Very excited that my final postdoctoral work is now online in Cell @cellpress.bsky.social.
www.sciencedirect.com/science/arti...
Using 16 (!) cryo-EM structures, we uncovered how the three proteins coronin, cofilin and AIP1 work together to rapidly disassemble actin filaments.
www.sciencedirect.com/science/arti...
Using 16 (!) cryo-EM structures, we uncovered how the three proteins coronin, cofilin and AIP1 work together to rapidly disassemble actin filaments.
October 13, 2025 at 9:04 AM
Very excited that my final postdoctoral work is now online in Cell @cellpress.bsky.social.
www.sciencedirect.com/science/arti...
Using 16 (!) cryo-EM structures, we uncovered how the three proteins coronin, cofilin and AIP1 work together to rapidly disassemble actin filaments.
www.sciencedirect.com/science/arti...
Using 16 (!) cryo-EM structures, we uncovered how the three proteins coronin, cofilin and AIP1 work together to rapidly disassemble actin filaments.
Cofilin-1 is a redox-sensitive guard of the NLRP3 inflammasome @natimmunol.nature.com
www.nature.com/articles/s41...
www.nature.com/articles/s41...
March 18, 2026 at 6:38 PM
Cofilin-1 is a redox-sensitive guard of the NLRP3 inflammasome @natimmunol.nature.com
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Chikireddy, Romet-Lemonne, Jégou et al. @romet-jegou-lab.bsky.social investigate how the crosslinker fascin delays cofilin-induced #actin filament disassembly. https://buff.ly/3EBL34j
In #Mechanobiology 2025: https://buff.ly/3EK0uaq
In #Mechanobiology 2025: https://buff.ly/3EK0uaq
February 18, 2025 at 4:17 PM
Chikireddy, Romet-Lemonne, Jégou et al. @romet-jegou-lab.bsky.social investigate how the crosslinker fascin delays cofilin-induced #actin filament disassembly. https://buff.ly/3EBL34j
In #Mechanobiology 2025: https://buff.ly/3EK0uaq
In #Mechanobiology 2025: https://buff.ly/3EK0uaq
Happy New Year!!
To celebrate 2025, here is our new pre-print showing a key role for cofilin and actin turnover in embryonic wound healing ... by modulating actin rigidity!! Work led by @anamcarmo.bsky.social, with key contributions by Ji Hong Sayo. 🪰🧪
www.biorxiv.org/content/10.1...
To celebrate 2025, here is our new pre-print showing a key role for cofilin and actin turnover in embryonic wound healing ... by modulating actin rigidity!! Work led by @anamcarmo.bsky.social, with key contributions by Ji Hong Sayo. 🪰🧪
www.biorxiv.org/content/10.1...
January 4, 2025 at 9:38 PM
Happy New Year!!
To celebrate 2025, here is our new pre-print showing a key role for cofilin and actin turnover in embryonic wound healing ... by modulating actin rigidity!! Work led by @anamcarmo.bsky.social, with key contributions by Ji Hong Sayo. 🪰🧪
www.biorxiv.org/content/10.1...
To celebrate 2025, here is our new pre-print showing a key role for cofilin and actin turnover in embryonic wound healing ... by modulating actin rigidity!! Work led by @anamcarmo.bsky.social, with key contributions by Ji Hong Sayo. 🪰🧪
www.biorxiv.org/content/10.1...
Innovative use by the authors of biophysical methods, including fluorescence fluctuation analysis, to show that the actin-severing protein cofilin contributes to wound closure by maintaining a flexible actin network
🧪
🧪
Happy New Year!!
To celebrate 2025, here is our new pre-print showing a key role for cofilin and actin turnover in embryonic wound healing ... by modulating actin rigidity!! Work led by @anamcarmo.bsky.social, with key contributions by Ji Hong Sayo. 🪰🧪
www.biorxiv.org/content/10.1...
To celebrate 2025, here is our new pre-print showing a key role for cofilin and actin turnover in embryonic wound healing ... by modulating actin rigidity!! Work led by @anamcarmo.bsky.social, with key contributions by Ji Hong Sayo. 🪰🧪
www.biorxiv.org/content/10.1...
January 5, 2025 at 5:13 PM
Innovative use by the authors of biophysical methods, including fluorescence fluctuation analysis, to show that the actin-severing protein cofilin contributes to wound closure by maintaining a flexible actin network
🧪
🧪
www.biorxiv.org/content/10.1...
Structural basis for alpha-actinin inhibition of cooperative cofilin binding to actin filaments
Structural basis for alpha-actinin inhibition of cooperative cofilin binding to actin filaments
August 6, 2026 at 2:48 PM
www.biorxiv.org/content/10.1...
Structural basis for alpha-actinin inhibition of cooperative cofilin binding to actin filaments
Structural basis for alpha-actinin inhibition of cooperative cofilin binding to actin filaments
For #fluorescencefriday here’s a super cofilactin rod-forming cofilin mutant we recently came across. Now to figure out what to do with it!
November 22, 2024 at 11:50 AM
For #fluorescencefriday here’s a super cofilactin rod-forming cofilin mutant we recently came across. Now to figure out what to do with it!
📢 PhD Thesis defense
📅 October 28th
📍Institut Jacques Monod
Inaara Kassamaly ( @romet-jegou-lab.bsky.social lab ) will defend her PhD thesis " Disassembly of young ADP·Pi actin filaments by cofilin, studied using microfluidics "
@univparissaclay.bsky.social
📅 October 28th
📍Institut Jacques Monod
Inaara Kassamaly ( @romet-jegou-lab.bsky.social lab ) will defend her PhD thesis " Disassembly of young ADP·Pi actin filaments by cofilin, studied using microfluidics "
@univparissaclay.bsky.social
October 5, 2026 at 8:01 AM
📢 PhD Thesis defense
📅 October 28th
📍Institut Jacques Monod
Inaara Kassamaly ( @romet-jegou-lab.bsky.social lab ) will defend her PhD thesis " Disassembly of young ADP·Pi actin filaments by cofilin, studied using microfluidics "
@univparissaclay.bsky.social
📅 October 28th
📍Institut Jacques Monod
Inaara Kassamaly ( @romet-jegou-lab.bsky.social lab ) will defend her PhD thesis " Disassembly of young ADP·Pi actin filaments by cofilin, studied using microfluidics "
@univparissaclay.bsky.social
Mechanistically, RhoA signaling termination triggered rapid actin disassembly through Slingshot-mediated cofilin disinhibition.
September 10, 2026 at 1:42 AM
Mechanistically, RhoA signaling termination triggered rapid actin disassembly through Slingshot-mediated cofilin disinhibition.
🍃 🧪 Actin-dependent Cellular Nanotube Contraction by Cofilin Binding
The authors propose that binding to actin filaments in cellular nanotubes by actin depolymerizing factor/cofilin creates torsional stress that leads to actin attachment and detachment to the nanotube tip, generating contraction.
The authors propose that binding to actin filaments in cellular nanotubes by actin depolymerizing factor/cofilin creates torsional stress that leads to actin attachment and detachment to the nanotube tip, generating contraction.
Myosin II independent contraction of actin filaments in membrane nanotubes https://www.biorxiv.org/content/10.1101/2025.09.04.674176v1
September 7, 2025 at 12:31 PM
🍃 🧪 Actin-dependent Cellular Nanotube Contraction by Cofilin Binding
The authors propose that binding to actin filaments in cellular nanotubes by actin depolymerizing factor/cofilin creates torsional stress that leads to actin attachment and detachment to the nanotube tip, generating contraction.
The authors propose that binding to actin filaments in cellular nanotubes by actin depolymerizing factor/cofilin creates torsional stress that leads to actin attachment and detachment to the nanotube tip, generating contraction.
Choreography of rapid actin filament disassembly by coronin, cofilin, and AIP1 pubmed.ncbi.nlm.nih.gov/41075793/ #cryoem
October 12, 2025 at 9:33 PM
Choreography of rapid actin filament disassembly by coronin, cofilin, and AIP1 pubmed.ncbi.nlm.nih.gov/41075793/ #cryoem
September 15, 2026 at 11:37 AM
Our new Journal of Neuroscience paper "Cofilin Inhibition Ameliorates PIEZO2 and AMPA Dysfunction in a Mouse Model of Angelman Syndrome (AS)” is out: www.jneurosci.org/content/45/4... 1/6
Cofilin Inhibition Ameliorates PIEZO2 and AMPA Dysfunction in a Mouse Model of Angelman Syndrome
Angelman syndrome (AS) is a neurogenetic disorder characterized by motor coordination and cognitive deficits. In AS, hippocampal neurons show reduced filamentous (F-)actin, a decrease we also reported...
www.jneurosci.org
November 6, 2025 at 8:03 PM
Our new Journal of Neuroscience paper "Cofilin Inhibition Ameliorates PIEZO2 and AMPA Dysfunction in a Mouse Model of Angelman Syndrome (AS)” is out: www.jneurosci.org/content/45/4... 1/6
Cofilin promotes actin turnover and flexibility to drive coordinated cell movements in vivo
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
www.biorxiv.org
April 24, 2026 at 11:40 AM
Cofilin promotes actin turnover and flexibility to drive coordinated cell movements in vivo
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Disease-associated mutations in TPM2 alter regulation of actin filament stability and cofilin-dependent dynamics
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
www.biorxiv.org
May 19, 2026 at 2:23 PM
Disease-associated mutations in TPM2 alter regulation of actin filament stability and cofilin-dependent dynamics
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
check out this new paper from the Murrell lab -
Cofilin-Mediated Filament Softening and Crosslinking Counterbalance to Enhance Actin Network Flexibility
journals.aps.org/prl/abstract...
Cofilin-Mediated Filament Softening and Crosslinking Counterbalance to Enhance Actin Network Flexibility
journals.aps.org/prl/abstract...
Cofilin-Mediated Filament Softening and Crosslinking Counterbalance to Enhance Actin Network Flexibility
Filamentous-actin ($F$-actin) crosslinking within the cell cytoskeleton mediates the transmission of mechanical forces, enabling changes in cell shape, as occurs during cell division and cell migratio...
journals.aps.org
November 23, 2024 at 12:16 AM
check out this new paper from the Murrell lab -
Cofilin-Mediated Filament Softening and Crosslinking Counterbalance to Enhance Actin Network Flexibility
journals.aps.org/prl/abstract...
Cofilin-Mediated Filament Softening and Crosslinking Counterbalance to Enhance Actin Network Flexibility
journals.aps.org/prl/abstract...
very satisfying to see these structures 27 years after first grappling with the Aip1-cofilin mechanism as a beginning graduate student!
October 13, 2025 at 3:56 PM
very satisfying to see these structures 27 years after first grappling with the Aip1-cofilin mechanism as a beginning graduate student!
Action of cofilin on ADP-Pi-containing actin filaments https://www.biorxiv.org/content/10.64898/2026.09.11.751010v1
September 14, 2026 at 12:46 PM
Action of cofilin on ADP-Pi-containing actin filaments https://www.biorxiv.org/content/10.64898/2026.09.11.751010v1
Characterization of a cofilin mutant with high actin bundling activity in living cells https://www.biorxiv.org/content/10.64898/2026.04.22.720186v1
April 26, 2026 at 5:30 AM
Characterization of a cofilin mutant with high actin bundling activity in living cells https://www.biorxiv.org/content/10.64898/2026.04.22.720186v1
Modulation of cofilin 1 phosphorylation induces juvenile-like plasticity in the adult mouse visual cortex. https://www.biorxiv.org/content/10.1101/2025.05.05.652250v1
May 10, 2025 at 3:15 PM
Modulation of cofilin 1 phosphorylation induces juvenile-like plasticity in the adult mouse visual cortex. https://www.biorxiv.org/content/10.1101/2025.05.05.652250v1
Cofilin Suppresses Tau-Induced Defects in Dense-Core Granule Formation and Aβ-Induced Neurodegeneration https://www.biorxiv.org/content/10.64898/2026.09.22.753479v1
September 28, 2026 at 12:15 AM
Cofilin Suppresses Tau-Induced Defects in Dense-Core Granule Formation and Aβ-Induced Neurodegeneration https://www.biorxiv.org/content/10.64898/2026.09.22.753479v1
A revised model of nuclear actin import: Importin 9 competes with cofilin, profilin, and RanGTP for actin binding https://www.biorxiv.org/content/10.1101/2025.09.24.678334v1
September 26, 2025 at 11:45 PM
A revised model of nuclear actin import: Importin 9 competes with cofilin, profilin, and RanGTP for actin binding https://www.biorxiv.org/content/10.1101/2025.09.24.678334v1
Having a great time at Japan College of Rheumatology meeting, Fukuoka.
Most recent head-explosion, new story from the JJ Chae wing of the Kastner machine: Cofilin-1 senses ROS by auto-inhibiting under oxidative conditions and releasing NLRP3.
Most recent head-explosion, new story from the JJ Chae wing of the Kastner machine: Cofilin-1 senses ROS by auto-inhibiting under oxidative conditions and releasing NLRP3.
April 26, 2025 at 6:01 AM
Having a great time at Japan College of Rheumatology meeting, Fukuoka.
Most recent head-explosion, new story from the JJ Chae wing of the Kastner machine: Cofilin-1 senses ROS by auto-inhibiting under oxidative conditions and releasing NLRP3.
Most recent head-explosion, new story from the JJ Chae wing of the Kastner machine: Cofilin-1 senses ROS by auto-inhibiting under oxidative conditions and releasing NLRP3.
New research finds plasma extracellular vesicle-associated cofilin 1 (CFL1) "represents a #Parkinsons -specific, blood-based marker with strong diagnostic accuracy & can distinguish PD from atypical parkinsonism"
onlinelibrary.wiley.com/doi/10.1002/...
onlinelibrary.wiley.com/doi/10.1002/...
September 2, 2026 at 6:50 PM
New research finds plasma extracellular vesicle-associated cofilin 1 (CFL1) "represents a #Parkinsons -specific, blood-based marker with strong diagnostic accuracy & can distinguish PD from atypical parkinsonism"
onlinelibrary.wiley.com/doi/10.1002/...
onlinelibrary.wiley.com/doi/10.1002/...