❗Honored to be cited in Signal Transduction and Targeted Therapy
👏Prof. Wei Xie’ team reported the mechanism by which the autism-associated molecule NLG1 regulates the maintenance of social memory in mice.
Brain_VTA offers AAV packaging services.
www.nature.com/articles/s41...

❗Honored to be cited in Nature Communications
👏Prof. Wei Xie’ team discovered that the autism-associated molecule NLG1 regulates the formation of social memory in mice via CCK interneurons in the dCA2 region.
Brain_VTA offers AAV packaging services.
www.nature.com/articles/s41...

Social interaction-mediated hippocampal NLG1 #Proteolysis & the resulting CTD fragment regulate #SynapticPlasticity via cofilin signaling, highlighting its role in social memory maintenance and as a #TherapeuticTarget.

#STTT #OpenAccess: doi.org/10.1038/s413...

This #STTT study reveals how social interaction-induced NLG1 cleavage regulates #SynapticPlasticity and spine strengthening, linking extra- and intracellular signaling to long-term social memory maintenance. @utoronto.ca

#OpenAccess: doi.org/10.1038/s413...

Teacup 23 was a wild ride! We ended up in Oolong's 3rd place match and had a heartbreaking defeat in overtime. We placed 11th overall.

Replay Codes:
CB 1 - RYES 7VM3 NQ55 GWH3
TC - R62P D5LA NLG1 F64E
RM - RGH6 FNK1 UDXJ FXY8
SZ - R9E1 FPNL NRC6 P51F
CB 2 - R9Q8 9937 3ATY 5W82

#compsplatoon

Social stimulation promotes #NLG1 proteolysis; the resulting NLG1-CTD maintains #SocialMemory by inhibiting #cofilin to strengthen dendritic spines, offering insight into memory maintenance mechanisms. #medsky

#STTT #OpenAccess: doi.org/10.1038/s413...

🚀From Bench to Paper | Unlocking the Secrets of Social Memory
Social interaction triggers #NLG1 proteolysis to generate NLG1-CTD, strengthening synapses and supporting social memory. Blocking this process impairs memory, while peptides can rescue it.
#Neuroscience #SocialMemory

#SocialInteraction triggers α- and γ-secretase cleavage of NLG1 in the #VentralHippocampuss, generating NLG1-CTD that inhibits #cofilin to strengthen #spines and maintain long-term potentiation and #SocialMemory. @utoronto.ca

#OpenAccess in #STTT: doi.org/10.1038/s413...

Perhaps the only good thing about this Twitch highlight cap nonsense is that it finally kicked my ass into gear collecting the last sets of highlights into highlight reels for youtube!

Got one more to go after this one! Enjoy some funnies from years ago :)
www.youtube.com/watch?v=NlG1...

www.youtube.com/watch?v=NLG1...

littleton strikes again! retrograde nmj signalling controlled by syx4 regulation of nlg1 and sytIV trafficking: https://elifesciences.org/content/5/e13881

also the weiner lab links pcdh with neuroligin: pcdh negatively regulates spine morphogenesis by inhibiting nlg1.
http://www.cell.com/cell-reports/fulltext/S2211-1247(17)30275-9