mTORC1 is activated when cells are fed with amino acids. New preprint with @robzonculab.bsky.social led by Rachel Jansen shows how the massive "CastiGATOR" complex is formed when arginine-free CASTOR1 binds to the GATOR2 complex to antagonize mTORC1 starved cells. tinyurl.com/yr6en6f4
May 14, 2025 at 3:30 PM
mTORC1 is activated when cells are fed with amino acids. New preprint with @robzonculab.bsky.social led by Rachel Jansen shows how the massive "CastiGATOR" complex is formed when arginine-free CASTOR1 binds to the GATOR2 complex to antagonize mTORC1 starved cells. tinyurl.com/yr6en6f4
Nature research paper: Structural basis for the dynamic regulation of mTORC1 by amino acids
go.nature.com/3V8r3Lw
go.nature.com/3V8r3Lw
Structural basis for the dynamic regulation of mTORC1 by amino acids - Nature
Using cryo-electron microscopy, the interactions of Sestrin2 and CASTOR1 with GATOR2 were resolved, revealing how mTORC1 activation is regulated and how nutrient availability triggers signalling for cellular growth.
go.nature.com
August 24, 2025 at 3:00 PM
Nature research paper: Structural basis for the dynamic regulation of mTORC1 by amino acids
go.nature.com/3V8r3Lw
go.nature.com/3V8r3Lw
mTORC1 activity licenses its own release from the lysosomal surface
www.cell.com/molecular-ce...
www.cell.com/molecular-ce...
mTORC1 activity licenses its own release from the lysosomal surface
The activation of mTORC1 is intricately linked to its subcellular localization, with
the Rag GTPases controlling its lysosomal recruitment in response to nutrient cues.
Acharya and Demetriades uncover...
www.cell.com
November 23, 2024 at 11:13 AM
mTORC1 activity licenses its own release from the lysosomal surface
www.cell.com/molecular-ce...
www.cell.com/molecular-ce...
Nutrient control of growth and metabolism through mTORC1 regulation of mRNA splicing 🧪
www.cell.com/molecular-ce...
www.cell.com/molecular-ce...
Nutrient control of growth and metabolism through mTORC1 regulation of mRNA splicing
Ogawa et al. show in Caenorhabditis elegans that the essential growth regulator mTORC1
extensively reprograms gene expression and alternative mRNA splicing. This splicing
regulation is critical for gr...
www.cell.com
November 21, 2024 at 1:54 PM
Nutrient control of growth and metabolism through mTORC1 regulation of mRNA splicing 🧪
www.cell.com/molecular-ce...
www.cell.com/molecular-ce...
Excited to share our work reporting that fly Lsp2 acts as a nutrient-induced physiological factor that amplifies mTORC1 output in TOP mRNA translation and regulates lifespan.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Lsp2 links mTORC1 to TOP mRNA translation and lifespan in Drosophila - Nature
In Drosophila, the protein Lsp2, which is induced by dietary essential amino acids, is a key physiological effector of mTORC1, and mutant flies that lack the Lsp2 gene exhibit reduced translation of T...
www.nature.com
September 25, 2026 at 1:55 PM
Excited to share our work reporting that fly Lsp2 acts as a nutrient-induced physiological factor that amplifies mTORC1 output in TOP mRNA translation and regulates lifespan.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Nutrient control of growth and metabolism through mTORC1 regulation of mRNA splicing
www.cell.com/molecular-ce...
www.cell.com/molecular-ce...
Nutrient control of growth and metabolism through mTORC1 regulation of mRNA splicing
Ogawa et al. show in Caenorhabditis elegans that the essential growth regulator mTORC1 extensively reprograms gene expression and alternative mRNA splicing. This splicing regulation is critical for growth, orchestrates growth-associated metabolism, and appears to be conserved. Maintaining mTORC1-induced splicing may be beneficial for longevity under conditions of mTORC1 inhibition.
www.cell.com
December 7, 2024 at 1:43 PM
Nutrient control of growth and metabolism through mTORC1 regulation of mRNA splicing
www.cell.com/molecular-ce...
www.cell.com/molecular-ce...
Lsp2 links mTORC1 to TOP mRNA translation and lifespan in Drosophila
#Drosophila
#Drosophila
Lsp2 links mTORC1 to TOP mRNA translation and lifespan in Drosophila
#Drosophila
PubMed link
pubmed.ncbi.nlm.nih.gov
September 24, 2026 at 10:23 AM
Lsp2 links mTORC1 to TOP mRNA translation and lifespan in Drosophila
#Drosophila
#Drosophila
A signaling pathway involving the metabolite G3P and the protein complex mTORC1 activates the production of triglycerides in the liver and may contribute to fatty liver disease, according to new work in cells and mice. #ScienceSignaling https://scim.ag/4hcImY2
Glycerol 3-phosphate activates lipid metabolism through GATOR2-dependent regulation of mTORC1
An mTORC1-activating signal that promotes triglyceride synthesis and its major hepatic source are revealed.
scim.ag
July 15, 2026 at 3:30 PM
A signaling pathway involving the metabolite G3P and the protein complex mTORC1 activates the production of triglycerides in the liver and may contribute to fatty liver disease, according to new work in cells and mice. #ScienceSignaling https://scim.ag/4hcImY2
Proud of new work tinyurl.com/yhz4c6ry from the lab by Zhicheng (Chen) Cui using single-particle cryo-EM on liposomes to show how mTORC1 integrates nutrient and growth factor signaling at lysosomes, collab. w/
G. Napolitano,A. Esposito, and A. Ballabio.
G. Napolitano,A. Esposito, and A. Ballabio.
November 16, 2024 at 4:31 PM
Proud of new work tinyurl.com/yhz4c6ry from the lab by Zhicheng (Chen) Cui using single-particle cryo-EM on liposomes to show how mTORC1 integrates nutrient and growth factor signaling at lysosomes, collab. w/
G. Napolitano,A. Esposito, and A. Ballabio.
G. Napolitano,A. Esposito, and A. Ballabio.
Finally in @nature.com 🎉
We uncovered step-wise mTORC1 activation on membrane: RAG–Ragulator recruits, RHEB pushes closer, and direct membrane contacts by RAPTOR + mTOR trigger full kinase activity.👉 The membrane is not just a platform — it’s part of the mechanism.
www.nature.com/articles/s41...
We uncovered step-wise mTORC1 activation on membrane: RAG–Ragulator recruits, RHEB pushes closer, and direct membrane contacts by RAPTOR + mTOR trigger full kinase activity.👉 The membrane is not just a platform — it’s part of the mechanism.
www.nature.com/articles/s41...
Structural basis for mTORC1 activation on the lysosomal membrane - Nature
Cryo-electron microscopy was used to study human mechanistic target of rapamycin complex 1 (mTORC1) activation on lysosomal membranes, showing progressive recruitment by RAG–Ragulator, RHEB and R...
www.nature.com
September 17, 2025 at 9:35 PM
Finally in @nature.com 🎉
We uncovered step-wise mTORC1 activation on membrane: RAG–Ragulator recruits, RHEB pushes closer, and direct membrane contacts by RAPTOR + mTOR trigger full kinase activity.👉 The membrane is not just a platform — it’s part of the mechanism.
www.nature.com/articles/s41...
We uncovered step-wise mTORC1 activation on membrane: RAG–Ragulator recruits, RHEB pushes closer, and direct membrane contacts by RAPTOR + mTOR trigger full kinase activity.👉 The membrane is not just a platform — it’s part of the mechanism.
www.nature.com/articles/s41...
Really nice to see out this interesting study from @carriesokol.bsky.social
Sensory neuronal mTORC1 kinase signaling establishes neuroimmune memory that initiates allergic immunity: Immunity www.cell.com/immunity/ful...
Sensory neuronal mTORC1 kinase signaling establishes neuroimmune memory that initiates allergic immunity: Immunity www.cell.com/immunity/ful...
Sensory neuronal mTORC1 kinase signaling establishes neuroimmune memory that initiates allergic immunity
How cumulative environmental allergen exposures are encoded by peripheral sensory
neurons to shape immune responsiveness is unclear. Zhu et al. show that protease allergens
induce an mTORC1-dependent,...
www.cell.com
September 22, 2026 at 9:04 PM
Really nice to see out this interesting study from @carriesokol.bsky.social
Sensory neuronal mTORC1 kinase signaling establishes neuroimmune memory that initiates allergic immunity: Immunity www.cell.com/immunity/ful...
Sensory neuronal mTORC1 kinase signaling establishes neuroimmune memory that initiates allergic immunity: Immunity www.cell.com/immunity/ful...
Version of Record
Structural basis for mTORC1 activation on the lysosomal membrane
www.nature.com/articles/s41...
Structural basis for mTORC1 activation on the lysosomal membrane
www.nature.com/articles/s41...
Structural basis for mTORC1 activation on the lysosomal membrane - Nature
Cryo-electron microscopy was used to study human mechanistic target of rapamycin complex 1 (mTORC1) activation on lysosomal membranes, showing progressive recruitment by RAG–Ragulator, RHEB and R...
www.nature.com
September 17, 2025 at 4:11 PM
Version of Record
Structural basis for mTORC1 activation on the lysosomal membrane
www.nature.com/articles/s41...
Structural basis for mTORC1 activation on the lysosomal membrane
www.nature.com/articles/s41...
Synergistic mTORC1 activation by IL-15 and IL-18 enhances NK cell cytotoxicity toward cancer cells @thierrywalzer.bsky.social
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
September 17, 2025 at 4:46 PM
Synergistic mTORC1 activation by IL-15 and IL-18 enhances NK cell cytotoxicity toward cancer cells @thierrywalzer.bsky.social
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
1/ Why can you encounter an allergen repeatedly before becoming allergic to it? In our new @cp-immunity.bsky.social paper, led by the wonderful Xueping Zhu, we asked whether the sensory neurons that first detect allergens might carry a record of earlier exposures. 🧵
www.cell.com/immunity/ful...
www.cell.com/immunity/ful...
Sensory neuronal mTORC1 kinase signaling establishes neuroimmune memory that initiates allergic immunity
How cumulative environmental allergen exposures are encoded by peripheral sensory
neurons to shape immune responsiveness is unclear. Zhu et al. show that protease allergens
induce an mTORC1-dependent,...
www.cell.com
September 23, 2026 at 2:33 PM
1/ Why can you encounter an allergen repeatedly before becoming allergic to it? In our new @cp-immunity.bsky.social paper, led by the wonderful Xueping Zhu, we asked whether the sensory neurons that first detect allergens might carry a record of earlier exposures. 🧵
www.cell.com/immunity/ful...
www.cell.com/immunity/ful...
tinyurl.com/mrce6bbb Fun to write this N&V together with Regina @hrshin.bsky.social, on the several cryoEM papers that build on her discovery of the fascinating LYCHOS protein and its role in cholesterol sensing and mTORC1 regulation!
Cholesterol finds its pocket in LYCHOS - Nature Structural & Molecular Biology
The lysosomal transmembrane protein LYCHOS enables activation of the master growth regulator mTORC1 kinase by cholesterol. Here we summarize recent structural findings that shed light on the LYCHOS ch...
tinyurl.com
April 28, 2025 at 3:42 PM
tinyurl.com/mrce6bbb Fun to write this N&V together with Regina @hrshin.bsky.social, on the several cryoEM papers that build on her discovery of the fascinating LYCHOS protein and its role in cholesterol sensing and mTORC1 regulation!
First post on bluesky gotta be the structure of mTORC1 on membrane! A great collaboration and interesting frontier for SPA cryoEM!
Proud of new work tinyurl.com/yhz4c6ry from the lab by Zhicheng (Chen) Cui using single-particle cryo-EM on liposomes to show how mTORC1 integrates nutrient and growth factor signaling at lysosomes, collab. w/
G. Napolitano,A. Esposito, and A. Ballabio.
G. Napolitano,A. Esposito, and A. Ballabio.
November 17, 2024 at 9:07 PM
First post on bluesky gotta be the structure of mTORC1 on membrane! A great collaboration and interesting frontier for SPA cryoEM!
A genetically encoded peptide inhibitor of mTORC1 is developed and reveals that nuclear mTORC1 regulates a specific set of genes and promotes cancer cell proliferation
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Genetically targeted mTORC1 inhibitor reveals transcriptional control by nuclear mTORC1 - Nature Chemical Biology
A genetically encoded peptide inhibitor of mTORC1, TerminaTOR, was developed that enables inhibition of subcellular mTORC1 and reveals that nuclear mTORC1 regulates a specific set of genes and promote...
www.nature.com
May 15, 2026 at 4:33 PM
A genetically encoded peptide inhibitor of mTORC1 is developed and reveals that nuclear mTORC1 regulates a specific set of genes and promotes cancer cell proliferation
www.nature.com/articles/s41...
www.nature.com/articles/s41...
#mTOR research field never ceases to amaze, what a tour de force! 👇🏼
mTORC1 senses glutamine and other amino acids through GCN2 | The EMBO Journal www.embopress.org/doi/full/10....
mTORC1 senses glutamine and other amino acids through GCN2 | The EMBO Journal www.embopress.org/doi/full/10....
mTORC1 senses glutamine and other amino acids through GCN2 | The EMBO Journal
imageimageDuring starvation, individual amino acid levels are thought to be relayed via distinct metabolic sensors, but how mTORC1 senses glutamine remains unclear. This study finds that GCN2 kinase acts as a unifying module in suppression of ...
www.embopress.org
September 2, 2025 at 8:29 AM
#mTOR research field never ceases to amaze, what a tour de force! 👇🏼
mTORC1 senses glutamine and other amino acids through GCN2 | The EMBO Journal www.embopress.org/doi/full/10....
mTORC1 senses glutamine and other amino acids through GCN2 | The EMBO Journal www.embopress.org/doi/full/10....
Lsp2 links mTORC1 to TOP mRNA translation and lifespan in Drosophila @Nature.com
Lsp2 links mTORC1 to TOP mRNA translation and lifespan in Drosophila
Nature, Published online: 23 September 2026; doi:10.1038/s41586-026-11029-xIn Drosophila, the protein Lsp2, which is induced by dietary essential amino acids, is a key physiological effector of mTORC1, and mutant flies that lack the Lsp2 gene exhibit reduced translation of TOP mRNAs and improved longevity.
dlvr.it
September 24, 2026 at 2:30 PM
Lsp2 links mTORC1 to TOP mRNA translation and lifespan in Drosophila @Nature.com
Online now: Sensory neuronal mTORC1 kinase signaling establishes neuroimmune memory that initiates allergic immunity
Sensory neuronal mTORC1 kinase signaling establishes neuroimmune memory that initiates allergic immunity
How cumulative environmental allergen exposures are encoded by peripheral sensory neurons to shape immune responsiveness is unclear. Zhu et al. show that protease allergens induce an mTORC1-dependent, metabolically trained state in sensory neurons that amplifies later neuroimmune responses to allergens and enables cross-sensitization to antigenically distinct allergens.
dlvr.it
September 22, 2026 at 2:48 PM
Online now: Sensory neuronal mTORC1 kinase signaling establishes neuroimmune memory that initiates allergic immunity
Nature research paper: Structural basis for mTORC1 activation on the lysosomal membrane
go.nature.com/3VmoKEU
go.nature.com/3VmoKEU
Structural basis for mTORC1 activation on the lysosomal membrane - Nature
Cryo-electron microscopy was used to study human mechanistic target of rapamycin complex 1 (mTORC1) activation on lysosomal membranes, showing progressive recruitment by RAG–Ragulator, RHEB and RAPTOR, culminating in mTOR–membrane engagement and full enzyme activation.
go.nature.com
September 18, 2025 at 5:28 PM
Nature research paper: Structural basis for mTORC1 activation on the lysosomal membrane
go.nature.com/3VmoKEU
go.nature.com/3VmoKEU
A new #ScienceSignaling study reveals how a cytokine cocktail used to activate natural killer cells for cancer #immunotherapy invigorates their antitumor abilities through a twin-pronged molecular pathway, potentially informing future clinical applications. https://scim.ag/4nt5SA2
Interleukins 15 and 18 synergistically prime the antitumor function of natural killer cells through noncanonical activation of mTORC1
mTORC1 activation by components of a cytokine cocktail enhances NK cell cytotoxicity toward cancer cells.
scim.ag
September 17, 2025 at 2:52 PM
A new #ScienceSignaling study reveals how a cytokine cocktail used to activate natural killer cells for cancer #immunotherapy invigorates their antitumor abilities through a twin-pronged molecular pathway, potentially informing future clinical applications. https://scim.ag/4nt5SA2
Direct sensing of dietary ω-6 linoleic acid through FABP5-mTORC1 signaling | Science www.science.org/doi/10.1126/...
Direct sensing of dietary ω-6 linoleic acid through FABP5-mTORC1 signaling
Diet influences macronutrient availability to cells, and although mechanisms of sensing dietary glucose and amino acids are well characterized, less is known about sensing lipids. We defined a nutrien...
www.science.org
March 16, 2025 at 6:07 AM
Direct sensing of dietary ω-6 linoleic acid through FABP5-mTORC1 signaling | Science www.science.org/doi/10.1126/...