#MethodMonday From now on, each week, we’ll highlight a different research method used at the #MRCWIMM, breaking down how it works and why it’s important. 🧪

Here we go!

Ever wondered how scientists can measure dozens of proteins on a single cell? #MassCytometry makes this possible!

#MethodMonday 🧪

So… how does #MassCytometry actually work? 🤔

1. Cells are stained with antibodies tagged to rare heavy metals
2. Each cell is vaporised and ionised in a plasma
3. Ions are separated by their mass and detected in a time-of-flight (TOF) mass spectrometer

#MethodMonday 🧪

What makes #MassCytometry such a powerful tool for the #MRCWIMM researchers?

#WIMMResearch #Immunology #Hematology #SingleCellScience

@medsci.ox.ac.uk @drakesmith-lab.bsky.social 🧬

#MethodMonday 🧪

Behind every powerful technique is a team of dedicated scientists.

Meet the MRC WIMM Mass Cytometry Facility, where our mass cytometer helps researchers explore biology at single-cell resolution.

#WIMMResearch #MassCytometry #CoreFacilities #ScienceBehindTheScenes #MeetTheTeam

Intrigued by immune cells in the #cardiovascular system? 🧬💉 Mass cytometry is our go-to for diving deep into immune cell ID—ideal for uncovering lipid-associated or perivascular macrophages in plaques. 🔬✨.. and we love Lego too! @LabMonaco @ Standard_BioT #MassCytometry#Immunology"

Using #MassCytometry, this #STTT study characterized the #ImmuneLandscape of #ESCC, demonstrating that targeting CD39⁺ T cells & PD-L1⁺ macrophages can reprogram the #TumorMicroenvironment to optimize #Immunotherapy response.

#OpenAccess: doi.org/10.1038/s413...

Diana Dudziak & Sabine Baumgart from Jena University Hospital and Axel Schulz, DRFZ, warmly welcomed the participants of the 8th German #MassCytometry User Forum in Jena. We are exited for inspiring presentations, engaging discussions and valuable exchanges throughout the event.

Each metal tag = one unique signal , all at single cell resolution → giving researchers incredibly detailed cellular maps.

Curious to dive deeper? 🎥 Watch the video: youtu.be/njlYmWdsElM

#MassCytometry #CyTOF #WIMMResearch #Immunology #SingleCellAnalysis 🧪🧬

🔓 #OpenAccess

𝐌𝐚𝐬𝐬 𝐬𝐩𝐞𝐜𝐭𝐫𝐨𝐦𝐞𝐭𝐫𝐢𝐜 𝐢𝐦𝐚𝐠𝐢𝐧𝐠 𝐚𝐧𝐝 𝐪𝐮𝐚𝐧𝐭𝐢𝐭𝐚𝐭𝐢𝐯𝐞 𝐚𝐧𝐚𝐥𝐲𝐬𝐢𝐬 𝐨𝐟 𝐭𝐡𝐞 𝐢𝐧 𝐯𝐢𝐯𝐨 𝐛𝐢𝐨𝐝𝐢𝐬𝐭𝐫𝐢𝐛𝐮𝐭𝐢𝐨𝐧 𝐨𝐟 𝐭𝐫𝐚𝐬𝐭𝐮𝐳𝐮𝐦𝐚𝐛 𝐮𝐬𝐢𝐧𝐠 𝐚 𝐫𝐡𝐨𝐝𝐢𝐮𝐦(𝐢𝐢𝐢) 𝐬𝐚𝐫𝐜𝐨𝐩𝐡𝐚𝐠𝐢𝐧𝐞 𝐜𝐨𝐦𝐩𝐥𝐞𝐱 by Michelle T. Ma 𝘦𝘵 𝘢𝘭.

#Masscytometry #rhodium #anti-tumor

🔗 doi.org/10.1039/D5QI00731C

The two days of our meeting have flown by. We had the opportunity to listen to inspiring presentations, sharing experiences, gain valuable insights into the latest techniques and applications of #masscytometry, engage in insightful discussions, and establish new collaborations.

After a successful day filled with exciting #masscytometry data and insightful discussions, we would like to thank all the speakers for their contributions.

Many thanks to all our industry partners for supporting our meeting. During the Techno Bites, they impressed us with their latest innovations for #masscytometry.