Our paper describing a novel DNA binding mode for MORC2 is published! Congratulations to Nika Fendler on her first, first author paper. This was an epic effort and revealed many new and unpredicted functions for MORC2. You can read about it here: tinyurl.com/MORC2-DNA
December 31, 2024 at 3:23 PM
Our paper describing a novel DNA binding mode for MORC2 is published! Congratulations to Nika Fendler on her first, first author paper. This was an epic effort and revealed many new and unpredicted functions for MORC2. You can read about it here: tinyurl.com/MORC2-DNA
✨Excited to share my first postdoc paper on chromatin remodeler, MORC2 ✨
Using #cryoEM & #singlemolecule imaging, we reveal how MORC2 compacts DNA 🔬🧬
Thanks to all collaborators from @wehi-research.bsky.social @ccemmp-outreach.bsky.social Uni Melb, Monash Uni, Seoul National Uni and Texas Uni!
Using #cryoEM & #singlemolecule imaging, we reveal how MORC2 compacts DNA 🔬🧬
Thanks to all collaborators from @wehi-research.bsky.social @ccemmp-outreach.bsky.social Uni Melb, Monash Uni, Seoul National Uni and Texas Uni!
Researchers learned a function of enzyme MORC2, that helps organise DNA and turn off genes when not needed. Mutations in MORC2 cause Charcot-Marie-Tooth disease, a rare condition that weakens muscles. These findings could lead to new treatments.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
July 2, 2025 at 6:19 AM
✨Excited to share my first postdoc paper on chromatin remodeler, MORC2 ✨
Using #cryoEM & #singlemolecule imaging, we reveal how MORC2 compacts DNA 🔬🧬
Thanks to all collaborators from @wehi-research.bsky.social @ccemmp-outreach.bsky.social Uni Melb, Monash Uni, Seoul National Uni and Texas Uni!
Using #cryoEM & #singlemolecule imaging, we reveal how MORC2 compacts DNA 🔬🧬
Thanks to all collaborators from @wehi-research.bsky.social @ccemmp-outreach.bsky.social Uni Melb, Monash Uni, Seoul National Uni and Texas Uni!
Very proud of this work where we define how the MORC2 ATPase directs CpG methylation of active human L1 transposons in early development.
Thanks to co-authors, funders & wonderful environment @lundstem.bsky.social
www.biorxiv.org/content/10.1...
Brief thread below (do people still do that?) 1/X
Thanks to co-authors, funders & wonderful environment @lundstem.bsky.social
www.biorxiv.org/content/10.1...
Brief thread below (do people still do that?) 1/X
MORC2 directs transcription-dependent CpG methylation of human LINE-1 transposons in early neurodevelopment
Methylation of CpG dinucleotides is essential for silencing genomic repeats such as LINE-1 retrotransposons (L1s) in the germline and soma. Evolutionarily-young L1s are transcribed in human pluripoten...
www.biorxiv.org
July 1, 2025 at 12:55 PM
Very proud of this work where we define how the MORC2 ATPase directs CpG methylation of active human L1 transposons in early development.
Thanks to co-authors, funders & wonderful environment @lundstem.bsky.social
www.biorxiv.org/content/10.1...
Brief thread below (do people still do that?) 1/X
Thanks to co-authors, funders & wonderful environment @lundstem.bsky.social
www.biorxiv.org/content/10.1...
Brief thread below (do people still do that?) 1/X
Researchers learned a function of enzyme MORC2, that helps organise DNA and turn off genes when not needed. Mutations in MORC2 cause Charcot-Marie-Tooth disease, a rare condition that weakens muscles. These findings could lead to new treatments.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
July 2, 2025 at 4:49 AM
Researchers learned a function of enzyme MORC2, that helps organise DNA and turn off genes when not needed. Mutations in MORC2 cause Charcot-Marie-Tooth disease, a rare condition that weakens muscles. These findings could lead to new treatments.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
A new collection of #mitochondrialdisease papers from last week!
biomed.news/bims-mitdis/...
@biomednews.bsky.social @gavinmcstay.bsky.social @mitoscientist.bsky.social @mitoscientists.bsky.social @mitoworld.bsky.social
Pleiotropic effects of MORC2 derive from its epigenetic signature
biomed.news/bims-mitdis/...
@biomednews.bsky.social @gavinmcstay.bsky.social @mitoscientist.bsky.social @mitoscientists.bsky.social @mitoworld.bsky.social
Pleiotropic effects of MORC2 derive from its epigenetic signature
May 4, 2025 at 8:46 AM
A new collection of #mitochondrialdisease papers from last week!
biomed.news/bims-mitdis/...
@biomednews.bsky.social @gavinmcstay.bsky.social @mitoscientist.bsky.social @mitoscientists.bsky.social @mitoworld.bsky.social
Pleiotropic effects of MORC2 derive from its epigenetic signature
biomed.news/bims-mitdis/...
@biomednews.bsky.social @gavinmcstay.bsky.social @mitoscientist.bsky.social @mitoscientists.bsky.social @mitoworld.bsky.social
Pleiotropic effects of MORC2 derive from its epigenetic signature
Winnie Tan our 5th Anders Early Career Award winner! Charcot Marie Tooth neuromuscular disease. Morc2 mutation early symptom onset worsening with age. Gastric cancer association of phosphoMORC2. ChIP-seq morc2 binds to open chromatin regions. A tour de force Winnie!
#LorneProteins2025
#LorneProteins2025
February 11, 2025 at 10:52 PM
Winnie Tan our 5th Anders Early Career Award winner! Charcot Marie Tooth neuromuscular disease. Morc2 mutation early symptom onset worsening with age. Gastric cancer association of phosphoMORC2. ChIP-seq morc2 binds to open chromatin regions. A tour de force Winnie!
#LorneProteins2025
#LorneProteins2025
Researchers identified a DNA binding region in the MORC2 protein that is essential for gene silencing. The site on the C-terminal domain reduces ATPase activity and traps DNA. Mutations can occur that disrupt silencing, showing MORC2's role in gene expression regulation. @yeastychic.bsky.social
Our paper describing a novel DNA binding mode for MORC2 is published! Congratulations to Nika Fendler on her first, first author paper. This was an epic effort and revealed many new and unpredicted functions for MORC2. You can read about it here: tinyurl.com/MORC2-DNA
April 11, 2025 at 3:58 AM
Researchers identified a DNA binding region in the MORC2 protein that is essential for gene silencing. The site on the C-terminal domain reduces ATPase activity and traps DNA. Mutations can occur that disrupt silencing, showing MORC2's role in gene expression regulation. @yeastychic.bsky.social
Pleiotropic effects of MORC2 derive from its epigenetic signature #RareDisease #Genetics academic.oup.com/brain/advanc...
Pleiotropic effects of MORC2 derive from its epigenetic signature
Peymani et al. investigate epigenetic variation in 50 clinically heterogeneous patients with mutations in MORC2. They identify a cross-tissue MORC2-specifi
academic.oup.com
May 2, 2025 at 8:19 AM
Pleiotropic effects of MORC2 derive from its epigenetic signature #RareDisease #Genetics academic.oup.com/brain/advanc...
New research led by Professor Yorgo Modis with patient-led global charity MORCure is exploring how mutations in MORC2 cause rare neurological disease. The project aims to inform future diagnosis and therapy for #M2RD patients.
🔗 buff.ly/hRJ9JGc
#CITIID @cam.ac.uk
🔗 buff.ly/hRJ9JGc
#CITIID @cam.ac.uk
Professor Yorgo Modis leads collaborative project on MORC2-related disorder | CITIID
Professor Yorgo Modis (Department of Medicine, University of Cambridge) is leading a research project with MORCure, a patient-led global charity that leads research, innovation and best practice for…
buff.ly
February 24, 2026 at 2:30 PM
New research led by Professor Yorgo Modis with patient-led global charity MORCure is exploring how mutations in MORC2 cause rare neurological disease. The project aims to inform future diagnosis and therapy for #M2RD patients.
🔗 buff.ly/hRJ9JGc
#CITIID @cam.ac.uk
🔗 buff.ly/hRJ9JGc
#CITIID @cam.ac.uk
MORC2 directs transcription-dependent CpG methylation of human LINE-1 transposons in early neurodevelopment https://www.biorxiv.org/content/10.1101/2025.06.11.658943v1
June 14, 2025 at 4:20 AM
MORC2 directs transcription-dependent CpG methylation of human LINE-1 transposons in early neurodevelopment https://www.biorxiv.org/content/10.1101/2025.06.11.658943v1
윤석열 앞에 놓인 미래는 파면과 파멸, 그리고 감옥뿐!
지난 10일, 비상행동 긴급집회 무대에 권영국 대표가 올랐습니다. 시민의 승리, 그리고 윤석열의 파면과 파멸을 확신하는 권영국 대표의 발언을 함께 들어봅시다!
youtube.com/shorts/moRC2...
지난 10일, 비상행동 긴급집회 무대에 권영국 대표가 올랐습니다. 시민의 승리, 그리고 윤석열의 파면과 파멸을 확신하는 권영국 대표의 발언을 함께 들어봅시다!
youtube.com/shorts/moRC2...
윤석열 앞에 놓인 미래는 파면과 파멸, 그리고 감옥뿐! | 250310 비상행동 긴급집회 권영국 당대표 발언
YouTube video by 정의당 TV
youtube.com
March 12, 2025 at 7:41 AM
윤석열 앞에 놓인 미래는 파면과 파멸, 그리고 감옥뿐!
지난 10일, 비상행동 긴급집회 무대에 권영국 대표가 올랐습니다. 시민의 승리, 그리고 윤석열의 파면과 파멸을 확신하는 권영국 대표의 발언을 함께 들어봅시다!
youtube.com/shorts/moRC2...
지난 10일, 비상행동 긴급집회 무대에 권영국 대표가 올랐습니다. 시민의 승리, 그리고 윤석열의 파면과 파멸을 확신하는 권영국 대표의 발언을 함께 들어봅시다!
youtube.com/shorts/moRC2...
The authors included RRIDs in their None paper! We value the author's support of reproducibility. #RRID #ReproducibleResearch #RRID
MORC2 is a phosphorylation-dependent DNA compaction machine
doi.org
July 23, 2025 at 7:01 AM
The authors included RRIDs in their None paper! We value the author's support of reproducibility. #RRID #ReproducibleResearch #RRID
A preprint using: lentiCRISPR v2 (RRID:Addgene_52961) from @addgene.bsky.social was published.
SciScore made a table with this resource, see “Automated Services” module (download as csv, xml or #jats) #methodsmatter #reproducibility
SciScore made a table with this resource, see “Automated Services” module (download as csv, xml or #jats) #methodsmatter #reproducibility
MORC2 Mediates Transcriptional Regulation Through Liquid-Liquid Phase Separation
www.biorxiv.org
March 23, 2026 at 12:01 PM
A preprint using: lentiCRISPR v2 (RRID:Addgene_52961) from @addgene.bsky.social was published.
SciScore made a table with this resource, see “Automated Services” module (download as csv, xml or #jats) #methodsmatter #reproducibility
SciScore made a table with this resource, see “Automated Services” module (download as csv, xml or #jats) #methodsmatter #reproducibility
RRIDs were included in this paper. RRIDs improve reproducibility in scientific research. #STMpublishing #STMpublishing #methodsmatter
Impaired PARP1-dependent DNA repair in MORC2 mutations drives axonal degeneration in Charcot-Marie-Tooth disease subtype 2Z and spinal muscular atrophy-like neuromotor disorders
doi.org
January 30, 2026 at 8:00 AM
RRIDs were included in this paper. RRIDs improve reproducibility in scientific research. #STMpublishing #STMpublishing #methodsmatter
A preprint using: Unknown (RRID:Addgene_48139) from @addgene.bsky.social was published.
SciScore made a table with this resource, see “Automated Services” module (download as csv, xml or #jats) #STMpublishing #RRID
SciScore made a table with this resource, see “Automated Services” module (download as csv, xml or #jats) #STMpublishing #RRID
MORC2 directs transcription-dependent CpG methylation of human LINE-1 transposons in early neurodevelopment
www.biorxiv.org
July 6, 2025 at 12:00 PM
A preprint using: Unknown (RRID:Addgene_48139) from @addgene.bsky.social was published.
SciScore made a table with this resource, see “Automated Services” module (download as csv, xml or #jats) #STMpublishing #RRID
SciScore made a table with this resource, see “Automated Services” module (download as csv, xml or #jats) #STMpublishing #RRID
Search dgrc.bio.indiana.edu/Home before synthesizing or rebuilding a human #cDNA sequence. Start with an existing human ORF plasmid and use it as starting DNA for your own cloning workflow. #humangenetics #humanhealth
Some samples include:
#TP53
#PTEN
#BRAF
#MAPT
#SNCA
#SOD1
#LDLR
#MORC2
Some samples include:
#TP53
#PTEN
#BRAF
#MAPT
#SNCA
#SOD1
#LDLR
#MORC2
Drosophila Genomics Resource Center
DGRC Drosophila Genomics Resource Center
dgrc.bio.indiana.edu
August 18, 2026 at 5:45 PM
Search dgrc.bio.indiana.edu/Home before synthesizing or rebuilding a human #cDNA sequence. Start with an existing human ORF plasmid and use it as starting DNA for your own cloning workflow. #humangenetics #humanhealth
Some samples include:
#TP53
#PTEN
#BRAF
#MAPT
#SNCA
#SOD1
#LDLR
#MORC2
Some samples include:
#TP53
#PTEN
#BRAF
#MAPT
#SNCA
#SOD1
#LDLR
#MORC2
The authors included RRIDs in their in Molecular Cancer paper! Thanks for making your methods matter! #OpenResearch #reproducibility #OpenScience
Targeting MORC2 activates transposable element-mediated viral mimicry and potentiates immune checkpoint blockade in triple-negative breast cancer
Read the full paper: Targeting MORC2 activates transposable element-mediated viral mimicry and potentiates immune checkpoint blockade in triple-negative breast cancer
doi.org
August 9, 2026 at 7:07 AM
The authors included RRIDs in their in Molecular Cancer paper! Thanks for making your methods matter! #OpenResearch #reproducibility #OpenScience
🔬 Research
MORC2 controls HIF-1α stability via an HDAC4-dependent mechanism to regulate erythropoiesis
Proceedings of the National Academy of Sciences, Volume 123, Issue 31,...
https://littlebunker.com/2026/08/05/research_papers-morc2-controls-hif-1-stability-via-an-hd-69850138/
MORC2 controls HIF-1α stability via an HDAC4-dependent mechanism to regulate erythropoiesis
Proceedings of the National Academy of Sciences, Volume 123, Issue 31,...
https://littlebunker.com/2026/08/05/research_papers-morc2-controls-hif-1-stability-via-an-hd-69850138/
August 5, 2026 at 2:00 PM
🔬 Research
MORC2 controls HIF-1α stability via an HDAC4-dependent mechanism to regulate erythropoiesis
Proceedings of the National Academy of Sciences, Volume 123, Issue 31,...
https://littlebunker.com/2026/08/05/research_papers-morc2-controls-hif-1-stability-via-an-hd-69850138/
MORC2 controls HIF-1α stability via an HDAC4-dependent mechanism to regulate erythropoiesis
Proceedings of the National Academy of Sciences, Volume 123, Issue 31,...
https://littlebunker.com/2026/08/05/research_papers-morc2-controls-hif-1-stability-via-an-hd-69850138/
Science Briefing
MORC2 Controls HIF-1α Stability via HDAC4 to Regulate Erythropoiesis Personalized briefing Discovery of the day · Cell Biology MORC2 controls HIF-1α stability via an HDAC4-dependent mechanism to regulate erythropoiesis Dear Abdel Halim Harrath, this is your personalized scientific…
MORC2 Controls HIF-1α Stability via HDAC4 to Regulate Erythropoiesis Personalized briefing Discovery of the day · Cell Biology MORC2 controls HIF-1α stability via an HDAC4-dependent mechanism to regulate erythropoiesis Dear Abdel Halim Harrath, this is your personalized scientific…
Science Briefing
MORC2 Controls HIF-1α Stability via HDAC4 to Regulate Erythropoiesis Personalized briefing Discovery of the day · Cell Biology MORC2 controls HIF-1α stability via an HDAC4-dependent mechanism to regulate erythropoiesis Dear Abdel Halim Harrath, this is your personalized scientific intelligence briefing — curated for your work in Cell Biology. Key finding Biology · Cell Biology Discovery of the day This study identifies MORC2 as a novel negative regulator of HIF-1α, revealing a competitive binding mechanism between MORC2 and HDAC4 for HIF-1α that governs its acetylation and stability.
blog.sciencebriefing.com
July 28, 2026 at 11:05 AM
Science Briefing
MORC2 Controls HIF-1α Stability via HDAC4 to Regulate Erythropoiesis Personalized briefing Discovery of the day · Cell Biology MORC2 controls HIF-1α stability via an HDAC4-dependent mechanism to regulate erythropoiesis Dear Abdel Halim Harrath, this is your personalized scientific…
MORC2 Controls HIF-1α Stability via HDAC4 to Regulate Erythropoiesis Personalized briefing Discovery of the day · Cell Biology MORC2 controls HIF-1α stability via an HDAC4-dependent mechanism to regulate erythropoiesis Dear Abdel Halim Harrath, this is your personalized scientific…
A new charity, MORCure, has been launched to support families affected by the rare genetic condition MORC2. How can we raise awareness? #GeneticAwareness
https://www.henleyherald.com/2026/07/06/new-charity-launched-to-support-families-affected-by-rare-genetic-condition-morc2/
https://www.henleyherald.com/2026/07/06/new-charity-launched-to-support-families-affected-by-rare-genetic-condition-morc2/
New charity launched to support families affected by rare genetic condition MORC2 - Henley Herald
Anna-mai Andrews has launched global charity MORCure after her daughter Amber was diagnosed with MORC2, an ultra-rare genetic condition, in 2022. MORC2...
www.henleyherald.com
July 6, 2026 at 5:29 PM
A new charity, MORCure, has been launched to support families affected by the rare genetic condition MORC2. How can we raise awareness? #GeneticAwareness
https://www.henleyherald.com/2026/07/06/new-charity-launched-to-support-families-affected-by-rare-genetic-condition-morc2/
https://www.henleyherald.com/2026/07/06/new-charity-launched-to-support-families-affected-by-rare-genetic-condition-morc2/
Meet Anna-mai Andrews, who launched MORCure to support families impacted by the rare MORC2 condition. How can we better support such causes? #GeneticAwareness
https://www.henleyherald.com/2026/07/06/new-charity-launched-to-support-families-affected-by-rare-genetic-condition-morc2/
https://www.henleyherald.com/2026/07/06/new-charity-launched-to-support-families-affected-by-rare-genetic-condition-morc2/
New charity launched to support families affected by rare genetic condition MORC2 - Henley Herald
Anna-mai Andrews has launched global charity MORCure after her daughter Amber was diagnosed with MORC2, an ultra-rare genetic condition, in 2022. MORC2...
www.henleyherald.com
July 6, 2026 at 4:29 PM
Meet Anna-mai Andrews, who launched MORCure to support families impacted by the rare MORC2 condition. How can we better support such causes? #GeneticAwareness
https://www.henleyherald.com/2026/07/06/new-charity-launched-to-support-families-affected-by-rare-genetic-condition-morc2/
https://www.henleyherald.com/2026/07/06/new-charity-launched-to-support-families-affected-by-rare-genetic-condition-morc2/
Peymani et al. identify a cross-tissue MORC2-specific epigenetic signature in 50 clinically heterogeneous patients with MORC2 mutations, and show that reduced expression of three genes with hypermethylated promoters can explain a number of symptoms. tinyurl.com/2urv2fsh
May 1, 2025 at 9:15 AM
Peymani et al. identify a cross-tissue MORC2-specific epigenetic signature in 50 clinically heterogeneous patients with MORC2 mutations, and show that reduced expression of three genes with hypermethylated promoters can explain a number of symptoms. tinyurl.com/2urv2fsh
