Voltage-gated sodium channels differentially encode mammalian proprioception via distinct cellular localization patterns.

Baseline CI did not alter responses to endurance exercise in those with early PD, suggesting that the beneficial effects of endurance exercise on disease progression and VO_2peak in people w...

<p xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="first" dir="auto" id="d10580405e136">Objectives: Different types of exercises that aim in the development of balance, motor ...

A Multimodal Dataset Addressing Motor Function in Autism  Nature

Background: Cerebral Small Vessel Disease (CSVD) significantly impacts motor functions, particularly gait dynamics, yet its analysis often lacks the integration of comprehensive tools that capture the multifaceted nature of gait disturbances. Traditional methods may not fully address the complexity of CSVD's impact on gait, underscoring the need for a detailed exploration of gait characteristics through advanced technological means. Objective: This study aims to elucidate the distinct gait patterns and postural adaptations present in patients with CSVD compared to a healthy older population, employing an integrative analysis combining sensor and video data to provide a holistic understanding of gait dynamics in CSVD. Methods: The study involved 90 participants over 50 years old, with 24 categorized as normal and 66 diagnosed with CSVD. Gait parameters were collected through accelerometer data for sensor-based parameters and video data for image posture parameters. Key statistical measures included step frequency, root mean square (RMS), step variability, step regularity, and step symmetry from sensor data; and knee angle, ankle angle, elbow angle, body trunk angles, and head posture from video analysis Results: Among the 29 participants with complete sensor and video data, significant differences were observed in step regularity (P value < .0045), RMS (P value < .0056 for certain walking tasks), and forward head posture angles between the CSVD and control groups, indicating altered gait dynamics in CSVD patients. Notably, the CSVD group exhibited a more pronounced forward head posture during walking tasks, suggesting potential balance or proprioceptive adaptations. Conclusions: The study provides compelling evidence of distinct gait disturbances in CSVD patients, highlighted by significant postural deviations and altered gait patterns when compared to healthy controls. The integration of sensor and video analysis offers a nuanced understanding of CSVD’s impact on gait, underscoring the value of comprehensive assessment tools in capturing the complex nature of gait disturbances.

A new electrical stimulation therapy for spinal muscle atrophy (SMA) has shown promise in reactivating motor neurons and improving movement. In a pilot clinical trial, three patients who received spinal...