Excellent new review by @claireocallaghan.bsky.social on how noradrenaline drives learning across multiple scales of neurobiological organization - from cells to networks www.cell.com/trends/cogni...
Noradrenaline drives learning across scales of time and neurobiological organisation
The noradrenergic system plays a diverse role in learning, from optimising learning
behaviour to modulating plasticity. Work bridging across micro- and macroscale levels
is revealing how noradrenaline...
www.cell.com
August 29, 2025 at 5:05 AM
Excellent new review by @claireocallaghan.bsky.social on how noradrenaline drives learning across multiple scales of neurobiological organization - from cells to networks www.cell.com/trends/cogni...
When they say it's noradrenaline for dinner:
November 7, 2024 at 4:45 AM
When they say it's noradrenaline for dinner:
Nouvel épisode"Montage de Perfusion". #emimcc
Aujourd’hui c'est : comment je perfuse de la NORADRENALINE.
Pour les moldus, la NORADRENALINE, est un médicament intraveineux qui va mimer l'action de la NORADRENALINE fabriquée par l'organisme, et qui est un puissant vasoconstricteur, pour resserrer
Aujourd’hui c'est : comment je perfuse de la NORADRENALINE.
Pour les moldus, la NORADRENALINE, est un médicament intraveineux qui va mimer l'action de la NORADRENALINE fabriquée par l'organisme, et qui est un puissant vasoconstricteur, pour resserrer
November 21, 2024 at 4:52 PM
Nouvel épisode"Montage de Perfusion". #emimcc
Aujourd’hui c'est : comment je perfuse de la NORADRENALINE.
Pour les moldus, la NORADRENALINE, est un médicament intraveineux qui va mimer l'action de la NORADRENALINE fabriquée par l'organisme, et qui est un puissant vasoconstricteur, pour resserrer
Aujourd’hui c'est : comment je perfuse de la NORADRENALINE.
Pour les moldus, la NORADRENALINE, est un médicament intraveineux qui va mimer l'action de la NORADRENALINE fabriquée par l'organisme, et qui est un puissant vasoconstricteur, pour resserrer
Very pleased to share that our study “Noradrenaline causes a spread of association in the hippocampal cognitive map” is out in @natcomms.nature.com (my final PhD paper, only 3.5 years post PhD! 🙃)
Find the paper here: www.nature.com/articles/s41...
Find the paper here: www.nature.com/articles/s41...
Noradrenaline causes a spread of association in the hippocampal cognitive map - Nature Communications
When forming a cognitive map, a trade-off exists between facilitating novel inferences and storing veridical copies of past experience. Here the authors show that the neuromodulator noradrenaline sets...
www.nature.com
March 20, 2026 at 10:26 AM
Very pleased to share that our study “Noradrenaline causes a spread of association in the hippocampal cognitive map” is out in @natcomms.nature.com (my final PhD paper, only 3.5 years post PhD! 🙃)
Find the paper here: www.nature.com/articles/s41...
Find the paper here: www.nature.com/articles/s41...
Noradrenaline drives learning across scales of time and neurobiological organisation www.cell.com/trends/cogni...
Noradrenaline drives learning across scales of time and neurobiological organisation
The noradrenergic system plays a diverse role in learning, from optimising learning
behaviour to modulating plasticity. Work bridging across micro- and macroscale levels
is revealing how noradrenaline...
www.cell.com
September 1, 2025 at 6:01 PM
Noradrenaline drives learning across scales of time and neurobiological organisation www.cell.com/trends/cogni...
Identification of the galanin-noradrenaline axis as a potential biomarker and therapeutic mechanisms underlying the antidepressant effects of psilocybin
CSF galanin and noradrenaline downregulation by psilocybin therapy in major depressive disorder
Neuropsychopharmacology - CSF galanin and noradrenaline downregulation by psilocybin therapy in major depressive disorder
www.nature.com
September 30, 2026 at 3:31 PM
Identification of the galanin-noradrenaline axis as a potential biomarker and therapeutic mechanisms underlying the antidepressant effects of psilocybin
nora short for noradrenaline
October 25, 2025 at 10:55 AM
nora short for noradrenaline
"The authors found that during deep sleep, a particular brain region released noradrenaline about once every 50 seconds. This made blood vessels in the brain tighten and relax in rhythmic patterns, which pumped CSF into brain tissues."
Really cool science!
Really cool science!
Blood vessels in the brain rhythmically constrict and dilate to drive waves of cleansing fluid through the organ
https://go.nature.com/3PwtwN2
https://go.nature.com/3PwtwN2
How the brain cleans itself during deep sleep
Blood vessels in the brain rhythmically constrict and dilate to drive waves of cleansing fluid through the organ.
go.nature.com
January 13, 2025 at 8:37 PM
"The authors found that during deep sleep, a particular brain region released noradrenaline about once every 50 seconds. This made blood vessels in the brain tighten and relax in rhythmic patterns, which pumped CSF into brain tissues."
Really cool science!
Really cool science!
froggit with noradrenaline 💀
October 23, 2024 at 12:55 PM
froggit with noradrenaline 💀
Adaptive learning is coordinated across behaviour, time and neurobiology (from synapses and dendrites, to astrocytes and the systems level).
If you’ve ever wondered how noradrenaline helps shape these multiscale learning processes, you might like this: www.cell.com/trends/cogni...
If you’ve ever wondered how noradrenaline helps shape these multiscale learning processes, you might like this: www.cell.com/trends/cogni...
August 29, 2025 at 1:35 AM
Adaptive learning is coordinated across behaviour, time and neurobiology (from synapses and dendrites, to astrocytes and the systems level).
If you’ve ever wondered how noradrenaline helps shape these multiscale learning processes, you might like this: www.cell.com/trends/cogni...
If you’ve ever wondered how noradrenaline helps shape these multiscale learning processes, you might like this: www.cell.com/trends/cogni...
rt if you listen to not like us brazilian phonk remix with noradrenaline activated!
October 19, 2024 at 11:29 AM
rt if you listen to not like us brazilian phonk remix with noradrenaline activated!
Happy to share that our paper is now out as a reviewed preprint : elifesciences.org/reviewed-pre...
June 30, 2026 at 5:08 PM
Happy to share that our paper is now out as a reviewed preprint : elifesciences.org/reviewed-pre...
Oh and please don't send me replies like "so why am I always stressed". Cortisol isn't the only stress hormone, dummy! You also have adrenaline, noradrenaline, catechol, vasopressin and dopamine.......... well you don't have that one......
April 10, 2025 at 3:32 PM
Oh and please don't send me replies like "so why am I always stressed". Cortisol isn't the only stress hormone, dummy! You also have adrenaline, noradrenaline, catechol, vasopressin and dopamine.......... well you don't have that one......
Random Fact of the Day:
Waking up suddenly to an alarm can cause a spike in noradrenaline (norepinephrine), a hormone & neurotransmitter associated with the body's fight/flight response. High levels of noradrenaline can interfere w/brain's ability to recall dreams upon waking.
Waking up suddenly to an alarm can cause a spike in noradrenaline (norepinephrine), a hormone & neurotransmitter associated with the body's fight/flight response. High levels of noradrenaline can interfere w/brain's ability to recall dreams upon waking.
July 31, 2024 at 5:04 PM
Random Fact of the Day:
Waking up suddenly to an alarm can cause a spike in noradrenaline (norepinephrine), a hormone & neurotransmitter associated with the body's fight/flight response. High levels of noradrenaline can interfere w/brain's ability to recall dreams upon waking.
Waking up suddenly to an alarm can cause a spike in noradrenaline (norepinephrine), a hormone & neurotransmitter associated with the body's fight/flight response. High levels of noradrenaline can interfere w/brain's ability to recall dreams upon waking.
*** New paper from the lab in Nature Comms !! *** “Noradrenaline causes a spread of association in the hippocampal cognitive map” by the amazing @reneecabbage.bsky.social in collab. w labs of Jill O’Reilly, Will Clarke, and modeling from Prakriti Parthasarathy and @tpvogels.bsky.social, see below!
Very pleased to share that our study “Noradrenaline causes a spread of association in the hippocampal cognitive map” is out in @natcomms.nature.com (my final PhD paper, only 3.5 years post PhD! 🙃)
Find the paper here: www.nature.com/articles/s41...
Find the paper here: www.nature.com/articles/s41...
Noradrenaline causes a spread of association in the hippocampal cognitive map - Nature Communications
When forming a cognitive map, a trade-off exists between facilitating novel inferences and storing veridical copies of past experience. Here the authors show that the neuromodulator noradrenaline sets...
www.nature.com
March 20, 2026 at 12:52 PM
*** New paper from the lab in Nature Comms !! *** “Noradrenaline causes a spread of association in the hippocampal cognitive map” by the amazing @reneecabbage.bsky.social in collab. w labs of Jill O’Reilly, Will Clarke, and modeling from Prakriti Parthasarathy and @tpvogels.bsky.social, see below!
My take on sepsis, circulation management in septic shock, peripheral noradrenaline
#EmergencyMedicine #EM #Sepsis #MedSky #EMedSky #MedEd #EMSky
#EmergencyMedicine #EM #Sepsis #MedSky #EMedSky #MedEd #EMSky
UK EM Field Notes #8
My take on sepsis, circulation management in septic shock, peripheral noradrenaline
open.substack.com
May 21, 2025 at 8:39 AM
Dopamine & noradrenaline: l'impact caché sur votre humeur et votre comportement. Comprenez les déséquilibres pour une meilleure santé mentale. #Neuroscience #SantéMentale #BienÊtre #Dopamine #Noradrénaline
October 5, 2026 at 7:02 AM
Dopamine & noradrenaline: l'impact caché sur votre humeur et votre comportement. Comprenez les déséquilibres pour une meilleure santé mentale. #Neuroscience #SantéMentale #BienÊtre #Dopamine #Noradrénaline
Happy to share the version of record of our locus coeruleus paper here:
www.nature.com/articles/s41...
Prior thread on some of our discoveries in this study:
bsky.app/profile/jere...
www.nature.com/articles/s41...
Prior thread on some of our discoveries in this study:
bsky.app/profile/jere...
September 16, 2026 at 7:22 PM
Happy to share the version of record of our locus coeruleus paper here:
www.nature.com/articles/s41...
Prior thread on some of our discoveries in this study:
bsky.app/profile/jere...
www.nature.com/articles/s41...
Prior thread on some of our discoveries in this study:
bsky.app/profile/jere...
LC influences OFC probablistic learning www.pnas.org/doi/10.1073/...
Orbitofrontal noradrenaline supports adaptive learning-rate adjustment in probabilistic reversal learning | PNAS
Adaptive decision-making in dynamic environments requires flexible adjustment of learning
speed to balance stability and flexibility. When outcomes...
www.pnas.org
July 16, 2026 at 6:16 AM
LC influences OFC probablistic learning www.pnas.org/doi/10.1073/...
One of my strong pet peeves: never start vasopressin based on a fixed cutoff for noradrenaline and never without an echo. I strongly oppose the algorithm proposed here #emimcc #cccsky
Mastering vasopressin in septic shock, pragmatic bedside guidance on its optimal use, emphasizing real-world constraints & evidence gaps:
💉 clinical pharmacology
⚖️ dosing
⏱️ timing
🩺 practical considerations
#FOAMcc @intenscaremed.bsky.social
🔓 rdcu.be/ePAno
💉 clinical pharmacology
⚖️ dosing
⏱️ timing
🩺 practical considerations
#FOAMcc @intenscaremed.bsky.social
🔓 rdcu.be/ePAno
November 13, 2025 at 8:25 AM
Sometimes you have to give noradrenaline in a hurry!
Here are the working party recommendations for administering peripheral noradrenaline.
#AnSky #MedSky
doi.org/10.1111/anae...
Here are the working party recommendations for administering peripheral noradrenaline.
#AnSky #MedSky
doi.org/10.1111/anae...
September 18, 2025 at 3:02 PM
Sometimes you have to give noradrenaline in a hurry!
Here are the working party recommendations for administering peripheral noradrenaline.
#AnSky #MedSky
doi.org/10.1111/anae...
Here are the working party recommendations for administering peripheral noradrenaline.
#AnSky #MedSky
doi.org/10.1111/anae...
Excessive increase in HR, terribly hyperdynamic LV with LVOTO? Vasopressin is wise.
Increased noradrenaline to 0,25cg/kg/h but no change in HR, no clinical signs of vasoconstriction. Why not just try more noradrenaline, check validity of BP, correct acidosis etc.
Increased noradrenaline to 0,25cg/kg/h but no change in HR, no clinical signs of vasoconstriction. Why not just try more noradrenaline, check validity of BP, correct acidosis etc.
March 20, 2025 at 6:43 PM
Excessive increase in HR, terribly hyperdynamic LV with LVOTO? Vasopressin is wise.
Increased noradrenaline to 0,25cg/kg/h but no change in HR, no clinical signs of vasoconstriction. Why not just try more noradrenaline, check validity of BP, correct acidosis etc.
Increased noradrenaline to 0,25cg/kg/h but no change in HR, no clinical signs of vasoconstriction. Why not just try more noradrenaline, check validity of BP, correct acidosis etc.
Saw some people w/ #ADHD wondering why they get anxiety spikes. The brain uses dopamine to make noradrenaline, noradrenaline deficiency can cause anxiety. The best "anxiety" med I've ever been on is Statera, which targets only Noradrenaline, is only approved to treat ADHD, not anxiety.
February 7, 2024 at 1:37 PM
Saw some people w/ #ADHD wondering why they get anxiety spikes. The brain uses dopamine to make noradrenaline, noradrenaline deficiency can cause anxiety. The best "anxiety" med I've ever been on is Statera, which targets only Noradrenaline, is only approved to treat ADHD, not anxiety.
another in the UK. I am not using special Doncaster noradrenaline or co-amoxiclav.
December 14, 2025 at 5:00 PM
another in the UK. I am not using special Doncaster noradrenaline or co-amoxiclav.