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The U.S. Air Force has started market research for a new electromagnetic battle management capability, the Department of the Air Force Multidomain Adaptive Management and Battle Space Awareness, or DA...

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Nature Reviews Neurology, Published online: 05 November 2026; doi:10.1038/s41582-026-01284-xNew WHO guidelines on risk reduction for cognitive decline and dementia call for a proactive, life-course approach. Clinicians have a key role in identifying and managing modifiable risk factors, and tailored multidomain interventions and population-based strategies are needed to make the promotion of cognitive health equitable and scalable.

Musculoskeletal pain is associated with alterations across brain, sensory, psychological, motor, and tissue domains, but the relative magnitude of these differences across domains and diagnoses…

The U.S. Air Force has started market research for a new electromagnetic battle management capability, the Department of the Air Force Multidomain Adaptive Management and Battle Space Awareness, or DA...

Nature Reviews Neurology, Published online: 05 November 2026; doi:10.1038/s41582-026-01284-xNew WHO guidelines on risk reduction for cognitive decline and dementia call for a proactive, life-course approach. Clinicians have a key role in identifying and managing modifiable risk factors, and tailored multidomain interventions and population-based strategies are needed to make the promotion of cognitive health equitable and scalable.

Background: Chronic disease and comorbid mental #Health problems disproportionately affect rural and underserved populations. #Digital self-management programs are potentially scalable, but evaluations often focus on narrow outcomes. Objective: This study examined 12-month longitudinal changes in psychological and multidomain outcomes among Pictou County Patient Empowerment Program participants and explored co-occurring changes and psychological moderators. Methods: This single-arm prospective interventional study enrolled 182 community-dwelling adults with ≥1 chronic condition in Pictou County, Nova Scotia, between October 2023 and August 2025 through community-based outreach. Median age was 60 (IQR 51‐68) years, 155 of 182 (85.2%) participants were women, and the median number of chronic conditions was 3 (IQR 1‐3). The initial 6-month #Digital intervention delivered brief daily modules targeting #PhysicalActivity, nutrition, stress regulation, sleep, habit formation, and social connection, followed by a 6-month lower-intensity maintenance period during which monthly group videoconference sessions continued to be offered. Outcomes were assessed at baseline, 6 months, and 12 months. Primary outcomes were illness perceptions (Brief Illness Perception Questionnaire), perceived stress (10-item Perceived Stress Scale [PSS-10]), disease-related worry (10-item Questionnaire on Distress in #Cancer Patients), life satisfaction (Satisfaction With Life Scale), and mental well-being (World #Health Organization-Five Well-Being Index [WHO-5]). Secondary outcomes assessed the physical, behavioral, and psychosocial domains. Generalized estimating equations estimated population-averaged longitudinal changes, adjusted for age, sex, relationship status, comorbidity burden, and baseline depression or anxiety medication use. Exploratory models examined co-occurring changes and moderation. Tests were 2-sided with =.05. Results: Across outcomes and follow-up assessments, completion ranged from 58.2% (95% CI 51.0%-65.2%; 106/182) to 65.4% (95% CI 58.2%‐71.9%; 119/182). At 12 months, illness perceptions decreased (β=−7.3, 95% CI −9.7 to −4.9), perceived stress decreased (β=−2.4, 95% CI −3.5 to −1.3), disease-related worry decreased (β=−6.3, 95% CI −7.8 to −4.7), life satisfaction increased (β=2.5, 95% CI 1.4‐3.5), and mental well-being increased (β=10.4, 95% CI 7.2‐13.5; all

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Growing evidence highlights the potential of multidomain lifestyle-based interventions to reduce the risk of cognitive decline among older adults at higher risk of cognitive impairment. Within these c...

A 24-month program of diet and exercise did not result in weight loss for older adults at risk for dementia.

The United States has pledged sustained defence expertise, multidomain training and combined exercises for the Guyana Defence Force under a declaration signe...

The design of RNA-guided nucleases with properties not limited by evolution can expand programmable genome-editing capabilities. However, generating diverse multidomain proteins with robust enzymatic ...

The design of RNA-guided nucleases with properties not limited by evolution can expand programmable genome-editing capabilities. However, generating diverse multidomain proteins with robust enzymatic ...