Hormone replacement therapy helps restore immune function in menopausal women, reducing inflammaging and preserving monocyte function. open-access
onlinelibrary.wiley.com/doi/10.1111/...
Extends what I previously summarized from immune system clocks
erictopol.substack.com/p/new-anti-a...
onlinelibrary.wiley.com/doi/10.1111/...
Extends what I previously summarized from immune system clocks
erictopol.substack.com/p/new-anti-a...
October 9, 2025 at 10:45 PM
Hormone replacement therapy helps restore immune function in menopausal women, reducing inflammaging and preserving monocyte function. open-access
onlinelibrary.wiley.com/doi/10.1111/...
Extends what I previously summarized from immune system clocks
erictopol.substack.com/p/new-anti-a...
onlinelibrary.wiley.com/doi/10.1111/...
Extends what I previously summarized from immune system clocks
erictopol.substack.com/p/new-anti-a...
Study: A distinct monocyte transcriptional state links systemic immune dysregulation to pulmonary impairment in long COVID
Published: 14 January 2026
www.nature.com/articles/s41...
Published: 14 January 2026
www.nature.com/articles/s41...
A distinct monocyte transcriptional state links systemic immune dysregulation to pulmonary impairment in long COVID - Nature Immunology
Li and colleagues describe a monocyte-specific transcriptional state along with a persistent elevation of inflammatory markers specifically found in individuals with long COVID who had mild-to-moderat...
www.nature.com
March 27, 2026 at 7:45 AM
Study: A distinct monocyte transcriptional state links systemic immune dysregulation to pulmonary impairment in long COVID
Published: 14 January 2026
www.nature.com/articles/s41...
Published: 14 January 2026
www.nature.com/articles/s41...
new out in Nature www.nature.com/articles/s41... Cancer cells impair monocyte-mediated T cell stimulation to evade immunity
Cancer cells impair monocyte-mediated T cell stimulation to evade immunity - Nature
Inflammatory monocytes are identified as important players in T cell restimulation in the tumour microenvironment.
www.nature.com
November 28, 2024 at 9:01 AM
new out in Nature www.nature.com/articles/s41... Cancer cells impair monocyte-mediated T cell stimulation to evade immunity
Cancer cells impair monocyte-mediated T cell stimulation to evade immunity 🧪
www.nature.com/articles/s41...
Congrats @obenaufa.bsky.social & team for the wonderful work
www.nature.com/articles/s41...
Congrats @obenaufa.bsky.social & team for the wonderful work
Cancer cells impair monocyte-mediated T cell stimulation to evade immunity - Nature
Inflammatory monocytes are identified as important players in T cell restimulation in the tumour microenvironment.
www.nature.com
November 27, 2024 at 5:11 PM
Cancer cells impair monocyte-mediated T cell stimulation to evade immunity 🧪
www.nature.com/articles/s41...
Congrats @obenaufa.bsky.social & team for the wonderful work
www.nature.com/articles/s41...
Congrats @obenaufa.bsky.social & team for the wonderful work
Open‑access review explores how targeting monocyte dynamics could offer new therapeutic approaches for multiple sclerosis, with insights from experimental models highlighting monocyte plasticity and inflammation resolution.
vist.ly/5jhn9
vist.ly/5jhn9
September 23, 2026 at 11:00 AM
Open‑access review explores how targeting monocyte dynamics could offer new therapeutic approaches for multiple sclerosis, with insights from experimental models highlighting monocyte plasticity and inflammation resolution.
vist.ly/5jhn9
vist.ly/5jhn9
Study: A distinct monocyte transcriptional state links systemic immune dysregulation to pulmonary impairment in long COVID
Published: 14 January 2026
www.nature.com/articles/s41...
Published: 14 January 2026
www.nature.com/articles/s41...
A distinct monocyte transcriptional state links systemic immune dysregulation to pulmonary impairment in long COVID - Nature Immunology
Li and colleagues describe a monocyte-specific transcriptional state along with a persistent elevation of inflammatory markers specifically found in individuals with long COVID who had mild-to-moderat...
www.nature.com
February 4, 2026 at 11:46 PM
Study: A distinct monocyte transcriptional state links systemic immune dysregulation to pulmonary impairment in long COVID
Published: 14 January 2026
www.nature.com/articles/s41...
Published: 14 January 2026
www.nature.com/articles/s41...
CSF1R regulates monocyte subset differentiation and intracellular metabolism @natcomms.nature.com
www.nature.com/articles/s41...
www.nature.com/articles/s41...
July 5, 2026 at 4:48 PM
CSF1R regulates monocyte subset differentiation and intracellular metabolism @natcomms.nature.com
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Brain-initiated hunger signals control circulating monocyte dynamics @sciimmunology.bsky.social
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Brain sensing of metabolic state regulates circulating monocytes
Brain-initiated hunger signals control circulating monocyte dynamics.
www.science.org
April 4, 2025 at 6:35 PM
Brain-initiated hunger signals control circulating monocyte dynamics @sciimmunology.bsky.social
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Our Paper out in @natureportfolio.bsky.social with correct link www.nature.com/articles/s41...
November 27, 2024 at 10:17 PM
Our Paper out in @natureportfolio.bsky.social with correct link www.nature.com/articles/s41...
Microglia & monocyte-derived cells were long assumed to have similar functions during remyelination. Our new paper @plosbiology.org shows non-redundant roles, with monocytes ultimately inhibiting remyelination. Team effort by Bianca Hill,Rebecca Holloway, Lindsey Forbes,Claire Davies
plos.io/3RryCLF
plos.io/3RryCLF
Monocyte-secreted Wnt reduces the efficiency of central nervous system remyelination
Remyelination in the central nervous system (CNS) is influenced by myeloid cells, which includes resident microglia and infiltrating monocytes that are difficult to distinguish. This study shows that ...
plos.io
April 22, 2025 at 9:30 PM
Microglia & monocyte-derived cells were long assumed to have similar functions during remyelination. Our new paper @plosbiology.org shows non-redundant roles, with monocytes ultimately inhibiting remyelination. Team effort by Bianca Hill,Rebecca Holloway, Lindsey Forbes,Claire Davies
plos.io/3RryCLF
plos.io/3RryCLF
@biorxivpreprint.bsky.social Multi-omics reveals a monocyte-macrophage-fibroblast axis in post-COVID-19 fibroinflammatory lung remodelling
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
September 18, 2026 at 2:28 AM
@biorxivpreprint.bsky.social Multi-omics reveals a monocyte-macrophage-fibroblast axis in post-COVID-19 fibroinflammatory lung remodelling
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
Brain-engrafted monocyte-derived macrophages from blood and skull-bone marrow exhibit distinct properties. @cp-neuron.bsky.social www.cell.com/neuron/fullt...
March 11, 2026 at 2:40 PM
Brain-engrafted monocyte-derived macrophages from blood and skull-bone marrow exhibit distinct properties. @cp-neuron.bsky.social www.cell.com/neuron/fullt...
Inflammation rewires the enteric nervous system through neurogenic monocyte recruitment
rupress.org/jem/article-... @jem.org @umasschan.bsky.social
rupress.org/jem/article-... @jem.org @umasschan.bsky.social
March 4, 2026 at 3:36 AM
Inflammation rewires the enteric nervous system through neurogenic monocyte recruitment
rupress.org/jem/article-... @jem.org @umasschan.bsky.social
rupress.org/jem/article-... @jem.org @umasschan.bsky.social
Monocyte-derived macrophages act as reinforcements when microglia fall short in Alzheimer’s disease
@natureneuro.bsky.social @maabella.bsky.social
www.nature.com/articles/s41...
@natureneuro.bsky.social @maabella.bsky.social
www.nature.com/articles/s41...
Monocyte-derived macrophages act as reinforcements when microglia fall short in Alzheimer’s disease - Nature Neuroscience
This article discusses a puzzling issue in brain pathology: why brain-resident microglia are insufficient for protection, and why myeloid cells are needed from the periphery. Several strategies are pr...
www.nature.com
January 6, 2025 at 6:34 PM
Monocyte-derived macrophages act as reinforcements when microglia fall short in Alzheimer’s disease
@natureneuro.bsky.social @maabella.bsky.social
www.nature.com/articles/s41...
@natureneuro.bsky.social @maabella.bsky.social
www.nature.com/articles/s41...
Up next in highlights from this month's #ScienceImmunology was a Focus commentary from Alexander Mildner and Simon Yona discussing the challenges of mapping the identities of recently described #monocyte subsets with different origins and functions.
Monocytes and their doppelgängers: An immunological crossroads
Monocyte research reveals “doppelgänger” populations that resemble classical monocytes but differ in origin, function, or migration.
www.science.org
November 14, 2024 at 6:14 PM
Up next in highlights from this month's #ScienceImmunology was a Focus commentary from Alexander Mildner and Simon Yona discussing the challenges of mapping the identities of recently described #monocyte subsets with different origins and functions.
Optogenetic vagal nerve stimulation attenuates heart failure by limiting the generation of monocyte-derived inflammatory CCRL2+ macrophages: @cp-immunity.bsky.social www.cell.com/immunity/ful...
Optogenetic vagal nerve stimulation attenuates heart failure by limiting the generation f monocyte-derived inflammatory CCRL2+ macrophages
Parasympathetic neuronal dysfunction is associated with heart failure, yet the underlying
mechanism is poorly understood. Here, Li et al. demonstrate that optogenetic activation
of the vagus nerve pre...
www.cell.com
June 27, 2025 at 3:10 PM
Optogenetic vagal nerve stimulation attenuates heart failure by limiting the generation of monocyte-derived inflammatory CCRL2+ macrophages: @cp-immunity.bsky.social www.cell.com/immunity/ful...
Cancer cells blunt monocyte IFN while increasing PGE2 to inhibit T cell immunity @obenaufa.bsky.social @aelewaut.bsky.social @guillemxtivill.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
November 28, 2024 at 12:26 PM
Cancer cells blunt monocyte IFN while increasing PGE2 to inhibit T cell immunity @obenaufa.bsky.social @aelewaut.bsky.social @guillemxtivill.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Eine schwere COVID19-Erkrankung steht im Zusammenhang mit dysregulierten Immunreaktionen. Dexamethason wirkt, indem es den fehlgeleiteten Status bestimmter Immunzellen, sogenannter Monozyten, neu verdrahtet.
July 3, 2024 at 10:17 PM
Eine schwere COVID19-Erkrankung steht im Zusammenhang mit dysregulierten Immunreaktionen. Dexamethason wirkt, indem es den fehlgeleiteten Status bestimmter Immunzellen, sogenannter Monozyten, neu verdrahtet.
Sex differences in pain duration
Finding interleukin-10 from monocytes as an/the explanation (in the experimental model and people
www.science.org/doi/10.1126/...
Finding interleukin-10 from monocytes as an/the explanation (in the experimental model and people
www.science.org/doi/10.1126/...
Monocyte-derived IL-10 drives sex differences in pain duration
Peripheral monocytes and IL-10 are associated with shorter pain duration in males in both mice and humans.
www.science.org
February 20, 2026 at 7:58 PM
Sex differences in pain duration
Finding interleukin-10 from monocytes as an/the explanation (in the experimental model and people
www.science.org/doi/10.1126/...
Finding interleukin-10 from monocytes as an/the explanation (in the experimental model and people
www.science.org/doi/10.1126/...
New from Germany
Autoantibody-Driven Monocyte Dysfunction in Post-COVID Syndrome with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome
www.medrxiv.org/content/10.1...
#LongCovid #MEcfs
Autoantibody-Driven Monocyte Dysfunction in Post-COVID Syndrome with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome
www.medrxiv.org/content/10.1...
#LongCovid #MEcfs
January 14, 2025 at 3:32 PM
New from Germany
Autoantibody-Driven Monocyte Dysfunction in Post-COVID Syndrome with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome
www.medrxiv.org/content/10.1...
#LongCovid #MEcfs
Autoantibody-Driven Monocyte Dysfunction in Post-COVID Syndrome with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome
www.medrxiv.org/content/10.1...
#LongCovid #MEcfs
Nature research paper: The transition from monocyte to tissue-resident macrophage requires DHPS
go.nature.com/4sSiFPX
go.nature.com/4sSiFPX
The transition from monocyte to tissue-resident macrophage requires DHPS - Nature
In mice, DHPS supports the maturation, maintenance and function of tissue-resident macrophages via the polyamine–hypusine axis, with implications for macrophage-targeting therapies.
go.nature.com
January 28, 2026 at 1:36 PM
Nature research paper: The transition from monocyte to tissue-resident macrophage requires DHPS
go.nature.com/4sSiFPX
go.nature.com/4sSiFPX
2) Link to the paper:
Kumar et al. A distinct monocyte transcriptional state links systemic immune dysregulation to pulmonary impairment in long COVID.
Kumar et al. A distinct monocyte transcriptional state links systemic immune dysregulation to pulmonary impairment in long COVID.
A distinct monocyte transcriptional state links systemic immune dysregulation to pulmonary impairment in long COVID
Nature Immunology - Li and colleagues describe a monocyte-specific transcriptional state along with a persistent elevation of inflammatory markers specifically found in individuals with long COVID...
www.nature.com
March 16, 2026 at 9:33 AM
2) Link to the paper:
Kumar et al. A distinct monocyte transcriptional state links systemic immune dysregulation to pulmonary impairment in long COVID.
Kumar et al. A distinct monocyte transcriptional state links systemic immune dysregulation to pulmonary impairment in long COVID.
Cancer cells impair monocyte-mediated T cell stimulation to evade immunity
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Cancer cells impair monocyte-mediated T cell stimulation to evade immunity - Nature
Inflammatory monocytes are identified as important players in T cell restimulation in the tumour microenvironment.
www.nature.com
December 1, 2024 at 10:12 AM
Cancer cells impair monocyte-mediated T cell stimulation to evade immunity
www.nature.com/articles/s41...
www.nature.com/articles/s41...