Lennartz et al. evaluate lipid enrichment in clathrin-coated pits and observe that the differential lipid partitioning into clathrin-coated pits is largely driven by the lipid asymmetry of the plasma ...

The gradual assembly and oligomerization of cell surface receptors are critical for regulating immune activation and turnover. Yet, how dynamic, spatiotemporally regulated assembly enables rapid and s...

Plants express diverse small GTP-binding proteins including Ras-associated binding (RAB) proteins that direct membrane trafficking and Rho-of-plant (ROP) proteins that mostly regulate cytoskeletal org...

Cell elongation is a fundamental process allowing plants to change size and shape, a process governed by several growth promoting hormones. While hormones such as brassinosteroids (BRs) and phytosulfo...

Auxin and calcium (Ca2+) are central plant signals that coordinate growth, development, and responses to environmental cues. Typically studied as largely parallel pathways, they are now increasingly recognized as interconnected networks whose activities converge at multiple regulatory levels. Recent advances in live imaging, biosensors, optogenetics, and structural approaches have revealed that auxin can rapidly trigger Ca2+ influx from the apoplast via TRANSPORT INHIBITOR RESPONSE1 (TIR1)/AUXIN-SIGNALING F-BOX (AFB)-dependent signaling mechanisms and Ca2+ channels, presumably involving cyclic nucleotides produced by TIR1/AFB auxin receptors. Conversely, Ca2+ signals arising from mechanosensing, wounding, and environmental stress can modulate auxin transport, signaling, and transcriptional outputs. Together, these discoveries highlight a dynamic, reciprocal signaling axis where Ca2+ acts both downstream and upstream of auxin to shape growth, development, tropisms, and regeneration.

Bacterial START domain proteins have a conserved helix-grip fold, but diverge from mammalian lipid transporters by utilizing a more versatile array of proc

During morphogenesis of multicellular organs, cells in distinct positions need to meet specific functional requirements to form the appropriate tissue…

Nature Reviews Molecular Cell Biology, Published online: 27 August 2026; doi:10.1038/s41580-026-01009-4This Review discusses recent insights into the mechanisms of immune signalling in plants and their regulation to achieve effective defence against pathogens while preserving plant fitness. It also explores the interplay between the immune system and environmental stresses, and strategies for engineering optimal disease-resistant plants.