#OCF_research
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👇Recent #research by Nicolas Girard, Gaëlle Blond and colleagues at Université de Strasbourg @unistra.fr

#Orthogonal tandem catalysis involving Au(i)-hydroacyloxylation and Rh(i)-hydroformylation reactions

#Chemsky #Organic #OCF_research
doi.org/10.1039/D5QO...
Orthogonal tandem catalysis involving Au(I)-hydroacyloxylation and Rh(I)-hydroformylation reactions
We report an orthogonal tandem catalysis (OTC) involving Au(i)-hydroacyloxylation and Rh(i)-hydroformylation highlighting their compatibility when these metals are employed in a reaction of homogeneou...
doi.org
April 8, 2025 at 10:27 AM
orgchemfront.rsc.org
👉Don't miss the research from Subhabrata Sen and co-workers, reported photo induced solvent free gem-diamination to α-amino-α-substituted α-amino esters
#Chemsky #Organic #OCF_research
doi.org/10.1039/D4QO...
Interrupted intramolecular [3 + 2] to 5-endo-dig cyclization: [3 + 2] cycloaddition of nitrile ylides of diazo esters: photo-induced solvent-free gem-diamination to synthesize α-amino-α-substituted α-...
In this work, we transition the blue LED-induced intramolecular [3 + 2] cycloaddition of nitrile ylides, generated from singlet carbenes of diazo esters, towards an intermolecular [3 + 2] cycloadditio...
doi.org
April 9, 2025 at 10:16 AM
orgchemfront.rsc.org
🔓 #OpenAccess research by Markus Tost and Uli Kazmaier from Saarland University

👉Synthesis of oxylipids via a boronic ester cycloetherification approach

#Chemsky #Organic #OCF_research

doi.org/10.1039/D5QO...
Synthesis of oxylipids via a boronic ester cycloetherification approach
Deprotonated trimethylsilylethanol can be used as a nucleophile in Matteson homologations. This O-protection group is stable under the usual reaction conditions of the Matteson reaction, but after two...
doi.org
April 17, 2025 at 11:35 AM
orgchemfront.rsc.org
📢Check out the #research article from Zhipeng Yu's group:
👉Acidic pH-modulated #photoswitching of sulfur-bridged seven-membered cyclic #azopyridines
🧪 #Azoarene #Chemsky #OCF_research

doi.org/10.1039/D5QO...
Acidic pH-modulated photoswitching of sulfur-bridged seven-membered cyclic azopyridines
Azoarene molecular photoswitches with bistability are a family of widely employed structure-tuning units for photopharmacology and smart material construction. Notably, medium-ring azobenzenes, especi...
doi.org
May 14, 2025 at 9:40 AM
orgchemfront.rsc.org
📢Check out the #OpenAccess #research by Bappaditya Gole et al.

👉Unveiling #stereoselective ladders via photo- #oligomerization of a diazaanthracene #macrocycle

#Chemsky #Organic #OCF_research
doi.org/10.1039/D5QO...
Unveiling stereoselective ladders via photo-oligomerization of a diazaanthracene macrocycle
We present an efficient light-driven oligomerization of a flat aromatic tetra-amide macrocycle containing photoresponsive 1,8-diazaanthracenes. Oligomers with molecular weights exceeding 10 kDa were s...
doi.org
April 30, 2025 at 9:49 AM
orgchemfront.rsc.org
👉 #Research from G. K. Surya Prakash et al. presented a high yielding protocol for the synthesis of valuable monofluoromethyl #ketones (MFMK)
@usc.edu 🧪
#Chemsky #Organic #OCF_research
doi.org/10.1039/D5QO...
Monofluoromethylation of acyl chlorides and chloroformates employing fluorobis(phenylsulfonyl)methane. Synthesis of monofluoromethyl ketones via selective zinc-mediated reductive desulfonylation
A high yielding protocol for the synthesis of valuable monofluoromethyl ketones (MFMK) utilizing fluorobis(phenylsulfonyl)methane (FBSM) is presented. The protocol allows the incorporation of the biol...
doi.org
May 20, 2025 at 9:34 AM
orgchemfront.rsc.org
📢Research article by Ryosuke Matsubara et al. form Kobe University

👉Carbazol-3-olate #photosensitizers enable #photocatalytic hydrodefluorination and Birch-type reduction reactions

#Chemsky #Organic #OCF_research
doi.org/10.1039/D5QO...
Carbazol-3-olate photosensitizers enable photocatalytic hydrodefluorination and Birch-type reduction reactions
Despite significant recent advances in the development of organic photosensitizers (PSs), designing a PS with both long-wavelength absorption and high reducing ability remains challenging. In this stu...
doi.org
April 23, 2025 at 11:07 AM
orgchemfront.rsc.org
👉Chemoselective transition-metal-free acylation of thioamides by N–C(S) bond cleavage using acyclic twisted thioamides

by Jin Zhang, Ruihong Wang, Michal Szostak et al. @rutgersuniversity.bsky.social

#Chemsky #Organic #OCF_research

doi.org/10.1039/D4QO...
Chemoselective transition-metal-free acylation of thioamides by N–C(S) bond cleavage using acyclic twisted thioamides
A new method for chemoselective transition-metal-free acylation of thioamides with ketones by N–C(S) bond cleavage is reported. The approach exploits acyclic twisted thioamides to accomplish selective...
doi.org
March 28, 2025 at 12:06 PM
orgchemfront.rsc.org
👉Check out the #research by Weilong Xie et al. from Donghua University

#Copper-catalyzed #radical transnitrilation of arylborons with dimethylmalononitrile and mechanistic insights
🧪 #Organic #catalysis #OCF_research
doi.org/10.1039/D5QO...
Copper-catalyzed radical transnitrilation of arylborons with dimethylmalononitrile and mechanistic insights
Aromatic nitriles hold a prominent position in organic synthesis due to the unique importance of the cyanide moiety and also the diverse transformations of such groups to various functionalities. Trad...
doi.org
May 19, 2025 at 9:24 AM
orgchemfront.rsc.org
🔓#OpenAccess research from Qing-Hua Song et al.

👉Successive energy-transfer catalytic dearomative reactions of quinolines with bicyclo[1.1.0]butanes for the synthesis of pyridine-fused 3D complicated molecules

#Chemsky #Organic #OCF_research
doi.org/10.1039/D5QO...
Successive energy-transfer catalytic dearomative reactions of quinolines with bicyclo[1.1.0]butanes for the synthesis of pyridine-fused 3D complicated molecules
Dearomative photocycloadditions are unique and hard to replace methods for the construction of various polycyclic strained molecules to increase saturation and create three-dimensional (3D) molecular ...
doi.org
March 27, 2025 at 10:03 AM
orgchemfront.rsc.org
#Research by Teruhisa Tsuchimoto and colleagues at Meiji University
Direct Suzuki–Miyaura cross-coupling of C(sp2)–B(dan) bonds: designed in pursuit of usability
🧪 #Chemsky #Organic #OCF_research
doi.org/10.1039/D5QO...
Direct Suzuki–Miyaura cross-coupling of C(sp2)–B(dan) bonds: designed in pursuit of usability
We developed practical reaction conditions and a procedure for the direct Suzuki–Miyaura cross-coupling (SMCC) of C(sp2)–B(dan) bonds. Below are important notes to successfully execute the direct SMCC...
doi.org
May 13, 2025 at 9:47 AM
orgchemfront.rsc.org
👉Don't miss the research by Masahiro Terada et al. from Tohoku University

🔓Pd-catalyzed site-specific heteroaromatic C–H/peri-C–H annulative coupling for synthesis of cyclopenta-fused polycyclic heteroarenes

#Chemsky #OpenAccess #OCF_research

doi.org/10.1039/D5QO...
Pd-catalyzed site-specific heteroaromatic C–H/peri-C–H annulative coupling for synthesis of cyclopenta-fused polycyclic heteroarenes
Cyclopenta-fused polycyclic heteroarenes (CP-PHAs) composed of acenaphthylene and heteroaromatic units have emerged as intriguing photoelectronic materials in view of the electron-accepting feature of...
doi.org
April 11, 2025 at 12:53 PM
orgchemfront.rsc.org
👉Check out the #research reported a simple and mild route for the synthesis of substituted thieno[2,3-b]chromen-4-one derivatives with pendant imine groups

by Abu Taleb Khan et al. from Indian Institute of Technology Guwahati
#Chemsky #Organic #OCF_research
doi.org/10.1039/D5QO...
A regioselective and sustainable approach for the synthesis of substituted thieno[2,3-b]chromen-4-ones with pendant imine groups via a base-promoted multicomponent reaction
A simple and mild route for the synthesis of substituted thieno[2,3-b]chromen-4-one derivatives with pendant imine groups is reported via a one-pot three-component reaction using 4-hydroxythiocoumarin...
doi.org
April 10, 2025 at 1:36 PM
orgchemfront.rsc.org
🔓Don't miss the #OpenAccess research:

👉Design and synthetic utility of new HAT #organocatalysts derived from commercially available diamines
#OCF_research #organic
Read it for free: doi.org/10.1039/D5QO...
Design and synthetic utility of new HAT organocatalysts derived from commercially available diamines
A series of hydrogen-atom transfer (HAT) organocatalysts were conveniently prepared from commercially available diamine compounds, and their utility in photoinduced HAT catalysis ability was investiga...
doi.org
June 18, 2025 at 11:25 AM
orgchemfront.rsc.org
🔥Check out the hot #OCF_research by Liang-Wen Feng, Xiaohua Liu et al.

👉Synergistic catalytic allenylic alkylation for stereodivergent construction of allenes bearing 1,3-axial and central chirality

doi.org/10.1039/D5QO...
Synergistic catalytic allenylic alkylation for stereodivergent construction of allenes bearing 1,3-axial and central chirality
A highly efficient asymmetric allenylic alkylation for the construction of allenes bearing allenyl axial and central chirality through synergistic Ni/Pd catalysis has been developed. This catalytic pr...
doi.org
June 18, 2025 at 11:23 AM
orgchemfront.rsc.org
🔓#OpenAccess research by Rishikesh Narayan et al. from Indian Institute of Technology Goa

👉1,2 Wagner–Meerwein shift in aza-Nazarov cyclization: Bi(iii)-catalyzed substrate-dependent #divergent synthesis of highly substituted #pyrroles and #indenes 🧪
#catalysis #OCF_research
doi.org/10.1039/D5QO...
1,2 Wagner–Meerwein shift in aza-Nazarov cyclization: Bi(III)-catalyzed substrate-dependent divergent synthesis of highly substituted pyrroles and indenes
The Nazarov reaction and its variants such as aza-Nazarov and iso-Nazarov cyclizations are versatile methods for the synthesis of five-membered ring systems including pyrroles and indenes. The 1,2-Wag...
doi.org
June 13, 2025 at 9:14 AM
orgchemfront.rsc.org
#OCF_research by Haijun Zhang et al. from University of Science and Technology of China

👉Modular access to functionalized azetidines via electrophilic azetidinylation

doi.org/10.1039/D5QO...
Modular access to functionalized azetidines via electrophilic azetidinylation
General methods for the rapid and direct incorporation of unconventional ring motifs into core scaffolds are highly sought-after in medicinal chemistry. However, approaches enabling the direct attachm...
doi.org
June 12, 2025 at 9:47 AM
orgchemfront.rsc.org
📢Don't miss the #OpenAccess research by Maurizio Fagnoni et al. at University of Pavia

👉Beyond HAT: harnessing TBADT for photocatalyzed Giese-type C(sp3)–C(sp3) bond formation through reductive #decarboxylation
#Organic #OCF_research
doi.org/10.1039/D5QO...
Beyond HAT: harnessing TBADT for photocatalyzed Giese-type C(sp3)–C(sp3) bond formation through reductive decarboxylation
The decatungstate anion as a tetrabutylammonium salt (TBADT) facilitates a variety of chemical transformations under mild conditions, primarily through hydrogen atom transfer (HAT) and marginally thro...
doi.org
June 9, 2025 at 9:52 AM
orgchemfront.rsc.org
📢Recent #OCF_research from our Editor-in-chief, Prof. Shengming Ma's group!

👉Copper-catalyzed aerobic oxidation of aldehydes to carboxylic acids
#Organic
doi.org/10.1039/D5QO...
Copper-catalyzed aerobic oxidation of aldehydes to carboxylic acids
An efficient, practical aerobic oxidation of aldehydes to carboxylic acids using O2 or air as the oxidant has been developed. The reaction was carried out with a catalytic amount each of Cu(NO3)2·3H2O...
doi.org
June 6, 2025 at 10:32 AM
orgchemfront.rsc.org
👉Conformational preference of N-difluoromethylated amides: contributions of hydrogen-bonding, steric, and stereoelectronic effects🧪

by Ryu Yamasaki et al. from Showa Pharmaceutical University
#OCF_research
doi.org/10.1039/D5QO...
Conformational preference of N-difluoromethylated amides: contributions of hydrogen-bonding, steric, and stereoelectronic effects
Fluorine, possessing the highest electronegativity among all elements, is frequently introduced to modify the structure and properties of compounds. Among fluorine-containing substituents, the difluor...
doi.org
June 5, 2025 at 9:12 AM
orgchemfront.rsc.org
📢Don't miss this #OCF_research from Omar Boutureira et al.

👉meta-Selective #thiofluoroalkylation of substituted #pyridines via Zincke imines

doi.org/10.1039/D5QO...
meta-Selective thiofluoroalkylation of substituted pyridines via Zincke imines
Zincke imines enable the regioselective thiofluoroalkylation of substituted pyridines, providing access to thioalkylated pyridines bearing a range of fluorination patterns. Crucial to the success of t...
doi.org
June 5, 2025 at 9:07 AM
orgchemfront.rsc.org
👉 Be sure to check out the research from Juan Li et al. at Jinan University

📢 Mechanistic insights into Ni–Al co-catalyzed #alkyne carbophosphination enabled by C–P bond activation
#OCF_research #Organic
Mechanistic insights into Ni–Al co-catalyzed alkyne carbophosphination enabled by C–P bond activation
Nickel–aluminum (Ni–Al) bimetallic catalysis has demonstrated remarkable efficiency in C–P bond activation, yet its underlying mechanism remains elusive. Key questions regarding the synergistic roles…
doi.org
June 1, 2025 at 7:00 AM
orgchemfront.rsc.org
👉 Don't miss this #research from Dmytro M. Volochnyuk, Serhiy V. Ryabukhin et al.

#Oxetane as a part of modern #medicinal chemistry toolbox: the advanced synthesis of 3,3-disubstituted building blocks 🧪 #OCF_research #organic

Access the full paper:
Oxetane as a part of modern medicinal chemistry toolbox: the advanced synthesis of 3,3-disubstituted building blocks
Despite numerous potential advantages of oxetanes, their restricted synthetic accessibility and propensity to ring-opening hamper their wide application in drug design. In this work, we disclose our…
doi.org
May 31, 2025 at 7:12 AM
orgchemfront.rsc.org
🔥Hot #research in Organic Chemistry Frontiers:

👉Enantioselective catalytic Urech hydantoin synthesis
#Organic #OCF_research

doi.org/10.1039/D5QO...
Enantioselective catalytic Urech hydantoin synthesis
5,5-Dicarbon-substituted hydantoins are the key skeletons of numerous drugs, but a general method for the enantioselective de novo synthesis of such scaffolds is elusive. On the other hand, Urech hyda...
doi.org
May 26, 2025 at 8:43 AM
orgchemfront.rsc.org
📢Palladium-catalyzed #chemoselective #decarboxylative coupling of alkynyl carboxylic acids with halogenated aryl triflates

#OpenAccess #research by Chau Ming So et al. from the Hong Kong Polytechnic University
#organic #OCF_research
🧪 doi.org/10.1039/D5QO...
Palladium-catalyzed chemoselective decarboxylative coupling of alkynyl carboxylic acids with halogenated aryl triflates
A palladium-catalyzed chemoselective decarboxylative coupling of alkynyl carboxylic acids with halogenated aryl triflates has been developed for the efficient synthesis of OTf-arylalkyne scaffolds. No...
doi.org
May 21, 2025 at 1:07 PM