#cofilin
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ijmonod.bsky.social
📢 PhD Thesis defense

📅 October 28th
📍Institut Jacques Monod

Inaara Kassamaly ( @romet-jegou-lab.bsky.social lab ) will defend her PhD thesis " Disassembly of young ADP·Pi actin filaments by cofilin, studied using microfluidics "

@univparissaclay.bsky.social
October 5, 2026 at 8:01 AM
icoa-umr7311.bsky.social
Offre de #stage de niveau #Master2 d'une durée de 6 mois dans l'équipe SB&C de l'ICOA sur le sujet : Conception d’inhibiteurs de type « stapled peptides » pour l’inhibition sélective de l’interaction LIMKs-cofilin.

Pour plus de détail et postuler : www.icoa.fr/wp-content/u...
October 2, 2026 at 8:05 AM
prepub-neurodegen.bsky.social
Cofilin Suppresses Tau-Induced Defects in Dense-Core Granule Formation and Aβ-Induced Neurodegeneration #NeuroDegeneration 🧪🧠
https://www.biorxiv.org/content/10.64898/2026.09.22.753479v1
September 28, 2026 at 1:01 AM
biorxiv-neursci.bsky.social
Cofilin Suppresses Tau-Induced Defects in Dense-Core Granule Formation and Aβ-Induced Neurodegeneration https://www.biorxiv.org/content/10.64898/2026.09.22.753479v1
September 28, 2026 at 12:15 AM
biorxivpreprint.bsky.social
Cofilin Suppresses Tau-Induced Defects in Dense-Core Granule Formation and Aβ-Induced Neurodegeneration https://www.biorxiv.org/content/10.64898/2026.09.22.753479v1
September 28, 2026 at 12:15 AM
www.biorxiv.org/content/10.6...

Action of cofilin on ADP-Pi-containing actin filaments
September 15, 2026 at 11:37 AM
biorxiv-biochem.bsky.social
Action of cofilin on ADP-Pi-containing actin filaments https://www.biorxiv.org/content/10.64898/2026.09.11.751010v1
September 14, 2026 at 12:46 PM
biorxivpreprint.bsky.social
Action of cofilin on ADP-Pi-containing actin filaments https://www.biorxiv.org/content/10.64898/2026.09.11.751010v1
September 14, 2026 at 12:46 PM
nfbot.bsky.social
A new mechanism of regulation of LIM kinases, LIMK1 and LIMK2, modulates their activity on cofilin and actin filament remodelling
A new mechanism of regulation of LIM kinases, LIMK1 and LIMK2, modulates their activity on cofilin and actin filament remodelling
News update via NF Bot
doi.org
September 13, 2026 at 4:06 PM
jboerckel.bsky.social
Mechanistically, RhoA signaling termination triggered rapid actin disassembly through Slingshot-mediated cofilin disinhibition.
September 10, 2026 at 1:42 AM
scienceofpd.bsky.social
New research finds plasma extracellular vesicle-associated cofilin 1 (CFL1) "represents a #Parkinsons -specific, blood-based marker with strong diagnostic accuracy & can distinguish PD from atypical parkinsonism"
onlinelibrary.wiley.com/doi/10.1002/...
September 2, 2026 at 6:50 PM
papers-neurodegen.bsky.social
Cofilin 1 Is an Extracellular Vesicle‐Associated Plasma Biomarker of Parkinson's Disease in Humans #NeuroDegeneration 🧪🧠
https://onlinelibrary.wiley.com/doi/10.1002/ana.78348?af=R
September 2, 2026 at 10:09 AM
jcellsci.bsky.social
Also in Issue 15:
- Research Highlights on oncogenic PIK3CA mutations and scaffold protein clustering in axons
- 'Apocalypse? Nah! Part I – future tense' from Mole
- Review on ‘Alterations of actin in aging'
journals.biologists.com/jcs/issue/13...
Schematic of actin and associated regulatory protein linked to diseases. Actin filaments are depicted as polymers of actin monomers (green). Cofilin (light purple) binds preferentially to filaments, inducing conformational changes that promote filament severing and turnover; dysregulation of cofilin activity and the formation of cofilin–actin aggregates have been implicated in neurodegenerative diseases such as AD and HD. The Arp2/3 complex (blue) nucleates branched actin networks by binding to the side of pre-existing filaments and generating daughter filaments; aberrant Arp2/3 activity has been linked to neurodegenerative diseases (AD and HD), as well as tumor cell invasion and metastasis. Formin (orange) promotes the nucleation and processive elongation of linear actin filaments by remaining associated with the growing barbed end; dysregulated formin activity has been linked to cancer cell migration and metastasis through the promotion of invasive actin-based structures such as lamellipodia and invadopodia. Tropomyosin (red) binds along the length of actin filaments in muscle, contributing to filament stabilization and regulating the access of other actin-binding proteins; mutations in tropomyosin isoforms are associated with congenital skeletal muscle myopathies and cardiomyopathies. Troponin (yellow) associates with tropomyosin on actin filaments and regulates actin–myosin interactions; mutations in troponin subunits are likewise linked to cardiomyopathies and skeletal muscle myopathies. Profilin (dark purple) binds actin monomers and facilitates their incorporation into growing filaments; mutations in profilin (e.g. PFN1) have been linked to familial ALS.
August 17, 2026 at 1:38 PM
www.biorxiv.org/content/10.1...

Structural basis for alpha-actinin inhibition of cooperative cofilin binding to actin filaments
August 6, 2026 at 2:48 PM
interactivefly.bsky.social
Biel, N., Rashid, F., Natua, S., Wang, T. Y., Chou, T. F., Nguyen, T. V. P., Golding, I., Kalsotra, A., Sokac, A. M. (2025). Reducing Cofilin dosage makes embryos resilient to heat stress. bioRxiv, www.biorxiv.org/content/10.1...
July 23, 2026 at 12:55 AM
kevin-dean.bsky.social
Are you more like cofilin, mDia1, or fascin?
July 21, 2026 at 11:43 PM
www.biorxiv.org/content/10.6...
Cofilin controls actin network identity by sorting actin binding proteins to distinct cytoskeletal structures
Proper cell physiology requires the co-assembly of multiple actin cytoskeletal networks that are tailored for specific functions. To maintain and promote the different functions of these networks, cel...
www.biorxiv.org
June 26, 2026 at 12:02 PM
www.biorxiv.org/content/10.6...
A new mechanism of regulation of LIM kinases, LIMK1 and LIMK2, modulates their activity on cofilin and actin filament remodelling
LIM kinases, LIMK1 and LIMK2, play a crucial role in cytoskeleton dynamics. They are involved in many physiological processes but also in several pathologies such as cancer, neuronal diseases and neur...
www.biorxiv.org
June 24, 2026 at 11:16 AM
oncogenesisnature.bsky.social
“Inhibition of LIMK by Cofilin-1 peptidomimetics enhances actin depolymerization and reduces metastasis of non-small cell lung cancer”

🔵 Yi-Jang Lee‘s latest research is now available to read in #Oncogenesis.

▶️ Read the full open access article here: www.nature.com/articles/s41...
June 23, 2026 at 8:19 AM
rridrobot.bsky.social
The authors included RRIDs in their paper! Thanks for making your methods matter! #methodsmatter #reproducibility #accelerateopenscience
Characterization of a cofilin mutant with high actin bundling activity in living cells
Read the full paper: Characterization of a cofilin mutant with high actin bundling activity in living cells
doi.org
June 11, 2026 at 7:03 AM
castltrastondrs.medsky.network
This study shifts focus toward host-directed therapies, offering a highly viable strategy to build broad-spectrum antiviral drugs capable of combating both current and future coronavirus outbreaks.
Mechanism Pathway Breakdown MELK Inhibition: The pathway triggers when OTSSP167 blocks the Maternal Embryonic Leucine Zipper Kinase (MELK). Cofilin-1 Activation: Blocking MELK prevents the phosphorylation of cofilin-1 at its S3 and T70 sites, turning it back into an active enzyme. Actin Disruption: Active cofilin-1 cuts and breaks down the host's actin filaments, dismantling the cell's structural skeleton. Viral Block: Without a stable actin infrastructure, human coronaviruses lose their internal cellular highway, halting their ability to enter, move, and replicate within the host.
June 11, 2026 at 4:00 AM
castltrastondrs.medsky.network
🧨The Disruptive Impact: Inhibiting MELK reverses this process. It activates cofilin-1, which rapidly breaks down actin filaments and blocks the viral life cycle at multiple stages

www.nature.com/articles/s41...

www.microbiologyresearch.org/content/jour...
Actin cytoskeleton remodeling disrupts physical barriers to infection and presents entry receptors to respiratory syncytial virus
RSV is the leading cause of infant hospitalizations and a significant cause of paediatric and geriatric morbidity worldwide. Recently, we reported that insulin-like growth factor 1 receptor (IGF1R) wa...
www.microbiologyresearch.org
June 11, 2026 at 4:00 AM
castltrastondrs.medsky.network
Viruses rely heavily on these actin structures to enter and move through the cell.
🧨The Molecular Switch: Mechanistically, MELK directly phosphorylates cofilin-1 (an actin-depolymerising protein) at the S3 and T70 sites. This phosphorylation suppresses cofilin-1's ability to sever actin
June 11, 2026 at 4:00 AM
proteinimaging.bsky.social
How do ROS drive inflammation? New in Nature Immunology: cofilin-1 binds and inhibits NLRP3 — and ROS disrupts that interaction to unlock inflammasome assembly. 🔓

Illustrations made using #ProteinImager

DOI: 10.1038/s41590-026-02490-x

#Immunology #NLRP3
May 29, 2026 at 10:12 AM
biorxivpreprint.bsky.social
A Novel Hydrogen Polysulfide Donor Alleviates Neuropathic Pain by Enhancing A-Type Potassium Currents via LIMK1-Cofilin Mediated Interaction between Filamin A and Kv4.2 https://www.biorxiv.org/content/10.64898/2026.05.25.727751v1
May 29, 2026 at 4:01 AM