I want to point out this doctor is recommending Tamiflu (oseltamivir), the antiviral used to treat/prevent influenza infection, for treatment of hantavirus.
Tamiflu works by inhibiting the enzyme neuraminidase, which influenza viruses use.
Hantaviruses do not even contain the enzyme neuraminidase.
Tamiflu works by inhibiting the enzyme neuraminidase, which influenza viruses use.
Hantaviruses do not even contain the enzyme neuraminidase.
Hey, guess what! There's nothing to worry about when it comes to Hantavirus because Ivermectin & Hydroxychloroquine can magically cure you just like it did for COVID-19! 🤮
May 4, 2026 at 3:22 PM
I want to point out this doctor is recommending Tamiflu (oseltamivir), the antiviral used to treat/prevent influenza infection, for treatment of hantavirus.
Tamiflu works by inhibiting the enzyme neuraminidase, which influenza viruses use.
Hantaviruses do not even contain the enzyme neuraminidase.
Tamiflu works by inhibiting the enzyme neuraminidase, which influenza viruses use.
Hantaviruses do not even contain the enzyme neuraminidase.
Cool paper from Florian Kramer & colleagues about a novel feature of circulating H5N1 clade 2.3.4.4. These viruses have a longer stalk in their neuraminidase (NA) enzyme, a key viral protein. This was not seen in past H5N1 strains (2002-2019)
Why does it matter?🧪
journals.asm.org/doi/10.1128/...
Why does it matter?🧪
journals.asm.org/doi/10.1128/...
Clade 2.3.4.4b H5N1 neuraminidase has a long stalk, which is in contrast to most highly pathogenic H5N1 viruses circulating between 2002 and 2020 | mBio
While the truncated version of the N1 neuraminidase stalk domain may be associated
with increased virulence in poultry, the long version of the stalk domain has been
associated with increased transmis...
journals.asm.org
March 1, 2025 at 12:40 PM
Cool paper from Florian Kramer & colleagues about a novel feature of circulating H5N1 clade 2.3.4.4. These viruses have a longer stalk in their neuraminidase (NA) enzyme, a key viral protein. This was not seen in past H5N1 strains (2002-2019)
Why does it matter?🧪
journals.asm.org/doi/10.1128/...
Why does it matter?🧪
journals.asm.org/doi/10.1128/...
In the end, #CDC was able to subtype the neuraminidase — the N of this #birdflu virus' name. It is the same #H5N1 that has been spreading in cows.
CDC submitted the genetic sequences of the hemagglutinin & the neuraminidase proteins to GISAID.
CDC submitted the genetic sequences of the hemagglutinin & the neuraminidase proteins to GISAID.
Updated: The contact and the confirmed case became ill the same day, suggesting a possible mutual exposure. Missouri's Dept of Health & Senior Services says serological testing "is being considered."
A health worker experienced mild symptoms, but tested negative for flu. #H5N1 #birdflu
A health worker experienced mild symptoms, but tested negative for flu. #H5N1 #birdflu
The plot thickens: #CDC reveals a close contact of the Missouri #H5 #birdflu case was sick at the same time but wasn't tested. Not clear why that info wasn't shared Thurs during an hour-long press briefing when CDC said Missouri was looking like a "one-off" case. www.statnews.com/2024/09/13/h...
September 14, 2024 at 12:13 AM
developed an innovative approach by creating a vaccine that stimulates immune responses against two key viral proteins- hemagglutinin (H5) AND neuraminidase (N1). Historically, most bird flu vaccines have concentrated primarily on the hemagglutinin protein. However, researchers here explored whether
April 22, 2025 at 4:04 PM
developed an innovative approach by creating a vaccine that stimulates immune responses against two key viral proteins- hemagglutinin (H5) AND neuraminidase (N1). Historically, most bird flu vaccines have concentrated primarily on the hemagglutinin protein. However, researchers here explored whether
✨Congratulations to Florian Krammer who won the Gardner Award #ESCV2025 ! And gave an outstanding lecture on neuraminidase -based broadly protective influenza vaccines
#EuropeanSocietyofClinicalVirology #Thessaloniki
#EuropeanSocietyofClinicalVirology #Thessaloniki
September 17, 2025 at 12:47 PM
✨Congratulations to Florian Krammer who won the Gardner Award #ESCV2025 ! And gave an outstanding lecture on neuraminidase -based broadly protective influenza vaccines
#EuropeanSocietyofClinicalVirology #Thessaloniki
#EuropeanSocietyofClinicalVirology #Thessaloniki
including neuraminidase could enhance vaccine efficacy. In its viral form, H5 acts like a key allowing the virus to enter and attach itself to host cells where it then starts to replicate. Vaccines with small, safe doses of H5 prompt the body to recognize, remember and destroy the problematic
April 22, 2025 at 4:04 PM
including neuraminidase could enhance vaccine efficacy. In its viral form, H5 acts like a key allowing the virus to enter and attach itself to host cells where it then starts to replicate. Vaccines with small, safe doses of H5 prompt the body to recognize, remember and destroy the problematic
Brief but notable observation:
Clade 2.3.4.4b A(H5N1) avian influenza in Canadian poultry has reassorted with a North American lineage virus, acquiring oseltamivir (Tamilflu) resistance. A concerning development in flu evolution. #IDSky 🧪
www.tandfonline.com/doi/full/10....
Clade 2.3.4.4b A(H5N1) avian influenza in Canadian poultry has reassorted with a North American lineage virus, acquiring oseltamivir (Tamilflu) resistance. A concerning development in flu evolution. #IDSky 🧪
www.tandfonline.com/doi/full/10....
Neuraminidase reassortment and oseltamivir resistance in clade 2.3.4.4b A(H5N1) viruses circulating among Canadian poultry, 2024
We report the detection of a clade 2.3.4.4b A(H5N1) reassortant virus with a neuraminidase surface protein derived from a North American lineage low-pathogenic avian influenza virus. This virus cau...
www.tandfonline.com
February 24, 2025 at 10:33 PM
Brief but notable observation:
Clade 2.3.4.4b A(H5N1) avian influenza in Canadian poultry has reassorted with a North American lineage virus, acquiring oseltamivir (Tamilflu) resistance. A concerning development in flu evolution. #IDSky 🧪
www.tandfonline.com/doi/full/10....
Clade 2.3.4.4b A(H5N1) avian influenza in Canadian poultry has reassorted with a North American lineage virus, acquiring oseltamivir (Tamilflu) resistance. A concerning development in flu evolution. #IDSky 🧪
www.tandfonline.com/doi/full/10....
current mRNA COVID-19 vaccines. For influenza, the neuraminidase protein is conserved across many strains of flu, prompting the immune response to multiple strains. The protein hemagglutinin is used to standardize flu vaccines because it is much more abundant on the surface of the virus. However, it
March 13, 2025 at 4:07 PM
current mRNA COVID-19 vaccines. For influenza, the neuraminidase protein is conserved across many strains of flu, prompting the immune response to multiple strains. The protein hemagglutinin is used to standardize flu vaccines because it is much more abundant on the surface of the virus. However, it
Read this commentary from my Vaccine co-EIC Florian Krammer on the need for NA components in next-generation flu vaccines:
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Next-generation seasonal influenza virus vaccines need a neuraminidase component
www.sciencedirect.com
March 10, 2025 at 11:57 AM
Read this commentary from my Vaccine co-EIC Florian Krammer on the need for NA components in next-generation flu vaccines:
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
A. Rasmussen: "H5N9 detection suggests reassortment of circulating H5N1 viruses with avian flu virus that contains the N9 neuraminidase (NA). She added that replication in coinfected hosts can produce unpredictable new reassortment viruses"
www.cidrap.umn.edu/avian-influe...
www.cidrap.umn.edu/avian-influe...
Tests identify H5N9 avian flu at California duck farm
www.cidrap.umn.edu
January 27, 2025 at 9:17 PM
A. Rasmussen: "H5N9 detection suggests reassortment of circulating H5N1 viruses with avian flu virus that contains the N9 neuraminidase (NA). She added that replication in coinfected hosts can produce unpredictable new reassortment viruses"
www.cidrap.umn.edu/avian-influe...
www.cidrap.umn.edu/avian-influe...
here is why systematic surveillance of H5 viruses is crucial, also in wildlife. Circulation of AI viruses in Canada with resistance to oseltamivir, which is one of the few drugs that can be used to prevent and (less well) treat H5N1 www.tandfonline.com/doi/full/10....
Neuraminidase reassortment and oseltamivir resistance in clade 2.3.4.4b A(H5N1) viruses circulating among Canadian poultry, 2024
We report the detection of a clade 2.3.4.4b A(H5N1) reassortant virus with a neuraminidase surface protein derived from a North American lineage low-pathogenic avian influenza virus. This virus cau...
www.tandfonline.com
February 23, 2025 at 9:02 AM
here is why systematic surveillance of H5 viruses is crucial, also in wildlife. Circulation of AI viruses in Canada with resistance to oseltamivir, which is one of the few drugs that can be used to prevent and (less well) treat H5N1 www.tandfonline.com/doi/full/10....
Just published, a study describing a taste-based flu test yes, chewing gum that could tell you if you have influenza. The gum contains a sensor that detects the flu enzyme neuraminidase & releases a compound called thymol that changes taste when the virus is present.
pubs.acs.org/doi/10.1021/...
pubs.acs.org/doi/10.1021/...
A Viral Neuraminidase-Specific Sensor for Taste-Based Detection of Influenza
Influenza has caused the deadliest pandemics in history, thereby prompting advances in our ability to ensure vigilance at all stages of future outbreaks. Quarantining patients early is crucial when it...
pubs.acs.org
October 8, 2025 at 5:29 PM
Just published, a study describing a taste-based flu test yes, chewing gum that could tell you if you have influenza. The gum contains a sensor that detects the flu enzyme neuraminidase & releases a compound called thymol that changes taste when the virus is present.
pubs.acs.org/doi/10.1021/...
pubs.acs.org/doi/10.1021/...
Southern Alberta's 472 confirmed measles cases 'tip of the iceberg,' health official says — 'Almost every single patient that I have swabbed in the ER for suspected measles has tested positive.' www.cbc.ca/news/canada/... @jenleecbc.bsky.social
𝗠𝗼𝗿𝗲 𝗵𝗲𝗮𝗹𝘁𝗵 𝗻𝗲𝘄𝘀 ⇢ CanadaHealthwatch.ca
𝗠𝗼𝗿𝗲 𝗵𝗲𝗮𝗹𝘁𝗵 𝗻𝗲𝘄𝘀 ⇢ CanadaHealthwatch.ca
May 31, 2025 at 2:35 PM
Southern Alberta's 472 confirmed measles cases 'tip of the iceberg,' health official says — 'Almost every single patient that I have swabbed in the ER for suspected measles has tested positive.' www.cbc.ca/news/canada/... @jenleecbc.bsky.social
𝗠𝗼𝗿𝗲 𝗵𝗲𝗮𝗹𝘁𝗵 𝗻𝗲𝘄𝘀 ⇢ CanadaHealthwatch.ca
𝗠𝗼𝗿𝗲 𝗵𝗲𝗮𝗹𝘁𝗵 𝗻𝗲𝘄𝘀 ⇢ CanadaHealthwatch.ca
Flu vaccines work, but they can be improved. If we are going to improve flu vaccines, let’s really improve them to protect as broadly as possible against the flu viruses that we are dealing with now and in the future. I’m on Team Neuraminidase Inclusivity!
March 10, 2025 at 12:43 PM
Flu vaccines work, but they can be improved. If we are going to improve flu vaccines, let’s really improve them to protect as broadly as possible against the flu viruses that we are dealing with now and in the future. I’m on Team Neuraminidase Inclusivity!
Exciting discovery that could help pave the way to a universal flu vaccine. Currently typical flu vax target flu-hemagglutinin (HA) protein as we see a strong immune response but HA is variable meaning annual vax updates. research focused on the less variable neuraminidase (NA) of flu. #immunosky 🧪🧵
April 9, 2025 at 2:59 PM
Exciting discovery that could help pave the way to a universal flu vaccine. Currently typical flu vax target flu-hemagglutinin (HA) protein as we see a strong immune response but HA is variable meaning annual vax updates. research focused on the less variable neuraminidase (NA) of flu. #immunosky 🧪🧵
AFluDiary Blog `Antiviral Research: N70S/Y155H Combined Mutation of Neuraminidase of Avian Influenza #H9N2 Virus confers oseltamivir and zanamivir resistance and pathogenicity to Mice' afludiary.blogspot.com/2026/10/anti...
Antiviral Research: N70S/Y155H Combined Mutation of Neuraminidase of Avian Influenza H9N2 Virus confers oseltamivir and zanamivir resistance and pathogenicity to Mice
Range Of Endemic H9N2 Viruses #19,357 LPAI H9N2 has gained a reputation for spreading uncontrollably in Asian and African poultry, for frequ...
afludiary.blogspot.com
October 3, 2026 at 10:11 AM
AFluDiary Blog `Antiviral Research: N70S/Y155H Combined Mutation of Neuraminidase of Avian Influenza #H9N2 Virus confers oseltamivir and zanamivir resistance and pathogenicity to Mice' afludiary.blogspot.com/2026/10/anti...
Sometimes when I allow my thoughts to wander I get stuck in a ratchet about how we should have listened to Edwin Kilbourne more (note the date):
pmc.ncbi.nlm.nih.gov/articles/PMC...
pmc.ncbi.nlm.nih.gov/articles/PMC...
Protective Effects of Specific Immunity to Viral Neuraminidase on Influenza Virus Infection of Mice
Antibody specific for viral neuraminidase can be demonstrated in mice following (i) pulmonary infection with influenza virus, (ii) immunization with ultraviolet-in-activated influenza virus, (iii) imm...
pmc.ncbi.nlm.nih.gov
December 7, 2024 at 8:20 PM
Sometimes when I allow my thoughts to wander I get stuck in a ratchet about how we should have listened to Edwin Kilbourne more (note the date):
pmc.ncbi.nlm.nih.gov/articles/PMC...
pmc.ncbi.nlm.nih.gov/articles/PMC...
Intra-patient neuraminidase mutations in avian H5N1 influenza virus reduce sialidase activity to complement weaker hemagglutinin binding and facilitate human infection
journals.plos.org/plospathogen...
journals.plos.org/plospathogen...
Intra-patient neuraminidase mutations in avian H5N1 influenza virus reduce sialidase activity to complement weaker hemagglutinin binding and facilitate human infection
Author summary Avian influenza viruses rarely infect humans because they bind poorly to receptors in the human airway. However, clade 2.2 H5N1 has caused an unusually high number of human infections, ...
journals.plos.org
January 24, 2026 at 1:36 PM
Intra-patient neuraminidase mutations in avian H5N1 influenza virus reduce sialidase activity to complement weaker hemagglutinin binding and facilitate human infection
journals.plos.org/plospathogen...
journals.plos.org/plospathogen...
Genetic analysis finds H5N1 in California child most similar to cattle genotype
Sequencing didn't show any mutations that hint at greater infectivity, transmissibility, or resistance to neuraminidase inhibitors.
www.cidrap.umn.edu/a...
Sequencing didn't show any mutations that hint at greater infectivity, transmissibility, or resistance to neuraminidase inhibitors.
www.cidrap.umn.edu/a...
December 10, 2024 at 10:38 PM
Genetic analysis finds H5N1 in California child most similar to cattle genotype
Sequencing didn't show any mutations that hint at greater infectivity, transmissibility, or resistance to neuraminidase inhibitors.
www.cidrap.umn.edu/a...
Sequencing didn't show any mutations that hint at greater infectivity, transmissibility, or resistance to neuraminidase inhibitors.
www.cidrap.umn.edu/a...
Influenza virus is continually changing. Dangerous new strains appear and threaten public health.
Two molecules cover the surface and together control the infectivity of the virus: hemagglutinin and neuraminidase
More at Molecule of the Month:
Two molecules cover the surface and together control the infectivity of the virus: hemagglutinin and neuraminidase
More at Molecule of the Month:
PDB101: Molecule of the Month: Influenza Neuraminidase
Neuraminidase is an important target for influenza drugs
pdb101.rcsb.org
January 12, 2026 at 5:22 PM
Influenza virus is continually changing. Dangerous new strains appear and threaten public health.
Two molecules cover the surface and together control the infectivity of the virus: hemagglutinin and neuraminidase
More at Molecule of the Month:
Two molecules cover the surface and together control the infectivity of the virus: hemagglutinin and neuraminidase
More at Molecule of the Month:
Boy a summer flu sucks of hell. If my posting On Here is increasing deranged, I blame hemagglutinin and neuraminidase.
June 3, 2025 at 11:24 PM
Boy a summer flu sucks of hell. If my posting On Here is increasing deranged, I blame hemagglutinin and neuraminidase.
Also for those who are curious- neuraminidase inhibitors prevent the virus from exiting the cells it infects to go on to infect more cells because the virus gets stuck to the cell’s sugars on the surface with its hemagglutinin protein (the neuraminidase enzyme cleaves them off normally). However…
November 18, 2024 at 5:39 PM
Also for those who are curious- neuraminidase inhibitors prevent the virus from exiting the cells it infects to go on to infect more cells because the virus gets stuck to the cell’s sugars on the surface with its hemagglutinin protein (the neuraminidase enzyme cleaves them off normally). However…
💉 Bientôt des vaccins plus efficaces contre la #grippe ?!
Utiliser davantage d'anticorps ciblant la protéine neuraminidase (le N de H1N1, H3N2, etc) et non l'hémagglutinine (le H) permettrait de gagner en protection contre l'infection et la transmission du virus.
1/3
Utiliser davantage d'anticorps ciblant la protéine neuraminidase (le N de H1N1, H3N2, etc) et non l'hémagglutinine (le H) permettrait de gagner en protection contre l'infection et la transmission du virus.
1/3
December 22, 2025 at 11:35 AM
💉 Bientôt des vaccins plus efficaces contre la #grippe ?!
Utiliser davantage d'anticorps ciblant la protéine neuraminidase (le N de H1N1, H3N2, etc) et non l'hémagglutinine (le H) permettrait de gagner en protection contre l'infection et la transmission du virus.
1/3
Utiliser davantage d'anticorps ciblant la protéine neuraminidase (le N de H1N1, H3N2, etc) et non l'hémagglutinine (le H) permettrait de gagner en protection contre l'infection et la transmission du virus.
1/3
Mark Von Itzstein holds today’s first lecture at #ICS2026 - translational and discovery #glycoscience aspects of research on influenza neuraminidase and parainfluenza haemagglutinin/neuraminidase … despite similarities, different compounds active as inhibitors.
July 8, 2026 at 7:26 AM
Mark Von Itzstein holds today’s first lecture at #ICS2026 - translational and discovery #glycoscience aspects of research on influenza neuraminidase and parainfluenza haemagglutinin/neuraminidase … despite similarities, different compounds active as inhibitors.
They screened B cell responses (antibody ) and found a really good contender in NA representing a promising target for broader protection ie potential for a universal vax = fewer vaccines needed maybe in the future 🤞
Identification of a seasonal influenza vaccine–induced broadly protective neuraminidase antibody | Journal of Experimental Medicine | Rockefeller University Press
Madsen et al. identify a neuraminidase-targeting human monoclonal antibody (mAb-297) induced by seasonal influenza vaccination that broadly protects agains
rupress.org
April 9, 2025 at 2:59 PM
They screened B cell responses (antibody ) and found a really good contender in NA representing a promising target for broader protection ie potential for a universal vax = fewer vaccines needed maybe in the future 🤞