Nature research paper: Substrate selectivity of the human RNA m5C methyltransferase NSUN2
go.nature.com/4v7ZeTt
go.nature.com/4v7ZeTt
Substrate selectivity of the human RNA m5C methyltransferase NSUN2 - Nature
NSUN2 is an enzyme that adds a small chemical mark to RNA molecules and uniquely selects its targets based on specific sequence patterns and structural features.
go.nature.com
May 29, 2026 at 9:16 AM
Nature research paper: Substrate selectivity of the human RNA m5C methyltransferase NSUN2
go.nature.com/4v7ZeTt
go.nature.com/4v7ZeTt
Les attaques contre l'indépendance des magistrats en témoignent : la France sort peu à peu de l'Etat de droit, alerte Magali Lafourcade, secrétaire générale de la Commission nationale consultative des droits de l'homme.
➡️ Lire l'entretien : https://www.altereco.media/m5c
➡️ Lire l'entretien : https://www.altereco.media/m5c
August 27, 2026 at 12:52 PM
Les attaques contre l'indépendance des magistrats en témoignent : la France sort peu à peu de l'Etat de droit, alerte Magali Lafourcade, secrétaire générale de la Commission nationale consultative des droits de l'homme.
➡️ Lire l'entretien : https://www.altereco.media/m5c
➡️ Lire l'entretien : https://www.altereco.media/m5c
Watched my friend calibrate my old 3d printer that's now his and decided to draw it on my phone while waiting for it to be done
#ankermake #m5c
#ankermake #m5c
February 5, 2025 at 5:04 AM
Watched my friend calibrate my old 3d printer that's now his and decided to draw it on my phone while waiting for it to be done
#ankermake #m5c
#ankermake #m5c
Scientists uncover protein that helps cancer cells dodge CAR-T cell therapy.
"Discovery could lead to new treatments for blood cancer patients currently facing limited options."
www.cell.com/cell/abstrac...
"Discovery could lead to new treatments for blood cancer patients currently facing limited options."
www.cell.com/cell/abstrac...
YTHDF2 promotes ATP synthesis and immune evasion in B cell malignancies
YTHDF2 modulates oncogenic transformation and immune evasion across multiple B cell cancers by stabilizing m5C-modified mRNAs and destabilizing m6A-modified mRNAs, thereby serving as a dual reader for both m5C and m6A modifications. Small molecules that target YTHDF2 reduce ATP synthesis and are therapeutic candidates for B cell malignancies, especially when combined with CAR-T therapy or bispecific engagers.
www.cell.com
December 21, 2024 at 3:36 AM
Scientists uncover protein that helps cancer cells dodge CAR-T cell therapy.
"Discovery could lead to new treatments for blood cancer patients currently facing limited options."
www.cell.com/cell/abstrac...
"Discovery could lead to new treatments for blood cancer patients currently facing limited options."
www.cell.com/cell/abstrac...
"YTHDF2 functions as a dual reader where it stabilizes mRNAs as a 5-methylcytosine (m5C) reader ..."
doi.org/10.1016/j.ce...
#RNA #RNAsky #RNAbiology
doi.org/10.1016/j.ce...
#RNA #RNAsky #RNAbiology
YTHDF2 promotes ATP synthesis and immune evasion in B cell malignancies
YTHDF2 modulates oncogenic transformation and immune evasion across multiple B cell
cancers by stabilizing m5C-modified mRNAs and destabilizing m6A-modified mRNAs, thereby
serving as a dual reader for...
www.cell.com
January 17, 2025 at 4:35 AM
"YTHDF2 functions as a dual reader where it stabilizes mRNAs as a 5-methylcytosine (m5C) reader ..."
doi.org/10.1016/j.ce...
#RNA #RNAsky #RNAbiology
doi.org/10.1016/j.ce...
#RNA #RNAsky #RNAbiology
Que faire quand l’agro-industrie accapare toutes les terres ? Se rassembler en coopérative citoyenne et acheter des hectares. Dans le Finistère, des terres sont ainsi louées à des agriculteurs qui veulent s’installer en bio.
Lire l'article ➡️ l.reporterre.net/m5C
Lire l'article ➡️ l.reporterre.net/m5C
May 24, 2026 at 7:00 PM
Que faire quand l’agro-industrie accapare toutes les terres ? Se rassembler en coopérative citoyenne et acheter des hectares. Dans le Finistère, des terres sont ainsi louées à des agriculteurs qui veulent s’installer en bio.
Lire l'article ➡️ l.reporterre.net/m5C
Lire l'article ➡️ l.reporterre.net/m5C
New public hub: Sci-ModoM RNA modification sites. 7.9M m6A, pseudouridine, m5C and 2'-O-methylation sites on hg38 and mm39, each with its coverage and percent modified.
Explore hub: genome.ucsc.edu/s/Lo...
More public hubs: genome.ucsc.edu/cgi-...
Explore hub: genome.ucsc.edu/s/Lo...
More public hubs: genome.ucsc.edu/cgi-...
September 21, 2026 at 2:46 PM
New public hub: Sci-ModoM RNA modification sites. 7.9M m6A, pseudouridine, m5C and 2'-O-methylation sites on hg38 and mm39, each with its coverage and percent modified.
Explore hub: genome.ucsc.edu/s/Lo...
More public hubs: genome.ucsc.edu/cgi-...
Explore hub: genome.ucsc.edu/s/Lo...
More public hubs: genome.ucsc.edu/cgi-...
Excited to share our latest work!
The oncogenic m5C writer NSUN2 achieves substrate specificity by recognizing RNA structure and conformational dynamics. RNA folding shapes methylation! Congratulations to the team! Thank you, colleagues and supporters! ttps://nature.com/articles/s41586-026-10582-9
The oncogenic m5C writer NSUN2 achieves substrate specificity by recognizing RNA structure and conformational dynamics. RNA folding shapes methylation! Congratulations to the team! Thank you, colleagues and supporters! ttps://nature.com/articles/s41586-026-10582-9
Substrate selectivity of the human RNA m5C methyltransferase NSUN2 - Nature
NSUN2 is an enzyme that adds a small chemical mark to RNA molecules and uniquely selects its targets based on specific sequence patterns and structural features.
nature.com
June 5, 2026 at 10:17 PM
Excited to share our latest work!
The oncogenic m5C writer NSUN2 achieves substrate specificity by recognizing RNA structure and conformational dynamics. RNA folding shapes methylation! Congratulations to the team! Thank you, colleagues and supporters! ttps://nature.com/articles/s41586-026-10582-9
The oncogenic m5C writer NSUN2 achieves substrate specificity by recognizing RNA structure and conformational dynamics. RNA folding shapes methylation! Congratulations to the team! Thank you, colleagues and supporters! ttps://nature.com/articles/s41586-026-10582-9
That made me think of the m5c bolte from the battlefield 2042 game
April 21, 2025 at 7:27 PM
That made me think of the m5c bolte from the battlefield 2042 game
Kamala’s Team Just Made A BOLD MOVE to CONTEST Trump's Win
YouTube video by Occupy Democrats
www.youtube.com
November 12, 2024 at 9:14 PM
We have been busing working on models to detect all 2'Ome-RNA modified nucleotides on top of PseudoU, m6A, m5C and Inosine using @nanoporetech.com direct RNA sequencing.
This is still very preliminary but here are a few examples of what it looks like on Human #rRNA prepared with standard lib prep 🤩
This is still very preliminary but here are a few examples of what it looks like on Human #rRNA prepared with standard lib prep 🤩
November 28, 2024 at 12:12 PM
We have been busing working on models to detect all 2'Ome-RNA modified nucleotides on top of PseudoU, m6A, m5C and Inosine using @nanoporetech.com direct RNA sequencing.
This is still very preliminary but here are a few examples of what it looks like on Human #rRNA prepared with standard lib prep 🤩
This is still very preliminary but here are a few examples of what it looks like on Human #rRNA prepared with standard lib prep 🤩
Search the Ever Growing list
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or Add Your Business to
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madeinca.ca
for Everything Canadian🇨🇦
or Add Your Business to
#madeincanada #buycanadian
madeinca.ca
July 22, 2026 at 3:09 AM
Search the Ever Growing list
for Everything Canadian🇨🇦
or Add Your Business to
#madeincanada #buycanadian
madeinca.ca
for Everything Canadian🇨🇦
or Add Your Business to
#madeincanada #buycanadian
madeinca.ca
Detection of stress-dependent m5C rRNA dynamics in E. coli using m5C-Rol-LAMP: qPCR-based method to quantify site-specific m5C in total bacterial RNA =>stress (heat, stressox) dependent changes in rRNA, from @kirstenjunglab.bsky.social lab 🦠 #rnasky
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
www.biorxiv.org
June 16, 2025 at 3:19 PM
Detection of stress-dependent m5C rRNA dynamics in E. coli using m5C-Rol-LAMP: qPCR-based method to quantify site-specific m5C in total bacterial RNA =>stress (heat, stressox) dependent changes in rRNA, from @kirstenjunglab.bsky.social lab 🦠 #rnasky
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
July 9, 2026 at 2:00 AM
ALYREF condensation stabilizes m5C-modified PARP10 mRNA and promotes PI3K-AKT signaling in ovarian cancer
www.embopress.org/doi/full/10....
www.embopress.org/doi/full/10....
December 2, 2025 at 9:20 AM
ALYREF condensation stabilizes m5C-modified PARP10 mRNA and promotes PI3K-AKT signaling in ovarian cancer
www.embopress.org/doi/full/10....
www.embopress.org/doi/full/10....
Flaviviridae RdRp exploits NSUN2-driven m5C methylation to establish persistent infection
journals.plos.org/plospathogen...
journals.plos.org/plospathogen...
Flaviviridae RdRp exploits NSUN2-driven m5C methylation to establish persistent infection
Author summary Flaviviridae viruses—including JEV, CSFV, and HCV—deploy intricate molecular strategies to subvert host innate immune surveillance and establish chronic infections, representing signifi...
journals.plos.org
December 5, 2025 at 2:15 PM
Flaviviridae RdRp exploits NSUN2-driven m5C methylation to establish persistent infection
journals.plos.org/plospathogen...
journals.plos.org/plospathogen...
New Insights on NSUN Genes in m5C Methylation and Diseases - Thailand Medical News
www.thailandmedical.news
December 1, 2025 at 1:17 AM
What is the role of m5C #RNAmodifications during neural development? This study shows that m5C reader protein Ybx1 plays a crucial role in promoting #CellCycle progression of embryonic cortical #ProgenitorCells, essential for proper cortical development @plosbiology.org 🧪 plos.io/3SUN4we
May 29, 2025 at 1:17 PM
What is the role of m5C #RNAmodifications during neural development? This study shows that m5C reader protein Ybx1 plays a crucial role in promoting #CellCycle progression of embryonic cortical #ProgenitorCells, essential for proper cortical development @plosbiology.org 🧪 plos.io/3SUN4we
What is the role of m5C #RNAmodifications during neural development? This study shows that m5C reader protein Ybx1 plays a crucial role in promoting #CellCycle progression of embryonic cortical #ProgenitorCells, essential for proper cortical development @plosbiology.org 🧪 plos.io/3SUN4we
May 29, 2025 at 8:39 AM
What is the role of m5C #RNAmodifications during neural development? This study shows that m5C reader protein Ybx1 plays a crucial role in promoting #CellCycle progression of embryonic cortical #ProgenitorCells, essential for proper cortical development @plosbiology.org 🧪 plos.io/3SUN4we
SWARM is an AI framework for nanopore direct RNA sequencing that detects m6A, pseudouridine (Ψ), and m5C mods at single-nucleotide & single-molecule resolution.
Key innovation: Crosstalk-aware training with non-target mods & validated cellular signals to reduce false positives.
2/6
Key innovation: Crosstalk-aware training with non-target mods & validated cellular signals to reduce false positives.
2/6
January 28, 2026 at 1:24 AM
SWARM is an AI framework for nanopore direct RNA sequencing that detects m6A, pseudouridine (Ψ), and m5C mods at single-nucleotide & single-molecule resolution.
Key innovation: Crosstalk-aware training with non-target mods & validated cellular signals to reduce false positives.
2/6
Key innovation: Crosstalk-aware training with non-target mods & validated cellular signals to reduce false positives.
2/6