Aberrant PCM1 accumulation in Trisomy 21 mislocalizes E3 ligases, delaying primary ciliogenesis https://www.biorxiv.org/content/10.64898/2026.09.14.751618v1
September 17, 2026 at 10:33 AM
Aberrant PCM1 accumulation in Trisomy 21 mislocalizes E3 ligases, delaying primary ciliogenesis https://www.biorxiv.org/content/10.64898/2026.09.14.751618v1
After months of searching, almost within reach... #synth #synthesizer
Roland SO-PCM1- 06 "Baroque" expansion Card for Roland JD /JV 800,880,1080 Rare! | eBay
Roland SO-PCM1- 06 "Baroque" expansion Card for Roland JD /JV 800,880,1080 Rare!. Condition is Used. Shipped with USPS Ground Advantage.
www.ebay.com
February 26, 2025 at 9:58 PM
After months of searching, almost within reach... #synth #synthesizer
Begar et al @cytolabkoc.bsky.social show PCM1 multimerization scaffolds centriolar satellite assembly & drives stepwise client recruitment. Disrupting this homeostasis impairs ciliary signaling & #mitosis. Key insights into how this membraneless organelle forms & remodels rupress.org/jcb/article/...
June 11, 2026 at 4:45 PM
Begar et al @cytolabkoc.bsky.social show PCM1 multimerization scaffolds centriolar satellite assembly & drives stepwise client recruitment. Disrupting this homeostasis impairs ciliary signaling & #mitosis. Key insights into how this membraneless organelle forms & remodels rupress.org/jcb/article/...
Centriolar satellites assemble via a hierarchical pathway driven by PCM1 multimerization. New study from Efe Begar, Elif Nur Firat-Karalar et al. @cytolabkoc.bsky.social (Koç University):
rupress.org/jcb/article/...
#Disease #Organelles #Cytoskeleton #Biochemistry #Centrioles #Cilia #Mitosis
rupress.org/jcb/article/...
#Disease #Organelles #Cytoskeleton #Biochemistry #Centrioles #Cilia #Mitosis
June 18, 2026 at 2:45 PM
Centriolar satellites assemble via a hierarchical pathway driven by PCM1 multimerization. New study from Efe Begar, Elif Nur Firat-Karalar et al. @cytolabkoc.bsky.social (Koç University):
rupress.org/jcb/article/...
#Disease #Organelles #Cytoskeleton #Biochemistry #Centrioles #Cilia #Mitosis
rupress.org/jcb/article/...
#Disease #Organelles #Cytoskeleton #Biochemistry #Centrioles #Cilia #Mitosis
Aggresome assembly & Huntingtin inclusion body formation at Centrosome
Role of centriolar satellites (PCM1 AZI1 CCDC14 KIAA0753 PIBF1) & CP110-CEP97-CEP290 module
Senescent fibroblasts fail to form aggresome, due to low centriolar satellites & CP110
#NatCellBio 2022
www.nature.com/articles/s41...
Role of centriolar satellites (PCM1 AZI1 CCDC14 KIAA0753 PIBF1) & CP110-CEP97-CEP290 module
Senescent fibroblasts fail to form aggresome, due to low centriolar satellites & CP110
#NatCellBio 2022
www.nature.com/articles/s41...
December 15, 2025 at 1:07 PM
Aggresome assembly & Huntingtin inclusion body formation at Centrosome
Role of centriolar satellites (PCM1 AZI1 CCDC14 KIAA0753 PIBF1) & CP110-CEP97-CEP290 module
Senescent fibroblasts fail to form aggresome, due to low centriolar satellites & CP110
#NatCellBio 2022
www.nature.com/articles/s41...
Role of centriolar satellites (PCM1 AZI1 CCDC14 KIAA0753 PIBF1) & CP110-CEP97-CEP290 module
Senescent fibroblasts fail to form aggresome, due to low centriolar satellites & CP110
#NatCellBio 2022
www.nature.com/articles/s41...
Next Efe Begar @cytolabkoc.bsky.social masterfully brought it all together with spatiotemporal organization of #CentriolarSatellites PCM1 scaffold for different client proteins, teasing with how it changes in different cell states & types. Check the preprint- doi.org/10.1101/2025... #UKCilia2026 /2
April 21, 2026 at 5:22 PM
Next Efe Begar @cytolabkoc.bsky.social masterfully brought it all together with spatiotemporal organization of #CentriolarSatellites PCM1 scaffold for different client proteins, teasing with how it changes in different cell states & types. Check the preprint- doi.org/10.1101/2025... #UKCilia2026 /2
THE ORB & DAVID GILMOUR ( FLOYD )
PROG OCT 2010
www.youtube.com/watch?v=PCm1...
@annlizz.bsky.social @oldprogger.bsky.social @progrockers.bsky.social @yoisholow.bsky.social @rinnegatto.bsky.social @martinharris15.bsky.social @railwaysiding77.bsky.social @darkhawk71.bsky.social
PROG OCT 2010
www.youtube.com/watch?v=PCm1...
@annlizz.bsky.social @oldprogger.bsky.social @progrockers.bsky.social @yoisholow.bsky.social @rinnegatto.bsky.social @martinharris15.bsky.social @railwaysiding77.bsky.social @darkhawk71.bsky.social
November 4, 2023 at 6:46 AM
Check out BARI member Su Guo’s @naturecomms paper where they uncover PCM1’s role in regulating daughter cell fate via centrosome-endosome interplay. www.nature.com/articles/s41... #neuroscience
PCM1 coordinates centrosome asymmetry with polarized endosome dynamics to regulate daughter cell fate - Nature Communications
Pcm1 bridges centrosome asymmetry and polarized endosome trafficking to regulate radial glia progenitor fate decisions, balancing self-renewal and differentiation in zebrafish and human cortical organ...
www.nature.com
January 30, 2026 at 6:32 PM
Check out BARI member Su Guo’s @naturecomms paper where they uncover PCM1’s role in regulating daughter cell fate via centrosome-endosome interplay. www.nature.com/articles/s41... #neuroscience
Centriolar satellites assemble via a hierarchical pathway driven by PCM1 multimerization. From Efe Begar, Elif Nur Firat-Karalar and colleagues @cytolabkoc.bsky.social: rupress.org/jcb/article/...
📕 Part of #Centrosomes and #Cilia 2026: rupress.org/jcb/collecti...
📕 Part of #Centrosomes and #Cilia 2026: rupress.org/jcb/collecti...
August 26, 2026 at 3:15 PM
Centriolar satellites assemble via a hierarchical pathway driven by PCM1 multimerization. From Efe Begar, Elif Nur Firat-Karalar and colleagues @cytolabkoc.bsky.social: rupress.org/jcb/article/...
📕 Part of #Centrosomes and #Cilia 2026: rupress.org/jcb/collecti...
📕 Part of #Centrosomes and #Cilia 2026: rupress.org/jcb/collecti...
Satellite view: dissection of PCM1 assembly processes reveals centriolar satellite structures. Ruth Kearney, Anushka Sharma, and Ciaran Morrison @uniofgalway.bsky.social discuss work from Begar et al. @cytolabkoc.bsky.social (doi.org/10.1083/jcb....) in Spotlight: rupress.org/jcb/article/...
#Cilia
#Cilia
July 24, 2026 at 1:45 PM
Satellite view: dissection of PCM1 assembly processes reveals centriolar satellite structures. Ruth Kearney, Anushka Sharma, and Ciaran Morrison @uniofgalway.bsky.social discuss work from Begar et al. @cytolabkoc.bsky.social (doi.org/10.1083/jcb....) in Spotlight: rupress.org/jcb/article/...
#Cilia
#Cilia
Thank you, Irma, I completely agree. Beyond identifying the ciliary kinases, being able to define their specific substrates and phosphorylation sites would be an important next step. This has been especially challenging for DYRKs and large proteins like PCM1.
August 26, 2025 at 6:17 PM
Thank you, Irma, I completely agree. Beyond identifying the ciliary kinases, being able to define their specific substrates and phosphorylation sites would be an important next step. This has been especially challenging for DYRKs and large proteins like PCM1.
If you haven't read/listened to @straczynski.bsky.social's TOGETHER WE WILL GO, this seems to be a great opportunity.
www.youtube.com/watch?v=PcM1...
www.youtube.com/watch?v=PcM1...
Together We Will Go by J. Michael Straczynski | Full Audiobook
YouTube video by Free Audiobook
www.youtube.com
September 5, 2025 at 1:52 PM
If you haven't read/listened to @straczynski.bsky.social's TOGETHER WE WILL GO, this seems to be a great opportunity.
www.youtube.com/watch?v=PcM1...
www.youtube.com/watch?v=PcM1...
1- Satellites assemble via a hierarchical pathway initiated by PCM1 scaffold formation followed by sequential recruitment of other satellite proteins.
2- PCM1 scaffold forms through multimerization and phase separation.
3- Satellite granules have distinct internal subdomains.
2- PCM1 scaffold forms through multimerization and phase separation.
3- Satellite granules have distinct internal subdomains.
July 31, 2025 at 4:59 AM
1- Satellites assemble via a hierarchical pathway initiated by PCM1 scaffold formation followed by sequential recruitment of other satellite proteins.
2- PCM1 scaffold forms through multimerization and phase separation.
3- Satellite granules have distinct internal subdomains.
2- PCM1 scaffold forms through multimerization and phase separation.
3- Satellite granules have distinct internal subdomains.
ドラゴンスピリット ラストボス BGM を PC88 OPNA に移植してみた【移植曲】DRAGON SPIRIT/Zawell/ナムコ/namco/YM2608
youtu.be/nAvbM_UwYh8
2021年に編曲したものはアーケード版と違いドラムにPCMを使っていたので、今回はFM音源のみの移植に拘り再編曲しました。アーケード版はFM音源8音(YM2151/OPM)でBGM、PCM1音でSE(効果音)の構成です。
今回は元BGMのFM音源8音を、FM音源6音+SSG3音に編曲しています。どのパートをSSG(PSG)で演奏しようか、代替できるか考えるのに結構苦労してます。^^;
youtu.be/nAvbM_UwYh8
2021年に編曲したものはアーケード版と違いドラムにPCMを使っていたので、今回はFM音源のみの移植に拘り再編曲しました。アーケード版はFM音源8音(YM2151/OPM)でBGM、PCM1音でSE(効果音)の構成です。
今回は元BGMのFM音源8音を、FM音源6音+SSG3音に編曲しています。どのパートをSSG(PSG)で演奏しようか、代替できるか考えるのに結構苦労してます。^^;
ドラゴンスピリット ラストボス BGM を PC88 OPNA に移植してみた【移植曲】DRAGON SPIRIT/Zawell/ナムコ/namco/YM2608
YouTube video by ぺんぺねっと™🐧ちゃんねる
youtu.be
November 10, 2024 at 5:59 AM
ドラゴンスピリット ラストボス BGM を PC88 OPNA に移植してみた【移植曲】DRAGON SPIRIT/Zawell/ナムコ/namco/YM2608
youtu.be/nAvbM_UwYh8
2021年に編曲したものはアーケード版と違いドラムにPCMを使っていたので、今回はFM音源のみの移植に拘り再編曲しました。アーケード版はFM音源8音(YM2151/OPM)でBGM、PCM1音でSE(効果音)の構成です。
今回は元BGMのFM音源8音を、FM音源6音+SSG3音に編曲しています。どのパートをSSG(PSG)で演奏しようか、代替できるか考えるのに結構苦労してます。^^;
youtu.be/nAvbM_UwYh8
2021年に編曲したものはアーケード版と違いドラムにPCMを使っていたので、今回はFM音源のみの移植に拘り再編曲しました。アーケード版はFM音源8音(YM2151/OPM)でBGM、PCM1音でSE(効果音)の構成です。
今回は元BGMのFM音源8音を、FM音源6音+SSG3音に編曲しています。どのパートをSSG(PSG)で演奏しようか、代替できるか考えるのに結構苦労してます。^^;
3/4 We identify novel substrates like #RPL22, #EIF3D and #PCM1, opening new doors to more functional insights into these #posttranslationalmodifications so far implicated primarily in #microtubule regulation. Their role in #cellbiology seems more than what is thought to be.
June 12, 2026 at 1:50 AM
3/4 We identify novel substrates like #RPL22, #EIF3D and #PCM1, opening new doors to more functional insights into these #posttranslationalmodifications so far implicated primarily in #microtubule regulation. Their role in #cellbiology seems more than what is thought to be.
Ozzfest @ Hyundai Pavilion 2004-07-31 (Black Sabbath, Judas Priest, Slayer, Slipknot, Dimmu Borgir, Superjoint Ritual, Hatebreed, Lamb Of God) https://ijwthstd.blogspot.com/2022/07/ozzfest-hyundai-pavilion-2004-07-31.html
Ozzfest @ Hyundai Pavilion 2004-07-31 (Black Sabbath, Judas Priest, Slayer, Slipknot, Dimmu Borgir, Superjoint Ritual, Hatebreed, Lamb Of God)
all at https://pixeldrain.com/l/QXfRcFPa LAMB OF GOD DEVORE,CA:HYUNDAI PAVILION 7/31/04 DSM6->PACLC->PCM1 DAT DAT -> TASCAM CDRW700->EAC->FL...
ijwthstd.blogspot.com
July 22, 2025 at 11:10 PM
Ozzfest @ Hyundai Pavilion 2004-07-31 (Black Sabbath, Judas Priest, Slayer, Slipknot, Dimmu Borgir, Superjoint Ritual, Hatebreed, Lamb Of God) https://ijwthstd.blogspot.com/2022/07/ozzfest-hyundai-pavilion-2004-07-31.html
Need some Latino metal to jam to? Why not #SaintDiablo?
The lyrics also go really hard.
www.youtube.com/watch?v=pcM1...
The lyrics also go really hard.
www.youtube.com/watch?v=pcM1...
Saint Diablo - Ancient Astronauts (official)
YouTube video by Eclipse Records
www.youtube.com
July 3, 2025 at 11:04 PM
Need some Latino metal to jam to? Why not #SaintDiablo?
The lyrics also go really hard.
www.youtube.com/watch?v=pcM1...
The lyrics also go really hard.
www.youtube.com/watch?v=pcM1...
実は結構音源が豪華でステレオの波形メモリ音源が4つ(内PCM1音として利用可能)なので、
GBの矩形波2音+波形メモリ音源2音+ノイズ(アドバンスにはこれに加えてPCM2音)と比べると豪華なんですよね。余裕の音だ。
GBの矩形波2音+波形メモリ音源2音+ノイズ(アドバンスにはこれに加えてPCM2音)と比べると豪華なんですよね。余裕の音だ。
ワンダースワン版のbeatmaniaが、異常に音が良かったのを思い出す。
November 22, 2024 at 2:33 PM
実は結構音源が豪華でステレオの波形メモリ音源が4つ(内PCM1音として利用可能)なので、
GBの矩形波2音+波形メモリ音源2音+ノイズ(アドバンスにはこれに加えてPCM2音)と比べると豪華なんですよね。余裕の音だ。
GBの矩形波2音+波形メモリ音源2音+ノイズ(アドバンスにはこれに加えてPCM2音)と比べると豪華なんですよね。余裕の音だ。
A paper using RRID:AB_889471 from @thermofishersci.bsky.social was just published. RRIDs improve reproducibility in scientific research. #methodsmatter #OpenScience #OpenScience
PCM1 coordinates centrosome asymmetry with polarized endosome dynamics to regulate daughter cell fate
doi.org
December 3, 2025 at 8:00 AM
A paper using RRID:AB_889471 from @thermofishersci.bsky.social was just published. RRIDs improve reproducibility in scientific research. #methodsmatter #OpenScience #OpenScience
(oui je sais les PCM1, on n'en a qu'un, mais je connais pas les autres os du crâne alors commencez pas à m'emmerder vous aviez qu'à la faire vous-mêmes si vous êtes pas contents !)
February 16, 2026 at 3:17 PM
(oui je sais les PCM1, on n'en a qu'un, mais je connais pas les autres os du crâne alors commencez pas à m'emmerder vous aviez qu'à la faire vous-mêmes si vous êtes pas contents !)
The authors included RRIDs in their None paper! Thanks for making your methods matter! #OpenScience #methodsmatter #RRID
CCHCR1 links P-body proteins to the centrosome and is required for ciliogenesis through interacting with OFD1 and PCM1
doi.org
September 7, 2025 at 7:02 AM
The authors included RRIDs in their None paper! Thanks for making your methods matter! #OpenScience #methodsmatter #RRID
Spotlight: New study by Begar et al. from @cytolabkoc.bsky.social (doi.org/10.1083/jcb....) reveals how PCM1 multimerization drives assembly of centriolar satellites and recruitment of client proteins. Kearney, Sharma, and Morrison highlight the findings: rupress.org/jcb/article/...
#Cilia
#Cilia
July 17, 2026 at 4:02 PM
Spotlight: New study by Begar et al. from @cytolabkoc.bsky.social (doi.org/10.1083/jcb....) reveals how PCM1 multimerization drives assembly of centriolar satellites and recruitment of client proteins. Kearney, Sharma, and Morrison highlight the findings: rupress.org/jcb/article/...
#Cilia
#Cilia
Paracoccidioidomycosis (PCM) is a serious fungal infection endemic to Latin America, mainly striking rural farmworkers. Estrogen protects women from symptomatic disease.
Learn more: https://dub.sh/pcm1
You may be rare, but you're not alone!
#rareDisease #rareDiseaseAwareness
Learn more: https://dub.sh/pcm1
You may be rare, but you're not alone!
#rareDisease #rareDiseaseAwareness
June 12, 2026 at 2:00 PM
Paracoccidioidomycosis (PCM) is a serious fungal infection endemic to Latin America, mainly striking rural farmworkers. Estrogen protects women from symptomatic disease.
Learn more: https://dub.sh/pcm1
You may be rare, but you're not alone!
#rareDisease #rareDiseaseAwareness
Learn more: https://dub.sh/pcm1
You may be rare, but you're not alone!
#rareDisease #rareDiseaseAwareness