In this manuscript, Sacco, Caputo, and colleagues demonstrate that modulation of the JAK2/STAT3 signaling pathway during in vitro myogenic differentiation promotes expansion of PAX7+ SMPCs in multiple...

The extracellular matrix (ECM) niche regulates skeletal muscle stem cell (MuSC) behavior. Using transcriptomic data and 3D imaging, they show that quiescent MuSCs express unique ECM markers, including...

In this report, Yamashita and colleagues investigate Notch1 signaling in PSC-derived iPax3 myogenic progenitors during muscle regeneration. Notch1 overexpression enhances myofiber maturation, while it...

Ewachiw et al. have provided the field with critical insight into the function of TDP-43 in satellite cells. They bred mice that allowed for the specific and conditional deletion of TDP-43 specificall...

In this article, Yilmaz and colleagues perform a large-scale transcriptomics metaanalysis with over 400 samples comparing established in vitro skeletal muscle models to in vivo skeletal muscle samples...

The role of alternative splicing in adult stem cell activation is poorly understood. Using muscle stem cells (MuSCs) as a model, Cheung et al. revealed rapid and extensive splicing changes during MuSC...

In this article, Barton and colleagues show that FAPs are an important source of IGF-I for skeletal muscle. The loss of FAP IGF-I has autocrine consequences, including blunted proliferation, delayed f...

Jeong et al. establish a high-resolution in vitro fate-map of porcine skeletal muscle formation from embryonic stem cells, uncovering dynamics of the developmental continuum at the single-cell level a...

Un avance que suena a terapia: células del estómago reprogramadas producen insulina en ratones y mejoran la glucosa. Detalles y datos clave. El avance es nítido y de alto calado biomédico: un equipo d...

Golann and colleagues found that predicted loss-of-function variants in the CDH15 gene (encoding M-cadherin) were associated with reduced lean mass. Similarly, CDH15KO mice displayed reduced muscle ma...

Our study elucidated that the mandible's alveolar bone marrow (al-BM) has the highest frequency of immunophenotypic hematopoietic stem cells (HSCs) among nine skeletal sites. HSCs in al-BM exhibited increased engraftment, increased quiescence, and reduced apoptosis. Additionally, al-BM is enriched with mesenchymal stromal and skeletal stem cells, suggesting al-BM’s unique, supportive microenvironment for HSCs.