Just published in Science Advances:
Mutations don't have the same cancer effect in driving development of melanoma at every age.
Across 5,472 tumors, we find BRAF V600E loses selective advantage with age, while NRAS Q61 gains it.
♋ 🧪 www.science.org/doi/10.1126/...
Mutations don't have the same cancer effect in driving development of melanoma at every age.
Across 5,472 tumors, we find BRAF V600E loses selective advantage with age, while NRAS Q61 gains it.
♋ 🧪 www.science.org/doi/10.1126/...
Age reshapes selection on melanoma driver mutations
Aging is a major risk factor for melanoma. However, it is unclear whether aging fuels tumor evolution by altering mutation rates, changing the microenvironmentally induced selection on drivers, or bot...
www.science.org
November 7, 2026 at 12:20 AM
Just published in Science Advances:
Mutations don't have the same cancer effect in driving development of melanoma at every age.
Across 5,472 tumors, we find BRAF V600E loses selective advantage with age, while NRAS Q61 gains it.
♋ 🧪 www.science.org/doi/10.1126/...
Mutations don't have the same cancer effect in driving development of melanoma at every age.
Across 5,472 tumors, we find BRAF V600E loses selective advantage with age, while NRAS Q61 gains it.
♋ 🧪 www.science.org/doi/10.1126/...
NRAS Q61H is uncommon, yet its estimated strength of selection also tends to rise with age. The NRAS pattern extends beyond one particular codon-61 substitution.
♋ 🧪 www.science.org/doi/10.1126/...
♋ 🧪 www.science.org/doi/10.1126/...
November 7, 2026 at 1:01 AM
NRAS Q61H is uncommon, yet its estimated strength of selection also tends to rise with age. The NRAS pattern extends beyond one particular codon-61 substitution.
♋ 🧪 www.science.org/doi/10.1126/...
♋ 🧪 www.science.org/doi/10.1126/...
Special thanks to my supervisor @nrascovan.bsky.social, who wrote a great thread summarizing our findings:
bsky.app/profile/nras...
bsky.app/profile/nras...
www.pnas.org/doi/10.1073/...
Our new paper is out in @pnas.org !
Our new study combines #ancientDNA and #archaeology to reveal how ancestry, inequality, and social status intersected in #Mendoza, #Argentina.
A research done at @institutpasteur.bsky.social with the support of @erc.europa.eu
🧵 1/16
Our new paper is out in @pnas.org !
Our new study combines #ancientDNA and #archaeology to reveal how ancestry, inequality, and social status intersected in #Mendoza, #Argentina.
A research done at @institutpasteur.bsky.social with the support of @erc.europa.eu
🧵 1/16
November 3, 2026 at 9:35 AM
Special thanks to my supervisor @nrascovan.bsky.social, who wrote a great thread summarizing our findings:
bsky.app/profile/nras...
bsky.app/profile/nras...
I suspect aging changes the tissue environment (fibroblasts, matrix, immunity), favoring NRAS-driven signaling over BRAF V600E-driven signaling. "Pathways" are really networks. Both activate MAPK, but differ in downstream effects. Why aging shifts their relative fitness remains to be tested.
November 8, 2026 at 5:43 AM
I suspect aging changes the tissue environment (fibroblasts, matrix, immunity), favoring NRAS-driven signaling over BRAF V600E-driven signaling. "Pathways" are really networks. Both activate MAPK, but differ in downstream effects. Why aging shifts their relative fitness remains to be tested.
Are you ready for Advent? 🎄
Our Christmas Shop has a range of Advent calendars and candles to help you count down to Christmas in style.
Explore this year's festive designs and find a seasonal favourite for your home or family.
Shop now: www.charitycardshop.com/nras
Our Christmas Shop has a range of Advent calendars and candles to help you count down to Christmas in style.
Explore this year's festive designs and find a seasonal favourite for your home or family.
Shop now: www.charitycardshop.com/nras
November 7, 2026 at 12:15 PM
Are you ready for Advent? 🎄
Our Christmas Shop has a range of Advent calendars and candles to help you count down to Christmas in style.
Explore this year's festive designs and find a seasonal favourite for your home or family.
Shop now: www.charitycardshop.com/nras
Our Christmas Shop has a range of Advent calendars and candles to help you count down to Christmas in style.
Explore this year's festive designs and find a seasonal favourite for your home or family.
Shop now: www.charitycardshop.com/nras
How does the NRAS team de-stress? 🧘♀️ Let us know yours in the comments below! 💬👇
#StressAwarenessWeek #RheumatoidArthritis #RAAwareness #ChronicIllness
#StressAwarenessWeek #RheumatoidArthritis #RAAwareness #ChronicIllness
November 5, 2026 at 9:00 AM
How does the NRAS team de-stress? 🧘♀️ Let us know yours in the comments below! 💬👇
#StressAwarenessWeek #RheumatoidArthritis #RAAwareness #ChronicIllness
#StressAwarenessWeek #RheumatoidArthritis #RAAwareness #ChronicIllness
Stage matters, but mutations still guide treatment in advanced melanoma: BRAF-mutant tumors can receive BRAF/MEK inhibitors, NRAS-mutant tumors may soon be targetable with tailored RAS therapies. Our findings suggest age may further refine treatment choices. But it has yet to be tested!
November 8, 2026 at 5:46 AM
Stage matters, but mutations still guide treatment in advanced melanoma: BRAF-mutant tumors can receive BRAF/MEK inhibitors, NRAS-mutant tumors may soon be targetable with tailored RAS therapies. Our findings suggest age may further refine treatment choices. But it has yet to be tested!
Though its uncertainty is substantial, NRAS Q61K likewise has an increasing modeled selection trajectory.
♋ 🧪 www.science.org/doi/10.1126/...
Selective effects are best estimated variant by variant—not assumed to be universal to a gene. But a similar pattern strongly reinforces a conclusion.
♋ 🧪 www.science.org/doi/10.1126/...
Selective effects are best estimated variant by variant—not assumed to be universal to a gene. But a similar pattern strongly reinforces a conclusion.
November 7, 2026 at 1:04 AM
Though its uncertainty is substantial, NRAS Q61K likewise has an increasing modeled selection trajectory.
♋ 🧪 www.science.org/doi/10.1126/...
Selective effects are best estimated variant by variant—not assumed to be universal to a gene. But a similar pattern strongly reinforces a conclusion.
♋ 🧪 www.science.org/doi/10.1126/...
Selective effects are best estimated variant by variant—not assumed to be universal to a gene. But a similar pattern strongly reinforces a conclusion.
NRAS Q61L shows the opposite pattern: both prevalence and estimated selection increase with age.
A mutation strongly favored in a melanoma from an older patient need not be strongly favored in a melanoma from a younger patient.
♋ 🧪 www.science.org/doi/10.1126/...
A mutation strongly favored in a melanoma from an older patient need not be strongly favored in a melanoma from a younger patient.
♋ 🧪 www.science.org/doi/10.1126/...
November 7, 2026 at 1:00 AM
NRAS Q61L shows the opposite pattern: both prevalence and estimated selection increase with age.
A mutation strongly favored in a melanoma from an older patient need not be strongly favored in a melanoma from a younger patient.
♋ 🧪 www.science.org/doi/10.1126/...
A mutation strongly favored in a melanoma from an older patient need not be strongly favored in a melanoma from a younger patient.
♋ 🧪 www.science.org/doi/10.1126/...
🎄 Having a Christmas clear-out? 💜
Make space for the festive season while supporting NRAS.
📚 Sell unwanted books through WeBuyBooks
🧱 Sell unwanted LEGO® bricks through WeBuyBricks
Donate the proceeds to help support people living with RA and JIA.
✨ Clear out. Give back. Make a difference. ✨
Make space for the festive season while supporting NRAS.
📚 Sell unwanted books through WeBuyBooks
🧱 Sell unwanted LEGO® bricks through WeBuyBricks
Donate the proceeds to help support people living with RA and JIA.
✨ Clear out. Give back. Make a difference. ✨
November 8, 2026 at 12:45 PM
🎄 Having a Christmas clear-out? 💜
Make space for the festive season while supporting NRAS.
📚 Sell unwanted books through WeBuyBooks
🧱 Sell unwanted LEGO® bricks through WeBuyBricks
Donate the proceeds to help support people living with RA and JIA.
✨ Clear out. Give back. Make a difference. ✨
Make space for the festive season while supporting NRAS.
📚 Sell unwanted books through WeBuyBooks
🧱 Sell unwanted LEGO® bricks through WeBuyBricks
Donate the proceeds to help support people living with RA and JIA.
✨ Clear out. Give back. Make a difference. ✨
Get Christmas ready with the NRAS Christmas Shop 🎄
You'll find plenty of festive favourites in our Christmas Shop, including advent calendars, cards, crackers, gift wrap and more.
Be quick, orders close on 12 December and stock is limited.
Browse the collection: www.charitycardshop.com/nras
You'll find plenty of festive favourites in our Christmas Shop, including advent calendars, cards, crackers, gift wrap and more.
Be quick, orders close on 12 December and stock is limited.
Browse the collection: www.charitycardshop.com/nras
November 1, 2026 at 12:30 PM
Get Christmas ready with the NRAS Christmas Shop 🎄
You'll find plenty of festive favourites in our Christmas Shop, including advent calendars, cards, crackers, gift wrap and more.
Be quick, orders close on 12 December and stock is limited.
Browse the collection: www.charitycardshop.com/nras
You'll find plenty of festive favourites in our Christmas Shop, including advent calendars, cards, crackers, gift wrap and more.
Be quick, orders close on 12 December and stock is limited.
Browse the collection: www.charitycardshop.com/nras
New NRAS local groups are here!
Join us in Ipswich and Maidenhead to connect with others affected by rheumatoid arthritis, share experiences, and access support in your local community.
Whether you're newly diagnosed or have had RA for years, everyone is welcome.
Register: 🔗 nras.org.uk/events
Join us in Ipswich and Maidenhead to connect with others affected by rheumatoid arthritis, share experiences, and access support in your local community.
Whether you're newly diagnosed or have had RA for years, everyone is welcome.
Register: 🔗 nras.org.uk/events
November 3, 2026 at 2:30 PM
New NRAS local groups are here!
Join us in Ipswich and Maidenhead to connect with others affected by rheumatoid arthritis, share experiences, and access support in your local community.
Whether you're newly diagnosed or have had RA for years, everyone is welcome.
Register: 🔗 nras.org.uk/events
Join us in Ipswich and Maidenhead to connect with others affected by rheumatoid arthritis, share experiences, and access support in your local community.
Whether you're newly diagnosed or have had RA for years, everyone is welcome.
Register: 🔗 nras.org.uk/events
@washumedicine.bsky.social physician-scientists at Siteman Cancer Center are developing a combination therapy for NRAS-mutated melanoma, a highly aggressive form of the disease. In an early-phase study, six of seven patients achieved a complete response. https://bit.ly/4ikzb8d @jci.org
November 4, 2026 at 2:45 PM
@washumedicine.bsky.social physician-scientists at Siteman Cancer Center are developing a combination therapy for NRAS-mutated melanoma, a highly aggressive form of the disease. In an early-phase study, six of seven patients achieved a complete response. https://bit.ly/4ikzb8d @jci.org
What do you find most useful on the NRAS website? What could we do better?
Help improve our online resources and make it easier for people affected by RA to find the support they need.
The survey takes just 5 minutes to complete.
Take the survey today: www.sogolytics.com/r/dl2Lly
Help improve our online resources and make it easier for people affected by RA to find the support they need.
The survey takes just 5 minutes to complete.
Take the survey today: www.sogolytics.com/r/dl2Lly
November 2, 2026 at 2:00 PM
What do you find most useful on the NRAS website? What could we do better?
Help improve our online resources and make it easier for people affected by RA to find the support they need.
The survey takes just 5 minutes to complete.
Take the survey today: www.sogolytics.com/r/dl2Lly
Help improve our online resources and make it easier for people affected by RA to find the support they need.
The survey takes just 5 minutes to complete.
Take the survey today: www.sogolytics.com/r/dl2Lly
The authors included RRIDs in their in Pigment Cell & Melanoma Research paper! We value the author's support of reproducibility. #reproducibility #OpenResearch #RRID
A genome‐wide CRISPR screen identifies FBXO42 involvement in resistance toward MEK inhibition in NRAS‐mutant melanoma
Read the full paper: A genome‐wide CRISPR screen identifies FBXO42 involvement in resistance toward MEK inhibition in NRAS‐mutant melanoma
doi.org
October 30, 2026 at 7:05 AM
The authors included RRIDs in their in Pigment Cell & Melanoma Research paper! We value the author's support of reproducibility. #reproducibility #OpenResearch #RRID
Signature of Leonard Welsted: Not much to look at. I left it pinned in its place, (Moray Papers, NRAS 217)
October 27, 2026 at 4:07 PM
Signature of Leonard Welsted: Not much to look at. I left it pinned in its place, (Moray Papers, NRAS 217)
Help shape the future of the NRAS website.
Whether you use our website for information, support or education, we'd love to hear about your experience. Complete our short 5-minute survey and help us create a better online experience for the RA community.
Take the survey: www.sogolytics.com/r/dl2Lly
Whether you use our website for information, support or education, we'd love to hear about your experience. Complete our short 5-minute survey and help us create a better online experience for the RA community.
Take the survey: www.sogolytics.com/r/dl2Lly
October 28, 2026 at 12:00 PM
Help shape the future of the NRAS website.
Whether you use our website for information, support or education, we'd love to hear about your experience. Complete our short 5-minute survey and help us create a better online experience for the RA community.
Take the survey: www.sogolytics.com/r/dl2Lly
Whether you use our website for information, support or education, we'd love to hear about your experience. Complete our short 5-minute survey and help us create a better online experience for the RA community.
Take the survey: www.sogolytics.com/r/dl2Lly
Nice picture. I went there in 2012 with the Regional Furniture Society. I subsequently found the Apethorpe letters in the NRAS 217 catalogue at Register House, Edinburgh, and Lord Moray agreed for me to read them.
October 26, 2026 at 7:28 AM
Nice picture. I went there in 2012 with the Regional Furniture Society. I subsequently found the Apethorpe letters in the NRAS 217 catalogue at Register House, Edinburgh, and Lord Moray agreed for me to read them.
Only two weeks left to enter our 25th Anniversary Raffle! 🎉
Every ticket helps support people living with rheumatoid arthritis while giving you the chance to win some fantastic prizes.
Don't miss out. Get your tickets today and help us celebrate 25 years of NRAS.
🔗 nras.org.uk/raffle/
Every ticket helps support people living with rheumatoid arthritis while giving you the chance to win some fantastic prizes.
Don't miss out. Get your tickets today and help us celebrate 25 years of NRAS.
🔗 nras.org.uk/raffle/
October 27, 2026 at 2:15 PM
Only two weeks left to enter our 25th Anniversary Raffle! 🎉
Every ticket helps support people living with rheumatoid arthritis while giving you the chance to win some fantastic prizes.
Don't miss out. Get your tickets today and help us celebrate 25 years of NRAS.
🔗 nras.org.uk/raffle/
Every ticket helps support people living with rheumatoid arthritis while giving you the chance to win some fantastic prizes.
Don't miss out. Get your tickets today and help us celebrate 25 years of NRAS.
🔗 nras.org.uk/raffle/
JoinTogether Movement & Exercise: Strength Training with RA
📅 Wednesday 11 November, 6.00pm-7.15pm
We're delighted to welcome Stacey Bielick, Strength Training Coach and NRAS member, to share her experience of strength training while living with RA.
🔗 Sign up today: nras.org.uk/event/jointo...
📅 Wednesday 11 November, 6.00pm-7.15pm
We're delighted to welcome Stacey Bielick, Strength Training Coach and NRAS member, to share her experience of strength training while living with RA.
🔗 Sign up today: nras.org.uk/event/jointo...
October 26, 2026 at 4:45 PM
JoinTogether Movement & Exercise: Strength Training with RA
📅 Wednesday 11 November, 6.00pm-7.15pm
We're delighted to welcome Stacey Bielick, Strength Training Coach and NRAS member, to share her experience of strength training while living with RA.
🔗 Sign up today: nras.org.uk/event/jointo...
📅 Wednesday 11 November, 6.00pm-7.15pm
We're delighted to welcome Stacey Bielick, Strength Training Coach and NRAS member, to share her experience of strength training while living with RA.
🔗 Sign up today: nras.org.uk/event/jointo...
Repubs have been systematically building a totalitarian Regině for my entire life, at least since Nixon. Gengrich's Permanent Republican Majority. McConnell's court stuffing. The NRAs funding of law degrees.
It smart, strategic, and effective.
It smart, strategic, and effective.
October 25, 2026 at 12:19 PM
Repubs have been systematically building a totalitarian Regině for my entire life, at least since Nixon. Gengrich's Permanent Republican Majority. McConnell's court stuffing. The NRAs funding of law degrees.
It smart, strategic, and effective.
It smart, strategic, and effective.
Huge congratulations to Helen for completing the Atlantic Coast Challenge in support of NRAS.
Reflecting Helen said: “My sister was diagnosed with RA at the age of 39 while raising young twins. Witnessing her courage and resilience in the face of such a relentless disease has been inspiring.”
Reflecting Helen said: “My sister was diagnosed with RA at the age of 39 while raising young twins. Witnessing her courage and resilience in the face of such a relentless disease has been inspiring.”
October 25, 2026 at 11:45 AM
Huge congratulations to Helen for completing the Atlantic Coast Challenge in support of NRAS.
Reflecting Helen said: “My sister was diagnosed with RA at the age of 39 while raising young twins. Witnessing her courage and resilience in the face of such a relentless disease has been inspiring.”
Reflecting Helen said: “My sister was diagnosed with RA at the age of 39 while raising young twins. Witnessing her courage and resilience in the face of such a relentless disease has been inspiring.”
Today we're reflecting on 25 years of supporting people living with RA and JIA. 🎂💚
Thank you to everyone who has trusted, supported and championed NRAS over the last 25 years.
Thank you to everyone who has trusted, supported and championed NRAS over the last 25 years.
October 18, 2026 at 8:00 AM
Today we're reflecting on 25 years of supporting people living with RA and JIA. 🎂💚
Thank you to everyone who has trusted, supported and championed NRAS over the last 25 years.
Thank you to everyone who has trusted, supported and championed NRAS over the last 25 years.
Rents have risen astronomically without forms of income rising the same way. NRAS properties ending. Lack of public housing.
All choices by government state and federal
All choices by government state and federal
October 16, 2026 at 11:34 PM
Rents have risen astronomically without forms of income rising the same way. NRAS properties ending. Lack of public housing.
All choices by government state and federal
All choices by government state and federal
The festive season is on its way. 🎄
Find everything from Christmas cards and advent calendars to candles, crackers, gift wrap, tags and more.
Every purchase supports people affected by RA and JIA, no one should have to face their condition alone.
Browse the shop: www.charitycardshop.com/nras
Find everything from Christmas cards and advent calendars to candles, crackers, gift wrap, tags and more.
Every purchase supports people affected by RA and JIA, no one should have to face their condition alone.
Browse the shop: www.charitycardshop.com/nras
October 17, 2026 at 10:00 AM
The festive season is on its way. 🎄
Find everything from Christmas cards and advent calendars to candles, crackers, gift wrap, tags and more.
Every purchase supports people affected by RA and JIA, no one should have to face their condition alone.
Browse the shop: www.charitycardshop.com/nras
Find everything from Christmas cards and advent calendars to candles, crackers, gift wrap, tags and more.
Every purchase supports people affected by RA and JIA, no one should have to face their condition alone.
Browse the shop: www.charitycardshop.com/nras