🎉 Over the moon to share the first paper from my lab!! We discovered an unexpected role for the cytokine OSM in lung epithelial homeostasis and repair. 🧵 1/n www.science.org/doi/10.1126/...
Macrophage-derived oncostatin M repairs the lung epithelial barrier during inflammatory damage
Tissue repair programs must function alongside antiviral immunity to restore the lung epithelial barrier following infection. We found that macrophage-derived oncostatin M (OSM) counteracted the patho...
www.science.org
July 11, 2025 at 1:03 AM
🎉 Over the moon to share the first paper from my lab!! We discovered an unexpected role for the cytokine OSM in lung epithelial homeostasis and repair. 🧵 1/n www.science.org/doi/10.1126/...
#WeekendRead! #InterferonsFriendsOrFoes?! @ruthfranklinlab.bsky.social, Medzhitov, Hoagland, Rodriguez-Morales &co show @science.org that macrophage-derived oncostatin M overcomes type I IFN detrimental responses during severe influenza lung infection by driving AT-II epithelial cell proliferation!
Macrophage-derived oncostatin M repairs the lung epithelial barrier during inflammatory damage
Tissue repair programs must function alongside antiviral immunity to restore the lung epithelial barrier following infection. We found that macrophage-derived oncostatin M (OSM) counteracted the patho...
www.science.org
July 12, 2025 at 2:10 PM
#WeekendRead! #InterferonsFriendsOrFoes?! @ruthfranklinlab.bsky.social, Medzhitov, Hoagland, Rodriguez-Morales &co show @science.org that macrophage-derived oncostatin M overcomes type I IFN detrimental responses during severe influenza lung infection by driving AT-II epithelial cell proliferation!
Lactic acid lover? Check out @ronni.bsky.social 's new work in
@cp-cellhostmicrobe.bsky.social showing how Enterococcus faecalis-derived LA suppresses macrophage activation, in turn promoting bacterial persistence and polymicrobial wound infection in vivo.
www.sciencedirect.com/science/arti...
@cp-cellhostmicrobe.bsky.social showing how Enterococcus faecalis-derived LA suppresses macrophage activation, in turn promoting bacterial persistence and polymicrobial wound infection in vivo.
www.sciencedirect.com/science/arti...
Enterococcus faecalis-derived lactic acid suppresses macrophage activation to facilitate persistent and polymicrobial wound infections
Macrophage activation is essential for innate immunity and antimicrobial defense. We show that Enterococcus faecalis suppresses macrophage activation …
www.sciencedirect.com
January 27, 2026 at 7:11 PM
Lactic acid lover? Check out @ronni.bsky.social 's new work in
@cp-cellhostmicrobe.bsky.social showing how Enterococcus faecalis-derived LA suppresses macrophage activation, in turn promoting bacterial persistence and polymicrobial wound infection in vivo.
www.sciencedirect.com/science/arti...
@cp-cellhostmicrobe.bsky.social showing how Enterococcus faecalis-derived LA suppresses macrophage activation, in turn promoting bacterial persistence and polymicrobial wound infection in vivo.
www.sciencedirect.com/science/arti...
Macrophage-derived oncostatin M repairs the lung epithelial barrier during inflammatory damage
www.science.org/doi/10.1126/...
@science.org @ruthfranklinlab.bsky.social @rmedzhitov.bsky.social
www.science.org/doi/10.1126/...
@science.org @ruthfranklinlab.bsky.social @rmedzhitov.bsky.social
July 10, 2025 at 10:27 PM
Macrophage-derived oncostatin M repairs the lung epithelial barrier during inflammatory damage
www.science.org/doi/10.1126/...
@science.org @ruthfranklinlab.bsky.social @rmedzhitov.bsky.social
www.science.org/doi/10.1126/...
@science.org @ruthfranklinlab.bsky.social @rmedzhitov.bsky.social
Hematopoietic aging drives lung fibrosis and profibrotic macrophage influx, stalling their maturation via reduced Treg-derived IL-10 @sciimmunology.bsky.social @asmafarhat.bsky.social
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
March 28, 2025 at 7:26 PM
Hematopoietic aging drives lung fibrosis and profibrotic macrophage influx, stalling their maturation via reduced Treg-derived IL-10 @sciimmunology.bsky.social @asmafarhat.bsky.social
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Wow after CAR-T cell therapies here come autologous monocyte derived macrophage infusion therapies. The treatment of end stage cirrhosis is liver transplantation, so alternative treatments to salvage the liver are needed.🧪
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Autologous macrophage therapy for liver cirrhosis: a phase 2 open-label randomized controlled trial - Nature Medicine
Results from the phase 2 MATCH01 clinical trial of autologous monocyte-derived macrophage therapy for liver cirrhosis revealed no liver-related severe adverse events or deaths in the treatment group.
www.nature.com
January 12, 2025 at 3:14 PM
Wow after CAR-T cell therapies here come autologous monocyte derived macrophage infusion therapies. The treatment of end stage cirrhosis is liver transplantation, so alternative treatments to salvage the liver are needed.🧪
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Malaria durably disrupts macrophage-to-macrophage crosstalk in the spleen #immunology
Malaria durably disrupts macrophage-to-macrophage crosstalk in the spleen
Blood-stage malaria transiently depletes and remodels splenic macrophages, but how distinct subsets recover remains unclear. A recent report by Mauel et al. shows that a yolk sac-derived CD163high red pulp macrophage subset is selectively and durably lost after malaria, disrupting a growth differentiation factor 15-dependent circuit that supports marginal metallophilic macrophages.
dlvr.it
September 30, 2026 at 11:16 AM
Malaria durably disrupts macrophage-to-macrophage crosstalk in the spleen #immunology
Macrophages produce metabolites that recruit immunosuppressive T helper 2 cells to fungal infection sites in the lungs, finds new #ScienceImmunology research in mice. The results provide insight into cues that induce immune responses that could prevent fungal clearance. https://scim.ag/3RcC7Jl
Macrophage-derived oxysterols organize T helper 2 cells to suppress type 1 inflammation during pulmonary fungal infection
Macrophage-derived oxysterols recruit GPR183+ TH2 cells into fungal lesions, suppressing type 1 immunity and promoting pathogen persistence.
scim.ag
July 21, 2026 at 3:00 PM
Macrophages produce metabolites that recruit immunosuppressive T helper 2 cells to fungal infection sites in the lungs, finds new #ScienceImmunology research in mice. The results provide insight into cues that induce immune responses that could prevent fungal clearance. https://scim.ag/3RcC7Jl
1/ Excited to share my first-ever first-author paper out now in Science Immunology! from @knapplab.bsky.social and co-supervised by @miershawig.bsky.social
We show that hematopoietic aging, independent of lung tissue aging, is sufficient to exacerbate fibrosis.
🔗 www.science.org/doi/10.1126/...
We show that hematopoietic aging, independent of lung tissue aging, is sufficient to exacerbate fibrosis.
🔗 www.science.org/doi/10.1126/...
An aging bone marrow exacerbates lung fibrosis by fueling profibrotic macrophage persistence
Hematopoietic aging drives lung fibrosis and profibrotic macrophage influx, stalling their maturation via reduced Treg-derived IL-10.
www.science.org
March 28, 2025 at 7:10 PM
1/ Excited to share my first-ever first-author paper out now in Science Immunology! from @knapplab.bsky.social and co-supervised by @miershawig.bsky.social
We show that hematopoietic aging, independent of lung tissue aging, is sufficient to exacerbate fibrosis.
🔗 www.science.org/doi/10.1126/...
We show that hematopoietic aging, independent of lung tissue aging, is sufficient to exacerbate fibrosis.
🔗 www.science.org/doi/10.1126/...
One of my favorite topics right now! Very nice review on The evolutionary tug-of-war of macrophage metabolism during bacterial infection from @timsparwasser.bsky.social
read here 👇
www.sciencedirect.com/science/arti...
read here 👇
www.sciencedirect.com/science/arti...
The evolutionary tug-of-war of macrophage metabolism during bacterial infection
The function and phenotype of macrophages are intimately linked with pathogen detection. On sensing pathogen-derived signals and molecules, macrophage…
www.sciencedirect.com
March 18, 2025 at 12:46 PM
One of my favorite topics right now! Very nice review on The evolutionary tug-of-war of macrophage metabolism during bacterial infection from @timsparwasser.bsky.social
read here 👇
www.sciencedirect.com/science/arti...
read here 👇
www.sciencedirect.com/science/arti...
Macrophage-derived oxysterols recruit GPR183+ TH2 cells into fungal lesions, suppressing type 1 immunity and promoting pathogen persistence @sciimmunology.bsky.social
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
July 17, 2026 at 8:08 PM
Macrophage-derived oxysterols recruit GPR183+ TH2 cells into fungal lesions, suppressing type 1 immunity and promoting pathogen persistence @sciimmunology.bsky.social
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Macrophage-derived CTSS drives the age-dependent disruption of the blood-CSF barrier: Neuron www.cell.com/neuron/fullt...
February 26, 2025 at 4:22 PM
Macrophage-derived CTSS drives the age-dependent disruption of the blood-CSF barrier: Neuron www.cell.com/neuron/fullt...
Happy to share the most recent preprint from the lab, the thesis work of Dr. Adam Krebs and a collaboration with many, including the Geissmann lab @mskcancercenter.bsky.social
Here is a short paper thread. #tuberculosis #macrophages 🦠
www.biorxiv.org/content/10.1...
Here is a short paper thread. #tuberculosis #macrophages 🦠
www.biorxiv.org/content/10.1...
Human iPSC derived alveolar macrophages reveal macrophage subtype specific functions of itaconate in M. tuberculosis host defense
M. tuberculosis must survive within multiple macrophage populations during infection, including alveolar macrophages (AM) and recruited inflammatory macrophages. In mice, itaconate, produced in macrop...
www.biorxiv.org
July 28, 2025 at 9:43 PM
Happy to share the most recent preprint from the lab, the thesis work of Dr. Adam Krebs and a collaboration with many, including the Geissmann lab @mskcancercenter.bsky.social
Here is a short paper thread. #tuberculosis #macrophages 🦠
www.biorxiv.org/content/10.1...
Here is a short paper thread. #tuberculosis #macrophages 🦠
www.biorxiv.org/content/10.1...
I’m so proud to have been able to contribute to this story! Check it out for a cool tale about tissue repair under inflammatory conditions! Congrats @daisyah.bsky.social and @ruthfranklinlab.bsky.social on putting out the lab’s first paper 🫁🐁🦠
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Macrophage-derived oncostatin M repairs the lung epithelial barrier during inflammatory damage
Tissue repair programs must function alongside antiviral immunity to restore the lung epithelial barrier following infection. We found that macrophage-derived oncostatin M (OSM) counteracted the patho...
www.science.org
July 10, 2025 at 6:30 PM
I’m so proud to have been able to contribute to this story! Check it out for a cool tale about tissue repair under inflammatory conditions! Congrats @daisyah.bsky.social and @ruthfranklinlab.bsky.social on putting out the lab’s first paper 🫁🐁🦠
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Wonder which #innate responses in your animal models are shared with or distinct from humans? We did too! To answer, we teamed up with @mcampomd.bsky.social and the Hawn lab to compare human and murine alveolar and monocyte-derived #macrophage responses to #Mtb. (1/4)
#TBSky #ImmunoSky #NewPI x 2
#TBSky #ImmunoSky #NewPI x 2
Shared and distinct responses of human and murine alveolar macrophages and monocyte-derived macrophages to Mycobacterium tuberculosis https://www.biorxiv.org/content/10.1101/2025.02.28.640814v1
March 11, 2025 at 9:38 PM
Wonder which #innate responses in your animal models are shared with or distinct from humans? We did too! To answer, we teamed up with @mcampomd.bsky.social and the Hawn lab to compare human and murine alveolar and monocyte-derived #macrophage responses to #Mtb. (1/4)
#TBSky #ImmunoSky #NewPI x 2
#TBSky #ImmunoSky #NewPI x 2
🔬 In JCB's November issue: image shows a #macrophage nibbling a #cancer cell. The bone marrow–derived mouse macrophage is expressing a Chimeric Antigen Receptor (green) that activates the Fc Receptor signaling pathway in response to Her2. From Rollins et al. rupress.org/jcb/issue/22...
November 10, 2025 at 3:03 PM
🔬 In JCB's November issue: image shows a #macrophage nibbling a #cancer cell. The bone marrow–derived mouse macrophage is expressing a Chimeric Antigen Receptor (green) that activates the Fc Receptor signaling pathway in response to Her2. From Rollins et al. rupress.org/jcb/issue/22...
Rémi Mounier, Bénédicte Chazaud @benchazaud.bsky.social @inserm.fr at Université Claude Bernard Lyon and co-workers show that immune #aging impairs #muscle #regeneration via #macrophage-derived anti-oxidant selenoprotein P.
-> www.embopress.org/doi/full/10....
-> www.embopress.org/doi/full/10....
July 19, 2025 at 8:19 AM
Rémi Mounier, Bénédicte Chazaud @benchazaud.bsky.social @inserm.fr at Université Claude Bernard Lyon and co-workers show that immune #aging impairs #muscle #regeneration via #macrophage-derived anti-oxidant selenoprotein P.
-> www.embopress.org/doi/full/10....
-> www.embopress.org/doi/full/10....
#MedSky🧪 #IDsky #immunosky #publichealth Age-associated changes to the bone marrow impact immune regulation in the lungs, which promotes inflammation and #fibrosis after lung injury.
@knapplab.bsky.social via @sciimmunology.bsky.social
www.science.org/doi/10.1126/...
@knapplab.bsky.social via @sciimmunology.bsky.social
www.science.org/doi/10.1126/...
An aging bone marrow exacerbates lung fibrosis by fueling profibrotic macrophage persistence
Hematopoietic aging drives lung fibrosis and profibrotic macrophage influx, stalling their maturation via reduced Treg-derived IL-10.
www.science.org
March 28, 2025 at 6:45 PM
#MedSky🧪 #IDsky #immunosky #publichealth Age-associated changes to the bone marrow impact immune regulation in the lungs, which promotes inflammation and #fibrosis after lung injury.
@knapplab.bsky.social via @sciimmunology.bsky.social
www.science.org/doi/10.1126/...
@knapplab.bsky.social via @sciimmunology.bsky.social
www.science.org/doi/10.1126/...
@biorxivpreprint.bsky.social Macrophage-derived extracellular vesicles promote T cell-dependent inflammatory pain resolution
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
March 6, 2026 at 5:43 PM
@biorxivpreprint.bsky.social Macrophage-derived extracellular vesicles promote T cell-dependent inflammatory pain resolution
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
Streptococcal meningoencephalitis disrupts homeostatic, skull bone marrow–derived monocyte and macrophage trajectories in the dura @sciimmunology.bsky.social
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
June 19, 2026 at 7:27 PM
Streptococcal meningoencephalitis disrupts homeostatic, skull bone marrow–derived monocyte and macrophage trajectories in the dura @sciimmunology.bsky.social
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Out Now! Salmonella-derived haem inhibits macrophage phagocytosis and promotes infection in mice #MicroSky
Salmonella-derived haem inhibits macrophage phagocytosis and promotes infection in mice
Nature Microbiology, Published online: 20 April 2026; doi:10.1038/s41564-026-02341-3SirM methyltransferase upregulates Salmonella HemL-dependent haem production to enable haem-dependent inhibition of phagocytosis and promote infection in mice.
go.nature.com
April 20, 2026 at 4:04 PM
Out Now! Salmonella-derived haem inhibits macrophage phagocytosis and promotes infection in mice #MicroSky
#WeekendRead! #LiveForever! Shawig Farhat Knapp &co show @ Science Immunology that aged bone marrow, not host’s age, increases #lung #fibrosis by decreasing IL10-producing Tregs & increasing monocyte-derived pro-fibrotic alveolar macrophages! www.science.org/doi/10.1126/...
An aging bone marrow exacerbates lung fibrosis by fueling profibrotic macrophage persistence
Hematopoietic aging drives lung fibrosis and profibrotic macrophage influx, stalling their maturation via reduced Treg-derived IL-10.
www.science.org
March 30, 2025 at 3:08 PM
#WeekendRead! #LiveForever! Shawig Farhat Knapp &co show @ Science Immunology that aged bone marrow, not host’s age, increases #lung #fibrosis by decreasing IL10-producing Tregs & increasing monocyte-derived pro-fibrotic alveolar macrophages! www.science.org/doi/10.1126/...
Enterococcus faecalis-derived lactic acid facilitates persistent and polymicrobial wound infections by suppressing macrophage activation https://www.biorxiv.org/content/10.1101/2025.01.31.635924v1
February 1, 2025 at 2:16 AM
Enterococcus faecalis-derived lactic acid facilitates persistent and polymicrobial wound infections by suppressing macrophage activation https://www.biorxiv.org/content/10.1101/2025.01.31.635924v1
#WeekendRead! #ImmunometabolismPower! Formiga, Sokol &co show @cp-cellhostmicrobe.bsky.social that #microbiota derived cadaverine 🧟♂️ controls macrophage metabolism & gut inflammation. Low 🧟♂️ activates NRF2 promoting OXPHOS & homeostasis, while high 🧟♂️ drives glycolysis & intestinal inflammation 🔥 !!
Immunometabolic reprogramming of macrophages by gut microbiota-derived cadaverine controls colon inflammation
de Oliveira Formiga et al. present that gut-microbiota-derived cadaverine reprograms
macrophage energy metabolism in a concentration-dependent fashion, promoting either
anti- or pro-inflammatory immun...
www.cell.com
October 4, 2025 at 3:07 PM
#WeekendRead! #ImmunometabolismPower! Formiga, Sokol &co show @cp-cellhostmicrobe.bsky.social that #microbiota derived cadaverine 🧟♂️ controls macrophage metabolism & gut inflammation. Low 🧟♂️ activates NRF2 promoting OXPHOS & homeostasis, while high 🧟♂️ drives glycolysis & intestinal inflammation 🔥 !!
