#Megakaryocyte
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shematologist.medsky.social
And it’s precursor the megakaryocyte
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Slide Look
May 6, 2025 at 1:20 AM
jsramek.bsky.social
Není zrovna chytré připravovat otázky do zkouškového test v poněkud infantilním rozpoložení. Právě jsem napsal:

Megakaryocyte, megakaryocyte, proč máš tak velké jádro?
a. abych tě lépe viděl
b. abych tě lépe slyšel
c. protože jsem spáchal endomitózu
d. protože nás několik spáchalo syncytium
January 29, 2026 at 12:10 PM
axonology.bsky.social
There is something #motherly about this megakaryocyte launching baby platelets into the bloodstream
#SciArtSeptember
#SciArt #immunoSky 🧪
Cartoon megakaryocyte #SciArtSeptember
September 29, 2024 at 3:34 PM
kmachlus.bsky.social
Call me biased, but I can't think of a better way to celebrate my first #FluorescenceFriday here than with this beautiful megakaryocyte making proplatelets 😍. Aren't these cells amazing?
🧪🩸 #hemesky
Megakaryocyte making elaborate network of proplatelets. DAPI staining of nuclei and beta-tubulin antibody used to stain cytoskeleton
November 15, 2024 at 12:59 PM
prelights.bsky.social
The megakaryocyte: trapped in a cage of its own making 𐂺

In this #preprint, @wclairemasson.bsky.social & colleagues report the discovery of novel structures controlling megakaryocyte protrusion events.

Excellent #preLight from @simoncleary.bsky.social ⬇️ 👀
prelights.biologists.com/highlights/m...
Megakaryocytes assemble a three-dimensional cage of extracellular matrix that controls their maturation and anchoring to the vascular niche - preLights
The megakaryocyte: trapped in a cage of its own making
prelights.biologists.com
February 25, 2025 at 11:08 AM
sarahjwu.bsky.social
Snow in Boston! Sharing a crazy "snowflake-like" mitosis in this megakaryocyte. Looking forward to being more active on this platform in the new year! #pathology #hemepath
December 20, 2024 at 1:31 PM
alexrampotas.bsky.social
Very eloquent presentation by Antonio Romera from @bethpsaila.bsky.social lab on megakaryocyte biology and ability to take on DNA damage! Fantastic work #ASH24
December 8, 2024 at 5:58 PM
ryan-mack.bsky.social
Megakaryocyte appreciation post from a recent culture
December 5, 2024 at 8:09 PM
zoltannagyphd.bsky.social
Insightful review on "Epigenetic regulation of hematopoietic stem cell fate" by Yiran Meng and Claus Nerlov #Hematology #Epigenetics #Megakaryocyte 🦴 www.sciencedirect.com/science/arti...
November 14, 2024 at 11:22 AM
microbecharmer.bsky.social
More hemepath friends! Megakaryocyte, myeloblast (note the Auer rod!), plasma cell, and ring sideroblast.
#Hemepath #Hematology #Hemesky

Find them here: tinyurl.com/ktc4sxe5
January 19, 2025 at 2:29 AM
zoltannagyphd.bsky.social
Mark your calendar! 🗓️ Abstract submission for #ISTH2025 closes on January 15, 2025. I am already excited about this incredible congress 🩸 #Platelets #Megakaryocyte #HemeSky
November 15, 2024 at 10:06 AM
apatgiri.bsky.social
Mitochondria Regulate the Cell Fate Decisions of Megakaryocyte-Erythroid Progenitors
November 18, 2024 at 3:44 PM
emily-boyd.bsky.social
It was an honor and a pleasure to share our work on the impact of PACSIN2 on megakaryocyte and erythrocyte development yesterday afternoon at ISTH 2025! #ISTH2025
June 24, 2025 at 5:06 PM
prelights.bsky.social
Insightful ‘postLight’ just uploaded by @simoncleary.bsky.social 👀

Simon revisits work discovering structures that control megakaryocyte protrusion events: extracellular matrix cages – work reviewed and published at @elife.bsky.social

#postLight: prelights.biologists.com/highlights/m...
Megakaryocytes assemble a three-dimensional cage of extracellular matrix that controls their maturation and anchoring to the vascular niche - preLights
The megakaryocyte: trapped in a cage of its own making
prelights.biologists.com
December 8, 2025 at 10:31 AM
osayko.bsky.social
Me reading about any new research that comes out on #LongCOVID. As a theater and French double major, my brain was simply not built for science. Like, I resent that I have to know what a megakaryocyte is.
A photo of a white man in a blue polo shirt with a popped collar sitting behind the wheel of a car looking out of the window. Caption reads “I don’t know what any of this shit is, and I’m scared.”
November 9, 2024 at 10:16 PM
ryanelliott.bsky.social
Emperipolesis (Greek: em – inside; peri – around; polemai – wander about) defined by Humble et al. as “the active penetration of one cell by another which remains intact.”

Here we have engulfed blood cells w/ conserved morphology within the cytoplasm of a megakaryocyte.
#hemesky #hemepath #pathsky
November 23, 2024 at 8:42 PM
zoltannagyphd.bsky.social
Feeling grateful to be invited to give a State-of-the-Art lecture at #ISTH2025 💙
Excited to speak alongside @hfalet.bsky.social & @abattacks.bsky.social in a session on #megakaryocyte biology & #platelet production.
Thanks to the organizers & expert chairs Neil Morgan & @nubama.bsky.social!
April 16, 2025 at 8:03 AM
jthjournal.bsky.social
Blocking tubulin detyrosination via VASH1-SVBP inhibition enhances proplatelet formation & boosts platelet counts—no impact on function. A novel understanding of the megakaryocyte tubulin code beyond tubulin isotypes. #Platelet #HemeSky www.jthjournal.org/article/S153...
June 19, 2025 at 2:05 PM
c0nc0rdance.bsky.social
And in other cells, this is an 'intentional' strategy to allow rapid replication (as in megakaryocytes).

The association with aging may also suggest another advantage: multiple copies of each chromosome minimize the impact of a single damaged chromosome.

The 'broken' genes are supplemented...
"Figure 1. Overview of megakaryopoiesis. Megakaryopoiesis is characterized by four steps: (1) proliferation in early stages; (2) endomitosis, which leads to polyploid MKs; (3) post-replicative stage with MK cytoplasmic maturation; and (4) proplatelet formation and MK fragmentation. CFU-MK = colony-forming unit megakaryocyte; PMKB = promegakaryoblast; MKB = megakaryoblast." Taken from: Mazzi et al (2018) "Megakaryocyte and polyploidization" Experimental Hematology 57 January 2018, p.1-13
December 30, 2024 at 1:52 PM
cytolady.bsky.social
Megakaryocyte in bone marrow (M)- these are a precursor cell that has differentiated from the
hematopoeitic stem cell in the bone marrow to become part of our bodies own hemostasis(clotting). The
megakaryocyte cytoplasm fragments & bcomes platelets.
December 23, 2024 at 5:39 PM
rpth.bsky.social
New discovery from Fabiola Del Carpio-Cano on the role of RUNX1 regulates platelet-megakaryocyte F13A1 expression, impacting clot stabilization.

Read the full study: www.rpthjournal.org/article/S247...

#platelets #RUNX1
www.rpthjournal.org
March 18, 2025 at 6:00 PM
zoltannagyphd.bsky.social
We are seeking a motivated PhD student to join our research group in Würzburg 🇩🇪! Explore fundamental mechanisms of #megakaryocyte development in a collaborative environment #WürzburgPlateletGroup #Phosphorylation #PhDPosition
Know someone who might be interested?
karriere.ukw.de/en/p/wissens...
November 20, 2024 at 11:52 AM
yilinmdphd.bsky.social
Activated #CART cell or megakaryocyte? Either way, color matches my shirt 😆 trying to grab #ASH24 souvenir before they are gone!
December 8, 2024 at 12:07 AM
c0nc0rdance.bsky.social
At the other extreme are the megakaryocytes, a type of bone marrow cell that produces your platelets, essential for clotting.

They can have 32 or more copies of each chromosome, but the exact factor of 2 varies by age, disease state, genetics.
Megakaryocyte and polyploidization
In mammals, platelets are produced in the blood by cytoplasmic fragmentation of megakaryocytes (MKs). Platelet production is thus dependent on both th…
www.sciencedirect.com
December 30, 2024 at 1:52 PM
hallinen.bsky.social
I love the Momma megakaryocyte. I’m team cell.
February 14, 2025 at 11:27 AM