火点けし頃の蜘蛛踊り PC2
20歳になりたてのジャーナリストくんです かわいい顔してるね
20歳になりたてのジャーナリストくんです かわいい顔してるね
November 3, 2026 at 1:47 PM
火点けし頃の蜘蛛踊り PC2
20歳になりたてのジャーナリストくんです かわいい顔してるね
20歳になりたてのジャーナリストくんです かわいい顔してるね
Unveiling the structural basis of lipid-dependent allosteric gating in PC1-PC2 ion channels, crucial for ADPKD. Discover how PG and PA keep channels closed! PMID:42420301, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-75084-8 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪
Structural basis of lipid-dependent allosteric gating mechanisms for PC1-PC2 ion channel | Nature Communications
The polycystin complex, consisting of one polycystin-1 (PC1) and three polycystin-2 (PC2), forms a cation channel localized to the primary cilium and is critically involved in autosomal dominant polycystic kidney disease (ADPKD). This study reveals an allosteric gating mechanism of the PC1-PC2 channel modulated by specific membrane lipids. In typical membrane environments, phosphatidylglycerol (PG) and phosphatidic acid (PA) bind to the channel central pore, maintaining it in a closed state. Dissociation of these lipids transitions the channel to a pre-open state. The cilia-enriched oxysterol 7β,27-dihydroxycholesterol (7β,27-DHC) stabilizes the channel in a more open but still non-conductive conformation through an allosteric mechanism. Lipid-mediated regulation is coupled to large conformational rearrangements of the TOP and voltage-sensor-like domains (VSDs) of the third PC2 subunit, which eventually leads to pore opening. This lipid-dependent modulation is also obser
doi.org
November 3, 2026 at 2:00 PM
サクリファイスのネガイPC2にきみともPC持ち込むのって法に触れる？
November 1, 2026 at 7:26 PM
サクリファイスのネガイPC2にきみともPC持ち込むのって法に触れる？
✦︎CoC6th
『白百合の殻』
KP
ゴン🥚
PC1 姉
綾 伊千花/せう🦐
PC2 妹
百波 咲来/せっかさん❄️
END-A 両生還にてシナリオエンドﾟ ･*:.｡❁
「一生一緒よ、ね？」
『白百合の殻』
KP
ゴン🥚
PC1 姉
綾 伊千花/せう🦐
PC2 妹
百波 咲来/せっかさん❄️
END-A 両生還にてシナリオエンドﾟ ･*:.｡❁
「一生一緒よ、ね？」
November 3, 2026 at 9:20 AM
✦︎CoC6th
『白百合の殻』
KP
ゴン🥚
PC1 姉
綾 伊千花/せう🦐
PC2 妹
百波 咲来/せっかさん❄️
END-A 両生還にてシナリオエンドﾟ ･*:.｡❁
「一生一緒よ、ね？」
『白百合の殻』
KP
ゴン🥚
PC1 姉
綾 伊千花/せう🦐
PC2 妹
百波 咲来/せっかさん❄️
END-A 両生還にてシナリオエンドﾟ ･*:.｡❁
「一生一緒よ、ね？」
🌼「白百合の殻」🍑
KP／🥚
PC／PL
PC1：綾 伊千花／せうぴ🦐
PC2：百波 咲来／雪花さん❄
ENDAにて。
幸せにおなり～～～～～～！！！！！！
privatter.me/page/6ae9a75...
KP／🥚
PC／PL
PC1：綾 伊千花／せうぴ🦐
PC2：百波 咲来／雪花さん❄
ENDAにて。
幸せにおなり～～～～～～！！！！！！
privatter.me/page/6ae9a75...
白百合の殻
卓報告
privatter.me
November 3, 2026 at 9:24 AM
🌼「白百合の殻」🍑
KP／🥚
PC／PL
PC1：綾 伊千花／せうぴ🦐
PC2：百波 咲来／雪花さん❄
ENDAにて。
幸せにおなり～～～～～～！！！！！！
privatter.me/page/6ae9a75...
KP／🥚
PC／PL
PC1：綾 伊千花／せうぴ🦐
PC2：百波 咲来／雪花さん❄
ENDAにて。
幸せにおなり～～～～～～！！！！！！
privatter.me/page/6ae9a75...
근황
입문탁 PC2와 상호 고정 로이스가 되었습니다
입문탁 PC2와 상호 고정 로이스가 되었습니다
지부장 입문
생각보다 엄청나게 즐기고 잇습니다
저 ㅈㅈ하게 PC2와 서류상으로 가족이 되고 싶음
생각보다 엄청나게 즐기고 잇습니다
저 ㅈㅈ하게 PC2와 서류상으로 가족이 되고 싶음
October 29, 2026 at 11:52 AM
근황
입문탁 PC2와 상호 고정 로이스가 되었습니다
입문탁 PC2와 상호 고정 로이스가 되었습니다
Everyone check this out (good news, this is fucking happening)!
www.tumblr.com/cooperzzz/83...
#123sms #123slaughtermestreet #pillarchase #notmine
www.tumblr.com/cooperzzz/83...
#123sms #123slaughtermestreet #pillarchase #notmine
Post by @cooperzzz · 1 image
💬 0 🔁 4 ❤️ 9 · THE 123 SMS X PC2 COLLAB IS HAPPENING
I REPEAT THE 123 SMS X PC2 COLLAB IS HAPPENING
www.tumblr.com
October 30, 2026 at 2:09 AM
Everyone check this out (good news, this is fucking happening)!
www.tumblr.com/cooperzzz/83...
#123sms #123slaughtermestreet #pillarchase #notmine
www.tumblr.com/cooperzzz/83...
#123sms #123slaughtermestreet #pillarchase #notmine
Drawing Base Creatures daily to help my art motivation.
Day 226: Funny enough, I was grinding the PC2 Halloween event yesterday - Don't worry about Pepper btw, they will get their soul back soon
- Requested by @0ldschool05.bsky.social
#cat #roblox #pillarchase2 #oc #ocart #art #artwork #fanart
Day 226: Funny enough, I was grinding the PC2 Halloween event yesterday - Don't worry about Pepper btw, they will get their soul back soon
- Requested by @0ldschool05.bsky.social
#cat #roblox #pillarchase2 #oc #ocart #art #artwork #fanart
November 2, 2026 at 4:34 AM
Drawing Base Creatures daily to help my art motivation.
Day 226: Funny enough, I was grinding the PC2 Halloween event yesterday - Don't worry about Pepper btw, they will get their soul back soon
- Requested by @0ldschool05.bsky.social
#cat #roblox #pillarchase2 #oc #ocart #art #artwork #fanart
Day 226: Funny enough, I was grinding the PC2 Halloween event yesterday - Don't worry about Pepper btw, they will get their soul back soon
- Requested by @0ldschool05.bsky.social
#cat #roblox #pillarchase2 #oc #ocart #art #artwork #fanart
🔥 Barrette mémoire RAM Samsung 1 Go DDR2 PC2-5300U 667 MHz – M378T2953EZ3-CE6
eBay · 6.52 €
#BonPlan #RAM #Promo
eBay · 6.52 €
#BonPlan #RAM #Promo
Barrette mémoire RAM Samsung 1 Go DDR2 PC2-5300U 667 MHz – M378T2953EZ3-CE6
eBay — 6.52 €
www.ebay.fr
November 3, 2026 at 7:31 AM
CoC 心は焦土
KP：ぱこたん
PC1：一宮 乃愛(ぬのや)
PC2：梔子 晋(拙僧)
▼エンドA 両生還
KP：ぱこたん
PC1：一宮 乃愛(ぬのや)
PC2：梔子 晋(拙僧)
▼エンドA 両生還
November 1, 2026 at 3:16 PM
CoC 心は焦土
KP：ぱこたん
PC1：一宮 乃愛(ぬのや)
PC2：梔子 晋(拙僧)
▼エンドA 両生還
KP：ぱこたん
PC1：一宮 乃愛(ぬのや)
PC2：梔子 晋(拙僧)
▼エンドA 両生還
이번에 나온 25주년 덥트 리플레이 읽어보는데(카타스트로프)
~대충 클래스메이트인 NPC가 PC1의 생일 축하해주는 상황~
PC2: 너 오늘 생일이었음?
PC1: ...
PC2: 뭐야 그는 얼빠진 반응은
PC1: 나한테는 오늘은 누나의 생일이라는 이미지라서
나: 아~ 둘이 쌍둥이구나~
PC1: 한 살 터울의 누나야
나: ?
그니까 생일이 같은데 연년생이라고? 아니 안될 건 없긴 하지만... 어쩌다가...?
~대충 클래스메이트인 NPC가 PC1의 생일 축하해주는 상황~
PC2: 너 오늘 생일이었음?
PC1: ...
PC2: 뭐야 그는 얼빠진 반응은
PC1: 나한테는 오늘은 누나의 생일이라는 이미지라서
나: 아~ 둘이 쌍둥이구나~
PC1: 한 살 터울의 누나야
나: ?
그니까 생일이 같은데 연년생이라고? 아니 안될 건 없긴 하지만... 어쩌다가...?
October 31, 2026 at 10:19 AM
이번에 나온 25주년 덥트 리플레이 읽어보는데(카타스트로프)
~대충 클래스메이트인 NPC가 PC1의 생일 축하해주는 상황~
PC2: 너 오늘 생일이었음?
PC1: ...
PC2: 뭐야 그는 얼빠진 반응은
PC1: 나한테는 오늘은 누나의 생일이라는 이미지라서
나: 아~ 둘이 쌍둥이구나~
PC1: 한 살 터울의 누나야
나: ?
그니까 생일이 같은데 연년생이라고? 아니 안될 건 없긴 하지만... 어쩌다가...?
~대충 클래스메이트인 NPC가 PC1의 생일 축하해주는 상황~
PC2: 너 오늘 생일이었음?
PC1: ...
PC2: 뭐야 그는 얼빠진 반응은
PC1: 나한테는 오늘은 누나의 생일이라는 이미지라서
나: 아~ 둘이 쌍둥이구나~
PC1: 한 살 터울의 누나야
나: ?
그니까 생일이 같은데 연년생이라고? 아니 안될 건 없긴 하지만... 어쩌다가...?
🔥 Barrette Mémoire 1Go RAM DDR2 Kingston KVR800D2N5/1G DIMM PC2-6400U 2Rx8
eBay · 6.25 €
#BonPlan #RAM #Promo
eBay · 6.25 €
#BonPlan #RAM #Promo
Barrette Mémoire 1Go RAM DDR2 Kingston KVR800D2N5/1G DIMM PC2-6400U 2Rx8
eBay — 6.25 €
www.ebay.fr
November 2, 2026 at 12:17 PM
Thankfully both Mario 85 and MX have new owners now
Brutum from PC2 tho is still owned by her
Brutum from PC2 tho is still owned by her
October 31, 2026 at 12:38 AM
Thankfully both Mario 85 and MX have new owners now
Brutum from PC2 tho is still owned by her
Brutum from PC2 tho is still owned by her
🔥 Barrette RAM Samsung 1 Go DDR2 PC2-5300U 667 MHz – HP – M393T2953FHA-CM9
eBay · 6.52 €
#BonPlan #RAM #Promo
eBay · 6.52 €
#BonPlan #RAM #Promo
Barrette RAM Samsung 1 Go DDR2 PC2-5300U 667 MHz – HP – M393T2953FHA-CM9
eBay — 6.52 €
www.ebay.fr
November 3, 2026 at 7:31 AM
Kingston Memoria RAM DDR2 2GB 800Mhz 667MHz PC2-5300 PC2-6400 240 pinos 1,8V modelo de memória de desktop NON ECC
De: R$31,19
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Uma das melhores opções que encontramos hoje ✅
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Uma das melhores opções que encontramos hoje ✅
👉 lupagrupos.com
Kingston Memoria RAM DDR2 2GB 800Mhz 667MHz PC2-5300 PC2-6400 240 pinos 1,8V modelo de memória de desktop NON ECC
AliExpress · R$30,72
linkvaro.com
November 3, 2026 at 6:10 AM
Kingston Memoria RAM DDR2 2GB 800Mhz 667MHz PC2-5300 PC2-6400 240 pinos 1,8V modelo de memória de desktop NON ECC
De: R$31,19
💸Por: R$30,72
🛒 Compre aqui: https://linkvaro.com/0gZh?src=bs
⭐⭐⭐⭐⭐ 4,8
🏪 Vendido por AliExpress
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Uma das melhores opções que encontramos hoje ✅
👉 lupagrupos.com
De: R$31,19
💸Por: R$30,72
🛒 Compre aqui: https://linkvaro.com/0gZh?src=bs
⭐⭐⭐⭐⭐ 4,8
🏪 Vendido por AliExpress
🔥 2% OFF
Uma das melhores opções que encontramos hoje ✅
👉 lupagrupos.com
PCの配線周りを未だに只管弄ってて……？？デスクトップPC2台分と付属の彼是が多過ぎるぜ🙄
October 30, 2026 at 10:53 AM
PCの配線周りを未だに只管弄ってて……？？デスクトップPC2台分と付属の彼是が多過ぎるぜ🙄
🔥 512 Mo DDR2 RAM 200 Broches SO-DIMM 2Rx16 PC2-5300S Samsung M470T6554EZ3-CE6
eBay · 5.90 €
#BonPlan #Promo
eBay · 5.90 €
#BonPlan #Promo
512 Mo DDR2 RAM 200 Broches SO-DIMM 2Rx16 PC2-5300S Samsung M470T6554EZ3-CE6
eBay — 5.90 €
www.ebay.fr
October 31, 2026 at 10:18 PM
🔥 512 Mo DDR2 RAM 200 Broches SO-DIMM 2Rx16 PC2-5300S Samsung M470T6554EZ3-CE6
eBay · 5.90 €
#BonPlan #Promo
eBay · 5.90 €
#BonPlan #Promo
512 Mo DDR2 RAM 200 Broches SO-DIMM 2Rx16 PC2-5300S Samsung M470T6554EZ3-CE6
eBay — 5.90 €
www.ebay.fr
October 31, 2026 at 10:18 PM
🔥 Kingston Mémoire RAM DDR2 2GB 800Mhz 667MHz PC2-5300 PC2-6400 240 Pins 1.8V NO T
eBay · 33.94 €
#BonPlan #RAM #Promo
eBay · 33.94 €
#BonPlan #RAM #Promo
Kingston Mémoire RAM DDR2 2GB 800Mhz 667MHz PC2-5300 PC2-6400 240 Pins 1.8V NO T
eBay — 33.94 €
www.ebay.fr
October 29, 2026 at 8:44 PM
🔥 Kingston Mémoire RAM DDR2 2GB 800Mhz 667MHz PC2-5300 PC2-6400 240 Pins 1.8V NO T
eBay · 33.94 €
#BonPlan #RAM #Promo
eBay · 33.94 €
#BonPlan #RAM #Promo
Kingston Mémoire RAM DDR2 2GB 800Mhz 667MHz PC2-5300 PC2-6400 240 Pins 1.8V NO T
eBay — 33.94 €
www.ebay.fr
October 29, 2026 at 8:44 PM
今気づいたけど私PC2台とVRゴーグル2機あるから、やろうと思えば一人で2人になれるのでは？(尚用途が思いつかない模様)
October 31, 2026 at 8:13 AM
今気づいたけど私PC2台とVRゴーグル2機あるから、やろうと思えば一人で2人になれるのでは？(尚用途が思いつかない模様)
This is Willie.AVI, my heavy retake of Suicide Mouse by Alexander Culafi using Steamboat Willie. My dream for it to be in a game like Pillar Chase 2 or have their own series. Also, it has its own story in the works with the first two chapters done. #RubberhoseTerror #pillarchase #pc2 #pillarchase2
October 30, 2026 at 6:27 PM
This is Willie.AVI, my heavy retake of Suicide Mouse by Alexander Culafi using Steamboat Willie. My dream for it to be in a game like Pillar Chase 2 or have their own series. Also, it has its own story in the works with the first two chapters done. #RubberhoseTerror #pillarchase #pc2 #pillarchase2
職場にお土産買うか悩むな。出張のタイミングが直後も直後なので。着物とPC2台で荷物が多いんだよな〜〜〜〜パンもある
November 2, 2026 at 7:03 AM
職場にお土産買うか悩むな。出張のタイミングが直後も直後なので。着物とPC2台で荷物が多いんだよな〜〜〜〜パンもある
Samsung memoria ram ddr2 4gb 8gb 667mhz 800mhz portátil memória sodimm PC2-5300 6400 ram 200pin 1.8v…
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November 3, 2026 at 4:00 PM
Samsung memoria ram ddr2 4gb 8gb 667mhz 800mhz portátil memória sodimm PC2-5300 6400 ram 200pin 1.8v…
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