Now MINI2P has become so small and light that mice can easily carry two of them, opening the doors for studies of circuit interactions. Congratulations, Weijian and team!
A new design framework brings two-photon miniscopes to 1g!
Our lab's MINI2P-II (1.1g) overcomes the widely accepted assumption that high optical performance and ultralow weight cannot coexist. A climbing mouse can carry two, a singing songbird one 🧵
www.biorxiv.org/content/10.6...
Our lab's MINI2P-II (1.1g) overcomes the widely accepted assumption that high optical performance and ultralow weight cannot coexist. A climbing mouse can carry two, a singing songbird one 🧵
www.biorxiv.org/content/10.6...
Multi-region two-photon calcium imaging in freely moving animals
Complex behaviors emerge from the coordinated activity of neural circuits distributed across widely separated brain regions. Existing optical approaches for monitoring neural activity lack the combine...
www.biorxiv.org
October 29, 2026 at 9:31 AM
Now MINI2P has become so small and light that mice can easily carry two of them, opening the doors for studies of circuit interactions. Congratulations, Weijian and team!
We’re bringing our multi-photon imaging tools to SfN!
Visit us at Booth #1437 in Washington, D.C., Nov 14-18 to see ScanImage + vDAQ, Mini2p, SLAP2, and vCAM. Stop by or message us for a demo!
#sfn26 #sfn2026 #neuroscience #multiphotonimaging
Visit us at Booth #1437 in Washington, D.C., Nov 14-18 to see ScanImage + vDAQ, Mini2p, SLAP2, and vCAM. Stop by or message us for a demo!
#sfn26 #sfn2026 #neuroscience #multiphotonimaging
November 5, 2026 at 4:29 PM
We’re bringing our multi-photon imaging tools to SfN!
Visit us at Booth #1437 in Washington, D.C., Nov 14-18 to see ScanImage + vDAQ, Mini2p, SLAP2, and vCAM. Stop by or message us for a demo!
#sfn26 #sfn2026 #neuroscience #multiphotonimaging
Visit us at Booth #1437 in Washington, D.C., Nov 14-18 to see ScanImage + vDAQ, Mini2p, SLAP2, and vCAM. Stop by or message us for a demo!
#sfn26 #sfn2026 #neuroscience #multiphotonimaging
Two-photon neurotechnology innovation 📢
@weijianzong.bsky.social and his Neurophotonics lab at Kavli NTNU have built a 1.1 gram brain microscope.
A 14-gram young zebra finch can carry it, and a mouse can carry two, one on each hemisphere. This breakthrough builds on his MINI2P from 2022 👇
@weijianzong.bsky.social and his Neurophotonics lab at Kavli NTNU have built a 1.1 gram brain microscope.
A 14-gram young zebra finch can carry it, and a mouse can carry two, one on each hemisphere. This breakthrough builds on his MINI2P from 2022 👇
A new design framework brings two-photon miniscopes to 1g!
Our lab's MINI2P-II (1.1g) overcomes the widely accepted assumption that high optical performance and ultralow weight cannot coexist. A climbing mouse can carry two, a singing songbird one 🧵
www.biorxiv.org/content/10.6...
Our lab's MINI2P-II (1.1g) overcomes the widely accepted assumption that high optical performance and ultralow weight cannot coexist. A climbing mouse can carry two, a singing songbird one 🧵
www.biorxiv.org/content/10.6...
Multi-region two-photon calcium imaging in freely moving animals
Complex behaviors emerge from the coordinated activity of neural circuits distributed across widely separated brain regions. Existing optical approaches for monitoring neural activity lack the combine...
www.biorxiv.org
October 29, 2026 at 9:02 AM
Two-photon neurotechnology innovation 📢
@weijianzong.bsky.social and his Neurophotonics lab at Kavli NTNU have built a 1.1 gram brain microscope.
A 14-gram young zebra finch can carry it, and a mouse can carry two, one on each hemisphere. This breakthrough builds on his MINI2P from 2022 👇
@weijianzong.bsky.social and his Neurophotonics lab at Kavli NTNU have built a 1.1 gram brain microscope.
A 14-gram young zebra finch can carry it, and a mouse can carry two, one on each hemisphere. This breakthrough builds on his MINI2P from 2022 👇
A new design framework brings two-photon miniscopes to 1g!
Our lab's MINI2P-II (1.1g) overcomes the widely accepted assumption that high optical performance and ultralow weight cannot coexist. A climbing mouse can carry two, a singing songbird one 🧵
www.biorxiv.org/content/10.6...
Our lab's MINI2P-II (1.1g) overcomes the widely accepted assumption that high optical performance and ultralow weight cannot coexist. A climbing mouse can carry two, a singing songbird one 🧵
www.biorxiv.org/content/10.6...
Multi-region two-photon calcium imaging in freely moving animals
Complex behaviors emerge from the coordinated activity of neural circuits distributed across widely separated brain regions. Existing optical approaches for monitoring neural activity lack the combine...
www.biorxiv.org
October 29, 2026 at 8:41 AM
A new design framework brings two-photon miniscopes to 1g!
Our lab's MINI2P-II (1.1g) overcomes the widely accepted assumption that high optical performance and ultralow weight cannot coexist. A climbing mouse can carry two, a singing songbird one 🧵
www.biorxiv.org/content/10.6...
Our lab's MINI2P-II (1.1g) overcomes the widely accepted assumption that high optical performance and ultralow weight cannot coexist. A climbing mouse can carry two, a singing songbird one 🧵
www.biorxiv.org/content/10.6...
The first bihemispheric 2P imaging in freely moving mice!
MINI2P-II records hundreds of connection-specified neurons from both hemispheres of the primary motor cortex (M1) across multiple days, during naturalistic ladder-climbing. A new experimental window into inter-hemispheric coordination!
MINI2P-II records hundreds of connection-specified neurons from both hemispheres of the primary motor cortex (M1) across multiple days, during naturalistic ladder-climbing. A new experimental window into inter-hemispheric coordination!
October 29, 2026 at 8:41 AM
The first bihemispheric 2P imaging in freely moving mice!
MINI2P-II records hundreds of connection-specified neurons from both hemispheres of the primary motor cortex (M1) across multiple days, during naturalistic ladder-climbing. A new experimental window into inter-hemispheric coordination!
MINI2P-II records hundreds of connection-specified neurons from both hemispheres of the primary motor cortex (M1) across multiple days, during naturalistic ladder-climbing. A new experimental window into inter-hemispheric coordination!
Thank you to the whole team behind MINI2P-II! Embla K-Skallerud and Shouwen Ma (co-first), Julija Arbaciauskaite, Rajat Saxena, Antonio Camara, Klaus Jenssen, Jonathan Whitlock, Gahr Manfred. Also our institute @kavlintnu.bsky.social, MPIBI, and the funding from @kavlifoundation.org and #NRC.
October 29, 2026 at 8:41 AM
Thank you to the whole team behind MINI2P-II! Embla K-Skallerud and Shouwen Ma (co-first), Julija Arbaciauskaite, Rajat Saxena, Antonio Camara, Klaus Jenssen, Jonathan Whitlock, Gahr Manfred. Also our institute @kavlintnu.bsky.social, MPIBI, and the funding from @kavlifoundation.org and #NRC.
The first ipsilateral dual-region 2P imaging in freely moving mice!
With a new optical implant, MINI2P-II achieves simultaneous ipsilateral imaging of the retrosplenial cortex and posterior parietal cortex, two adjacent regions previously inaccessible in this manner in freely moving mice!
With a new optical implant, MINI2P-II achieves simultaneous ipsilateral imaging of the retrosplenial cortex and posterior parietal cortex, two adjacent regions previously inaccessible in this manner in freely moving mice!
October 29, 2026 at 8:41 AM
The first ipsilateral dual-region 2P imaging in freely moving mice!
With a new optical implant, MINI2P-II achieves simultaneous ipsilateral imaging of the retrosplenial cortex and posterior parietal cortex, two adjacent regions previously inaccessible in this manner in freely moving mice!
With a new optical implant, MINI2P-II achieves simultaneous ipsilateral imaging of the retrosplenial cortex and posterior parietal cortex, two adjacent regions previously inaccessible in this manner in freely moving mice!
Congratulations Weijian and the whole team!! So excited to use MINI2P-II and looking forward to exciting discoveries together 🤩🤩
October 29, 2026 at 9:12 AM
Congratulations Weijian and the whole team!! So excited to use MINI2P-II and looking forward to exciting discoveries together 🤩🤩
The first large-scale 2P calcium imaging in freely singing songbirds!
At 1.1g, MINI2P-II enables high-quality 2P imaging in freely moving zebra finches, including juveniles as young as 44 days old, in the critical song-learning period when birds are far too small to carry existing 2P miniscopes.
At 1.1g, MINI2P-II enables high-quality 2P imaging in freely moving zebra finches, including juveniles as young as 44 days old, in the critical song-learning period when birds are far too small to carry existing 2P miniscopes.
October 29, 2026 at 8:41 AM
The first large-scale 2P calcium imaging in freely singing songbirds!
At 1.1g, MINI2P-II enables high-quality 2P imaging in freely moving zebra finches, including juveniles as young as 44 days old, in the critical song-learning period when birds are far too small to carry existing 2P miniscopes.
At 1.1g, MINI2P-II enables high-quality 2P imaging in freely moving zebra finches, including juveniles as young as 44 days old, in the critical song-learning period when birds are far too small to carry existing 2P miniscopes.
Want to get clean calcium signals from tons of deep-brain neurons in freely moving animals?
Check to this www.science.org/doi/10.1126/... @ScienceAdvances!
We show how correcting GRIN lens aberrations transforms MINI2P performance, revealing sparse HD coding in sensory thalamus!
Check to this www.science.org/doi/10.1126/... @ScienceAdvances!
We show how correcting GRIN lens aberrations transforms MINI2P performance, revealing sparse HD coding in sensory thalamus!
Extended field-of-view two-photon imaging in the deep brain of freely behaving mice using lightweight microfabricated corrective optics
Investigating neural circuits underlying complex behavior requires high-resolution imaging of large neuronal populations during naturalistic conditions. Miniaturized two-photon microscopes (MINI2Ps) e...
www.science.org
October 17, 2026 at 5:16 PM
Want to get clean calcium signals from tons of deep-brain neurons in freely moving animals?
Check to this www.science.org/doi/10.1126/... @ScienceAdvances!
We show how correcting GRIN lens aberrations transforms MINI2P performance, revealing sparse HD coding in sensory thalamus!
Check to this www.science.org/doi/10.1126/... @ScienceAdvances!
We show how correcting GRIN lens aberrations transforms MINI2P performance, revealing sparse HD coding in sensory thalamus!
🔬 Join us for our upcoming webinar, Best Practices for Freely Moving In-Vivo Imaging with the Mini2P, and explore what it takes to successfully implement the Mini2P microscope in a research laboratory.
📅 November 4, 2026
11:00 AM EST
https://bit.ly/4yQSY54
📅 November 4, 2026
11:00 AM EST
https://bit.ly/4yQSY54
October 15, 2026 at 5:52 PM
🔬 Join us for our upcoming webinar, Best Practices for Freely Moving In-Vivo Imaging with the Mini2P, and explore what it takes to successfully implement the Mini2P microscope in a research laboratory.
📅 November 4, 2026
11:00 AM EST
https://bit.ly/4yQSY54
📅 November 4, 2026
11:00 AM EST
https://bit.ly/4yQSY54
A half-century old question may have its final answer. Using high-resolution #Mini2P microscopes, we find no evidence of local topography in #PlaceCells. Place fields of neighbouring cells are no more similar than those of randomly selected cells. 🧠🗺️ Out now in @pnas.org www.pnas.org/doi/10.1073/...
Place cells in CA1 lack topographical organization of firing locations | PNAS
Topography is a well-described and well-known concept for cortical organization in
primary sensory and motor cortices of mammalian brains. Similar ...
www.pnas.org
February 19, 2026 at 11:53 AM
A half-century old question may have its final answer. Using high-resolution #Mini2P microscopes, we find no evidence of local topography in #PlaceCells. Place fields of neighbouring cells are no more similar than those of randomly selected cells. 🧠🗺️ Out now in @pnas.org www.pnas.org/doi/10.1073/...
A miniature two-photon microscope #Mini2P
Congratulations to the brilliant Weijian Zong, who today received a FRIPRO grant by The Research Council of Norway for the miniature microscope #Mini2P, that allows researchers to see 👀 cognitive functions emerge from thousands of collaborating neurons in the brain 🧠 of a freely behaving mouse!
December 6, 2024 at 7:24 PM
A miniature two-photon microscope #Mini2P
Me: Can I get a Dr. House?
Mom: We have a Dr. House at home
The Dr. House at home:
(It me, I sprained my ankle)
Mom: We have a Dr. House at home
The Dr. House at home:
(It me, I sprained my ankle)
November 17, 2025 at 10:54 PM
Me: Can I get a Dr. House?
Mom: We have a Dr. House at home
The Dr. House at home:
(It me, I sprained my ankle)
Mom: We have a Dr. House at home
The Dr. House at home:
(It me, I sprained my ankle)
Excited to be here at the @mpfneuro.bsky.social #Sunposium26 where we are demonstrating our Mini2P with Spark Lasers.
If you're nearby, visit us at booth 102!🔬
If you're nearby, visit us at booth 102!🔬
March 10, 2026 at 6:51 PM
Excited to be here at the @mpfneuro.bsky.social #Sunposium26 where we are demonstrating our Mini2P with Spark Lasers.
If you're nearby, visit us at booth 102!🔬
If you're nearby, visit us at booth 102!🔬
Excited to share work we have been doing in collaboration with @mpfneuro.bsky.social, at #Sunposium2026 Conference, March 9–11.
Featured Talks
🧠 Overview of Thorlabs Life Science Imaging Objectives; Lira Scott, PhD
🔬 Recent Advances in Mini2P Imaging; Jeff Brooker, CTO
https://bit.ly/4r9KAc7
Featured Talks
🧠 Overview of Thorlabs Life Science Imaging Objectives; Lira Scott, PhD
🔬 Recent Advances in Mini2P Imaging; Jeff Brooker, CTO
https://bit.ly/4r9KAc7
March 3, 2026 at 3:02 PM
Excited to share work we have been doing in collaboration with @mpfneuro.bsky.social, at #Sunposium2026 Conference, March 9–11.
Featured Talks
🧠 Overview of Thorlabs Life Science Imaging Objectives; Lira Scott, PhD
🔬 Recent Advances in Mini2P Imaging; Jeff Brooker, CTO
https://bit.ly/4r9KAc7
Featured Talks
🧠 Overview of Thorlabs Life Science Imaging Objectives; Lira Scott, PhD
🔬 Recent Advances in Mini2P Imaging; Jeff Brooker, CTO
https://bit.ly/4r9KAc7
We are excited to partner with the @mpfneuro.bsky.social to advance brain research through cutting-edge imaging technology!
This collaboration brings our Mini2P two-photon microscope and other advanced imaging systems to MPFI, enabling researchers to observe neural activity in unprecedented detail.
This collaboration brings our Mini2P two-photon microscope and other advanced imaging systems to MPFI, enabling researchers to observe neural activity in unprecedented detail.
We are excited to announce a new partnership with @thorlabs.bsky.social that will give our researchers access to groundbreaking new Mini2P imaging. Read more about the Thorlabs Innovation Center at MPFI & how it will allow scientists to see neural activity in unprecedented detail:🔬 buff.ly/rdRbRfG
March 27, 2025 at 1:36 PM
We are excited to partner with the @mpfneuro.bsky.social to advance brain research through cutting-edge imaging technology!
This collaboration brings our Mini2P two-photon microscope and other advanced imaging systems to MPFI, enabling researchers to observe neural activity in unprecedented detail.
This collaboration brings our Mini2P two-photon microscope and other advanced imaging systems to MPFI, enabling researchers to observe neural activity in unprecedented detail.
Come check out Moser group posters today at SFN!! ❤️We have: NPX, mini2P, recordings across HPC-EC circuit, remapping, ontogeny of torus, sweeps, all-optical stim, time coding, grid cell hot spot maps, LEC, RSC, SUB & minute scale oscillations!
8:00 AM-12:00 PM
190.01-190.11
8:00 AM-12:00 PM
190.01-190.11
November 22, 2024 at 10:37 AM
Come check out Moser group posters today at SFN!! ❤️We have: NPX, mini2P, recordings across HPC-EC circuit, remapping, ontogeny of torus, sweeps, all-optical stim, time coding, grid cell hot spot maps, LEC, RSC, SUB & minute scale oscillations!
8:00 AM-12:00 PM
190.01-190.11
8:00 AM-12:00 PM
190.01-190.11
2/6
To test this, we used #Mini2P 🔬 to image thousands of CA1 neurons simultaneously in freely moving mice 🐭
This allowed us to combine high anatomical precision with natural behavior.
To test this, we used #Mini2P 🔬 to image thousands of CA1 neurons simultaneously in freely moving mice 🐭
This allowed us to combine high anatomical precision with natural behavior.
February 20, 2026 at 12:17 PM
2/6
To test this, we used #Mini2P 🔬 to image thousands of CA1 neurons simultaneously in freely moving mice 🐭
This allowed us to combine high anatomical precision with natural behavior.
To test this, we used #Mini2P 🔬 to image thousands of CA1 neurons simultaneously in freely moving mice 🐭
This allowed us to combine high anatomical precision with natural behavior.
Please join us for a seminar and live demo with our friends @thorlabs.bsky.social on 9/2 at 2 pm - Seminar followed by live demo
Mini2P: Freely Behaving Two-Photon Imaging
@harvardmed.bsky.social
220 Longwood Ave, Goldenson Room 229
Live Demo continues: 9/3 and 9/4, 9 am - 4 pm, Goldenson Room 245
Mini2P: Freely Behaving Two-Photon Imaging
@harvardmed.bsky.social
220 Longwood Ave, Goldenson Room 229
Live Demo continues: 9/3 and 9/4, 9 am - 4 pm, Goldenson Room 245
August 26, 2025 at 8:41 PM
Please join us for a seminar and live demo with our friends @thorlabs.bsky.social on 9/2 at 2 pm - Seminar followed by live demo
Mini2P: Freely Behaving Two-Photon Imaging
@harvardmed.bsky.social
220 Longwood Ave, Goldenson Room 229
Live Demo continues: 9/3 and 9/4, 9 am - 4 pm, Goldenson Room 245
Mini2P: Freely Behaving Two-Photon Imaging
@harvardmed.bsky.social
220 Longwood Ave, Goldenson Room 229
Live Demo continues: 9/3 and 9/4, 9 am - 4 pm, Goldenson Room 245
My lab University College London is looking for an experimental postdoc to join our team. Interested in circuits underlying visually guided behavior, chronic #Neuropixel recordings or 2-photon imaging (Benchtop, #Mini2p)? Then check out our lab homepage www.ruedigerlab.com, apply & spread the word
November 22, 2024 at 7:09 AM
My lab University College London is looking for an experimental postdoc to join our team. Interested in circuits underlying visually guided behavior, chronic #Neuropixel recordings or 2-photon imaging (Benchtop, #Mini2p)? Then check out our lab homepage www.ruedigerlab.com, apply & spread the word
Gcamp8s/6s (TetO-Niell style) with mini2p at 40Hz (= bad bench2p)
January 8, 2025 at 12:45 PM
Gcamp8s/6s (TetO-Niell style) with mini2p at 40Hz (= bad bench2p)
...meanwhile: comparison objective size 2pRAM vs. mini2p
January 8, 2025 at 11:32 AM
...meanwhile: comparison objective size 2pRAM vs. mini2p
hmm. I worry more about that with Caiman and demixing… But we currently do not denoise. We have pretty noisy mini2p data currently that may benefit, though.
January 8, 2025 at 10:57 AM
hmm. I worry more about that with Caiman and demixing… But we currently do not denoise. We have pretty noisy mini2p data currently that may benefit, though.