Background/Purpose: Rheumatoid arthritis (RA) amplifies the risk of multimorbidity and polypharmacy, even in relatively younger patients, via chronic systemic inflammation and the increased burden of ...

Multimorbidity, chronic disease accumulation, and cardiometabolic clustering of multimorbidity are associated with higher imaging service use and higher imaging costs in older adults. These findings s...

Background Long COVID has emerged as a major public health concern in the United States, yet geographic variation in its prevalence remains poorly understood. This study examines how state-level diffe...

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Our findings suggest that higher consumption of UPFs increases the risk of cancer and cardiometabolic multimorbidity.

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We know that multimorbidity–defined as the presence of two or more chronic diseases–can increase health-care utilisation and we know that demand for medical imaging has been increasing globally. But h...

Increasing multimorbidity among people with human immunodeficiency virus (PWH; HIV) in sub-Saharan Africa can result in hospitalization. We investigated longitudinal associations between multimorbidity trajectories and hospitalization risk within the African Cohort Study (AFRICOS).MethodsAFRICOS enrolls people with and without HIV from HIV clinics in Uganda, Kenya, Tanzania, and Nigeria. These analyses restricted PWH aged ≥18 years enrolled between 2013 and 2024. Multimorbidity (≥chronic conditions in addition to HIV) was ascertained from International Classification of Diseases codes and clinical measurements. Multimorbidity was categorized into 3 trajectories: resilient, developed, and continued. Hospitalization reasons were ascertained by medical record review. Andersen–Gill extensions of Cox proportional hazards models estimated adjusted hazard ratios (aHRs) and 95% confidence intervals (CIs) for the association of multimorbidity trajectory and hospitalization.ResultsAmong 3028 PWH, 36.6% (n = 1109) had multimorbidity at enrollment. Over 17 740 person-years, 721 hospitalizations occurred (incidence density: 4.06 per 100 person-years). Systemic infections (n = 209, 29.0%), predominantly malaria (n = 182, 87.1%), led admissions. In adjusted models, PWH with continued multimorbidity had a significantly higher risk of hospitalization (aHR = 1.27, 95% CI: 1.06–1.53) compared with resilient PWH.ConclusionsPWH with continued multimorbidity have a significantly increased risk of hospitalization. Intervening early with optimal ART and comprehensive chronic disease management is critical for improving long-term outcomes in sub-Saharan Africa.

CONCLUSIONS: The C2PS is a pragmatic and reliable tool to harmonize heterogeneous neuropsychiatric phenotypic data for large multi-national studies. Observations in 1,325 individuals with CNVs at 16p11.2 or 22q11.2 reveal variant-specific psychiatric profiles, emphasize burden and impact of psychiatric multimorbidity, and provide insights beyond categorical diagnoses.

This talk explains the DSM-5 Alternative Model for Personality Disorders, focusing on its dimensional approach with the Level of Personality Functioning.

Background Complex multiple long-term conditions (C-MLTC) are commonly defined as the presence of four or more long-term conditions, and their prevalence is pro...

Sex-specific pathways, genetic-socioeconomic interactions, and age-related progression patterns offer three actionable insights for multimorbidity prevention.

Background Treatment burden is a key determinant of outcomes for people living with multimorbidity (PLWMM). However, contextually appropriate measures are lacki...

Background Substantial increases in UK consulting rates, mean consultation duration, and clinical workload were observed between 2007 and 2014. To the authors’ knowledge, no analysis of more recent…