An oral norovirus vaccine generates mucosal immunity and reduces viral shedding in a phase 2 placebo-controlled challenge study | Science Translational Medicine www.science.org/doi/10.1126/... 🧪
An oral norovirus vaccine generates mucosal immunity and reduces viral shedding in a phase 2 placebo-controlled challenge study
An oral norovirus vaccine stimulates systemic and mucosal immune responses that predict protection against infection in a phase 2 challenge study.
www.science.org
May 14, 2025 at 6:48 PM
An oral norovirus vaccine generates mucosal immunity and reduces viral shedding in a phase 2 placebo-controlled challenge study | Science Translational Medicine www.science.org/doi/10.1126/... 🧪
In the US alone, each year, norovirus causes ~20 million acute gastroenteritis cases, 70,000 hospitalizations, up to 800 deaths, at a cost of ~$10.6 billion annually.
An pill vaccine shows considerable promise in a clinical trial, establishing mucosal immunity
www.science.org/doi/10.1126/...
An pill vaccine shows considerable promise in a clinical trial, establishing mucosal immunity
www.science.org/doi/10.1126/...
An oral norovirus vaccine tablet was safe and elicited mucosal immunity in older adults in a phase 1b clinical trial
An oral norovirus vaccine tablet is safe and induces strong mucosal and systemic immune responses in adults aged 55 to 80 years.
www.science.org
March 6, 2025 at 12:02 AM
In the US alone, each year, norovirus causes ~20 million acute gastroenteritis cases, 70,000 hospitalizations, up to 800 deaths, at a cost of ~$10.6 billion annually.
An pill vaccine shows considerable promise in a clinical trial, establishing mucosal immunity
www.science.org/doi/10.1126/...
An pill vaccine shows considerable promise in a clinical trial, establishing mucosal immunity
www.science.org/doi/10.1126/...
For those wondering why we seem to be so behind when it comes to effective mucosal vaccines against respiratory viruses, this really excellent overview from leaders in the field offers a great summary:
www.nature.com/articles/s41...
few additional points for those who want a bit more detail🧵:
www.nature.com/articles/s41...
few additional points for those who want a bit more detail🧵:
Challenges for developing broad-based mucosal vaccines for respiratory viruses - Nature Biotechnology
Nature Biotechnology - Challenges for developing broad-based mucosal vaccines for respiratory viruses
www.nature.com
December 7, 2024 at 2:41 PM
For those wondering why we seem to be so behind when it comes to effective mucosal vaccines against respiratory viruses, this really excellent overview from leaders in the field offers a great summary:
www.nature.com/articles/s41...
few additional points for those who want a bit more detail🧵:
www.nature.com/articles/s41...
few additional points for those who want a bit more detail🧵:
the body, something that traditional mucosal vaccines have struggled to achieve. In short, this method of vaccine delivery targets mucosal AND systemic immunity. That’s a win-win situation. Researchers compared floss to drops, sublingual, and even intranasal routes. The floss outperformed
July 25, 2025 at 4:06 PM
the body, something that traditional mucosal vaccines have struggled to achieve. In short, this method of vaccine delivery targets mucosal AND systemic immunity. That’s a win-win situation. Researchers compared floss to drops, sublingual, and even intranasal routes. The floss outperformed
This is absolutely crucial research since mucosal immunity is longer lasting and more effective if we can get it right. It stops the infection at the entry point- our mucosa.
And opens the doors to other vaccines that will use mucosal immunity.
Please consider volunteering for this.
#COVID
And opens the doors to other vaccines that will use mucosal immunity.
Please consider volunteering for this.
#COVID
Volunteers needed to test no-needle COVID vaccine made in Hamilton
Hamilton Spectator
April 21, 2025
By Joanna Frketich
stillcoviding.ca/en/news/volu...
#CovidIsNotOver #COVID #vaccines #health #research #Ontario
Hamilton Spectator
April 21, 2025
By Joanna Frketich
stillcoviding.ca/en/news/volu...
#CovidIsNotOver #COVID #vaccines #health #research #Ontario
Volunteers needed to test no-needle COVID vaccine made in Hamilton
stillcoviding.ca
April 21, 2025 at 9:08 PM
This is absolutely crucial research since mucosal immunity is longer lasting and more effective if we can get it right. It stops the infection at the entry point- our mucosa.
And opens the doors to other vaccines that will use mucosal immunity.
Please consider volunteering for this.
#COVID
And opens the doors to other vaccines that will use mucosal immunity.
Please consider volunteering for this.
#COVID
A nasal Covid booster vaccine that achieves mucosal immunity to block infection. Lessons from China that the US fails to act on
insight.jci.org/articles/vie...
insight.jci.org/articles/vie...
February 11, 2026 at 2:55 PM
A nasal Covid booster vaccine that achieves mucosal immunity to block infection. Lessons from China that the US fails to act on
insight.jci.org/articles/vie...
insight.jci.org/articles/vie...
Vaccines save lives.
“… the promise of nasal vaccines is that they could induce mucosal immunity along with a systemic immune response.”
“… the promise of nasal vaccines is that they could induce mucosal immunity along with a systemic immune response.”
Will nasal vaccines consign injections to history?
Nasal vaccines could offer protection against airborne pathogens at their point of entry into the body.
www.nature.com
November 13, 2025 at 1:20 PM
Vaccines save lives.
“… the promise of nasal vaccines is that they could induce mucosal immunity along with a systemic immune response.”
“… the promise of nasal vaccines is that they could induce mucosal immunity along with a systemic immune response.”
A big month for progress on mucosal Covid vaccines!
- A 35th mucosal vax in clinical trial
- Encouraging preclinical results for intranasal self-amplifying mRNA vax from Spain
Nextgen Covid vax update @plos.org absolutelymaybe.plos.org/2025/09/30/t...
....1/2
#Covid #Covid19 #Vaccines
- A 35th mucosal vax in clinical trial
- Encouraging preclinical results for intranasal self-amplifying mRNA vax from Spain
Nextgen Covid vax update @plos.org absolutelymaybe.plos.org/2025/09/30/t...
....1/2
#Covid #Covid19 #Vaccines
A Big Month for Progress on Mucosal Covid Vaccination (NextGen Vax Update 33) - Absolutely Maybe
It was a bumper month for mucosal Covid vaccines. There were some phase 1 results for an intranasal vaccine from China: It’s…
absolutelymaybe.plos.org
October 1, 2025 at 7:20 AM
A big month for progress on mucosal Covid vaccines!
- A 35th mucosal vax in clinical trial
- Encouraging preclinical results for intranasal self-amplifying mRNA vax from Spain
Nextgen Covid vax update @plos.org absolutelymaybe.plos.org/2025/09/30/t...
....1/2
#Covid #Covid19 #Vaccines
- A 35th mucosal vax in clinical trial
- Encouraging preclinical results for intranasal self-amplifying mRNA vax from Spain
Nextgen Covid vax update @plos.org absolutelymaybe.plos.org/2025/09/30/t...
....1/2
#Covid #Covid19 #Vaccines
The idea: coat flat dental floss with vaccine formulations (proteins, mRNA, inactivated virus, nanoparticles), floss it along the gumline, for direct antigen delivery through the junctional epithelium, one of the leakiest mucosal barriers in the body.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Floss-based vaccination targets the gingival sulcus for mucosal and systemic immunization - Nature Biomedical Engineering
Floss-based vaccination exploits the leaky junctional epithelium of the gingival sulcus to deliver different types of vaccine, inducing robust mucosal and systemic immunity and providing protection ag...
www.nature.com
July 22, 2025 at 5:05 PM
The idea: coat flat dental floss with vaccine formulations (proteins, mRNA, inactivated virus, nanoparticles), floss it along the gumline, for direct antigen delivery through the junctional epithelium, one of the leakiest mucosal barriers in the body.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
How does the immune system make "decisions" at mucosal barriers? My new perspective explores how seeing strategic cell interactions through the lens of game theory could reveal fresh insights into mucosal immune homeostasis and disease. 🧵 1/7
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Organismal mucosal immunology: A perspective through the eyes of game theory
In complex organisms, functional units must interact cohesively to maintain homeostasis, especially within mucosal barriers that house diverse, specia…
www.sciencedirect.com
December 15, 2024 at 11:48 AM
How does the immune system make "decisions" at mucosal barriers? My new perspective explores how seeing strategic cell interactions through the lens of game theory could reveal fresh insights into mucosal immune homeostasis and disease. 🧵 1/7
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
FULL FORCE FRIDAY:🆕September 25th 4⃣1⃣🎧
MUCOSAL - Amalgamated States EP 🇺🇸⚛️
5 Track EP from Minnesota, U.S. Death Metal outfit⚛️
BC➡️hpgd.bandcamp.com/album/amalga...⚛️
#Mucosal #AmalgamatedStates #DeathMetal #hpgd666 #ClawHammerPR #FFFSep25 #KMäN
MUCOSAL - Amalgamated States EP 🇺🇸⚛️
5 Track EP from Minnesota, U.S. Death Metal outfit⚛️
BC➡️hpgd.bandcamp.com/album/amalga...⚛️
#Mucosal #AmalgamatedStates #DeathMetal #hpgd666 #ClawHammerPR #FFFSep25 #KMäN
September 25, 2026 at 3:12 AM
FULL FORCE FRIDAY:🆕September 25th 4⃣1⃣🎧
MUCOSAL - Amalgamated States EP 🇺🇸⚛️
5 Track EP from Minnesota, U.S. Death Metal outfit⚛️
BC➡️hpgd.bandcamp.com/album/amalga...⚛️
#Mucosal #AmalgamatedStates #DeathMetal #hpgd666 #ClawHammerPR #FFFSep25 #KMäN
MUCOSAL - Amalgamated States EP 🇺🇸⚛️
5 Track EP from Minnesota, U.S. Death Metal outfit⚛️
BC➡️hpgd.bandcamp.com/album/amalga...⚛️
#Mucosal #AmalgamatedStates #DeathMetal #hpgd666 #ClawHammerPR #FFFSep25 #KMäN
#NatMicroPicks
C. diff vaccine! 🦠💉
A protective mucosal vaccine formulation that provides sterilizing immunity to clear C. difficile from the host.
#MicroSky
www.nature.com/articles/s41...
C. diff vaccine! 🦠💉
A protective mucosal vaccine formulation that provides sterilizing immunity to clear C. difficile from the host.
#MicroSky
www.nature.com/articles/s41...
Mucosal vaccination clears Clostridioides difficile colonization - Nature
Mucosal administration of a multivalent, adjuvanted vaccine against Clostridioides difficile promoted bacterial clearance and protected against morbidity, mortality, tissue damage and recurrence ...
www.nature.com
February 22, 2026 at 6:44 AM
#NatMicroPicks
C. diff vaccine! 🦠💉
A protective mucosal vaccine formulation that provides sterilizing immunity to clear C. difficile from the host.
#MicroSky
www.nature.com/articles/s41...
C. diff vaccine! 🦠💉
A protective mucosal vaccine formulation that provides sterilizing immunity to clear C. difficile from the host.
#MicroSky
www.nature.com/articles/s41...
Detection of Anti-SARS-CoV-2 Mucosal Immunoglobulin A in Clinical Saliva Samples After a Dose of Novavax COVID-19 Vaccine
Detection of Anti‐SARS‐CoV‐2 Mucosal Immunoglobulin A in Clinical Saliva Samples After a Dose of Novavax COVID‐19 Vaccine
Immunoglobulin (Ig) A acts as a first line of defense against respiratory pathogens. Mucosal IgA in salivary and nasal passages has a rapid response to antigens and can play a protective role against...
onlinelibrary.wiley.com
October 24, 2025 at 4:23 AM
Detection of Anti-SARS-CoV-2 Mucosal Immunoglobulin A in Clinical Saliva Samples After a Dose of Novavax COVID-19 Vaccine
Mucosal Viruses in ME/CFS: A Missing Piece of the Puzzle?
www.mdpi.com/1422-0067/26...
"Emerging evidence from saliva, mucosal tissues, & longitudinal studies suggests latent viruses can persist and periodically reactivate at mucosal sites, potentially driving immune dysregulation"
#MEcfs #PwME
www.mdpi.com/1422-0067/26...
"Emerging evidence from saliva, mucosal tissues, & longitudinal studies suggests latent viruses can persist and periodically reactivate at mucosal sites, potentially driving immune dysregulation"
#MEcfs #PwME
www.mdpi.com
November 24, 2025 at 2:40 AM
Mucosal Viruses in ME/CFS: A Missing Piece of the Puzzle?
www.mdpi.com/1422-0067/26...
"Emerging evidence from saliva, mucosal tissues, & longitudinal studies suggests latent viruses can persist and periodically reactivate at mucosal sites, potentially driving immune dysregulation"
#MEcfs #PwME
www.mdpi.com/1422-0067/26...
"Emerging evidence from saliva, mucosal tissues, & longitudinal studies suggests latent viruses can persist and periodically reactivate at mucosal sites, potentially driving immune dysregulation"
#MEcfs #PwME
An exciting development for a new Covid vaccine: inhaled single dose induces strong mucosal immunity and protection in multiple species, including non-human primates, and prevents transmission across all variants assessed
nature.com/articles/s41...
nature.com/articles/s41...
December 13, 2023 at 4:38 PM
An exciting development for a new Covid vaccine: inhaled single dose induces strong mucosal immunity and protection in multiple species, including non-human primates, and prevents transmission across all variants assessed
nature.com/articles/s41...
nature.com/articles/s41...
Mucosal vaccines, the new hope for future infectious disease prevention!
Scientists call for action of mucosal immunity research, aiming to block pathogens at the mucosal layer, creating a new chapter for infectious disease defense. #TIC2025
Open Access
www.sciencedirect.com/science/arti...
Scientists call for action of mucosal immunity research, aiming to block pathogens at the mucosal layer, creating a new chapter for infectious disease defense. #TIC2025
Open Access
www.sciencedirect.com/science/arti...
June 14, 2025 at 4:29 AM
Mucosal vaccines, the new hope for future infectious disease prevention!
Scientists call for action of mucosal immunity research, aiming to block pathogens at the mucosal layer, creating a new chapter for infectious disease defense. #TIC2025
Open Access
www.sciencedirect.com/science/arti...
Scientists call for action of mucosal immunity research, aiming to block pathogens at the mucosal layer, creating a new chapter for infectious disease defense. #TIC2025
Open Access
www.sciencedirect.com/science/arti...
February 20, 2026 at 6:56 PM
It's Coming! The Mucosal Immunology Podcast to launch on MONDAY! 🌟
Explore groundbreaking insights and inspiring stories in the world of mucosal immunology - brought to you by SMI and @mucosalimmunol.bsky.social.
#MucosalImmunology #SciencePodcast #ImmunologyResearch #PodcastLaunch
Explore groundbreaking insights and inspiring stories in the world of mucosal immunology - brought to you by SMI and @mucosalimmunol.bsky.social.
#MucosalImmunology #SciencePodcast #ImmunologyResearch #PodcastLaunch
January 24, 2025 at 4:04 PM
It's Coming! The Mucosal Immunology Podcast to launch on MONDAY! 🌟
Explore groundbreaking insights and inspiring stories in the world of mucosal immunology - brought to you by SMI and @mucosalimmunol.bsky.social.
#MucosalImmunology #SciencePodcast #ImmunologyResearch #PodcastLaunch
Explore groundbreaking insights and inspiring stories in the world of mucosal immunology - brought to you by SMI and @mucosalimmunol.bsky.social.
#MucosalImmunology #SciencePodcast #ImmunologyResearch #PodcastLaunch
Nature research paper: Mucosal vaccination clears Clostridioides difficile colonization
go.nature.com/4qMs2OX
go.nature.com/4qMs2OX
Mucosal vaccination clears Clostridioides difficile colonization - Nature
Mucosal administration of a multivalent, adjuvanted vaccine against Clostridioides difficile promoted bacterial clearance and protected against morbidity, mortality, tissue damage and recurrence in mice.
go.nature.com
February 20, 2026 at 4:14 PM
Nature research paper: Mucosal vaccination clears Clostridioides difficile colonization
go.nature.com/4qMs2OX
go.nature.com/4qMs2OX
🌟 Exciting News! 🌟 The Society for Mucosal Immunology is now on Bluesky!
Join us as we continue advancing mucosal immunology with engaging discussions, research highlights, and community updates. 🌍🔬
👉 Find us here: socmucimm.org
@mucosalimmunol.bsky.social #MucosalImmunology #ScienceCommunity
Join us as we continue advancing mucosal immunology with engaging discussions, research highlights, and community updates. 🌍🔬
👉 Find us here: socmucimm.org
@mucosalimmunol.bsky.social #MucosalImmunology #ScienceCommunity
Society for Mucosal Immunology | Advancing Research, Education, & Collaboration
The Society for Mucosal Immunology is a diverse group of more than 700 scientists and clinicians from 34 countries advancing research and education related to the field of mucosal immunology.
socmucimm.org
November 19, 2024 at 10:00 PM
🌟 Exciting News! 🌟 The Society for Mucosal Immunology is now on Bluesky!
Join us as we continue advancing mucosal immunology with engaging discussions, research highlights, and community updates. 🌍🔬
👉 Find us here: socmucimm.org
@mucosalimmunol.bsky.social #MucosalImmunology #ScienceCommunity
Join us as we continue advancing mucosal immunology with engaging discussions, research highlights, and community updates. 🌍🔬
👉 Find us here: socmucimm.org
@mucosalimmunol.bsky.social #MucosalImmunology #ScienceCommunity
day 6 of girl cold: i have crafted little sculptures from my mucosal secretions to set around my tissue table as wards against romantic advances
March 8, 2025 at 2:22 PM
day 6 of girl cold: i have crafted little sculptures from my mucosal secretions to set around my tissue table as wards against romantic advances
Phase ! trial of oral Norovirus vaccine candidate Here is the original manuscript published in Science translational Med. the vaccine candidate is a recombinant Adenovirus 5 based technology formulated for oral administration.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
March 6, 2025 at 7:07 PM
Phase ! trial of oral Norovirus vaccine candidate Here is the original manuscript published in Science translational Med. the vaccine candidate is a recombinant Adenovirus 5 based technology formulated for oral administration.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
IL-1 family signalling drives mucosal defence against systemic Candida albicans infection | @natmicrobiol.nature.com
www.nature.com/articles/s41...
www.nature.com/articles/s41...
IL-1 family signalling drives mucosal defence against systemic Candida albicans infection - Nature Microbiology
IL-1 family signalling drives host mucosal defence against Candida albicans and, together with neutrophils, prevents mucosal–systemic dissemination and life-threatening fungal disease.
www.nature.com
September 24, 2026 at 11:21 AM
IL-1 family signalling drives mucosal defence against systemic Candida albicans infection | @natmicrobiol.nature.com
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Dear mucosal immunologists!
Registration for the European Mucosal Immunology Group (EMIG) meeting in Aachen, Germany is now open.
Register and see you this July in Aachen! 👇🏼
emig2025.de
@petterbrodin.bsky.social @wiag.bsky.social @mucosalimmunol.bsky.social @societymucosalimm.bsky.social
Registration for the European Mucosal Immunology Group (EMIG) meeting in Aachen, Germany is now open.
Register and see you this July in Aachen! 👇🏼
emig2025.de
@petterbrodin.bsky.social @wiag.bsky.social @mucosalimmunol.bsky.social @societymucosalimm.bsky.social
January 25, 2025 at 2:25 PM
Dear mucosal immunologists!
Registration for the European Mucosal Immunology Group (EMIG) meeting in Aachen, Germany is now open.
Register and see you this July in Aachen! 👇🏼
emig2025.de
@petterbrodin.bsky.social @wiag.bsky.social @mucosalimmunol.bsky.social @societymucosalimm.bsky.social
Registration for the European Mucosal Immunology Group (EMIG) meeting in Aachen, Germany is now open.
Register and see you this July in Aachen! 👇🏼
emig2025.de
@petterbrodin.bsky.social @wiag.bsky.social @mucosalimmunol.bsky.social @societymucosalimm.bsky.social