#SodiumChannels
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lampertlab.bsky.social
1/5 Are you interested in the role of Nav1.9 in AP generation? And what do all the other #sodiumchannels do in the nociceptor? In a study led by the MD student Phil Köster in the lab, we performed manual patch clamp on all Navs known to be expressed in sensory neurons. Nav1.1,2,3,5,6,7,8,9.
jgp.org Journal of General Physiology @jgp.org · Jan 21
Köster, Stiehl, @lampertlab.bsky.social and colleagues characterize eight sodium channel subtypes relevant to #nociception and use a computer model to simulate the response of two types of nociceptive nerve fibers. https://buff.ly/4hku7gH

#Biophysics #Neuroscience #IonChannels
January 30, 2025 at 8:49 PM
nyupainresearch.bsky.social
Check out this article on Voltage-gated sodium channels NaV1.1 and NaV1.6 each play unique and crucial roles in proprioception, shaping motor control and the structure of skeletal muscles #Proprioception #SodiumChannels #MotorFunction www.science.org/doi/10.1126/...
Differential encoding of mammalian proprioception by voltage-gated sodium channels
Voltage-gated sodium channels differentially encode mammalian proprioception via distinct cellular localization patterns.
www.science.org
April 9, 2025 at 4:17 PM
lampertlab.bsky.social
⏰ Abstract deadline tomorrow! Join us in Grindelwald, Feb 4–6, 2026 Worldwide Sodium Channel Conference!
Robert Stewart (Harvard) talks on Nav1.8 inhibition & new Nav blockers for pain 💥Accepted abstracts → special issue @jgp.org👉 sodiumchannelconference2026.org
#WSCC26 #SodiumChannels #PainResearch
November 1, 2025 at 8:21 AM
plosbiology.org
Mammalian #muscle fiber contractions require voltage-gated #SodiumChannels. This study shows that #zebrafish fast muscle fibers don't require Nav channels, suggesting how anatomical & physiological differences from mouse muscles ensure efficient contraction @plosbiology.org 🧪https://plos.io/49BMaOD
AChRs and nuclei labeling with α-bungarotoxin (red) and Hoechst (blue), respectively, in fast muscle fibers from control (CT, top) and mutant fish (DM, bottom). Measurements were made on Z-stacks images of whole fibers by dividing each fiber at its equator and applying Z-projection to each half. Z-projections of the upper half of a representative CT and DM fiber are shown (upper panels). Euclidean distance transformation of half-fiber Z-projection generated a distance mapping visualized by colored gradient (lower panels). Bar = 30 µm.
November 6, 2025 at 9:04 AM
plosbiology.org
Mammalian #muscle fiber contractions require voltage-gated #SodiumChannels. This study shows that #zebrafish fast muscle fibers don't require Nav channels, suggesting how anatomical & physiological differences from mouse muscles ensure efficient contraction
@plosbiology.org 🧪 plos.io/49BMaOD
AChRs and nuclei labeling with α-bungarotoxin (red) and Hoechst (blue), respectively, in fast muscle fibers from control (CT, top) and mutant fish (DM, bottom). Measurements were made on Z-stacks images of whole fibers by dividing each fiber at its equator and applying Z-projection to each half. Z-projections of the upper half of a representative CT and DM fiber are shown (upper panels). Euclidean distance transformation of half-fiber Z-projection generated a distance mapping visualized by colored gradient (lower panels). Bar = 30 µm.
November 6, 2025 at 6:36 PM
plosbiology.org
Mammalian #muscle fiber contractions require voltage-gated #SodiumChannels. This study shows that #zebrafish fast muscle fibers don't require Nav channels, suggesting how anatomical & physiological differences from mouse muscles ensure efficient contraction @plosbiology.org 🧪https://plos.io/49BMaOD
AChRs and nuclei labeling with α-bungarotoxin (red) and Hoechst (blue), respectively, in fast muscle fibers from control (CT, top) and mutant fish (DM, bottom). Measurements were made on Z-stacks images of whole fibers by dividing each fiber at its equator and applying Z-projection to each half. Z-projections of the upper half of a representative CT and DM fiber are shown (upper panels). Euclidean distance transformation of half-fiber Z-projection generated a distance mapping visualized by colored gradient (lower panels). Bar = 30 µm.
November 6, 2025 at 1:58 PM
plosbiology.org
Mammalian #muscle fiber contractions require voltage-gated #SodiumChannels. This study shows that #zebrafish fast muscle fibers don't require Nav channels, suggesting how anatomical & physiological differences from mouse muscles ensure efficient contraction @plosbiology.org 🧪https://plos.io/49BMaOD
AChRs and nuclei labeling with α-bungarotoxin (red) and Hoechst (blue), respectively, in fast muscle fibers from control (CT, top) and mutant fish (DM, bottom). Measurements were made on Z-stacks images of whole fibers by dividing each fiber at its equator and applying Z-projection to each half. Z-projections of the upper half of a representative CT and DM fiber are shown (upper panels). Euclidean distance transformation of half-fiber Z-projection generated a distance mapping visualized by colored gradient (lower panels). Bar = 30 µm.
November 6, 2025 at 5:28 PM
nanocardiology.bsky.social
www.nature.com/articles/s41...
Delighted to have contributed to this exciting work led by Mikhail Tarasov and Przemysław Radwański. By combining #MINFLUX #nanoscopy with #singlechannel #patchclamp, we identified #cooperative #gating of clustered NaV1.5 #sodiumchannels. 🧵
Nanoscale organization in the cell membrane dynamically modulates the biophysics of voltage-gated sodium channels - Nature Communications
Authors show how voltage-gated sodium channels influence each other’s gating kinetics when localized in sufficient proximity to each other as part of clusters in the membrane. These nanoscale effects ...
www.nature.com
May 11, 2026 at 9:39 PM
uhsolutions.bsky.social
READ FULL ARTICLE ON PAIN ON-LINE: #Suzetrigine #NonopioidAnalgesic #Painef="/hashtag/PainManagement" class="hover:underline text-blue-600 dark:text-sky-400 no-card-link">#PainManagement #FDAApproval #AcutePain #PainRelief #ClinicalTrials #SodiumChannels #VertexPharmaceuticals #ChronicPain #Opioid="/hashtag/OpioidAlternatives" class="hover:underline text-blue-600 dark:text-sky-400 no-card-link">#OpioidAlternatives #PatientSafety #QualityOfLife #InnovativeTreatments #Pain #Medicine #Opioid
Discovering Suzetrigine: A New Era in Pain Relief
Suzetrigine: A Safer Nonopioid Analgesic In the ever-evolving world of pain management, a groundbreaking development has emerged that could change the landscape of treatment for millions of individuals suffering from acute pain. Suzetrigine, the first nonopioid analgesic approved by the FDA in 25 years, is generating excitement among pain specialists like Dr. Brett Stacey, a seasoned expert in the field and a professor of anesthesiology and pain medicine at the University of Washington School of Medicine.
ultimatehealingsolutions.com
February 28, 2025 at 2:49 PM
epilepsiajournal.bsky.social
SCN9A variants are associated with pain disorders.
doi.org/10.1111/epi....

#epilepsy #ILAE #epilepsia #febrileseizures #GEFS+ #geneticepilepsy #SCN9A #sodiumchannels
July 1, 2025 at 2:11 PM
naniontech.bsky.social
Attending WSCC26 in Grindelwald? Let’s connect.

Feb 4–6, the global sodium channel community meets in person. Our Senior Scientist Markus Rapedius will be on site and presenting a poster on APC-based analysis of excitability in ALS iPSC-derived motor neurons (with Axol).

#WSCC26 #SodiumChannels
January 26, 2026 at 2:02 PM