#NADPH
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frezzalab.bsky.social
www.nature.com/articles/s41...
Mitochondrial NADPH fuels mitochondrial fatty acid synthesis and lipoylation to power oxidative metabolism
Nature Cell Biology - Kim et al. show that NAD+ kinase 2 serves as a source of mitochondrial NADPH to support mitochondrial fatty acid synthesis, protein lipoylation and mitochondrial oxidative...
www.nature.com
April 21, 2025 at 2:29 PM
alexmartiniere.bsky.social
Our paper is out !!! NADPH oxidases and aquaporins within membrane nanodomains form a functional unit for ROS signaling.

Great work by arthur-poitout.bsky.social and amazing collaborator jbfiche.bsky.social, Jose Ugalde, A Meyer yvonjaillais.bsky.social!

www.pnas.org/doi/10.1073/pnas.2529740123
June 23, 2026 at 8:03 AM
rina.fluffy.monster
I’ve done 10 hours of NADPH measurements and they’re all shite
March 3, 2026 at 2:57 PM
natmetabolism.nature.com
RESEARCH | Y Shah, H Crawford,
@lyssiotislab.bsky.social et al. (U of Michigan):

Disruptions in NADPH-producing enzymes accelerate the formation of pancreatic precancerous lesions 🧪
NADPH-producing enzymes restrict the formation of pancreatic precancerous lesions - Nature Metabolism
Temporal profiling of central carbon metabolism during KrasG12D-driven acinar-to-ductal metaplasia reveals that disruptions in NADPH-producing enzymes accelerate the formation of pancreatic precancerous lesions.
dlvr.it
May 7, 2026 at 6:02 PM
heniek-htw.bsky.social
Dimorphic roles for NADPH in ferroptosis. NADPH promotes lipid synthesis for phospholipid production and is used by enzymes like heme-containing NADPH oxidases (NOXs) that transfer electrons from cytosolic NADPH to generate ROS, which promote lipid peroxidation (PUFA-OOH).
January 5, 2025 at 5:03 PM
natcellbio.nature.com
☕Kim et al. show that NAD+ kinase 2 serves as a source of mitochondrial #NADPH to support #mitochondria fatty acid synthesis, protein lipoylation and mitochondrial oxidative #metabolism.
rdcu.be/ekymW
bit.ly/3GC89sm
Mitochondrial NADPH fuels mitochondrial fatty acid synthesis and lipoylation to power oxidative metabolism - Nature Cell Biology
Kim et al. show that NAD+ kinase 2 serves as a source of mitochondrial NADPH to support mitochondrial fatty acid synthesis, protein lipoylation and mitochondrial oxidative metabolism.
bit.ly
May 3, 2025 at 2:29 PM
nature.com
Nature research paper: Chanoclavine synthase operates by an NADPH-independent superoxide mechanism

https://go.nature.com/4i4UsAa
Chanoclavine synthase operates by an NADPH-independent superoxide mechanism - Nature
The unique structure and mechanism of chanoclavine synthase (EasC), a haem catalase that uses superoxide for substrate transformation in ergot alkaloid biosynthesis, are revealed in this study, challenging established catalase mechanisms.
go.nature.com
March 6, 2025 at 8:45 AM
schwarzlanderlab.bsky.social
www.uni-muenster.de/news/view.ph...
Researchers develop sensors for the “charge” of biological cells
A team led by plant biotechnologist Prof Markus Schwarzländer has developed biosensors that can be used to measure the ratio of NADPH to NADP⁺ in living cells in real time for the first time.
www.uni-muenster.de
December 20, 2024 at 4:25 PM
labwaggoner.bsky.social
Neutrophil NADPH oxidase breaks the inflammatory IL-1β/IL-17A circuit to enhance pathogen clearance during respiratory virus infections @natcomms.nature.com @kingscollegelondon.bsky.social
www.nature.com/articles/s41...
August 5, 2026 at 6:34 PM
macauleylab.bsky.social
www.nature.com/articles/s41...
Mitochondrial NADPH fuels mitochondrial fatty acid synthesis and lipoylation to power oxidative metabolism - Nature Cell Biology
Kim et al. show that NAD+ kinase 2 serves as a source of mitochondrial NADPH to support mitochondrial fatty acid synthesis, protein lipoylation and mitochondrial oxidative metabolism.
www.nature.com
April 27, 2025 at 10:47 AM
ucdavisplants.bsky.social
🔬From the New Phytologist: Optimizing ROS signaling in plants: A review explores how post-translational modifications regulate NADPH oxidases, balancing stress response & growth. (Savithramma P. Dinesh-Kumar)
▶️ nph.onlinelibrary.wiley.com/doi/10.1111/...
#PlantScience #PlantBiology
Orchestrating ROS regulation: coordinated post‐translational modification switches in NADPH oxidases
Reactive oxygen species (ROS) are among the most important signaling molecules, playing a significant role in plant growth, development, and responses to various environmental stresses. Respiratory b...
nph.onlinelibrary.wiley.com
March 14, 2025 at 4:35 PM
natmetabolism.nature.com
Increasing cytosolic NADPH to mimic exercise
Nature Metabolism, Published online: 08 September 2026; doi:10.1038/s42255-026-01580-2In this issue of Nature Metabolism, Wu et al. reveal that cytosolic NADPH, a pentose phosphate pathway metabolite, drives a physiological cardiac hypertrophic response that is protective against heart attack injury and can be raised by a candidate spermidine derivative.
dlvr.it
September 15, 2026 at 9:38 AM
lyssiotislab.bsky.social
🚨New @lyssiotislab.bsky.social paper led by @radykm.bsky.social in @NatureMetabolism
"NADPH-producing enzymes restrict the formation of pancreatic precancerous lesions"
🧵Follow for a tweetorial... and bonus highlight of Vousden Lab co-published study and News & Views link from Wellen Lab!
April 6, 2026 at 8:00 PM
natmetabolism.nature.com
Increasing cytosolic NADPH to mimic exercise
Nature Metabolism, Published online: 08 September 2026; doi:10.1038/s42255-026-01580-2In this issue of Nature Metabolism, Wu et al. reveal that cytosolic NADPH, a pentose phosphate pathway metabolite, drives a physiological cardiac hypertrophic response that is protective against heart attack injury and can be raised by a candidate spermidine derivative.
dlvr.it
September 8, 2026 at 9:37 AM
natplants.nature.com
New Article: "Ancient peptide–redox signalling underlies sperm motility in Marchantia" rdcu.be/ftegk

Sperm-derived RALF1 is perceived by the FER–LLG receptor complex, triggering NADPH oxidase activation & ROS production in sperm, which thereby promotes sperm motility. #PlantScience
July 10, 2026 at 12:05 PM
learndirt.bsky.social
🤓 The gardening word of the day is [Chlorophyll]:

The photosynthetic pigment chlorophyll captures the energy from sunlight, converts it, and stores it in the energy-storage molecules ATP and NADPH while freeing oxygen from water in the cells.
January 23, 2026 at 12:30 PM
gittacoaker.bsky.social
Marchantia has two RBOHs. Double mutant = disorganized cell mass. Conditional mutant analyses show they are required to sustain morphogenesis via cuticle-cell-wall integrity. Clever study. www.sciencedirect.com/science/arti...
Indispensable roles of RBOH-mediated ROS production in development and morphogenesis of Marchantia polymorpha
Reactive oxygen species (ROS) are now well established as essential signaling molecules in eukaryotes. In plants, NADPH oxidases, known as respiratory…
www.sciencedirect.com
June 12, 2026 at 6:45 PM
awartiovaara.bsky.social
5 yrs ago I needed a tool to find patients with low blood NAD+. @LiliyaEuro succeeded to develop a scalable, accurate test for main redox regulators from any biological material: NAD+, NADH, NADP+, NADPH, GSH, GSSG from a single sample. This became @NADMED_Ltd.
December 14, 2024 at 8:58 PM
profmattjohnson.bsky.social
Our new preprint 🚨🌱☀️on flourescent biosensing of ATP levels in chloroplasts in vivo shows disequilibrium between proton motive force and ATP levels. We show PGR5 dependent cyclic electron transfer does not augment ATP/NADPH ratios @gustaf23.bsky.social 🙌

www.biorxiv.org/cgi/content/...
November 12, 2025 at 3:42 PM
nature.com
Nature research paper: Sleep pressure accumulates in a voltage-gated lipid peroxidation memory

https://go.nature.com/4bG20He
Sleep pressure accumulates in a voltage-gated lipid peroxidation memory - Nature
Sleep-inducing neurons in Drosophila rely on Hyperkinetic, the β-subunit of the KV1 channel Shaker, to monitor sleep need by translating lipid peroxidation events into changes in the oxidation state of a stably bound NADPH cofactor.
go.nature.com
March 21, 2025 at 3:00 PM
danvec.bsky.social
The CBL/CIPK26/CPK5/RBOHD module confers initiation and systemic propagation of PAMP-triggered immune signaling in plants. @science.org #ScienceAdvances

www.science.org/doi/10.1126/...
A bi-kinase module sensitizes and potentiates plant immune signaling
Mutual activation of a Ca2+ sensing bi-kinase module potentiates NADPH oxidase activation to facilitate systemic immunity.
www.science.org
January 27, 2025 at 2:32 PM
realbiomassspec.bsky.social
Rapid quantitation of NAD+/NADH and NADPH/NADP+ with mass spectrometry by using calibration constants #RedoxBiol www.sciencedirect.com/science/arti...
Rapid quantitation of NAD+/NADH and NADPH/NADP+ with mass spectrometry by using calibration constants
NAD+/NADH and NADPH/NADP+ are important indicators of cellular redox status, but they cannot be reliably calculated from the relative intensities of m…
www.sciencedirect.com
December 14, 2025 at 6:47 PM
smwadgymar.bsky.social
This is wild? "We show that introducing a nanoscale, structurally and functionally preserved thylakoid system into corneal cells enables light-driven bona fide photosynthetic production of NADPH and ATP, similar to plant leaves, which alleviates oxidative stress and inflammation."
July 9, 2026 at 4:05 PM
gittacoaker.bsky.social
nph.onlinelibrary.wiley.com/doi/10.1111/...
Orchestrating ROS regulation: coordinated post‐translational modification switches in NADPH oxidases
Reactive oxygen species (ROS) are among the most important signaling molecules, playing a significant role in plant growth, development, and responses to various environmental stresses. Respiratory b...
nph.onlinelibrary.wiley.com
March 16, 2025 at 7:02 PM
stripplab.bsky.social
Based on their new Cryo-EM structure, Adams & Li investigate the redox flow from NADPH toward NAD and ferredoxin in the electron bifurcating protein complex NfnABC from C. saccharolyticus
www.nature.com/articles/s42...
February 17, 2025 at 3:30 PM