@babliadhikary.bsky.social, Higashi et al. show that PAK4 drives dynamic vertex remodeling in cells and embryos through spatiotemporal regulation of #myosin II. Inhibition of PAK4 disrupts tissue packing and compromises junctional continuity and barrier function. rupress.org/jcb/article/...
July 20, 2026 at 4:01 PM
@babliadhikary.bsky.social, Higashi et al. show that PAK4 drives dynamic vertex remodeling in cells and embryos through spatiotemporal regulation of #myosin II. Inhibition of PAK4 disrupts tissue packing and compromises junctional continuity and barrier function. rupress.org/jcb/article/...
Thanks @raghavan-thiaga.bsky.social and @kuba-sedzinski.bsky.social for writing the beautiful spotlight article on our PAK4 study.
Spotlight: @babliadhikary.bsky.social et al. (rupress.org/jcb/article/...) describe the role of PAK4 in vertex remodeling, thereby maintaining epithelial integrity and barrier function. @raghavan-thiaga.bsky.social and @kuba-sedzinski.bsky.social discuss the study: rupress.org/jcb/article/...
August 17, 2026 at 6:18 PM
Thanks @raghavan-thiaga.bsky.social and @kuba-sedzinski.bsky.social for writing the beautiful spotlight article on our PAK4 study.
A wonderful collaboration between Tomo Higashi and Ann Miller's labs about how the kinase PAK4 regulates cell junction remodeling to allow cell rearrrangment 🧪
@babliadhikary.bsky.social, Higashi et al. show that PAK4 drives dynamic vertex remodeling in cells and embryos through spatiotemporal regulation of #myosin II. Inhibition of PAK4 disrupts tissue packing and compromises junctional continuity and barrier function. rupress.org/jcb/article/...
July 20, 2026 at 11:00 PM
A wonderful collaboration between Tomo Higashi and Ann Miller's labs about how the kinase PAK4 regulates cell junction remodeling to allow cell rearrrangment 🧪
Traumatic heterotopic ossification (HO) is an abnormal bone formation after injury. A study explores how necroptotic macrophages and p21-activated kinase 4 (Pak4) influence this process, revealing potential therapeutic targets.👍
#bone #Pak4
@brjournal.bsky.social
www.nature.com/articles/s41...
#bone #Pak4
@brjournal.bsky.social
www.nature.com/articles/s41...
November 11, 2025 at 5:46 AM
Traumatic heterotopic ossification (HO) is an abnormal bone formation after injury. A study explores how necroptotic macrophages and p21-activated kinase 4 (Pak4) influence this process, revealing potential therapeutic targets.👍
#bone #Pak4
@brjournal.bsky.social
www.nature.com/articles/s41...
#bone #Pak4
@brjournal.bsky.social
www.nature.com/articles/s41...
PAK4 promotes vertex remodeling to maintain epithelial integrity and barrier function
rupress.org/jcb/article-...
rupress.org/jcb/article-...
PAK4 promotes vertex remodeling to maintain epithelial integrity and barrier function
Adhikary et al. show that PAK4 drives dynamic vertex remodeling in cells and embryos through spatiotemporal regulation of myosin II. Inhibition of PAK4 dis
rupress.org
July 21, 2026 at 11:27 AM
PAK4 promotes vertex remodeling to maintain epithelial integrity and barrier function
rupress.org/jcb/article-...
rupress.org/jcb/article-...
Spotlight: @babliadhikary.bsky.social et al. (rupress.org/jcb/article/...) describe the role of PAK4 in vertex remodeling, thereby maintaining epithelial integrity and barrier function. @raghavan-thiaga.bsky.social and @kuba-sedzinski.bsky.social discuss the study: rupress.org/jcb/article/...
August 17, 2026 at 6:00 PM
Spotlight: @babliadhikary.bsky.social et al. (rupress.org/jcb/article/...) describe the role of PAK4 in vertex remodeling, thereby maintaining epithelial integrity and barrier function. @raghavan-thiaga.bsky.social and @kuba-sedzinski.bsky.social discuss the study: rupress.org/jcb/article/...
Thrilled to share my first publication from my PhD is now out in Journal of Cell Biology!!!! 😇 💖 Have you ever wondered how multicellular vertices are maintained and remodeled in an epithelia? 💭 Here, we investigate the role of junctional kinase PAK4 in vertex maintenance and remodeling!
@babliadhikary.bsky.social, Higashi et al. show that PAK4 drives dynamic vertex remodeling in cells and embryos through spatiotemporal regulation of #myosin II. Inhibition of PAK4 disrupts tissue packing and compromises junctional continuity and barrier function. rupress.org/jcb/article/...
July 20, 2026 at 10:28 PM
Thrilled to share my first publication from my PhD is now out in Journal of Cell Biology!!!! 😇 💖 Have you ever wondered how multicellular vertices are maintained and remodeled in an epithelia? 💭 Here, we investigate the role of junctional kinase PAK4 in vertex maintenance and remodeling!
Really lovely work. The complementary stories in the @jcb.org from the Higashi + Miller labs and the Yu lab come together to create an even clearer and more interesting story
rupress.org/jcb/article/...
rupress.org/jcb/article/...
PAK4 promotes vertex remodeling to maintain epithelial integrity and barrier function
Adhikary et al. show that PAK4 drives dynamic vertex remodeling in cells and embryos through spatiotemporal regulation of myosin II. Inhibition of PAK4 dis
rupress.org
August 20, 2026 at 5:42 PM
Really lovely work. The complementary stories in the @jcb.org from the Higashi + Miller labs and the Yu lab come together to create an even clearer and more interesting story
rupress.org/jcb/article/...
rupress.org/jcb/article/...
We got Nerdrosoft HQ in #CitiesSkylines2 before we got Nerdrosoft HQ in #SoftwareInc...
www.youtube.com/watch?v=paK4...
You reckon I should try and recreate this in Software Inc?
www.youtube.com/watch?v=paK4...
You reckon I should try and recreate this in Software Inc?
Building a Software Company HQ in Cities: Skylines 2 | Columbia County #24
YouTube video by ConflictNerd
www.youtube.com
January 22, 2025 at 5:27 PM
We got Nerdrosoft HQ in #CitiesSkylines2 before we got Nerdrosoft HQ in #SoftwareInc...
www.youtube.com/watch?v=paK4...
You reckon I should try and recreate this in Software Inc?
www.youtube.com/watch?v=paK4...
You reckon I should try and recreate this in Software Inc?
Spotlight @jcb.org: @babliadhikary.bsky.social et al. (rupress.org/jcb/article/...) describe the role of PAK4 in vertex remodeling, thereby maintaining epithelial integrity & barrier function. @raghavan-thiaga.bsky.social and @kuba-sedzinski.bsky.social discuss the study: rupress.org/jcb/article/...
August 17, 2026 at 6:00 PM
Spotlight @jcb.org: @babliadhikary.bsky.social et al. (rupress.org/jcb/article/...) describe the role of PAK4 in vertex remodeling, thereby maintaining epithelial integrity & barrier function. @raghavan-thiaga.bsky.social and @kuba-sedzinski.bsky.social discuss the study: rupress.org/jcb/article/...
PAK4 dynamics at actively remodeling vertices 🌟 ⚡👀
Check out our recent preprint
www.biorxiv.org/content/10.1...
Check out our recent preprint
www.biorxiv.org/content/10.1...
October 6, 2025 at 4:43 PM
PAK4 dynamics at actively remodeling vertices 🌟 ⚡👀
Check out our recent preprint
www.biorxiv.org/content/10.1...
Check out our recent preprint
www.biorxiv.org/content/10.1...
PAK4: A vanguard of epithelial vertex remodeling. Raghavan Thiagarajan @raghavan-thiaga.bsky.social and Jakub Sedzinski @kuba-sedzinski.bsky.social @ucph.bsky.social discuss new work by @babliadhikary.bsky.social et al. (rupress.org/jcb/article/...) in Spotlight: rupress.org/jcb/article/...
August 24, 2026 at 1:45 PM
PAK4: A vanguard of epithelial vertex remodeling. Raghavan Thiagarajan @raghavan-thiaga.bsky.social and Jakub Sedzinski @kuba-sedzinski.bsky.social @ucph.bsky.social discuss new work by @babliadhikary.bsky.social et al. (rupress.org/jcb/article/...) in Spotlight: rupress.org/jcb/article/...
PAK4 promotes vertex remodeling to maintain epithelial integrity and barrier function. New study from Babli Adhikary @babliadhikary.bsky.social @umich.edu, Tomohito Higashi (Fukushima Medical University) and colleagues:
rupress.org/jcb/article/...
#Cytoskeleton #Adhesion #Physiology
rupress.org/jcb/article/...
#Cytoskeleton #Adhesion #Physiology
July 27, 2026 at 1:45 PM
PAK4 promotes vertex remodeling to maintain epithelial integrity and barrier function. New study from Babli Adhikary @babliadhikary.bsky.social @umich.edu, Tomohito Higashi (Fukushima Medical University) and colleagues:
rupress.org/jcb/article/...
#Cytoskeleton #Adhesion #Physiology
rupress.org/jcb/article/...
#Cytoskeleton #Adhesion #Physiology
Are you interested in how multicellular vertices resolve in epithelia?
Checkout our recent bioRxiv preprint www.biorxiv.org/content/10.1...
(Scroll down to see some cool videos)
Checkout our recent bioRxiv preprint www.biorxiv.org/content/10.1...
(Scroll down to see some cool videos)
PAK4 promotes vertex remodeling to maintain epithelial integrity and barrier function
Cell-cell junctions are essential for epithelial integrity and barrier function, but the mechanisms regulating their remodeling remain unclear. Here, we investigated the role of the junctional kinase ...
www.biorxiv.org
October 5, 2025 at 3:06 PM
Are you interested in how multicellular vertices resolve in epithelia?
Checkout our recent bioRxiv preprint www.biorxiv.org/content/10.1...
(Scroll down to see some cool videos)
Checkout our recent bioRxiv preprint www.biorxiv.org/content/10.1...
(Scroll down to see some cool videos)
Renal tubular PAK4 contributes to tissue damage during ischemia−reperfusion injury, while PAK4 PROTAC mitigated ischemia−reperfusion injury by reducing oxidative stress and promoting fatty acid β-oxidation. https://bit.ly/JASN0649
#ASNJASN
#BasicResearch
#ASNJASN
#BasicResearch
March 23, 2025 at 6:00 PM
Renal tubular PAK4 contributes to tissue damage during ischemia−reperfusion injury, while PAK4 PROTAC mitigated ischemia−reperfusion injury by reducing oxidative stress and promoting fatty acid β-oxidation. https://bit.ly/JASN0649
#ASNJASN
#BasicResearch
#ASNJASN
#BasicResearch
In @jcb.org, @babliadhikary.bsky.social et al. show that PAK4 drives dynamic vertex remodeling in cells and embryos through spatiotemporal regulation of #myosin II. Inhibition of PAK4 disrupts tissue packing and compromises junctional continuity and barrier function. rupress.org/jcb/article/...
July 20, 2026 at 4:01 PM
In @jcb.org, @babliadhikary.bsky.social et al. show that PAK4 drives dynamic vertex remodeling in cells and embryos through spatiotemporal regulation of #myosin II. Inhibition of PAK4 disrupts tissue packing and compromises junctional continuity and barrier function. rupress.org/jcb/article/...
PAK4 promotes vertex remodeling to maintain epithelial integrity and barrier function https://www.biorxiv.org/content/10.1101/2025.10.02.680170v1
October 5, 2025 at 4:30 AM
PAK4 promotes vertex remodeling to maintain epithelial integrity and barrier function https://www.biorxiv.org/content/10.1101/2025.10.02.680170v1
Nuevo Video
www.vidlii.com/watch?v=Lfyb...
Ya Resubi Mis Videos - Loquendo
Pensaban que no iba a subir nada chingó papa
www.vidlii.com/watch?v=Lfyb...
Ya Resubi Mis Videos - Loquendo
Pensaban que no iba a subir nada chingó papa
Ya Resubi Mis Videos - Loquendo - VidLii
Por fin los Resubi los videos de mi Canal Anterior Pakito
Bluesky
bsky.app/profile/pak4-06.bsky.social
SpaceHey
https://spacehey.com/el...
www.vidlii.com
September 20, 2026 at 4:36 AM
Nuevo Video
www.vidlii.com/watch?v=Lfyb...
Ya Resubi Mis Videos - Loquendo
Pensaban que no iba a subir nada chingó papa
www.vidlii.com/watch?v=Lfyb...
Ya Resubi Mis Videos - Loquendo
Pensaban que no iba a subir nada chingó papa
Glioblastoma-derived migrasomes promote migration and invasion by releasing PAK4 and LAMA4
www.nature.com/articles/s42...
www.nature.com/articles/s42...
Glioblastoma-derived migrasomes promote migration and invasion by releasing PAK4 and LAMA4 - Communications Biology
Observation of migrasomes in glioblastoma (GBM) and analysis of migrasome-enriched proteins revealed that migrasomes promote GBM migration and invasion by releasing the extracellular matrix-associated...
www.nature.com
January 30, 2025 at 11:40 PM
Glioblastoma-derived migrasomes promote migration and invasion by releasing PAK4 and LAMA4
www.nature.com/articles/s42...
www.nature.com/articles/s42...
The authors included RRIDs in their in Communications Biology paper! RRIDs improve reproducibility in scientific research. #OpenScience #reproducibility #accelerateopenscience
Targeting PAK4 promotes Gemcitabine-induced pyroptosis in pancreatic cancer via NLRP1/caspase-3/GSDME axis - Communications Biology
PAK4 promotes Mdm2-mediated NLRP1 ubiquitination and degradation by phosphorylating Mdm2 at Ser186, thereby suppressing GEM-induced pyroptosis via the NLRP1/caspase-9/caspase-3/GSDME axis in pancreatic cancer cells
doi.org
May 28, 2026 at 7:04 AM
The authors included RRIDs in their in Communications Biology paper! RRIDs improve reproducibility in scientific research. #OpenScience #reproducibility #accelerateopenscience
The authors included RRIDs in their paper! RRIDs improve reproducibility in scientific research. #STMpublishing #OpenScience #OpenScience
PAK4 promotes vertex remodeling to maintain epithelial integrity and barrier function
doi.org
October 24, 2025 at 7:00 AM
The authors included RRIDs in their paper! RRIDs improve reproducibility in scientific research. #STMpublishing #OpenScience #OpenScience
The authors included RRIDs in their None paper! Thanks for making your methods matter! #reproducibility #accelerateopenscience #STMpublishing
Mbt/PAK4 together with SRC modulates N-Cadherin adherens junctions in the developing Drosophila eye
doi.org
August 15, 2025 at 7:02 AM
The authors included RRIDs in their None paper! Thanks for making your methods matter! #reproducibility #accelerateopenscience #STMpublishing
RRID:CVCL_2219 was used by the authors of the Communications Biology paper "Glioblastoma-derived migrasomes promote migration and invasion by releasing PAK4 and LAMA4". We appreciate the author's support of reproducibility. #reproducibility #accelerateopenscience
doi.org
January 29, 2025 at 11:34 PM
RRID:CVCL_2219 was used by the authors of the Communications Biology paper "Glioblastoma-derived migrasomes promote migration and invasion by releasing PAK4 and LAMA4". We appreciate the author's support of reproducibility. #reproducibility #accelerateopenscience
This has been an amazing collaborative project. Huge shout out to Tomohito Higashi (Fukushima University) for brining our attention to PAK4 and collaborating with us.
Thanks to all the authors including my Undergrad Alex Chang, who made valuable contribution to the project.
Thanks to all the authors including my Undergrad Alex Chang, who made valuable contribution to the project.
October 5, 2025 at 3:06 PM
This has been an amazing collaborative project. Huge shout out to Tomohito Higashi (Fukushima University) for brining our attention to PAK4 and collaborating with us.
Thanks to all the authors including my Undergrad Alex Chang, who made valuable contribution to the project.
Thanks to all the authors including my Undergrad Alex Chang, who made valuable contribution to the project.