#MuscleAtrophy
dont feel bad, i cant do a single regular push up #MuscleAtrophy
December 10, 2024 at 8:07 AM
Skeletal muscle atrophy is a feature of several diseases, but are there any therapeutic targets to reverse it? This study shows that Optineurin regulates #muscle homeostasis, binding JUP & activating the PI3K-AKT pathway to prevent #MuscleAtrophy in mice @plosbiology.org 🧪 plos.io/3Nyce4s
January 23, 2026 at 9:10 AM
Skeletal muscle atrophy is a feature of several diseases, but are there any therapeutic targets to reverse it? This study shows that Optineurin regulates #muscle homeostasis, binding JUP & activating the PI3K-AKT pathway to prevent #MuscleAtrophy in mice @plosbiology.org 🧪 plos.io/3Nyce4s
January 23, 2026 at 5:30 PM
Skeletal muscle atrophy is a feature of several diseases, but are there any therapeutic targets to reverse it? This study shows that Optineurin regulates #muscle homeostasis, binding JUP & activating the PI3K-AKT pathway to prevent #MuscleAtrophy in mice @plosbiology.org 🧪 plos.io/3Nyce4s
January 23, 2026 at 2:02 PM
#Article in #MedComm
Negative Impact of p21-Activated Kinase 4-Mediated AMP-Activated Protein Kinase Inhibition on Sarcopenia in Mice and Humans doi.org/10.1002/mco2...

#AMPK #mitochondria #MuscleAtrophy #PAK4 #PROTAC
Negative Impact of p21‐Activated Kinase 4‐Mediated AMP‐Activated Protein Kinase Inhibition on Sarcopenia in Mice and Humans
PAK4 is overexpressed in muscle atrophy and negatively correlates with muscle mass and function in humans. Inhibiting PAK4 activates AMPK/PGC-1α-driven mitochondrial biogenesis by blocking AMPKα2-S4...
doi.org
December 12, 2025 at 7:42 AM
March 17, 2026 at 8:51 PM
February 20, 2026 at 7:23 PM
February 8, 2026 at 2:08 AM
January 11, 2026 at 9:51 PM
Oral compound #Z526 combats #cancerassociatedcachexia by inhibiting NF‑κB signaling and reducing #OxidativeStress, alleviating #MuscleAtrophy, improving strength and prolonging survival in #tumor‑bearing mice. @fudan-university.bsky.social

#OpenAccess: doi.org/10.1016/j.ge...
January 5, 2026 at 5:34 PM
📖 Publication Alert: New research by Miranda et al. examined whether deleting Keap1 – a negative regulator of NRF2 – could prevent against disuse-induced #muscleatrophy. #MusclePhysiology #RedoxBiology

Read Study
https://faseb.onlinelibrary.wiley.com/doi/10.1096/fj.202402810R
December 18, 2025 at 3:00 PM