NOTCH1 Drives Sexually Dimorphic Immune Responses in Hepatocellular Carcinoma - by Katherine Lindblad1, @amaialujambio.bsky.social and colleagues doi.org/10.1158/2159...
November 20, 2024 at 6:38 PM
NOTCH1 Drives Sexually Dimorphic Immune Responses in Hepatocellular Carcinoma - by Katherine Lindblad1, @amaialujambio.bsky.social and colleagues doi.org/10.1158/2159...
Very excited to share our latest publication on the role of NOTCH1 in sexual dimorphism in liver cancer and published in
Cancer Discovery! Super proud of Katie Lindblad for leading this study as part of her outstanding PhD work.
Cancer Discovery! Super proud of Katie Lindblad for leading this study as part of her outstanding PhD work.
NOTCH1 Drives Sexually Dimorphic Immune Responses in Hepatocellular Carcinoma - by Katherine Lindblad1, @amaialujambio.bsky.social and colleagues doi.org/10.1158/2159...
November 21, 2024 at 5:42 PM
Very excited to share our latest publication on the role of NOTCH1 in sexual dimorphism in liver cancer and published in
Cancer Discovery! Super proud of Katie Lindblad for leading this study as part of her outstanding PhD work.
Cancer Discovery! Super proud of Katie Lindblad for leading this study as part of her outstanding PhD work.
July 21, 2025 at 5:14 PM
New #stemcellreports paper: Effect of Notch1 signaling on muscle engraftment and maturation from pluripotent stem cells. #MyoBlue tinyurl.com/yn7fzafj
Effect of Notch1 signaling on muscle engraftment and maturation from pluripotent stem cells
In this report, Yamashita and colleagues investigate Notch1 signaling in PSC-derived
iPax3 myogenic progenitors during muscle regeneration. Notch1 overexpression enhances
myofiber maturation, while it...
tinyurl.com
February 2, 2025 at 5:06 PM
New #stemcellreports paper: Effect of Notch1 signaling on muscle engraftment and maturation from pluripotent stem cells. #MyoBlue tinyurl.com/yn7fzafj
NOTCH1 S2513 is critical for the regulation of NICD levels impacting the segmentation clock in hiPSC-derived PSM cells and somitoids https://www.biorxiv.org/content/10.1101/2024.12.10.627712v1
December 16, 2024 at 5:31 AM
NOTCH1 S2513 is critical for the regulation of NICD levels impacting the segmentation clock in hiPSC-derived PSM cells and somitoids https://www.biorxiv.org/content/10.1101/2024.12.10.627712v1
Bruton tyrosine kinase inhibitors (#BTKis) appeared to offset the adverse prognostic impact of #NOTCH1 mutations in chronic lymphocytic leukemia (#CLL). Study in European Journal of Haematology.
Read more: https://bit.ly/4gTTqam
#RareDisease #Leukemia #Hematology #Oncology #OncSky #RareSky
Read more: https://bit.ly/4gTTqam
#RareDisease #Leukemia #Hematology #Oncology #OncSky #RareSky
BTK Inhibitors Overcome Poor Prognosis of CLL With NOTCH1 Mutations
BTKis neutralized the adverse prognostic effect of NOTCH1 mutations in chronic lymphocytic leukemia (CLL), a study found.
bit.ly
October 6, 2025 at 3:00 PM
Bruton tyrosine kinase inhibitors (#BTKis) appeared to offset the adverse prognostic impact of #NOTCH1 mutations in chronic lymphocytic leukemia (#CLL). Study in European Journal of Haematology.
Read more: https://bit.ly/4gTTqam
#RareDisease #Leukemia #Hematology #Oncology #OncSky #RareSky
Read more: https://bit.ly/4gTTqam
#RareDisease #Leukemia #Hematology #Oncology #OncSky #RareSky
Another beautiful paper by @craigedbrown.bsky.social's team, gosh these folks are productive! www.cell.com/cell-reports... #angiogenesis
Angiogenesis in the mature mouse cortex is governed in a regional- and Notch1-dependent manner
The angiogenic capacity of the mature healthy brain and its underlying mechanisms
are unclear. Raudales et al. show that rates of cerebral angiogenesis follow regional
gradients and are regulated by e...
www.cell.com
November 28, 2024 at 10:27 PM
Another beautiful paper by @craigedbrown.bsky.social's team, gosh these folks are productive! www.cell.com/cell-reports... #angiogenesis
Which amino acid is most required for T cell leukemia?
Did you guess...histidine?
excited to see this out, congrats to Komal and @herranzlab.bsky.social and coauthors!
www.biorxiv.org/content/10.6...
Did you guess...histidine?
excited to see this out, congrats to Komal and @herranzlab.bsky.social and coauthors!
www.biorxiv.org/content/10.6...
A dietary pan-amino acid dropout screen in vivo reveals a critical role for histidine in T-ALL
Dietary interventions show therapeutic potential in cancer, but systematic comparisons are lacking. We performed a dietary pan-amino acid dropout screen in an orthotopic model of NOTCH1-driven T-cell ...
www.biorxiv.org
December 31, 2025 at 6:38 PM
Which amino acid is most required for T cell leukemia?
Did you guess...histidine?
excited to see this out, congrats to Komal and @herranzlab.bsky.social and coauthors!
www.biorxiv.org/content/10.6...
Did you guess...histidine?
excited to see this out, congrats to Komal and @herranzlab.bsky.social and coauthors!
www.biorxiv.org/content/10.6...
Congrats to the team! Here we directly image and quantify cerebral #angiogenesis and pruning in vivo. Found interesting regional differences and dependence on #notch signalling. Where you look does matter!
www.cell.com/cell-reports...
www.cell.com/cell-reports...
Angiogenesis in the mature mouse cortex is governed in a regional- and Notch1-dependent manner
The angiogenic capacity of the mature healthy brain and its underlying mechanisms
are unclear. Raudales et al. show that rates of cerebral angiogenesis follow regional
gradients and are regulated by e...
www.cell.com
November 28, 2024 at 10:12 PM
Congrats to the team! Here we directly image and quantify cerebral #angiogenesis and pruning in vivo. Found interesting regional differences and dependence on #notch signalling. Where you look does matter!
www.cell.com/cell-reports...
www.cell.com/cell-reports...
NOTCH1 mutations may influence immunotherapy outcomes in advanced esophageal cancer.
In RATIONALE-302, patients with NOTCH1 mutations saw improved OS with tislelizumab vs chemo.
Full summary via
@ASCOPost
: ascopost.com/news/april-2...
#OncologyResearch #ASCO25
In RATIONALE-302, patients with NOTCH1 mutations saw improved OS with tislelizumab vs chemo.
Full summary via
@ASCOPost
: ascopost.com/news/april-2...
#OncologyResearch #ASCO25
Advanced Esophageal Cancer: <em>NOTCH1</em> Mutation and Efficacy of Tislelizumab
“Although multiple agents targeting PD-1 have been approved as second-line treatment for esophageal squamous cell carcinoma, only a fraction of patients derive long-term survival. Hence, reliable pred...
ascopost.com
April 18, 2025 at 4:30 PM
NOTCH1 mutations may influence immunotherapy outcomes in advanced esophageal cancer.
In RATIONALE-302, patients with NOTCH1 mutations saw improved OS with tislelizumab vs chemo.
Full summary via
@ASCOPost
: ascopost.com/news/april-2...
#OncologyResearch #ASCO25
In RATIONALE-302, patients with NOTCH1 mutations saw improved OS with tislelizumab vs chemo.
Full summary via
@ASCOPost
: ascopost.com/news/april-2...
#OncologyResearch #ASCO25
Tight control
of Notch1 intracellular domain (NICD) stability to tune devel-
opmental timing in the context of human somitogenesis.
Original paper: genesdev.cshlp.org/content/gene...
of Notch1 intracellular domain (NICD) stability to tune devel-
opmental timing in the context of human somitogenesis.
Original paper: genesdev.cshlp.org/content/gene...
July 18, 2025 at 7:19 PM
Tight control
of Notch1 intracellular domain (NICD) stability to tune devel-
opmental timing in the context of human somitogenesis.
Original paper: genesdev.cshlp.org/content/gene...
of Notch1 intracellular domain (NICD) stability to tune devel-
opmental timing in the context of human somitogenesis.
Original paper: genesdev.cshlp.org/content/gene...
#Sepsis
DLL4+ Neutrophil induces PANoptosis of Septic 🫁 Notch1+ Endothelial Cell in CLP🐭
DLL4+ Neutrophil ⏫by extracellular cold-inducible RNA-binding protein
PANoptosis is a ZBP1-induced integrated death mode (cleaved GSDMD+, cleaved caspase 3+, pMLKL+)
#JCI 2025
www.jci.org/articles/vie...
DLL4+ Neutrophil induces PANoptosis of Septic 🫁 Notch1+ Endothelial Cell in CLP🐭
DLL4+ Neutrophil ⏫by extracellular cold-inducible RNA-binding protein
PANoptosis is a ZBP1-induced integrated death mode (cleaved GSDMD+, cleaved caspase 3+, pMLKL+)
#JCI 2025
www.jci.org/articles/vie...
March 13, 2026 at 12:15 PM
#Sepsis
DLL4+ Neutrophil induces PANoptosis of Septic 🫁 Notch1+ Endothelial Cell in CLP🐭
DLL4+ Neutrophil ⏫by extracellular cold-inducible RNA-binding protein
PANoptosis is a ZBP1-induced integrated death mode (cleaved GSDMD+, cleaved caspase 3+, pMLKL+)
#JCI 2025
www.jci.org/articles/vie...
DLL4+ Neutrophil induces PANoptosis of Septic 🫁 Notch1+ Endothelial Cell in CLP🐭
DLL4+ Neutrophil ⏫by extracellular cold-inducible RNA-binding protein
PANoptosis is a ZBP1-induced integrated death mode (cleaved GSDMD+, cleaved caspase 3+, pMLKL+)
#JCI 2025
www.jci.org/articles/vie...
"PKC induces Has2-dependent HA synthesis, which maintains ADAM10 protein levels required for Notch1 cleavage via CD44 signaling"
Protein Kinase C Promotes Notch1 Cleavage Through Both Ligand-Dependent and Hyaluronic Acid–ADAM10-Dependent Mechanisms
Protein Kinase C Promotes Notch1 Cleavage Through Both Ligand-Dependent and Hyaluronic Acid–ADAM10-Dependent Mechanisms
www.mdpi.com
August 1, 2026 at 8:22 PM
"PKC induces Has2-dependent HA synthesis, which maintains ADAM10 protein levels required for Notch1 cleavage via CD44 signaling"
Protein Kinase C Promotes Notch1 Cleavage Through Both Ligand-Dependent and Hyaluronic Acid–ADAM10-Dependent Mechanisms
Protein Kinase C Promotes Notch1 Cleavage Through Both Ligand-Dependent and Hyaluronic Acid–ADAM10-Dependent Mechanisms
Thanks Jeff. Adult MG express low-moderate levels of both Notch1 and Notch2, and barely detectable levels of Notch3/4. Notch1/2 double KO phenocopies the Rbpj mutant, implying that these are the relevant isoforms.
April 29, 2025 at 11:36 PM
Thanks Jeff. Adult MG express low-moderate levels of both Notch1 and Notch2, and barely detectable levels of Notch3/4. Notch1/2 double KO phenocopies the Rbpj mutant, implying that these are the relevant isoforms.
increase in macrophage-tumor cell NF-kB/ Notch1 signaling, which results in MenaINV induction. Blocking the Notch pathway during paclitaxel treatment stops this effect.
February 1, 2025 at 5:22 PM
increase in macrophage-tumor cell NF-kB/ Notch1 signaling, which results in MenaINV induction. Blocking the Notch pathway during paclitaxel treatment stops this effect.
Studies of T cell acute lymphoblastic leukemia reveal that canagliflozin possesses potent anti-leukaemic effects underpinned by proliferative defects, cell cycle disruption and apoptosis, actions synergized by restriction of serine and glycine www.sciencedirect.com/science/arti...
Canagliflozin synergises with serine restriction mediating anti-leukaemic effects in T-cell acute lymphoblastic leukaemia
T-cell acute lymphoblastic leukaemia (T-ALL) is a haematological malignancy commonly driven by NOTCH1 activating mutations. A concomitant feature asso…
www.sciencedirect.com
October 20, 2025 at 7:40 PM
Studies of T cell acute lymphoblastic leukemia reveal that canagliflozin possesses potent anti-leukaemic effects underpinned by proliferative defects, cell cycle disruption and apoptosis, actions synergized by restriction of serine and glycine www.sciencedirect.com/science/arti...
Traumatic brain injury has a lasting impact on hippocampal neurogenesis and Notch1 is involved in regulating this injury response https://www.biorxiv.org/content/10.64898/2026.02.03.703567v1
February 6, 2026 at 4:15 AM
Traumatic brain injury has a lasting impact on hippocampal neurogenesis and Notch1 is involved in regulating this injury response https://www.biorxiv.org/content/10.64898/2026.02.03.703567v1
Breast cancer stem cells mediated CD8+ T cell exhaustion among different molecular subtypes of breast cancer regulated via NOTCH1/RBPJ/PD-L1 axis https://www.biorxiv.org/content/10.64898/2026.05.22.727059v1
May 26, 2026 at 4:50 PM
Breast cancer stem cells mediated CD8+ T cell exhaustion among different molecular subtypes of breast cancer regulated via NOTCH1/RBPJ/PD-L1 axis https://www.biorxiv.org/content/10.64898/2026.05.22.727059v1
Notch1 activation in basal cells triggers a progressive basal-to-luminal cell-fate switch in the mouse mammary gland but also in adult cells of the lacrimal, salivary and prostatic glands
Silvia Fre and coworkers @frelab.bsky.social @institutcurie.bsky.social
www.embopress.org/doi/full/10....
Silvia Fre and coworkers @frelab.bsky.social @institutcurie.bsky.social
www.embopress.org/doi/full/10....
April 7, 2025 at 11:05 AM
Notch1 activation in basal cells triggers a progressive basal-to-luminal cell-fate switch in the mouse mammary gland but also in adult cells of the lacrimal, salivary and prostatic glands
Silvia Fre and coworkers @frelab.bsky.social @institutcurie.bsky.social
www.embopress.org/doi/full/10....
Silvia Fre and coworkers @frelab.bsky.social @institutcurie.bsky.social
www.embopress.org/doi/full/10....
The Notch1 intracellular domain orchestrates mechanotransduction of fluid shear stress https://www.biorxiv.org/content/10.1101/2025.07.13.663563v1
July 14, 2025 at 1:31 PM
The Notch1 intracellular domain orchestrates mechanotransduction of fluid shear stress https://www.biorxiv.org/content/10.1101/2025.07.13.663563v1
Really pleased to share the labs first publication in paediatric T-cell leukaemia. We find that the type 2 diabetes drug canagliflozin possesses anti-leukaemic effects that can be enhanced via dietary restriction of serine.
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Canagliflozin synergises with serine restriction mediating anti-leukaemic effects in T-cell acute lymphoblastic leukaemia
T-cell acute lymphoblastic leukaemia (T-ALL) is a haematological malignancy commonly driven by NOTCH1 activating mutations. A concomitant feature asso…
www.sciencedirect.com
October 21, 2025 at 9:37 AM
Really pleased to share the labs first publication in paediatric T-cell leukaemia. We find that the type 2 diabetes drug canagliflozin possesses anti-leukaemic effects that can be enhanced via dietary restriction of serine.
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
🚨 📣 NEW PAPER ALERT 🚨📣
Probably, our most exciting discovery yet!!
We performed the first-ever dietary pan-amino acid dropout screen in cancer in vivo using T-ALL as a model, and surprisingly found histidine as critically needed for T-ALL progression
www.biorxiv.org/content/10.6...
Probably, our most exciting discovery yet!!
We performed the first-ever dietary pan-amino acid dropout screen in cancer in vivo using T-ALL as a model, and surprisingly found histidine as critically needed for T-ALL progression
www.biorxiv.org/content/10.6...
A dietary pan-amino acid dropout screen in vivo reveals a critical role for histidine in T-ALL
Dietary interventions show therapeutic potential in cancer, but systematic comparisons are lacking. We performed a dietary pan-amino acid dropout screen in an orthotopic model of NOTCH1-driven T-cell ...
www.biorxiv.org
December 24, 2025 at 2:26 AM
🚨 📣 NEW PAPER ALERT 🚨📣
Probably, our most exciting discovery yet!!
We performed the first-ever dietary pan-amino acid dropout screen in cancer in vivo using T-ALL as a model, and surprisingly found histidine as critically needed for T-ALL progression
www.biorxiv.org/content/10.6...
Probably, our most exciting discovery yet!!
We performed the first-ever dietary pan-amino acid dropout screen in cancer in vivo using T-ALL as a model, and surprisingly found histidine as critically needed for T-ALL progression
www.biorxiv.org/content/10.6...
Endurance training increases a ubiquitylated form of histone H3 in the skeletal muscle, supporting Notch1 upregulation in an MDM2-dependent manner
physoc.onlinelibrary.wiley.com/doi/10.1113/...
physoc.onlinelibrary.wiley.com/doi/10.1113/...
Endurance training increases a ubiquitylated form of histone H3 in the skeletal muscle, supporting Notch1 upregulation in an MDM2‐dependent manner
Abstract figure legend Whether epigenetic silencing histone marks play a role once skeletal muscle adaptations have occurred after endurance training remains unclear. In the Polycomb repressive compl....
physoc.onlinelibrary.wiley.com
September 6, 2025 at 7:14 PM
Endurance training increases a ubiquitylated form of histone H3 in the skeletal muscle, supporting Notch1 upregulation in an MDM2-dependent manner
physoc.onlinelibrary.wiley.com/doi/10.1113/...
physoc.onlinelibrary.wiley.com/doi/10.1113/...
NOTCH1 dimeric signaling drives T-cell leukemia progression and suggests targeting it could improve T-ALL treatment outcomes.
by Tamiro F, Padovano C (...) Giambra V et 12 al. in Blood #MedSky
📖 read the article:
by Tamiro F, Padovano C (...) Giambra V et 12 al. in Blood #MedSky
📖 read the article:
NOTCH1 dimeric signaling is essential for T-cell leukemogenesis and leukemia maintenance
Key Points. In human T-ALL, a NOTCH1 dimers - HES4 axis primes an isoform switch in the TP53 gene favouring the anti-apoptotic Δ133p53 isoform.NOTCH1 dimer
ashpublications.org
March 7, 2025 at 12:51 PM
NOTCH1 dimeric signaling drives T-cell leukemia progression and suggests targeting it could improve T-ALL treatment outcomes.
by Tamiro F, Padovano C (...) Giambra V et 12 al. in Blood #MedSky
📖 read the article:
by Tamiro F, Padovano C (...) Giambra V et 12 al. in Blood #MedSky
📖 read the article:
Excited to share our new study, now out on bioRxiv: www.biorxiv.org/content/10.6...
In this work, we identify CK1α as a novel positive regulator of NOTCH1 signaling and uncover a previously unknown phosphorylation-dependent regulatory mechanism centered on N1ICD residue S1970.
In this work, we identify CK1α as a novel positive regulator of NOTCH1 signaling and uncover a previously unknown phosphorylation-dependent regulatory mechanism centered on N1ICD residue S1970.
LinkedIn
This link will take you to a page that’s not on LinkedIn
lnkd.in
May 7, 2026 at 9:12 AM
Excited to share our new study, now out on bioRxiv: www.biorxiv.org/content/10.6...
In this work, we identify CK1α as a novel positive regulator of NOTCH1 signaling and uncover a previously unknown phosphorylation-dependent regulatory mechanism centered on N1ICD residue S1970.
In this work, we identify CK1α as a novel positive regulator of NOTCH1 signaling and uncover a previously unknown phosphorylation-dependent regulatory mechanism centered on N1ICD residue S1970.