a CA2 neuron contacting vasculature in mouse hippocampus. c/o Dr. Rob Wine, NIEHS/NIH
Register: svi.nl/webinarinvitation
#Microscopy
230 GB ZEISS Lightsheet 7 dataset, stitched, deconvolved & rendered in Huygens: a CA2 neuron contacting vasculature in mouse hippocampus. c/o Dr. Rob Wine, NIEHS/NIH
Register: svi.nl/webinarinvitation
#Microscopy
November 3, 2026 at 9:00 AM
Webinar Nov 10, 9:30 & 18:00 CET: Working with Extremely Large Datasets.
230 GB ZEISS Lightsheet 7 dataset, stitched, deconvolved & rendered in Huygens: a CA2 neuron contacting vasculature in mouse hippocampus. c/o Dr. Rob Wine, NIEHS/NIH
Register: svi.nl/webinarinvitation
#Microscopy
230 GB ZEISS Lightsheet 7 dataset, stitched, deconvolved & rendered in Huygens: a CA2 neuron contacting vasculature in mouse hippocampus. c/o Dr. Rob Wine, NIEHS/NIH
Register: svi.nl/webinarinvitation
#Microscopy
A #fluorescencefriday from the Godwin lab shows the regenerating #axolotl spinal cord with nuclei in grey, axon (neuronal) extensions in green and #macrophages in magenta. The macrophages on the axonal tips guiding their extension overlap in white.
#microscopy #fluorescentproteins #lightsheet
#microscopy #fluorescentproteins #lightsheet
October 30, 2026 at 2:00 PM
A #fluorescencefriday from the Godwin lab shows the regenerating #axolotl spinal cord with nuclei in grey, axon (neuronal) extensions in green and #macrophages in magenta. The macrophages on the axonal tips guiding their extension overlap in white.
#microscopy #fluorescentproteins #lightsheet
#microscopy #fluorescentproteins #lightsheet
A deviation away from my usual lightsheet imaging, this work uses spatial transcriptomic data to map thousands of cells inside lymph nodes, revealing how different immune cells organise themselves into distinct cellular ‘suburbs’.
Check out the online exhibit here: www.wehi.edu.au/news/art-of-...
Check out the online exhibit here: www.wehi.edu.au/news/art-of-...
Art of Science 2026: Discovery in full colour
WEHI’s Art of Science exhibition returns in 2026 with a vibrant collection of images and moving works that reveal the beauty, complexity and ingenuity behind medical research.
www.wehi.edu.au
October 29, 2026 at 7:20 AM
A deviation away from my usual lightsheet imaging, this work uses spatial transcriptomic data to map thousands of cells inside lymph nodes, revealing how different immune cells organise themselves into distinct cellular ‘suburbs’.
Check out the online exhibit here: www.wehi.edu.au/news/art-of-...
Check out the online exhibit here: www.wehi.edu.au/news/art-of-...
Today I want to highlight a study from Elvan Böke lab at CRG in Barcelona as a perfect example why it makes sense to use tissue clearing and lightsheet microscopy.
October 20, 2026 at 10:09 AM
Today I want to highlight a study from Elvan Böke lab at CRG in Barcelona as a perfect example why it makes sense to use tissue clearing and lightsheet microscopy.
Today I want to highlight other typical lightsheet microscopy use – in toto embryo imaging with laser ablation. In a recent Biophysical J paper Timo Betz and co. from Uni of Göttingen studied how robust zebrafish gastrulation is to mechanical perturbation by laser ablation. Tl;DR: very robust.
October 21, 2026 at 9:28 AM
Today I want to highlight other typical lightsheet microscopy use – in toto embryo imaging with laser ablation. In a recent Biophysical J paper Timo Betz and co. from Uni of Göttingen studied how robust zebrafish gastrulation is to mechanical perturbation by laser ablation. Tl;DR: very robust.
The team at Bruker Luxendo are experts in combining lightsheet and photomanipulation, with a lot of such microscopes already installed. As another great example, I recommend the series of publications from Matteo Rauzi lab.
October 21, 2026 at 9:30 AM
The team at Bruker Luxendo are experts in combining lightsheet and photomanipulation, with a lot of such microscopes already installed. As another great example, I recommend the series of publications from Matteo Rauzi lab.
paper: www.cell.com/biophysj/ful...
If you need to image a full volume of a quite large spherical embryo every 3 minutes for multiple hours, while performing laser ablation in between, you need a lightsheet microscope.
If you need to image a full volume of a quite large spherical embryo every 3 minutes for multiple hours, while performing laser ablation in between, you need a lightsheet microscope.
October 21, 2026 at 9:28 AM
paper: www.cell.com/biophysj/ful...
If you need to image a full volume of a quite large spherical embryo every 3 minutes for multiple hours, while performing laser ablation in between, you need a lightsheet microscope.
If you need to image a full volume of a quite large spherical embryo every 3 minutes for multiple hours, while performing laser ablation in between, you need a lightsheet microscope.
If you want to quantify the number and distribution of structures in your tissue in an unibased way, there is no other way than lightsheet. Here, the oocytes in mouse ovaries were counted in 3D over the animal's life span with obvious implications for infertility research in aging women.
October 20, 2026 at 10:09 AM
If you want to quantify the number and distribution of structures in your tissue in an unibased way, there is no other way than lightsheet. Here, the oocytes in mouse ovaries were counted in 3D over the animal's life span with obvious implications for infertility research in aging women.
The 3D lightsheet approach is not only more precise but also faster than doing traditional histology on sections. It goes without saying that this approach only works if good data handling and automated image analysis pipeline follows image acquisition.
Nature Aging: www.nature.com/articles/s43...
Nature Aging: www.nature.com/articles/s43...
Three-dimensional mapping of intact ovaries reveals the aging dynamics of the ovarian reserve - Nature Aging
The spatiotemporal dynamics of the depletion of the ovarian reserve remain incompletely understood. Combining whole-ovary imaging, AI and modeling, the authors mapped over 85,000 mouse oocytes and fou...
www.nature.com
October 20, 2026 at 10:11 AM
The 3D lightsheet approach is not only more precise but also faster than doing traditional histology on sections. It goes without saying that this approach only works if good data handling and automated image analysis pipeline follows image acquisition.
Nature Aging: www.nature.com/articles/s43...
Nature Aging: www.nature.com/articles/s43...
Bruker Luxendo MuVi SPIM was used for lightsheet microscopy of the BABB-cleared ovaries.
www.bruker.com/en/products-...
Video caption: Oocytes labeled by DDX4 antibody (magenta) and all nuclei in ovaries labeled by TO-PRO-3 (green). Supplementary Video 1 from the publication.
www.bruker.com/en/products-...
Video caption: Oocytes labeled by DDX4 antibody (magenta) and all nuclei in ovaries labeled by TO-PRO-3 (green). Supplementary Video 1 from the publication.
MuVi SPIM
The MuVi SPIM is a customizable light-sheet microscope with 4 illumination and detection combinations for quickly imaging large volumes.
www.bruker.com
October 20, 2026 at 10:12 AM
Bruker Luxendo MuVi SPIM was used for lightsheet microscopy of the BABB-cleared ovaries.
www.bruker.com/en/products-...
Video caption: Oocytes labeled by DDX4 antibody (magenta) and all nuclei in ovaries labeled by TO-PRO-3 (green). Supplementary Video 1 from the publication.
www.bruker.com/en/products-...
Video caption: Oocytes labeled by DDX4 antibody (magenta) and all nuclei in ovaries labeled by TO-PRO-3 (green). Supplementary Video 1 from the publication.
another #fluorescencefriday example representing new antibody testing for the @mind-western.bsky.social @shahrzadbahrampour.bsky.social NF-H (axonal marker pink) and NeuN (neuronal marker green) #lightsheet 🔬 of cleared 🐁 🧠
October 16, 2026 at 6:23 PM
another #fluorescencefriday example representing new antibody testing for the @mind-western.bsky.social @shahrzadbahrampour.bsky.social NF-H (axonal marker pink) and NeuN (neuronal marker green) #lightsheet 🔬 of cleared 🐁 🧠
despite what the spammers in my inbox would like you to think, i am not the one who can sell the abstract concept of a moth to you.
But if you do want some moths here's a guide https://nationalmothweek.org/mothing-101/
But if you do want some moths here's a guide https://nationalmothweek.org/mothing-101/
Mothing 101
nationalmothweek.org
October 10, 2026 at 12:58 AM
despite what the spammers in my inbox would like you to think, i am not the one who can sell the abstract concept of a moth to you.
But if you do want some moths here's a guide https://nationalmothweek.org/mothing-101/
But if you do want some moths here's a guide https://nationalmothweek.org/mothing-101/
🔬 A #3DThursday fan favorite from #BINA2026! This is a tiny, lab-grown model of a lung, meant to mimic the structure and function of real tissues. I think we showed this #organoid to everyone who stopped by ...💜
🔬: #mesoSPIM Lightsheet
🥼: Hei Ming Lai, Illumos
🎬: #syGlass, v2.7.1
#I2KxBINA2026
🔬: #mesoSPIM Lightsheet
🥼: Hei Ming Lai, Illumos
🎬: #syGlass, v2.7.1
#I2KxBINA2026
October 8, 2026 at 3:59 PM
🔬 A #3DThursday fan favorite from #BINA2026! This is a tiny, lab-grown model of a lung, meant to mimic the structure and function of real tissues. I think we showed this #organoid to everyone who stopped by ...💜
🔬: #mesoSPIM Lightsheet
🥼: Hei Ming Lai, Illumos
🎬: #syGlass, v2.7.1
#I2KxBINA2026
🔬: #mesoSPIM Lightsheet
🥼: Hei Ming Lai, Illumos
🎬: #syGlass, v2.7.1
#I2KxBINA2026
#fluorescencefriday another test for the @mind-western.bsky.social and @shahrzadbahrampour.bsky.social labelling for MOG (Myelin Oligodendrocyte Glycoprotein) in a young 🐁 🧠 cleared and imaged
By lightsheet 🔬
By lightsheet 🔬
October 2, 2026 at 7:01 PM
#fluorescencefriday another test for the @mind-western.bsky.social and @shahrzadbahrampour.bsky.social labelling for MOG (Myelin Oligodendrocyte Glycoprotein) in a young 🐁 🧠 cleared and imaged
By lightsheet 🔬
By lightsheet 🔬
This week we are @uwmadison.bsky.social for @bioimagingna.bsky.social #I2KxBINA2026. Come chat with our team about our line of microscopes from spinning disk to multiphoton to lightsheet all run by our high- #speed #accuracy #performance software SlideBook.
September 28, 2026 at 4:24 PM
This week we are @uwmadison.bsky.social for @bioimagingna.bsky.social #I2KxBINA2026. Come chat with our team about our line of microscopes from spinning disk to multiphoton to lightsheet all run by our high- #speed #accuracy #performance software SlideBook.
our facility is testing few antibodies for one of our users and this is the stain for NF-H for axons using lightsheet microscopy in a cleared 🐁 🧠 #fluorescencefriday @shahrzadbahrampour.bsky.social @kesummers.bsky.social @mind-western.bsky.social
September 25, 2026 at 9:47 PM
our facility is testing few antibodies for one of our users and this is the stain for NF-H for axons using lightsheet microscopy in a cleared 🐁 🧠 #fluorescencefriday @shahrzadbahrampour.bsky.social @kesummers.bsky.social @mind-western.bsky.social
We also used a Lattice Lightsheet microscope to perform high-temporal resolution live imaging of cultured cells. This set up allowed us to catch a dividing cell in the act. Our favorite is an example showing the microtubule dynamics during the first division of a regenerating protoplast. (8/n)
September 25, 2026 at 2:28 PM
We also used a Lattice Lightsheet microscope to perform high-temporal resolution live imaging of cultured cells. This set up allowed us to catch a dividing cell in the act. Our favorite is an example showing the microtubule dynamics during the first division of a regenerating protoplast. (8/n)
🪰 500 timepoints of Drosophila gastrulation playing in a browser tab from static files, orbited live. SiMView recording with Philipp Keller at @hhmijanelia.bsky.social. #lightsheet
Demo: demos.luxarviewer.dev/d/gsplats_4...
Demo: demos.luxarviewer.dev/d/gsplats_4...
September 23, 2026 at 8:47 AM
🪰 500 timepoints of Drosophila gastrulation playing in a browser tab from static files, orbited live. SiMView recording with Philipp Keller at @hhmijanelia.bsky.social. #lightsheet
Demo: demos.luxarviewer.dev/d/gsplats_4...
Demo: demos.luxarviewer.dev/d/gsplats_4...
🐟 The microscopy piece: Gaussian splatting, volumes as Gaussian mixtures, ~100x smaller. 17 volumes, 12 datasets, 4 modalities: median 99x (6 to 340x) at 26 to 67 dB PSNR, minutes per volume on one GPU. This frame: 2.2 M splats. #lightsheet
Demo: demos.luxarviewer.dev/d/gsplats_4...
Demo: demos.luxarviewer.dev/d/gsplats_4...
September 23, 2026 at 8:47 AM
🐟 The microscopy piece: Gaussian splatting, volumes as Gaussian mixtures, ~100x smaller. 17 volumes, 12 datasets, 4 modalities: median 99x (6 to 340x) at 26 to 67 dB PSNR, minutes per volume on one GPU. This frame: 2.2 M splats. #lightsheet
Demo: demos.luxarviewer.dev/d/gsplats_4...
Demo: demos.luxarviewer.dev/d/gsplats_4...
🐟 Channels and timepoints are just axes. A zebrafish neuromast (iSIM, 100 timepoints) recorded by @adrianjacobo.bsky.social's lab: membranes and nuclei as two layers, each with its own window, colormap and blending. #lightsheet
Demo: demos.luxarviewer.dev/d/gsplats_4...
Demo: demos.luxarviewer.dev/d/gsplats_4...
September 23, 2026 at 8:49 AM
🐟 Channels and timepoints are just axes. A zebrafish neuromast (iSIM, 100 timepoints) recorded by @adrianjacobo.bsky.social's lab: membranes and nuclei as two layers, each with its own window, colormap and blending. #lightsheet
Demo: demos.luxarviewer.dev/d/gsplats_4...
Demo: demos.luxarviewer.dev/d/gsplats_4...
I had a dream that I came into work and the lightsheet was filled with tater tots. How's your morning going? 🤣
September 16, 2026 at 10:35 AM
I had a dream that I came into work and the lightsheet was filled with tater tots. How's your morning going? 🤣
More applications, more flexibility, more discoveries.
ZEISS Lattice Lightsheet 7 has evolved. ✨
The latest enhancements expand what researchers can do with 3D imaging, enabling a broader range of applications across samples, experiments, and biological questions.
ZEISS Lattice Lightsheet 7 has evolved. ✨
The latest enhancements expand what researchers can do with 3D imaging, enabling a broader range of applications across samples, experiments, and biological questions.
September 9, 2026 at 6:12 AM
More applications, more flexibility, more discoveries.
ZEISS Lattice Lightsheet 7 has evolved. ✨
The latest enhancements expand what researchers can do with 3D imaging, enabling a broader range of applications across samples, experiments, and biological questions.
ZEISS Lattice Lightsheet 7 has evolved. ✨
The latest enhancements expand what researchers can do with 3D imaging, enabling a broader range of applications across samples, experiments, and biological questions.
Shape the future of light: PhD opportunities in photonics in the Huisken lab. Excellent research network. Apply through the Max Planck School of Photonics. Deadline 1 Dec 2026.
www.photonics.school/
#LSFM #lightsheet #Flamingo
www.photonics.school/
#LSFM #lightsheet #Flamingo
September 7, 2026 at 12:13 PM
Shape the future of light: PhD opportunities in photonics in the Huisken lab. Excellent research network. Apply through the Max Planck School of Photonics. Deadline 1 Dec 2026.
www.photonics.school/
#LSFM #lightsheet #Flamingo
www.photonics.school/
#LSFM #lightsheet #Flamingo