A conserved GTPase complex gates exocytosis for defence and parasitism across alveolates #protists www.nature.com/articles/s41...
October 5, 2026 at 10:00 AM
A conserved GTPase complex gates exocytosis for defence and parasitism across alveolates #protists www.nature.com/articles/s41...
GTPBP1 is a GTPase implicated in neurodevelopment. Our cryo-EM maps show GTPBP1 delivering tRNA to ribosome.
Due to delayed GTPase dissociation, mRNA decoding is more stringent than with bona fide delivery factor eEF1A.
Congrats to Denis Susorov and collab with Pestova lab! tinyurl.com/3smdvt3v
Due to delayed GTPase dissociation, mRNA decoding is more stringent than with bona fide delivery factor eEF1A.
Congrats to Denis Susorov and collab with Pestova lab! tinyurl.com/3smdvt3v
December 5, 2025 at 6:30 PM
GTPBP1 is a GTPase implicated in neurodevelopment. Our cryo-EM maps show GTPBP1 delivering tRNA to ribosome.
Due to delayed GTPase dissociation, mRNA decoding is more stringent than with bona fide delivery factor eEF1A.
Congrats to Denis Susorov and collab with Pestova lab! tinyurl.com/3smdvt3v
Due to delayed GTPase dissociation, mRNA decoding is more stringent than with bona fide delivery factor eEF1A.
Congrats to Denis Susorov and collab with Pestova lab! tinyurl.com/3smdvt3v
Membrane Trafficking Seminar series returns this week with two exciting talks exploring GTPase regulation and the making of lysosomes! Join @felixmendu.bsky.social @franbottanelli.bsky.social and me for an afternoon of fun cell biology.
For more details: felixcampelo.wixsite.com/membranetraf...
For more details: felixcampelo.wixsite.com/membranetraf...
October 5, 2026 at 7:01 AM
Membrane Trafficking Seminar series returns this week with two exciting talks exploring GTPase regulation and the making of lysosomes! Join @felixmendu.bsky.social @franbottanelli.bsky.social and me for an afternoon of fun cell biology.
For more details: felixcampelo.wixsite.com/membranetraf...
For more details: felixcampelo.wixsite.com/membranetraf...
Hi! I’m @vitoryang.bsky.social, a PhD candidate studying how cells migrate collectively during development. My work focuses on cytoskeleton dynamics and Rho GTPase signalling, using Drosophila border cells as a genetically tractable in vivo model.
September 6, 2026 at 7:33 AM
Hi! I’m @vitoryang.bsky.social, a PhD candidate studying how cells migrate collectively during development. My work focuses on cytoskeleton dynamics and Rho GTPase signalling, using Drosophila border cells as a genetically tractable in vivo model.
The lab is on a roll. 2nd preprint in as many weeks!
High levels of Cdc42 GTPase underlie an all-or-none decision to fuse.
Great team effort led by PhD students @sajjitasaha.bsky.social and @aiswaryasajeevan.bsky.social
www.biorxiv.org/content/10.1...
@biology-unige.bsky.social
High levels of Cdc42 GTPase underlie an all-or-none decision to fuse.
Great team effort led by PhD students @sajjitasaha.bsky.social and @aiswaryasajeevan.bsky.social
www.biorxiv.org/content/10.1...
@biology-unige.bsky.social
High levels of Cdc42 GTPase underlie an all-or-none decision to fuse
Cdc42 is a Rho-family GTPase conserved across eukaryotes, where it plays essential roles in cell polarization. In single-celled yeast systems, Cdc42 is a key driver of symmetry breaking and polarized ...
www.biorxiv.org
May 6, 2025 at 11:20 AM
The lab is on a roll. 2nd preprint in as many weeks!
High levels of Cdc42 GTPase underlie an all-or-none decision to fuse.
Great team effort led by PhD students @sajjitasaha.bsky.social and @aiswaryasajeevan.bsky.social
www.biorxiv.org/content/10.1...
@biology-unige.bsky.social
High levels of Cdc42 GTPase underlie an all-or-none decision to fuse.
Great team effort led by PhD students @sajjitasaha.bsky.social and @aiswaryasajeevan.bsky.social
www.biorxiv.org/content/10.1...
@biology-unige.bsky.social
Beautiful imaging on the cover but also check out the beautiful imaging inside and our story on #endosomes and #GTPase cascades
👋🏻Our November issue's out!
Cover: Imaging #Ovulation
👉🏼Comments on #embryo models & #MembraneContactSites
🔬on: #PlasmaMembrane #endosomes #CellDeath #metabolism #mTOR #BiomolecularCondensation #gastruloids #organoids #ProteinQualityControl & more!
www.nature.com/ncb/volumes/...
Cover: Imaging #Ovulation
👉🏼Comments on #embryo models & #MembraneContactSites
🔬on: #PlasmaMembrane #endosomes #CellDeath #metabolism #mTOR #BiomolecularCondensation #gastruloids #organoids #ProteinQualityControl & more!
www.nature.com/ncb/volumes/...
November 20, 2024 at 6:36 PM
Beautiful imaging on the cover but also check out the beautiful imaging inside and our story on #endosomes and #GTPase cascades
You Wu and David J. Reiner @tamu.bsky.social provide in vivo evidence for the long-proposed role of the Ras effector Ral, a small #GTPase, in regulating the metazoan #exocyst complex. rupress.org/jcb/article/...
#Celegans #Development #Trafficking
#Celegans #Development #Trafficking
October 6, 2026 at 4:00 PM
You Wu and David J. Reiner @tamu.bsky.social provide in vivo evidence for the long-proposed role of the Ras effector Ral, a small #GTPase, in regulating the metazoan #exocyst complex. rupress.org/jcb/article/...
#Celegans #Development #Trafficking
#Celegans #Development #Trafficking
Out Now! A conserved GTPase complex gates exocytosis for defence and parasitism across alveolates #MicroSky
A conserved GTPase complex gates exocytosis for defence and parasitism across alveolates
Nature Microbiology, Published online: 02 October 2026; doi:10.1038/s41564-026-02501-5A GTPase complex conserved across alveolates gates exocytosis in the parasite Toxoplasma and the ciliate Tetrahymena. In Toxoplasma, an added apical vesicle tightens control over rhoptry secretion, a process critical to host cell invasion.
go.nature.com
October 2, 2026 at 10:16 AM
Out Now! A conserved GTPase complex gates exocytosis for defence and parasitism across alveolates #MicroSky
Thrilled to share our paper "A conserved GTPase complex gates exocytosis for defence and parasitism across alveolates" Ciliates are fantastic to understand rhoptry exocytosis, and cryo-ET once again reveals so much🤩 Thanks to all who contributed. @martacova.bsky.social @yiweichang.bsky.social
Out Now! A conserved GTPase complex gates exocytosis for defence and parasitism across alveolates #MicroSky
A conserved GTPase complex gates exocytosis for defence and parasitism across alveolates
Nature Microbiology, Published online: 02 October 2026; doi:10.1038/s41564-026-02501-5A GTPase complex conserved across alveolates gates exocytosis in the parasite Toxoplasma and the ciliate Tetrahymena. In Toxoplasma, an added apical vesicle tightens control over rhoptry secretion, a process critical to host cell invasion.
go.nature.com
October 2, 2026 at 1:48 PM
Thrilled to share our paper "A conserved GTPase complex gates exocytosis for defence and parasitism across alveolates" Ciliates are fantastic to understand rhoptry exocytosis, and cryo-ET once again reveals so much🤩 Thanks to all who contributed. @martacova.bsky.social @yiweichang.bsky.social
One key question is how adhesion & cell shape change are regulated. Cell-cell signaling via small GTPases of the Ras superfamily is key. In their active state they bind proteins like Canoe/Afadin and “turn them on”. We’re seeking to understand how the small GTPase Rap1 regulates Canoe. 5/n
November 30, 2024 at 2:25 PM
One key question is how adhesion & cell shape change are regulated. Cell-cell signaling via small GTPases of the Ras superfamily is key. In their active state they bind proteins like Canoe/Afadin and “turn them on”. We’re seeking to understand how the small GTPase Rap1 regulates Canoe. 5/n
The story behind the paper told by first author Marta Cova go.nature.com/3VxsmXQ
October 5, 2026 at 6:47 PM
The story behind the paper told by first author Marta Cova go.nature.com/3VxsmXQ
For all you interested in small GTPase biology and membrane pattern formation - this is an essential read from the labs of Peter Bieling and Bill Bement
www.embopress.org/doi/full/10....
www.embopress.org/doi/full/10....
April 4, 2025 at 1:56 PM
For all you interested in small GTPase biology and membrane pattern formation - this is an essential read from the labs of Peter Bieling and Bill Bement
www.embopress.org/doi/full/10....
www.embopress.org/doi/full/10....
Nice paper by Ji Sun and Dario Alessi labs describing multiple distinct Rab GTPase binding sites in the LRRK2 kinase involved in Parkinson Disease.
May 5, 2026 at 10:40 PM
Nice paper by Ji Sun and Dario Alessi labs describing multiple distinct Rab GTPase binding sites in the LRRK2 kinase involved in Parkinson Disease.
Mapping the endosomal proximity proteome reveals Retromer as a hub for RAB GTPase regulation. https://www.biorxiv.org/content/10.1101/2024.11.22.622898v1
Mapping the endosomal proximity proteome reveals Retromer as a hub for RAB GTPase regulation. https://www.biorxiv.org/content/10.1101/2024.11.22.622898v1
Endosomal retrieval and recycling of integral cargo proteins is essential for cell, tissue and organ
www.biorxiv.org
November 23, 2024 at 2:30 AM
Mapping the endosomal proximity proteome reveals Retromer as a hub for RAB GTPase regulation. https://www.biorxiv.org/content/10.1101/2024.11.22.622898v1
Exciting work from neighbor Jörn Coers at Duke identifying a new class of host defense GTPases. Out of a genetic screen they identify the human Giant GTPase GVIN1 (previously annotated as a human pseudogene) in coatomer-based restriction of Burkholderia motility. 1808 aas long!
Human giant GTPase GVIN1 forms an antimicrobial coatomer around the intracellular bacterial pathogen Burkholderia thailandensis
Several human pathogens exploit the kinetic forces generated by polymerizing actin to power their intracellular motility. Human cell-autonomous immune responses activated by the cytokine interferon-ga...
www.biorxiv.org
April 14, 2025 at 4:14 PM
Exciting work from neighbor Jörn Coers at Duke identifying a new class of host defense GTPases. Out of a genetic screen they identify the human Giant GTPase GVIN1 (previously annotated as a human pseudogene) in coatomer-based restriction of Burkholderia motility. 1808 aas long!
My PhD paper is in press @cellpress.bsky.social and now online: www.sciencedirect.com/science/arti...!
Contents: weird #NPCs in yeast and flies, #CLEM, in situ #cryoET and more!
Made possible by the amazing @becklab.bsky.social team at @mpibp.bsky.social and collaborators! #TeamTomo
Contents: weird #NPCs in yeast and flies, #CLEM, in situ #cryoET and more!
Made possible by the amazing @becklab.bsky.social team at @mpibp.bsky.social and collaborators! #TeamTomo
The small GTPase Ran defines nuclear pore complex asymmetry
Nuclear pore complexes (NPCs) bridge across the nuclear envelope and mediate nucleocytoplasmic exchange. They consist of hundreds of nucleoporin build…
www.sciencedirect.com
August 18, 2025 at 4:26 PM
My PhD paper is in press @cellpress.bsky.social and now online: www.sciencedirect.com/science/arti...!
Contents: weird #NPCs in yeast and flies, #CLEM, in situ #cryoET and more!
Made possible by the amazing @becklab.bsky.social team at @mpibp.bsky.social and collaborators! #TeamTomo
Contents: weird #NPCs in yeast and flies, #CLEM, in situ #cryoET and more!
Made possible by the amazing @becklab.bsky.social team at @mpibp.bsky.social and collaborators! #TeamTomo
I am very grateful to Franz Hagn, his team and colleagues for making this possible. Atomic resolution of the inactive, active and downstream effector ICR/RIP-bound active ROP GTPase RACB. The complex may form a positively charged interface for plasma membrane interaction.
doi.org/10.1038/s420...
doi.org/10.1038/s420...
Nucleotide-dependent switching and RIPb effector recognition of the barley susceptibility factor RACB - Communications Biology
High-resolution structures of the plant small GTPase RACB show how switching between inactive and active states enables RIPb effector binding, providing a physical link between the cell membrane and m...
doi.org
May 21, 2026 at 3:51 PM
I am very grateful to Franz Hagn, his team and colleagues for making this possible. Atomic resolution of the inactive, active and downstream effector ICR/RIP-bound active ROP GTPase RACB. The complex may form a positively charged interface for plasma membrane interaction.
doi.org/10.1038/s420...
doi.org/10.1038/s420...
Stress-induced anxiety is associated with increased activity of the protein Rap1 in the ventral hippocampus and can be prevented by injecting a Rap1 inhibitor, a new #ScienceAdvances study shows. scim.ag/3HQyymQ
Enhanced Rap1 small GTPase activity in the ventral hippocampus drives stress-induced anxiety
Chronic stress activates Rap1 in vHPC PNs to promote anxiety-like behaviors by increasing their intrinsic excitability.
scim.ag
June 11, 2025 at 8:14 PM
Stress-induced anxiety is associated with increased activity of the protein Rap1 in the ventral hippocampus and can be prevented by injecting a Rap1 inhibitor, a new #ScienceAdvances study shows. scim.ag/3HQyymQ
Bacterial cell division folks take note: @eswaralab.bsky.social lab reports that GpsB interacts with FtsZ and stimulates FtsZ GTPase activity in multiple G+ organisms (not just in #staph)! It also serves as an alternative to FtsA in anchoring FtsZ.
www.molbiolcell.org/doi/10.1091/...
www.molbiolcell.org/doi/10.1091/...
GpsB interacts with FtsZ in multiple species and may serve as an accessory Z-ring anchor | Molecular Biology of the Cell
Bacterial cytokinesis commences when a tubulin-like GTPase, FtsZ, forms a Z-ring to mark the division site. Synchronized movement of Z-ring filaments and peptidoglycan synthesis along the axis of divi...
www.molbiolcell.org
January 10, 2025 at 2:56 PM
Bacterial cell division folks take note: @eswaralab.bsky.social lab reports that GpsB interacts with FtsZ and stimulates FtsZ GTPase activity in multiple G+ organisms (not just in #staph)! It also serves as an alternative to FtsA in anchoring FtsZ.
www.molbiolcell.org/doi/10.1091/...
www.molbiolcell.org/doi/10.1091/...
Avl9 defines a family of DENN domain GTPase-activating proteins rupress.org/jcb/article-...
Avl9 defines a family of DENN domain GTPase-activating proteins
Using computational protein–protein interaction screens, Vignogna and Fromme identify Avl9 as a GTPase-activating protein for Arf-family GTPases. They demo
rupress.org
September 10, 2026 at 3:24 PM
Avl9 defines a family of DENN domain GTPase-activating proteins rupress.org/jcb/article-...
Rho, PKA, GTPase-activating protein, receptor signaling - what's not to like about this work on the coat colour of the calico cat?
Fellow Genetics professors - rejoice! This is pedagogy heaven: the paradigmatic epiallele in calico cats … is built on a cis-regulatory deletion, not a coding mutation!
We can teach it all off 1 paper!
1. Woo
2. Hoooo!!!
H/t @lianafaye.bsky.social
www.biorxiv.org/content/10.1...
We can teach it all off 1 paper!
1. Woo
2. Hoooo!!!
H/t @lianafaye.bsky.social
www.biorxiv.org/content/10.1...
Molecular and genetic characterization of sex-linked orange coat color in the domestic cat
The Sex-linked orange mutation in domestic cats causes variegated patches of reddish/yellow hair and is a defining signature of random X-inactivation in female tortoiseshell and calico cats. Unlike th...
www.biorxiv.org
November 30, 2024 at 1:46 PM
Rho, PKA, GTPase-activating protein, receptor signaling - what's not to like about this work on the coat colour of the calico cat?
Erick from the Ringgaard Lab & John from the Den identified FipA as polar guiding factor for the GTPase FlhF to enable polar flagellation of many bacteria. Made possible by great collaborations and funding from the DFG (TRR174). Version of record now out in eLife: doi.org/10.7554/eLif...
December 5, 2024 at 4:04 PM
Erick from the Ringgaard Lab & John from the Den identified FipA as polar guiding factor for the GTPase FlhF to enable polar flagellation of many bacteria. Made possible by great collaborations and funding from the DFG (TRR174). Version of record now out in eLife: doi.org/10.7554/eLif...
Allosteric Biosensors Unravel GTPase-Effector Feedback by Klaus Hahn and team: www.biorxiv.org/content/10.6...
May 19, 2026 at 9:46 AM
Allosteric Biosensors Unravel GTPase-Effector Feedback by Klaus Hahn and team: www.biorxiv.org/content/10.6...