Check out this breakthrough: engineered zwitterionic polycarboxybetaine targets brain metastases effectively, minimizing systemic effects and enhancing drug delivery! PMID:42425968, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-74888-y #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪
Engineered zwitterion-nanodelivery for precision targeting of brain metastases | Nature Communications
The central nervous system is a critical reservoir for cancer metastasis, underscoring the urgent need for effective strategies for targeted drug delivery that minimize systemic side effects. Here, we present a zwitterionic polycarboxybetaine (PCB) designed to achieve selective accumulation within the tumor vasculature of brain metastases, thereby facilitating the rapid release of therapeutics without relying on external stimuli in preclinical models. PCB selectively targets the betaine-γ-aminobutyric acid transporter 1 (BGT1) at the blood-brain-tumor barrier (BBTB), enabling localized enrichment of nanoparticles within the tumor vasculature. The intrinsic mechanical flexibility of PCB activates the Piezo1 ion channel in endothelial cells, resulting in calcium ion influx and enhanced calpain activity, which together facilitate the degradation of VE-cadherin. The burst-release mechanism improves vascular permeability and compromises the integrity of the tumor vascular barrier, allowing
doi.org
November 8, 2026 at 7:00 AM
Les metastases du cancer bollorectal.
November 3, 2026 at 5:59 PM
Les metastases du cancer bollorectal.
A older relative who had previously had kidney cancer 10 years ago just found out they have metastases in brain and lung. A few weeks from no symptoms to nearly paralyzed.
Cancer sucks.
Cancer sucks.
November 5, 2026 at 10:45 PM
A older relative who had previously had kidney cancer 10 years ago just found out they have metastases in brain and lung. A few weeks from no symptoms to nearly paralyzed.
Cancer sucks.
Cancer sucks.
Maybe the Democrats learned from the last round that "let bygones be bygones" is not a healing approach: the cancer just goes into hiding and metastases immediately when given the smallest chance.
The World is watching. Do your job.
The World is watching. Do your job.
November 4, 2026 at 7:14 AM
Maybe the Democrats learned from the last round that "let bygones be bygones" is not a healing approach: the cancer just goes into hiding and metastases immediately when given the smallest chance.
The World is watching. Do your job.
The World is watching. Do your job.
Despite advances in systemic cancer treatments, patients with ocular metastases continue to experience poor long-term survival, according to results of a study published in the American Journal of Ophthalmology.
Learn more: https://bit.ly/4iF86eZ
Learn more: https://bit.ly/4iF86eZ
Ocular Metastases Carry Poor Prognosis Despite Systemic Therapy Advances
Ocular metastases frequently originate from breast or lung cancer and are linked to poor long-term survival.
bit.ly
November 4, 2026 at 6:09 PM
Despite advances in systemic cancer treatments, patients with ocular metastases continue to experience poor long-term survival, according to results of a study published in the American Journal of Ophthalmology.
Learn more: https://bit.ly/4iF86eZ
Learn more: https://bit.ly/4iF86eZ
Could targeting specific bacteria slow the growth of breast cancer bone metastases? doi.org/10.1172/jci....
Roberto Pacifici & team discover gut bacteria called SFB speed up breast cancer bone spread in mice through immune cells-mediated inflammation.
@the-asci.org
Roberto Pacifici & team discover gut bacteria called SFB speed up breast cancer bone spread in mice through immune cells-mediated inflammation.
@the-asci.org
November 6, 2026 at 5:09 PM
Could targeting specific bacteria slow the growth of breast cancer bone metastases? doi.org/10.1172/jci....
Roberto Pacifici & team discover gut bacteria called SFB speed up breast cancer bone spread in mice through immune cells-mediated inflammation.
@the-asci.org
Roberto Pacifici & team discover gut bacteria called SFB speed up breast cancer bone spread in mice through immune cells-mediated inflammation.
@the-asci.org
🔴 #$NVCR — Regulatory Rejection
FDA Not Approvable Letter for Optune Mya PMA - Brain Metastases from NSCLC
Novocure received a Not Approvable Letter from the FDA for the PMA application for Optune Mya for adult patients with brain metastases from NSCLC followin…
https://biostock.app/symbols/NVCR
FDA Not Approvable Letter for Optune Mya PMA - Brain Metastases from NSCLC
Novocure received a Not Approvable Letter from the FDA for the PMA application for Optune Mya for adult patients with brain metastases from NSCLC followin…
https://biostock.app/symbols/NVCR
November 9, 2026 at 3:49 PM
🔴 #$NVCR — Regulatory Rejection
FDA Not Approvable Letter for Optune Mya PMA - Brain Metastases from NSCLC
Novocure received a Not Approvable Letter from the FDA for the PMA application for Optune Mya for adult patients with brain metastases from NSCLC followin…
https://biostock.app/symbols/NVCR
FDA Not Approvable Letter for Optune Mya PMA - Brain Metastases from NSCLC
Novocure received a Not Approvable Letter from the FDA for the PMA application for Optune Mya for adult patients with brain metastases from NSCLC followin…
https://biostock.app/symbols/NVCR
Removing neutrophils reduced lung metastases in mice. The decline came with fewer “hybrid” cancer cells—the intermediate state most likely to spread. doi.org/hcq385
Bad neighbors: How immune cells help cancer cells get ready to spread
Most cancer deaths are not caused by the original tumor, but by metastases, which form when cancer cells leave the original tumor and spread to other organs.
medicalxpress.com
November 3, 2026 at 5:21 PM
Removing neutrophils reduced lung metastases in mice. The decline came with fewer “hybrid” cancer cells—the intermediate state most likely to spread. doi.org/hcq385
Aspirin did not reduce recurrence after treatment for colorectal cancer that had spread to the liver—a contrast with earlier observational evidence suggesting a protective effect. doi.org/hcktd2
Aspirin does not prevent recurrence after treatment for colorectal cancer liver metastases
Colorectal cancer is one of the most common cancers in Norway, which also has one of the highest incidence rates in the world.
medicalxpress.com
November 8, 2026 at 10:00 PM
Aspirin did not reduce recurrence after treatment for colorectal cancer that had spread to the liver—a contrast with earlier observational evidence suggesting a protective effect. doi.org/hcktd2
C'est un des problèmes du cancer ...
Les métastases !!!
Les métastases !!!
November 1, 2026 at 7:39 PM
C'est un des problèmes du cancer ...
Les métastases !!!
Les métastases !!!
Si on distribue un arsenal à des troupeaux de connards et qu'en plus le pouvoir n'arrête pas de leur dire qu'ils sont admirables et que quoi qu'il arrive leur quasi-impunité est garantie, on ne peut rien espérer de mieux.
La Ve République a pourri par la tête, mais les métastases vont déjà loin
La Ve République a pourri par la tête, mais les métastases vont déjà loin
November 7, 2026 at 7:12 PM
Si on distribue un arsenal à des troupeaux de connards et qu'en plus le pouvoir n'arrête pas de leur dire qu'ils sont admirables et que quoi qu'il arrive leur quasi-impunité est garantie, on ne peut rien espérer de mieux.
La Ve République a pourri par la tête, mais les métastases vont déjà loin
La Ve République a pourri par la tête, mais les métastases vont déjà loin
Attention aux métastases...
November 2, 2026 at 3:11 PM
Attention aux métastases...
Nothing is harder than losing a loved one by @freric1973
Nothing is harder than losing a loved one by @freric1973
And again fate has struck. This time it hit a friend who was older. Nobody expected it with him. He has always had problems urinating. Well, 3 weeks ago the shock. Metastases in the abdomen and prostate, the cancer had grown so quietly. The doctors didn't dare to open his body…
feetlove1973.de
November 7, 2026 at 1:00 AM
Nothing is harder than losing a loved one by @freric1973
Combined vs Staged Resection for Rectal Cancer Liver Metastases
by Marchegiani F, Dhote A (...) Tzedakis S et 10 al. in Br J Surg
#Surgery #SurgSky #GeneralSurgery #MedSky
by Marchegiani F, Dhote A (...) Tzedakis S et 10 al. in Br J Surg
#Surgery #SurgSky #GeneralSurgery #MedSky
Combined vs Staged Resection for Rectal Cancer Liver Metastases
Combined and staged surgery had similar complication rates and survival in a French national cohort. Severe complications occurred in 39.7% of combined and 45.3% of staged patients (p = 0.20). Median overall survival was 52.4 months with combined surgery and 57.3 months with staged surgery (p = 0.30
www.stitches.today
November 5, 2026 at 9:47 PM
Combined vs Staged Resection for Rectal Cancer Liver Metastases
by Marchegiani F, Dhote A (...) Tzedakis S et 10 al. in Br J Surg
#Surgery #SurgSky #GeneralSurgery #MedSky
by Marchegiani F, Dhote A (...) Tzedakis S et 10 al. in Br J Surg
#Surgery #SurgSky #GeneralSurgery #MedSky
Le Cancer [de La FRANCE 🇲🇫 ] et ses métastases... Suivez la liste est longue !
November 3, 2026 at 9:12 AM
Le Cancer [de La FRANCE 🇲🇫 ] et ses métastases... Suivez la liste est longue !
Nothing is harder than losing a loved one by @freric1973
Nothing is harder than losing a loved one by @freric1973
And again fate has struck. This time it hit a friend who was older. Nobody expected it with him. He has always had problems urinating. Well, 3 weeks ago the shock. Metastases in the abdomen and prostate, the cancer had grown so quietly. The doctors didn't dare to open his body…
feetlove1973.de
November 7, 2026 at 2:00 AM
Nothing is harder than losing a loved one by @freric1973
What weakens T cells in colorectal liver metastases?
Dr Giovanni Sitia, Ospedale San Raffaele, leads a study in Science Advances on IFNAR1 loss with #UniSR Profs Chiara Bonini, Luca Guidotti, Antonio Esposito and colleagues Supported by Fondazione AIRC: bit.ly/4sEKmMo
Dr Giovanni Sitia, Ospedale San Raffaele, leads a study in Science Advances on IFNAR1 loss with #UniSR Profs Chiara Bonini, Luca Guidotti, Antonio Esposito and colleagues Supported by Fondazione AIRC: bit.ly/4sEKmMo
November 5, 2026 at 1:07 PM
What weakens T cells in colorectal liver metastases?
Dr Giovanni Sitia, Ospedale San Raffaele, leads a study in Science Advances on IFNAR1 loss with #UniSR Profs Chiara Bonini, Luca Guidotti, Antonio Esposito and colleagues Supported by Fondazione AIRC: bit.ly/4sEKmMo
Dr Giovanni Sitia, Ospedale San Raffaele, leads a study in Science Advances on IFNAR1 loss with #UniSR Profs Chiara Bonini, Luca Guidotti, Antonio Esposito and colleagues Supported by Fondazione AIRC: bit.ly/4sEKmMo
#NVCR Novocure Provides Regulatory Update on U.S. FDA Premarket Approval Application for Optune Mya® for Brain Metastases from No…
https://www.stocktitan.net/news/NVCR/novocure-provides-regulatory-update-on-u-s-fda-premarket-approval-z5tl5w8y57f9.html?utm_source=stocktitan-bluesky&utm_medium=social
https://www.stocktitan.net/news/NVCR/novocure-provides-regulatory-update-on-u-s-fda-premarket-approval-z5tl5w8y57f9.html?utm_source=stocktitan-bluesky&utm_medium=social
Novocure Provides Regulatory Update on U.S. FDA Premarket Approval Application for Optune Mya® for Brain Metastases from Non-Small Cell Lung Cancer
Stock Titan provides an ultra-fast stock market news feed and multiple tools for traders and investors.
www.stocktitan.net
November 9, 2026 at 12:00 PM
#NVCR Novocure Provides Regulatory Update on U.S. FDA Premarket Approval Application for Optune Mya® for Brain Metastases from No…
https://www.stocktitan.net/news/NVCR/novocure-provides-regulatory-update-on-u-s-fda-premarket-approval-z5tl5w8y57f9.html?utm_source=stocktitan-bluesky&utm_medium=social
https://www.stocktitan.net/news/NVCR/novocure-provides-regulatory-update-on-u-s-fda-premarket-approval-z5tl5w8y57f9.html?utm_source=stocktitan-bluesky&utm_medium=social
Netanyahu est une tumeur maligne, ses acolytes des métastases.
Sans le soutien financier et militaire des USA et de l'Europe🇪🇺, Israël serait une démocratie pluri-culturelle, multi-confessionnelle, et multi-ethnique non belliqueuse.
Virons ces 💩 génocidaires et ses financeurs pour ramener la paix.
Sans le soutien financier et militaire des USA et de l'Europe🇪🇺, Israël serait une démocratie pluri-culturelle, multi-confessionnelle, et multi-ethnique non belliqueuse.
Virons ces 💩 génocidaires et ses financeurs pour ramener la paix.
November 9, 2026 at 2:22 PM
Netanyahu est une tumeur maligne, ses acolytes des métastases.
Sans le soutien financier et militaire des USA et de l'Europe🇪🇺, Israël serait une démocratie pluri-culturelle, multi-confessionnelle, et multi-ethnique non belliqueuse.
Virons ces 💩 génocidaires et ses financeurs pour ramener la paix.
Sans le soutien financier et militaire des USA et de l'Europe🇪🇺, Israël serait une démocratie pluri-culturelle, multi-confessionnelle, et multi-ethnique non belliqueuse.
Virons ces 💩 génocidaires et ses financeurs pour ramener la paix.
#LEmpriseBolloré
Ou, pour citer un internaute discret sous le post original :
"Les metastases du cancer bollorectal"
(et Onfray est donc chez bollo ! aaahahahha.... drôle. et sans surprise. onfray, la fulgurante dégénérescence incarnée..)
Ou, pour citer un internaute discret sous le post original :
"Les metastases du cancer bollorectal"
(et Onfray est donc chez bollo ! aaahahahha.... drôle. et sans surprise. onfray, la fulgurante dégénérescence incarnée..)
ERRATUM
Nous republions la version corrigée de cette infographie, parue dans le rapport "Le système Bolloré, de la prédation financière à la croisade politique", suite à une erreur concernant l'appartenance du média Franc-Tireur à la galaxie Bolloré.
Nous republions la version corrigée de cette infographie, parue dans le rapport "Le système Bolloré, de la prédation financière à la croisade politique", suite à une erreur concernant l'appartenance du média Franc-Tireur à la galaxie Bolloré.
November 3, 2026 at 11:21 PM
#LEmpriseBolloré
Ou, pour citer un internaute discret sous le post original :
"Les metastases du cancer bollorectal"
(et Onfray est donc chez bollo ! aaahahahha.... drôle. et sans surprise. onfray, la fulgurante dégénérescence incarnée..)
Ou, pour citer un internaute discret sous le post original :
"Les metastases du cancer bollorectal"
(et Onfray est donc chez bollo ! aaahahahha.... drôle. et sans surprise. onfray, la fulgurante dégénérescence incarnée..)
Le principal responsable c’est l’empaffé 🇺🇸 et son double retrait de l’accord de Paris. Ce gros con est un cancer climatique et il produit des métastases (les extrêmes droites) même « déboulonné » il continuera à nuire 🔥👿💩
November 7, 2026 at 10:54 AM
Le principal responsable c’est l’empaffé 🇺🇸 et son double retrait de l’accord de Paris. Ce gros con est un cancer climatique et il produit des métastases (les extrêmes droites) même « déboulonné » il continuera à nuire 🔥👿💩