We measured gene expression in the blood of wild song sparrows after simulated territorial intrusion. This was a paired design, comparing response to local vs. foreign songs.
The coolest result... song-associated genes (FOXP2, NRXN1) had higher expression when birds heard local songs!
The coolest result... song-associated genes (FOXP2, NRXN1) had higher expression when birds heard local songs!
September 24, 2026 at 8:50 PM
We measured gene expression in the blood of wild song sparrows after simulated territorial intrusion. This was a paired design, comparing response to local vs. foreign songs.
The coolest result... song-associated genes (FOXP2, NRXN1) had higher expression when birds heard local songs!
The coolest result... song-associated genes (FOXP2, NRXN1) had higher expression when birds heard local songs!
In vivo dissection of human NRXN1 isoforms reveals gain-of-function pathogenicity of schizophrenia-associated 3′ deletions #RareDisease #Genetics academic.oup.com/hmg/article/...
September 20, 2026 at 3:32 PM
In vivo dissection of human NRXN1 isoforms reveals gain-of-function pathogenicity of schizophrenia-associated 3′ deletions #RareDisease #Genetics academic.oup.com/hmg/article/...
RRIDs were included in this in Science paper. RRIDs improve reproducibility in scientific research. #accelerateopenscience #RRID #OpenResearch
Thalamic NRXN1-mediated input to human cortical progenitors drives excitatory neurogenesis
Read the full paper: Thalamic NRXN1-mediated input to human cortical progenitors drives excitatory neurogenesis
doi.org
September 16, 2026 at 7:37 PM
RRIDs were included in this in Science paper. RRIDs improve reproducibility in scientific research. #accelerateopenscience #RRID #OpenResearch
Expression of human NRXN1 isoforms in C. elegans neurons revealed gain-of-function of schizophrenia-associated 3′ deletions! Work by Dustin Haskell (now @lawrenceuni.bsky.social), and with immense thanks to @kristenbrennand.bsky.social! academic.oup.com/hmg/article/...
In vivo dissection of human NRXN1 isoforms reveals gain-of-function pathogenicity of schizophrenia-associated 3′ deletions
Abstract. Heterozygous deletions in NRXN1, encoding the presynaptic adhesion molecule Neurexin 1, are among the most frequently identified rare variants in
academic.oup.com
September 10, 2026 at 7:19 PM
Expression of human NRXN1 isoforms in C. elegans neurons revealed gain-of-function of schizophrenia-associated 3′ deletions! Work by Dustin Haskell (now @lawrenceuni.bsky.social), and with immense thanks to @kristenbrennand.bsky.social! academic.oup.com/hmg/article/...
#Thalamic NRXN1-mediated input to #human #cortical progenitors drives excitatory #neurogenesis | Science www.science.org/doi/10.1126/...
Thalamic NRXN1-mediated input to human cortical progenitors drives excitatory neurogenesis
The human cerebral cortex develops through coordinated signals from within the cortex and from other brain regions, including the thalamus. However, how thalamic neuronal projections influence early h...
www.science.org
September 9, 2026 at 5:38 PM
#Thalamic NRXN1-mediated input to #human #cortical progenitors drives excitatory #neurogenesis | Science www.science.org/doi/10.1126/...
Assembloids as a useful platform to determine the interaction and biological significance of cross-layer interaction. Great work👍👍👍 www.science.org/doi/abs/10.1...
Thalamic NRXN1-mediated input to human cortical progenitors drives excitatory neurogenesis
The human cerebral cortex develops through coordinated signals from within the cortex and from other brain regions, including the thalamus. However, how thalamic neuronal projections influence early h...
www.science.org
September 8, 2026 at 2:09 PM
Assembloids as a useful platform to determine the interaction and biological significance of cross-layer interaction. Great work👍👍👍 www.science.org/doi/abs/10.1...
Congrats to Claudia Nguyen and the @bhadurilab.bsky.social team members on this super cool paper using human corticothalamic assembloids to reveal mechanisms by which thalamic innervation regulates corticogenesis during neurodevelopment.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Thalamic NRXN1-mediated input to human cortical progenitors drives excitatory neurogenesis
The human cerebral cortex develops through coordinated signals from within the cortex and from other brain regions, including the thalamus. However, how thalamic neuronal projections influence early h...
www.science.org
September 4, 2026 at 12:32 PM
Congrats to Claudia Nguyen and the @bhadurilab.bsky.social team members on this super cool paper using human corticothalamic assembloids to reveal mechanisms by which thalamic innervation regulates corticogenesis during neurodevelopment.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Thalamic NRXN1-mediated input to human cortical progenitors drives excitatory neurogenesis
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Thalamic NRXN1-mediated input to human cortical progenitors drives excitatory neurogenesis
The human cerebral cortex develops through coordinated signals from within the cortex and from other brain regions, including the thalamus. However, how thalamic neuronal projections influence early h...
www.science.org
September 4, 2026 at 10:34 AM
Thalamic NRXN1-mediated input to human cortical progenitors drives excitatory neurogenesis
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
6) One of the clearest hits in DecodeME was for the gene CA10 on chromosome 17.
It's involved in neurexin binding, so it has a clear connection to other genes on the list, such as NRXN1 (neurexin 1) and NLGN1 (Neuroligin 1).
It's involved in neurexin binding, so it has a clear connection to other genes on the list, such as NRXN1 (neurexin 1) and NLGN1 (Neuroligin 1).
August 16, 2026 at 7:33 AM
6) One of the clearest hits in DecodeME was for the gene CA10 on chromosome 17.
It's involved in neurexin binding, so it has a clear connection to other genes on the list, such as NRXN1 (neurexin 1) and NLGN1 (Neuroligin 1).
It's involved in neurexin binding, so it has a clear connection to other genes on the list, such as NRXN1 (neurexin 1) and NLGN1 (Neuroligin 1).
5) We can also look at the individual genes that drive these associations with synapses. For DecodeME, these included synaptic genes such as:
LRRC7
STAU1
ARFGEF2
CACNAIE
DCC
PEBP1
VWC2
NEURL1
INA
SHISA6
DENND1A
NRXN1
....
etc.
LRRC7
STAU1
ARFGEF2
CACNAIE
DCC
PEBP1
VWC2
NEURL1
INA
SHISA6
DENND1A
NRXN1
....
etc.
August 16, 2026 at 7:33 AM
5) We can also look at the individual genes that drive these associations with synapses. For DecodeME, these included synaptic genes such as:
LRRC7
STAU1
ARFGEF2
CACNAIE
DCC
PEBP1
VWC2
NEURL1
INA
SHISA6
DENND1A
NRXN1
....
etc.
LRRC7
STAU1
ARFGEF2
CACNAIE
DCC
PEBP1
VWC2
NEURL1
INA
SHISA6
DENND1A
NRXN1
....
etc.
The authors included RRIDs in their in Disease Models & Mechanisms paper! Thanks for making your methods matter! #reproducibility #ReproducibleResearch #methodsmatter
Unique and overlapping behavioral effects of isoform-specific NRXN1 deletions
Read the full paper: Unique and overlapping behavioral effects of isoform-specific NRXN1 deletions
doi.org
August 9, 2026 at 7:03 AM
The authors included RRIDs in their in Disease Models & Mechanisms paper! Thanks for making your methods matter! #reproducibility #ReproducibleResearch #methodsmatter
Autism-associated NRXN1α deletion rewires the H3K27me3 landscape and epigenetically disrupts human neural induction. https://www.biorxiv.org/content/10.64898/2026.08.03.742563v1
August 4, 2026 at 10:17 AM
Autism-associated NRXN1α deletion rewires the H3K27me3 landscape and epigenetically disrupts human neural induction. https://www.biorxiv.org/content/10.64898/2026.08.03.742563v1
Autism-associated NRXN1α deletion rewires the H3K27me3 landscape and epigenetically disrupts human neural induction. https://www.biorxiv.org/content/10.64898/2026.08.03.742563v1
August 4, 2026 at 10:17 AM
Autism-associated NRXN1α deletion rewires the H3K27me3 landscape and epigenetically disrupts human neural induction. https://www.biorxiv.org/content/10.64898/2026.08.03.742563v1
📃Scientific paper: TNS1 and NRXN1 Genes Interacting With Early-Life Smoking Exposure in Asthma-Plus-Eczema Susceptibility
Ref.: The Korean Academy of Asthma, Allergy and Clinical Immunology; The Korean Academy of Pediatric Allergy and Respiratory Disease, 2023
➡️ Continued on ES/IODE
Ref.: The Korean Academy of Asthma, Allergy and Clinical Immunology; The Korean Academy of Pediatric Allergy and Respiratory Disease, 2023
➡️ Continued on ES/IODE
August 2, 2026 at 5:02 PM
📃Scientific paper: TNS1 and NRXN1 Genes Interacting With Early-Life Smoking Exposure in Asthma-Plus-Eczema Susceptibility
Ref.: The Korean Academy of Asthma, Allergy and Clinical Immunology; The Korean Academy of Pediatric Allergy and Respiratory Disease, 2023
➡️ Continued on ES/IODE
Ref.: The Korean Academy of Asthma, Allergy and Clinical Immunology; The Korean Academy of Pediatric Allergy and Respiratory Disease, 2023
➡️ Continued on ES/IODE
NLGN3 emerges as a key mediator of exercise-driven metabolic benefits and a promising therapeutic target for obesity-associated insulin resistance.
Read here ➡️ doi.org/10.2337/db25-0259
Read here ➡️ doi.org/10.2337/db25-0259
June 18, 2026 at 10:15 PM
NLGN3 emerges as a key mediator of exercise-driven metabolic benefits and a promising therapeutic target for obesity-associated insulin resistance.
Read here ➡️ doi.org/10.2337/db25-0259
Read here ➡️ doi.org/10.2337/db25-0259
This work has now been accepted - Congrats to all involved!
doi.org/10.1242/dmm....
#Neurodevelopment #Genetics #Zebrafish
doi.org/10.1242/dmm....
#Neurodevelopment #Genetics #Zebrafish
June 16, 2026 at 12:13 PM
This work has now been accepted - Congrats to all involved!
doi.org/10.1242/dmm....
#Neurodevelopment #Genetics #Zebrafish
doi.org/10.1242/dmm....
#Neurodevelopment #Genetics #Zebrafish
New research explains how one gene causes many brain disorders
New research explains how one gene causes many brain disorders
Narrative review links NRXN1 genetic variations to schizophrenia, autism, and other neuropsychiatric disorders
vellito.com
May 17, 2026 at 3:30 PM
New research explains how one gene causes many brain disorders
Distinct synaptic mechanisms underlie NRXN1 variant and disorder background-dependent phenotypes in iPSC-derived neurons
Distinct synaptic mechanisms underlie NRXN1 variant and disorder background-dependent phenotypes in iPSC-derived neurons
English et al. demonstrate that NRXN1-deletion iPSC-derived neurons exhibit distinct autism spectrum disorder- and schizophrenia-related synaptic phenotypes in excitatory-inhibitory signaling, revealing disorder-specific impairments in synaptic function and offering mechanistic insight relevant to therapeutic development for NRXN1-associated synaptopathies.
dlvr.it
April 7, 2026 at 7:50 PM
Distinct synaptic mechanisms underlie NRXN1 variant and disorder background-dependent phenotypes in iPSC-derived neurons
A paper using RRID:AB_2534077 from @thermofishersci.bsky.social was just published in Cell Reports. RRIDs improve reproducibility in scientific research. #OpenResearch #STMpublishing #methodsmatter
Distinct synaptic mechanisms underlie NRXN1 variant and disorder background-dependent phenotypes in iPSC-derived neurons
Read the full paper: Distinct synaptic mechanisms underlie NRXN1 variant and disorder background-dependent phenotypes in iPSC-derived neurons
doi.org
March 25, 2026 at 7:02 AM
A paper using RRID:AB_2534077 from @thermofishersci.bsky.social was just published in Cell Reports. RRIDs improve reproducibility in scientific research. #OpenResearch #STMpublishing #methodsmatter
Authors published a paper in Biorxiv, they used MATLAB in the study. Including #RRIDs will make this less ambiguous.
SciScore made a table with this resource, see “Automated Services” module (download as csv, xml or #jats) #OpenScience #RRID
SciScore made a table with this resource, see “Automated Services” module (download as csv, xml or #jats) #OpenScience #RRID
In vivo dissection of human NRXN1 isoforms reveals gain-of-function pathogenicity of schizophrenia-associated 3’ deletions
www.biorxiv.org
March 22, 2026 at 12:00 PM
Authors published a paper in Biorxiv, they used MATLAB in the study. Including #RRIDs will make this less ambiguous.
SciScore made a table with this resource, see “Automated Services” module (download as csv, xml or #jats) #OpenScience #RRID
SciScore made a table with this resource, see “Automated Services” module (download as csv, xml or #jats) #OpenScience #RRID
🚀#R2D2MHEarlyCareerResearchers campaign
Thomas Dinneen, postdoctoral research fellow at @sickkidsto.bsky.social in the group of @louisegallagher.bsky.social, translates findings from the pilot study of families with #NRXN1 deletions into precision medicine.
#HorizonEU #Resilience #RareDisease
Thomas Dinneen, postdoctoral research fellow at @sickkidsto.bsky.social in the group of @louisegallagher.bsky.social, translates findings from the pilot study of families with #NRXN1 deletions into precision medicine.
#HorizonEU #Resilience #RareDisease
March 11, 2026 at 10:03 AM
🚀#R2D2MHEarlyCareerResearchers campaign
Thomas Dinneen, postdoctoral research fellow at @sickkidsto.bsky.social in the group of @louisegallagher.bsky.social, translates findings from the pilot study of families with #NRXN1 deletions into precision medicine.
#HorizonEU #Resilience #RareDisease
Thomas Dinneen, postdoctoral research fellow at @sickkidsto.bsky.social in the group of @louisegallagher.bsky.social, translates findings from the pilot study of families with #NRXN1 deletions into precision medicine.
#HorizonEU #Resilience #RareDisease
New Neurexin and Neuroligin antibodies just joined our Synaptic Cleft Antibody Collection, available through @addgene.bsky.social:
🔹 IPI-NRXN1α
🔹 IPI-NRXN2α
🔹 IPI-NRXN3α
🔹 IPI-NLGN2
🔹 IPI-NLGN3
View more data ➡️ buff.ly/YYL1WWE
🔹 IPI-NRXN1α
🔹 IPI-NRXN2α
🔹 IPI-NRXN3α
🔹 IPI-NLGN2
🔹 IPI-NLGN3
View more data ➡️ buff.ly/YYL1WWE
Synaptic cleft antibody collection
Neuronal communication and neurological function rely on chemical signaling across a narrow extracellular space known as the synaptic cleft. Proteins posi
buff.ly
February 27, 2026 at 5:57 PM
New Neurexin and Neuroligin antibodies just joined our Synaptic Cleft Antibody Collection, available through @addgene.bsky.social:
🔹 IPI-NRXN1α
🔹 IPI-NRXN2α
🔹 IPI-NRXN3α
🔹 IPI-NLGN2
🔹 IPI-NLGN3
View more data ➡️ buff.ly/YYL1WWE
🔹 IPI-NRXN1α
🔹 IPI-NRXN2α
🔹 IPI-NRXN3α
🔹 IPI-NLGN2
🔹 IPI-NLGN3
View more data ➡️ buff.ly/YYL1WWE
Assessing the impact of mono- and bi-allelic deletions in NRXN1 on synaptic function https://www.biorxiv.org/content/10.64898/2026.02.20.707024v1
February 21, 2026 at 10:16 AM
Assessing the impact of mono- and bi-allelic deletions in NRXN1 on synaptic function https://www.biorxiv.org/content/10.64898/2026.02.20.707024v1
Assessing the impact of mono- and bi-allelic deletions in NRXN1 on synaptic function https://www.biorxiv.org/content/10.64898/2026.02.20.707024v1
February 21, 2026 at 10:16 AM
Assessing the impact of mono- and bi-allelic deletions in NRXN1 on synaptic function https://www.biorxiv.org/content/10.64898/2026.02.20.707024v1
New #Neurexin and #Neuroligin antibodies just joined our Synaptic Cleft Antibody Collection today, available through @addgene.bsky.social —
🔹 IPI-NRXN1α
🔹 IPI-NRXN2α
🔹 IPI-NRXN3α
🔹 IPI-NLGN2
🔹 IPI-NLGN3
buff.ly/YYL1WWE
🔹 IPI-NRXN1α
🔹 IPI-NRXN2α
🔹 IPI-NRXN3α
🔹 IPI-NLGN2
🔹 IPI-NLGN3
buff.ly/YYL1WWE
Synaptic cleft antibody collection
Neuronal communication and neurological function rely on chemical signaling across a narrow extracellular space known as the synaptic cleft. Proteins posi
buff.ly
February 20, 2026 at 5:57 PM
New #Neurexin and #Neuroligin antibodies just joined our Synaptic Cleft Antibody Collection today, available through @addgene.bsky.social —
🔹 IPI-NRXN1α
🔹 IPI-NRXN2α
🔹 IPI-NRXN3α
🔹 IPI-NLGN2
🔹 IPI-NLGN3
buff.ly/YYL1WWE
🔹 IPI-NRXN1α
🔹 IPI-NRXN2α
🔹 IPI-NRXN3α
🔹 IPI-NLGN2
🔹 IPI-NLGN3
buff.ly/YYL1WWE