The #lncRNA-encoded #micropeptide ANCHOR promotes lateral #root growth & #drought tolerance in #rice
www.pnas.org/doi/abs/10.1...
#PlantSci @pnas.org @plant-sci.bsky.social @healthycrops.bsky.social @cropsci.bsky.social @irriofficial.bsky.social @planteditors.bsky.social @plantgenetics.bsky.social
www.pnas.org/doi/abs/10.1...
#PlantSci @pnas.org @plant-sci.bsky.social @healthycrops.bsky.social @cropsci.bsky.social @irriofficial.bsky.social @planteditors.bsky.social @plantgenetics.bsky.social
The lncRNA-encoded micropeptide ANCHOR promotes lateral root growth and drought tolerance in rice | PNAS
Lateral roots (LRs) are important components of plant root systems, determining the
robustness of root system architecture and influencing water up...
www.pnas.org
November 7, 2026 at 1:07 PM
The #lncRNA-encoded #micropeptide ANCHOR promotes lateral #root growth & #drought tolerance in #rice
www.pnas.org/doi/abs/10.1...
#PlantSci @pnas.org @plant-sci.bsky.social @healthycrops.bsky.social @cropsci.bsky.social @irriofficial.bsky.social @planteditors.bsky.social @plantgenetics.bsky.social
www.pnas.org/doi/abs/10.1...
#PlantSci @pnas.org @plant-sci.bsky.social @healthycrops.bsky.social @cropsci.bsky.social @irriofficial.bsky.social @planteditors.bsky.social @plantgenetics.bsky.social
i'm looking at yet another paper that studies "The lncRNA-encoded micropeptide" that does XYZ. I would like to remind everyone, that this means its a protein-coding transcript, not a non-coding RNA ...
November 3, 2026 at 5:23 PM
i'm looking at yet another paper that studies "The lncRNA-encoded micropeptide" that does XYZ. I would like to remind everyone, that this means its a protein-coding transcript, not a non-coding RNA ...
Can a noncoding RNA's peptide shape rice roots?
Overexpressing the lncRNA-encoded micropeptide ANCHOR in rice produces significantly longer and wider lateral roots and enhances drought tolerance, while ANCHOR knockouts show opposite phenotypes.
#Drought
doi.org/10.1073/pnas.2623578123
Overexpressing the lncRNA-encoded micropeptide ANCHOR in rice produces significantly longer and wider lateral roots and enhances drought tolerance, while ANCHOR knockouts show opposite phenotypes.
#Drought
doi.org/10.1073/pnas.2623578123
The lncRNA-encoded micropeptide ANCHOR promotes lateral root growth and drought tolerance in rice.
Proceedings of the National Academy of Sciences
jclub.com.au
November 7, 2026 at 1:28 PM
Can a noncoding RNA's peptide shape rice roots?
Overexpressing the lncRNA-encoded micropeptide ANCHOR in rice produces significantly longer and wider lateral roots and enhances drought tolerance, while ANCHOR knockouts show opposite phenotypes.
#Drought
doi.org/10.1073/pnas.2623578123
Overexpressing the lncRNA-encoded micropeptide ANCHOR in rice produces significantly longer and wider lateral roots and enhances drought tolerance, while ANCHOR knockouts show opposite phenotypes.
#Drought
doi.org/10.1073/pnas.2623578123
Cytoplasmic recapping commences the translation of a micropeptide, MARS from MALAT1 after the removal of an inhibitory RNA G-quadruplex https://www.biorxiv.org/content/10.64898/2026.10.13.758904v1
October 15, 2026 at 12:19 PM
Cytoplasmic recapping commences the translation of a micropeptide, MARS from MALAT1 after the removal of an inhibitory RNA G-quadruplex https://www.biorxiv.org/content/10.64898/2026.10.13.758904v1
Cytoplasmic recapping commences the translation of a micropeptide, MARS from MALAT1 after the removal of an inhibitory RNA G-quadruplex https://www.biorxiv.org/content/10.64898/2026.10.13.758904v1
October 15, 2026 at 12:19 PM
Cytoplasmic recapping commences the translation of a micropeptide, MARS from MALAT1 after the removal of an inhibitory RNA G-quadruplex https://www.biorxiv.org/content/10.64898/2026.10.13.758904v1
ノンコーディングRNAからの翻訳
核内で働くとされていたノンコーディングRNA(Malat1)が、細胞質で微小ペプチドを産生することを発見。RNA配列内の反復配列B1 SINEがリボソームエントリーサイト(IRES)として働くらしい
面白いです！
www.science.org/doi/10.1126/...
核内で働くとされていたノンコーディングRNA(Malat1)が、細胞質で微小ペプチドを産生することを発見。RNA配列内の反復配列B1 SINEがリボソームエントリーサイト(IRES)として働くらしい
面白いです！
www.science.org/doi/10.1126/...
A B1 SINE element within the mouse Malat1 long noncoding RNA acts as an internal ribosome entry site mediating micropeptide translation
In most cells, Malat1 long noncoding RNA localizes to the nucleus where it affects splicing and chromatin function. In mouse neurons, Malat1 is exported to the cytoplasm where it is translated to…
www.science.org
October 15, 2026 at 10:00 AM
ノンコーディングRNAからの翻訳
核内で働くとされていたノンコーディングRNA(Malat1)が、細胞質で微小ペプチドを産生することを発見。RNA配列内の反復配列B1 SINEがリボソームエントリーサイト(IRES)として働くらしい
面白いです！
www.science.org/doi/10.1126/...
核内で働くとされていたノンコーディングRNA(Malat1)が、細胞質で微小ペプチドを産生することを発見。RNA配列内の反復配列B1 SINEがリボソームエントリーサイト(IRES)として働くらしい
面白いです！
www.science.org/doi/10.1126/...
RESEARCH PAPER: Honeybadger, a PVT1-derived micropeptide, is a critical negative regulator of RAS–MAPK signaling in MYC-driven tumors
By Paithane et al. and Anindya Bagchi
➡️ https://genesdev.cshlp.org/content/40/19-20/1706.abstract
And:
➡️ https://genesdev.cshlp.org/content/40/19-20/1688.abstract
By Paithane et al. and Anindya Bagchi
➡️ https://genesdev.cshlp.org/content/40/19-20/1706.abstract
And:
➡️ https://genesdev.cshlp.org/content/40/19-20/1688.abstract
October 12, 2026 at 6:05 PM
RESEARCH PAPER: Honeybadger, a PVT1-derived micropeptide, is a critical negative regulator of RAS–MAPK signaling in MYC-driven tumors
By Paithane et al. and Anindya Bagchi
➡️ https://genesdev.cshlp.org/content/40/19-20/1706.abstract
And:
➡️ https://genesdev.cshlp.org/content/40/19-20/1688.abstract
By Paithane et al. and Anindya Bagchi
➡️ https://genesdev.cshlp.org/content/40/19-20/1706.abstract
And:
➡️ https://genesdev.cshlp.org/content/40/19-20/1688.abstract
🆕 ADVANCE ONLINE 🆕
RESEARCH PAPER: Honeybadger, a PVT1-derived micropeptide, is a critical negative regulator of RAS–MAPK signaling in MYC-driven tumors
By Paithane et al. and Anindya Bagchi
➡️ https://ow.ly/9HXs50ZR96x
Also read about Firefox:
➡️ https://ow.ly/LsW750ZR96p
RESEARCH PAPER: Honeybadger, a PVT1-derived micropeptide, is a critical negative regulator of RAS–MAPK signaling in MYC-driven tumors
By Paithane et al. and Anindya Bagchi
➡️ https://ow.ly/9HXs50ZR96x
Also read about Firefox:
➡️ https://ow.ly/LsW750ZR96p
September 28, 2026 at 3:10 PM
🆕 ADVANCE ONLINE 🆕
RESEARCH PAPER: Honeybadger, a PVT1-derived micropeptide, is a critical negative regulator of RAS–MAPK signaling in MYC-driven tumors
By Paithane et al. and Anindya Bagchi
➡️ https://ow.ly/9HXs50ZR96x
Also read about Firefox:
➡️ https://ow.ly/LsW750ZR96p
RESEARCH PAPER: Honeybadger, a PVT1-derived micropeptide, is a critical negative regulator of RAS–MAPK signaling in MYC-driven tumors
By Paithane et al. and Anindya Bagchi
➡️ https://ow.ly/9HXs50ZR96x
Also read about Firefox:
➡️ https://ow.ly/LsW750ZR96p
In the second paper, the team identified Honeybadger, a micropeptide encoded by an alternative transcript of the long noncoding RNA PVT1, as a critical negative regulator of RAS-MAPK signaling in MYC-driven tumors.
Drs. Largaespada & Dehm were also co-authors on this paper.
doi.org/10.1101/gad....
Drs. Largaespada & Dehm were also co-authors on this paper.
doi.org/10.1101/gad....
Honeybadger, a micropeptide encoded by an alternative PVT1 transcript, is a critical negative regulator of RAS–MAPK signaling in MYC-driven tumors
A biweekly scientific journal publishing high-quality research in molecular biology and genetics, cancer biology, biochemistry, and related fields
doi.org
August 28, 2026 at 10:48 PM
In the second paper, the team identified Honeybadger, a micropeptide encoded by an alternative transcript of the long noncoding RNA PVT1, as a critical negative regulator of RAS-MAPK signaling in MYC-driven tumors.
Drs. Largaespada & Dehm were also co-authors on this paper.
doi.org/10.1101/gad....
Drs. Largaespada & Dehm were also co-authors on this paper.
doi.org/10.1101/gad....
Our editors write:
- Maize kernel dehydration: A micropeptide decelerator rdcu.be/d2zZN
A highlight of this paper in @cellpress.bsky.social : "A Zea genus-specific micropeptide controls kernel dehydration in maize"
cell.com/cell/fulltex...
- Maize kernel dehydration: A micropeptide decelerator rdcu.be/d2zZN
A highlight of this paper in @cellpress.bsky.social : "A Zea genus-specific micropeptide controls kernel dehydration in maize"
cell.com/cell/fulltex...
A micropeptide decelerator
Nature Plants - A micropeptide decelerator
rdcu.be
December 19, 2024 at 10:33 AM
Our editors write:
- Maize kernel dehydration: A micropeptide decelerator rdcu.be/d2zZN
A highlight of this paper in @cellpress.bsky.social : "A Zea genus-specific micropeptide controls kernel dehydration in maize"
cell.com/cell/fulltex...
- Maize kernel dehydration: A micropeptide decelerator rdcu.be/d2zZN
A highlight of this paper in @cellpress.bsky.social : "A Zea genus-specific micropeptide controls kernel dehydration in maize"
cell.com/cell/fulltex...
[2/3] become accomplices in the spread of cancer. A study by the team of Professor Hu Ying from the Department of Life Sciences and Medicine of Harbin Institute of Technology found the "rebellion promoter" hidden in cells - a new micropeptide named "UEIS" and developed its response
July 10, 2026 at 8:04 AM
[2/3] become accomplices in the spread of cancer. A study by the team of Professor Hu Ying from the Department of Life Sciences and Medicine of Harbin Institute of Technology found the "rebellion promoter" hidden in cells - a new micropeptide named "UEIS" and developed its response
[1/3] 2026-07-10 15:46:56 - [The Harbin Institute of Technology team discovered a new type of immune-modulating micropeptide] The immune system in the human body is supposed to be the main force in clearing cancer cells, but inside tumors, some immune cells are often "incited" and
July 10, 2026 at 8:04 AM
[1/3] 2026-07-10 15:46:56 - [The Harbin Institute of Technology team discovered a new type of immune-modulating micropeptide] The immune system in the human body is supposed to be the main force in clearing cancer cells, but inside tumors, some immune cells are often "incited" and
[2/3] become accomplices in the spread of cancer. A study by the team of Professor Hu Ying from the Department of Life Sciences and Medicine of Harbin Institute of Technology found the "rebellion promoter" hidden in cells - a new micropeptide named "UEIS" and developed its response
July 10, 2026 at 7:54 AM
[2/3] become accomplices in the spread of cancer. A study by the team of Professor Hu Ying from the Department of Life Sciences and Medicine of Harbin Institute of Technology found the "rebellion promoter" hidden in cells - a new micropeptide named "UEIS" and developed its response
[1/3] 2026-07-10 15:46:56 - [The Harbin Institute of Technology team discovered a new type of immune-modulating micropeptide] The immune system in the human body is supposed to be the main force in clearing cancer cells, but inside tumors, some immune cells are often "incited" and
July 10, 2026 at 7:54 AM
[1/3] 2026-07-10 15:46:56 - [The Harbin Institute of Technology team discovered a new type of immune-modulating micropeptide] The immune system in the human body is supposed to be the main force in clearing cancer cells, but inside tumors, some immune cells are often "incited" and
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Nature research paper: Probing condensate microenvironments with a micropeptide killswitch
https://go.nature.com/4mMlGyc
https://go.nature.com/4mMlGyc
Probing condensate microenvironments with a micropeptide killswitch - Nature
Targeting a non-natural micropeptide ‘killswitch’ to several biomolecular condensates altered condensate compositions and revealed condensate functions in human cells
go.nature.com
June 9, 2025 at 12:34 PM
Nature research paper: Probing condensate microenvironments with a micropeptide killswitch
https://go.nature.com/4mMlGyc
https://go.nature.com/4mMlGyc
Xiao et. al. show that Malat1, a long non-coding RNA commonly associated with cancer, has a distinct role in neuronal development and synaptic function. In neurons, Malat1 is exported to the cytoplasm and translated into a micropeptide.
Read more here:
➡️https://tinyurl.com/gd351557
Read more here:
➡️https://tinyurl.com/gd351557
May 31, 2024 at 6:57 PM
Xiao et. al. show that Malat1, a long non-coding RNA commonly associated with cancer, has a distinct role in neuronal development and synaptic function. In neurons, Malat1 is exported to the cytoplasm and translated into a micropeptide.
Read more here:
➡️https://tinyurl.com/gd351557
Read more here:
➡️https://tinyurl.com/gd351557
凝集体の機能を操作する
細胞内凝集体機能を操作するアプローチとして非天然のマイクロペプチド「キルスイッチ」を発見。細胞内凝集体にリクルートすることで、凝集体の可動性やタンパク質組成を変化させることができる
短い配列で十分なことに驚きました
www.nature.com/articles/s41...
細胞内凝集体機能を操作するアプローチとして非天然のマイクロペプチド「キルスイッチ」を発見。細胞内凝集体にリクルートすることで、凝集体の可動性やタンパク質組成を変化させることができる
短い配列で十分なことに驚きました
www.nature.com/articles/s41...
Probing condensate microenvironments with a micropeptide killswitch - Nature
Targeting a non-natural micropeptide ‘killswitch’ to several biomolecular condensates altered condensate compositions and revealed condensate functions in human cells
www.nature.com
June 5, 2025 at 10:02 AM
凝集体の機能を操作する
細胞内凝集体機能を操作するアプローチとして非天然のマイクロペプチド「キルスイッチ」を発見。細胞内凝集体にリクルートすることで、凝集体の可動性やタンパク質組成を変化させることができる
短い配列で十分なことに驚きました
www.nature.com/articles/s41...
細胞内凝集体機能を操作するアプローチとして非天然のマイクロペプチド「キルスイッチ」を発見。細胞内凝集体にリクルートすることで、凝集体の可動性やタンパク質組成を変化させることができる
短い配列で十分なことに驚きました
www.nature.com/articles/s41...
🌟Online today
Hu and colleagues report that a micropeptide encoded by the lncRNA USP30-AS1 promotes tumor growth by undergoing phase separation with TBK1 and attenuating cGAS–STING–type I IFN signaling in tumor-associated macrophages.
www.nature.com/articles/s43...
Hu and colleagues report that a micropeptide encoded by the lncRNA USP30-AS1 promotes tumor growth by undergoing phase separation with TBK1 and attenuating cGAS–STING–type I IFN signaling in tumor-associated macrophages.
www.nature.com/articles/s43...
A micropeptide encoded by the lncRNA USP30-AS1 promotes tumor growth by attenuating cGAS–STING–type I IFN signaling in macrophages - Nature Cancer
Hu and colleagues report that a micropeptide encoded by the lncRNA USP30-AS1 promotes tumor growth by undergoing phase separation with TBK1 and attenuating cGAS–STING–type I IFN signaling in tumor-ass...
www.nature.com
July 9, 2026 at 2:28 PM
🌟Online today
Hu and colleagues report that a micropeptide encoded by the lncRNA USP30-AS1 promotes tumor growth by undergoing phase separation with TBK1 and attenuating cGAS–STING–type I IFN signaling in tumor-associated macrophages.
www.nature.com/articles/s43...
Hu and colleagues report that a micropeptide encoded by the lncRNA USP30-AS1 promotes tumor growth by undergoing phase separation with TBK1 and attenuating cGAS–STING–type I IFN signaling in tumor-associated macrophages.
www.nature.com/articles/s43...
Anyhow I would be very surprised is many of these lncRNAs would be able to produce enough micropeptide copie to make it essential for cellular viability...
December 6, 2024 at 3:19 PM
Anyhow I would be very surprised is many of these lncRNAs would be able to produce enough micropeptide copie to make it essential for cellular viability...
1/7
Killswitch (KS) is a non-natural, self-associating micropeptide that can be genetically fused to condensate proteins or recruited via GFP-nanobody. It immobilizes scaffold proteins without affecting soluble pools—letting us perturb condensates selectively in live cells.
Killswitch (KS) is a non-natural, self-associating micropeptide that can be genetically fused to condensate proteins or recruited via GFP-nanobody. It immobilizes scaffold proteins without affecting soluble pools—letting us perturb condensates selectively in live cells.
June 4, 2025 at 3:29 PM
1/7
Killswitch (KS) is a non-natural, self-associating micropeptide that can be genetically fused to condensate proteins or recruited via GFP-nanobody. It immobilizes scaffold proteins without affecting soluble pools—letting us perturb condensates selectively in live cells.
Killswitch (KS) is a non-natural, self-associating micropeptide that can be genetically fused to condensate proteins or recruited via GFP-nanobody. It immobilizes scaffold proteins without affecting soluble pools—letting us perturb condensates selectively in live cells.
What controls condensate composition and function beyond binding stoichiometry? We show that condensate microenvironments play a key role, and can be probed by a micropeptide killswitch in live cells. www.nature.com/articles/s41... in @nature.com with @yaotianzhang.bsky.social Denes Hnisz & team.
www.nature.com
June 4, 2025 at 3:29 PM
What controls condensate composition and function beyond binding stoichiometry? We show that condensate microenvironments play a key role, and can be probed by a micropeptide killswitch in live cells. www.nature.com/articles/s41... in @nature.com with @yaotianzhang.bsky.social Denes Hnisz & team.
Killswitch (KS) is a non-natural, self-associating micropeptide that can be genetically fused to condensate proteins or recruited via GFP-nanobody. It immobilizes scaffold proteins without affecting soluble pools—letting us perturb condensates selectively in live cells.
June 4, 2025 at 3:21 PM
Killswitch (KS) is a non-natural, self-associating micropeptide that can be genetically fused to condensate proteins or recruited via GFP-nanobody. It immobilizes scaffold proteins without affecting soluble pools—letting us perturb condensates selectively in live cells.