Yesterday, my office had the pleasure of welcoming students from Mount Holyoke College’s MHC in D.C. Program. My staff were able to share their roles and responsibilities, and highlight the work of state government.
November 7, 2026 at 4:57 PM
Yesterday, my office had the pleasure of welcoming students from Mount Holyoke College’s MHC in D.C. Program. My staff were able to share their roles and responsibilities, and highlight the work of state government.
Hi babes and a horny #monochromemonday from the #MILEHIGHCLUB
#rt if you enjoy the #pov
🍆😝 💦💦💦
#mcm #bwc #gay #mirrorselfie #gaythailand #gaygermany #gayberlin #schwul #mhc #maleart #gayart
#rt if you enjoy the #pov
🍆😝 💦💦💦
#mcm #bwc #gay #mirrorselfie #gaythailand #gaygermany #gayberlin #schwul #mhc #maleart #gayart
November 9, 2026 at 3:15 AM
Hi babes and a horny #monochromemonday from the #MILEHIGHCLUB
#rt if you enjoy the #pov
🍆😝 💦💦💦
#mcm #bwc #gay #mirrorselfie #gaythailand #gaygermany #gayberlin #schwul #mhc #maleart #gayart
#rt if you enjoy the #pov
🍆😝 💦💦💦
#mcm #bwc #gay #mirrorselfie #gaythailand #gaygermany #gayberlin #schwul #mhc #maleart #gayart
I’m still waiting for a naturopath to find a herbal tea that substantially alters HLA-II MHC genes at source. Or maybe a special ginger and garlic smoothie which substitutes parents.
November 8, 2026 at 12:02 AM
I’m still waiting for a naturopath to find a herbal tea that substantially alters HLA-II MHC genes at source. Or maybe a special ginger and garlic smoothie which substitutes parents.
MHC II-expressing bone marrow megakaryocytes are noncanonical antigen-presenting cells and activate CD4+ T cells ex vivo
www.cell.com/cell-reports... @cp-cellreports.bsky.social @kmachlus.bsky.social @bostonchildrens.bsky.social
www.cell.com/cell-reports... @cp-cellreports.bsky.social @kmachlus.bsky.social @bostonchildrens.bsky.social
November 4, 2026 at 9:00 PM
MHC II-expressing bone marrow megakaryocytes are noncanonical antigen-presenting cells and activate CD4+ T cells ex vivo
www.cell.com/cell-reports... @cp-cellreports.bsky.social @kmachlus.bsky.social @bostonchildrens.bsky.social
www.cell.com/cell-reports... @cp-cellreports.bsky.social @kmachlus.bsky.social @bostonchildrens.bsky.social
'We found that ∼20% of bone marrow MKs express MHCII & co-stimulatory receptors CD80, CD86, CD40, and CD83. These MKs process and present antigen to activate T cells ex vivo in an MHC II-dependent manner. MK/T cell interactions induced TGF-β1 secretion and promoted induced #Treg differentiation'
MHC II-expressing bone marrow megakaryocytes are noncanonical antigen-presenting cells and activate CD4+ T cells ex vivo
Camacho et al. show a subset of megakaryocytes, best known as platelet-producing cells,
also have immune functions. MHC II-expressing megakaryocytes process antigen ex vivo,
activate CD4+ T cells, and...
www.cell.com
November 4, 2026 at 9:30 AM
'We found that ∼20% of bone marrow MKs express MHCII & co-stimulatory receptors CD80, CD86, CD40, and CD83. These MKs process and present antigen to activate T cells ex vivo in an MHC II-dependent manner. MK/T cell interactions induced TGF-β1 secretion and promoted induced #Treg differentiation'
"Relationships Among MHC Diversity, Parasites and Secondary Sexual Colouration"
Now out in Molecular Ecology - led by Allegra Love, with many collaborators.
onlinelibrary.wiley.com/doi/10.1111/...
Now out in Molecular Ecology - led by Allegra Love, with many collaborators.
onlinelibrary.wiley.com/doi/10.1111/...
November 2, 2026 at 6:13 PM
"Relationships Among MHC Diversity, Parasites and Secondary Sexual Colouration"
Now out in Molecular Ecology - led by Allegra Love, with many collaborators.
onlinelibrary.wiley.com/doi/10.1111/...
Now out in Molecular Ecology - led by Allegra Love, with many collaborators.
onlinelibrary.wiley.com/doi/10.1111/...
A library of ~12,000 viral ORFs from 513 species uncovered hundreds of viral regulators impacting cell proliferation, MHC I presentation, and interferon signaling. PMID:42392077, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00583-0 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪
https://www.cell.com/cell/fulltext/S0092-8674(26)00583-0
No description available
www.cell.com
November 8, 2026 at 8:00 AM
11/ The cells surviving rituximab weren’t dormant. Against depth-matched EBV− cells they scored higher on MHC I, MHC II, antigen processing and activation in all 7 patients, with antigen presentation the top GSEA hit (NES 2.05, q=0.010).
November 2, 2026 at 9:33 PM
11/ The cells surviving rituximab weren’t dormant. Against depth-matched EBV− cells they scored higher on MHC I, MHC II, antigen processing and activation in all 7 patients, with antigen presentation the top GSEA hit (NES 2.05, q=0.010).
6) How does this happen? Reprogrammed cDC1-like cells interact with T cells through MHC class I and CD40 signaling to drive imgTLS formation.
November 4, 2026 at 4:46 PM
6) How does this happen? Reprogrammed cDC1-like cells interact with T cells through MHC class I and CD40 signaling to drive imgTLS formation.
MHC-II deficiency in a large Algerian cohort: Clinical, immunological, and genetic characterization. New study from Lydia Lamara Mahammed, Brahim Belaid, Yu Lung Lau (University of Hong Kong), Reda Djidjik (University of Health Sciences, Algiers) and colleagues:
rupress.org/jhi/article/...
#IEIs
rupress.org/jhi/article/...
#IEIs
November 6, 2026 at 2:45 PM
MHC-II deficiency in a large Algerian cohort: Clinical, immunological, and genetic characterization. New study from Lydia Lamara Mahammed, Brahim Belaid, Yu Lung Lau (University of Hong Kong), Reda Djidjik (University of Health Sciences, Algiers) and colleagues:
rupress.org/jhi/article/...
#IEIs
rupress.org/jhi/article/...
#IEIs
SenseNova-Loop-9B-Preview 👀 A looped multimodal model from SenseNova
huggingface.co/sensenova/Se...
- 9B
- Apache 2.0
- 56 layer executions via weight sharing
- Up to 256K context
- Hybrid attention + two stream mHC
huggingface.co/sensenova/Se...
- 9B
- Apache 2.0
- 56 layer executions via weight sharing
- Up to 256K context
- Hybrid attention + two stream mHC
November 2, 2026 at 1:32 PM
SenseNova-Loop-9B-Preview 👀 A looped multimodal model from SenseNova
huggingface.co/sensenova/Se...
- 9B
- Apache 2.0
- 56 layer executions via weight sharing
- Up to 256K context
- Hybrid attention + two stream mHC
huggingface.co/sensenova/Se...
- 9B
- Apache 2.0
- 56 layer executions via weight sharing
- Up to 256K context
- Hybrid attention + two stream mHC
New in Nature Communications: In collaboration with scientists from the Freie Universität Berlin, we found evidence that MHC class I, a key immune protein, passes through a surprisingly dynamic state while it is loaded with peptides. 👇
doi.org/10.1038/s414...
doi.org/10.1038/s414...
November 5, 2026 at 12:50 PM
New in Nature Communications: In collaboration with scientists from the Freie Universität Berlin, we found evidence that MHC class I, a key immune protein, passes through a surprisingly dynamic state while it is loaded with peptides. 👇
doi.org/10.1038/s414...
doi.org/10.1038/s414...
The authors included RRIDs in their in The Journal of Clinical Endocrinology & Metabolism paper! Thanks for making your methods matter! #RRID #BetterScience #reproducibility
High-resolution MHC sequencing reveals novel genetic risk variants underlying antithyroid drug-induced agranulocytosis
Read the full paper: High-resolution MHC sequencing reveals novel genetic risk variants underlying antithyroid drug-induced agranulocytosis
doi.org
November 6, 2026 at 8:01 AM
The authors included RRIDs in their in The Journal of Clinical Endocrinology & Metabolism paper! Thanks for making your methods matter! #RRID #BetterScience #reproducibility
@bioxcell.bsky.social's resource, RRID:AB_10949298, was just reported to be used in the paper. RRIDs improve reproducibility in scientific research. #reproducibility #ReproducibleResearch #BetterScience
MHC II-expressing bone marrow megakaryocytes are noncanonical antigen-presenting cells and activate CD4+ T cells ex vivo
Read the full paper: MHC II-expressing bone marrow megakaryocytes are noncanonical antigen-presenting cells and activate CD4+ T cells ex vivo
doi.org
November 6, 2026 at 8:00 AM
@bioxcell.bsky.social's resource, RRID:AB_10949298, was just reported to be used in the paper. RRIDs improve reproducibility in scientific research. #reproducibility #ReproducibleResearch #BetterScience
A ginkgo leaf garnish and a bit of char for this #manholecovermonday
November 9, 2026 at 10:56 AM
A ginkgo leaf garnish and a bit of char for this #manholecovermonday
Nature research paper: T and B cells recognize splicing-derived neutrophil neoantigens in lupus
go.nature.com/3W6D7AQ
go.nature.com/3W6D7AQ
T and B cells recognize splicing-derived neutrophil neoantigens in lupus - Nature
In systemic lupus erythematosus, aberrant splicing in neutrophils generates novel peptides that are presented on MHC I, driving CD4+ and CD8+ T cell activation, clonal expansion and IgG autoantibody responses, establishing neoantigen-driven autoimmune immunity.
go.nature.com
November 2, 2026 at 4:27 PM
Nature research paper: T and B cells recognize splicing-derived neutrophil neoantigens in lupus
go.nature.com/3W6D7AQ
go.nature.com/3W6D7AQ
The Quest of the Snow Queen
Saturday, December 5th - a Zoom seminar
Info at cgjungny.org
Explore a classic quest narrative: to connect the masculine and feminine; to undergo the necessary trials of life, and to move toward wholeness.
CEs NYS SW, LP, MHC, LCAT
Saturday, December 5th - a Zoom seminar
Info at cgjungny.org
Explore a classic quest narrative: to connect the masculine and feminine; to undergo the necessary trials of life, and to move toward wholeness.
CEs NYS SW, LP, MHC, LCAT
November 7, 2026 at 9:57 PM
The Quest of the Snow Queen
Saturday, December 5th - a Zoom seminar
Info at cgjungny.org
Explore a classic quest narrative: to connect the masculine and feminine; to undergo the necessary trials of life, and to move toward wholeness.
CEs NYS SW, LP, MHC, LCAT
Saturday, December 5th - a Zoom seminar
Info at cgjungny.org
Explore a classic quest narrative: to connect the masculine and feminine; to undergo the necessary trials of life, and to move toward wholeness.
CEs NYS SW, LP, MHC, LCAT
Chinese Tiangong Space Station Tracking
The Tiangong Space Station is currently over 45F75XV5+FW
Latitude -40.80635519
Longitude -114.04019995
Orbiting at 15,641.83 miles/hour
Altitude of 392.43 km
At 11 : 50 UTC, in 1 hour time, the Tiangong spacestation will be passing over CHGM+MHC, Võ Vă...
The Tiangong Space Station is currently over 45F75XV5+FW
Latitude -40.80635519
Longitude -114.04019995
Orbiting at 15,641.83 miles/hour
Altitude of 392.43 km
At 11 : 50 UTC, in 1 hour time, the Tiangong spacestation will be passing over CHGM+MHC, Võ Vă...
November 7, 2026 at 10:50 AM
Chinese Tiangong Space Station Tracking
The Tiangong Space Station is currently over 45F75XV5+FW
Latitude -40.80635519
Longitude -114.04019995
Orbiting at 15,641.83 miles/hour
Altitude of 392.43 km
At 11 : 50 UTC, in 1 hour time, the Tiangong spacestation will be passing over CHGM+MHC, Võ Vă...
The Tiangong Space Station is currently over 45F75XV5+FW
Latitude -40.80635519
Longitude -114.04019995
Orbiting at 15,641.83 miles/hour
Altitude of 392.43 km
At 11 : 50 UTC, in 1 hour time, the Tiangong spacestation will be passing over CHGM+MHC, Võ Vă...
A novel viral ORFeome library with ~12,000 vORFs from 513 species reveals hundreds of viral regulators influencing cell growth, MHC I presentation, and interferon signaling. PMID:42392077, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00583-0 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪
https://www.cell.com/cell/fulltext/S0092-8674(26)00583-0
No description available
www.cell.com
November 4, 2026 at 2:00 PM
“SMPD3 enhances MHC-I surface presentation to drive CD8⁺ T-cell immunity in colorectal cancer”
🔵 Kehong Zheng‘s latest research is now available to read in #Oncogenesis.
▶️ Read the full open access article here: www.nature.com/articles/s41...
🔵 Kehong Zheng‘s latest research is now available to read in #Oncogenesis.
▶️ Read the full open access article here: www.nature.com/articles/s41...
November 5, 2026 at 1:14 PM
“SMPD3 enhances MHC-I surface presentation to drive CD8⁺ T-cell immunity in colorectal cancer”
🔵 Kehong Zheng‘s latest research is now available to read in #Oncogenesis.
▶️ Read the full open access article here: www.nature.com/articles/s41...
🔵 Kehong Zheng‘s latest research is now available to read in #Oncogenesis.
▶️ Read the full open access article here: www.nature.com/articles/s41...
Li et al. show that pancreatic α cells acquire major histocompatibility complex class II-dependent antigen-presenting capacity during #type1diabetes progression.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Pancreatic α cells function as MHC class II–dependent antigen-presenting cells in type 1 diabetes
Type 1 diabetes (T1D) is an autoimmune disease characterized by T cell–mediated destruction of pancreatic β cells, in which antigen presentation is essential. Although professional antigen-presenting ...
www.science.org
November 5, 2026 at 9:04 AM
Li et al. show that pancreatic α cells acquire major histocompatibility complex class II-dependent antigen-presenting capacity during #type1diabetes progression.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Researchers at TGen and City of Hope have leveraged AlphaFold3 to model the complex three-part molecular triad at the heart of our immune defense: MHC (the display molecule), Peptide (the invader fragment) and TCR (the T cell receptor). 🔗 https://bit.ly/3V7WSrt
November 5, 2026 at 4:40 PM
Researchers at TGen and City of Hope have leveraged AlphaFold3 to model the complex three-part molecular triad at the heart of our immune defense: MHC (the display molecule), Peptide (the invader fragment) and TCR (the T cell receptor). 🔗 https://bit.ly/3V7WSrt
CRV Science Labs ⚗️
🔬 Sub-Domain Partitioning of Proto-RAG Recombinases, Lamprey VLR Solenoids, and MHC/TCR Beta-Sandwiches Resolves the Dual Origin of Vertebrate Adaptive Immunity — A 64-taxon, 1.96 Mb phylogenomic and 3…
https://crvscience.com/labs/discoveries/vertebrate-adaptive-immunity-rag-vlr
🔬 Sub-Domain Partitioning of Proto-RAG Recombinases, Lamprey VLR Solenoids, and MHC/TCR Beta-Sandwiches Resolves the Dual Origin of Vertebrate Adaptive Immunity — A 64-taxon, 1.96 Mb phylogenomic and 3…
https://crvscience.com/labs/discoveries/vertebrate-adaptive-immunity-rag-vlr
CRV Science Labs ⚗️
🔬 Sub-Domain Partitioning of Proto-RAG Recombinases, Lamprey VLR Solenoids, and MHC/TCR Beta-Sandwiches Resolves the Dual Origin of Vertebrate Adaptive Immunity — A 64-taxon, 1.96 Mb phylogenomic and 3D structural synthesis demonstrates that sub-domain boundary partitioning of P…
crvscience.com
November 4, 2026 at 3:43 AM
CRV Science Labs ⚗️
🔬 Sub-Domain Partitioning of Proto-RAG Recombinases, Lamprey VLR Solenoids, and MHC/TCR Beta-Sandwiches Resolves the Dual Origin of Vertebrate Adaptive Immunity — A 64-taxon, 1.96 Mb phylogenomic and 3…
https://crvscience.com/labs/discoveries/vertebrate-adaptive-immunity-rag-vlr
🔬 Sub-Domain Partitioning of Proto-RAG Recombinases, Lamprey VLR Solenoids, and MHC/TCR Beta-Sandwiches Resolves the Dual Origin of Vertebrate Adaptive Immunity — A 64-taxon, 1.96 Mb phylogenomic and 3…
https://crvscience.com/labs/discoveries/vertebrate-adaptive-immunity-rag-vlr