The authors included RRIDs in their in Science Advances paper! We value the author's support of reproducibility. #OpenResearch #ReproducibleResearch #methodsmatter
Caspase-2 kills cells with extra centrosomes
Read the full paper: Caspase-2 kills cells with extra centrosomes
doi.org
October 30, 2026 at 7:05 AM
The authors included RRIDs in their in Science Advances paper! We value the author's support of reproducibility. #OpenResearch #ReproducibleResearch #methodsmatter
Francis Barr and coworkers describe a new principle for phosphatase substrate recognition, where disordered regions of phosphatase regulatory subunits mimic kinase-activating subunits, & are themselves differentially regulated by PLK1
@tomogolgier.bsky.social et al
link.springer.com/article/10.1...
@tomogolgier.bsky.social et al
link.springer.com/article/10.1...
Activator mimicry by PP6 regulatory subunits directs Aurora A dephosphorylation in mitosis - The EMBO Journal
Aurora A kinase is a conserved regulator of mitotic spindle assembly whose activity must be precisely balanced to ensure genome stability. Its activation at centrosomes and spindle microtubules is pro...
link.springer.com
October 27, 2026 at 12:48 PM
Francis Barr and coworkers describe a new principle for phosphatase substrate recognition, where disordered regions of phosphatase regulatory subunits mimic kinase-activating subunits, & are themselves differentially regulated by PLK1
@tomogolgier.bsky.social et al
link.springer.com/article/10.1...
@tomogolgier.bsky.social et al
link.springer.com/article/10.1...
"Neurons can grow axons without centrosomes. With them, microtubules rebuild faster, and axons grow straighter and to the right place."
Very pleased to see our preprint @biorxiv-cellbio.bsky.social being picked up by Jeny Jose from the @prelights.bsky.social team @biologists.bsky.social Don’t miss it 👇🏻👇🏻👇🏻
They said flies could develop without centrosomes. The embryos may beg to differ.
Jeny Jose highlights a recent #preprint from Beatriz González & colleagues @araujolabub.bsky.social – post includes an insightful authors’ response
#preLight ⬇️
prelights.biologists.com/highlights/c...
Jeny Jose highlights a recent #preprint from Beatriz González & colleagues @araujolabub.bsky.social – post includes an insightful authors’ response
#preLight ⬇️
prelights.biologists.com/highlights/c...
October 22, 2026 at 10:05 PM
"Neurons can grow axons without centrosomes. With them, microtubules rebuild faster, and axons grow straighter and to the right place."
Our latest work from the Barr lab in @oxfordbiochemistry.bsky.social is now out in @embojournal.org
Activator mimicry by PP6 regulatory subunits directs Aurora A dephosphorylation in mitosis | EMBO Journal
#cellcycle #mitosis
link.springer.com/article/10.1...
Activator mimicry by PP6 regulatory subunits directs Aurora A dephosphorylation in mitosis | EMBO Journal
#cellcycle #mitosis
link.springer.com/article/10.1...
Activator mimicry by PP6 regulatory subunits directs Aurora A dephosphorylation in mitosis - The EMBO Journal
Aurora A kinase is a conserved regulator of mitotic spindle assembly whose activity must be precisely balanced to ensure genome stability. Its activation at centrosomes and spindle microtubules is pro...
link.springer.com
October 22, 2026 at 1:24 PM
Our latest work from the Barr lab in @oxfordbiochemistry.bsky.social is now out in @embojournal.org
Activator mimicry by PP6 regulatory subunits directs Aurora A dephosphorylation in mitosis | EMBO Journal
#cellcycle #mitosis
link.springer.com/article/10.1...
Activator mimicry by PP6 regulatory subunits directs Aurora A dephosphorylation in mitosis | EMBO Journal
#cellcycle #mitosis
link.springer.com/article/10.1...
They said flies could develop without centrosomes. The embryos may beg to differ.
Jeny Jose highlights a recent #preprint from Beatriz González & colleagues @araujolabub.bsky.social – post includes an insightful authors’ response
#preLight ⬇️
prelights.biologists.com/highlights/c...
Jeny Jose highlights a recent #preprint from Beatriz González & colleagues @araujolabub.bsky.social – post includes an insightful authors’ response
#preLight ⬇️
prelights.biologists.com/highlights/c...
Centrosome Loss Alters Axonal and Muscle Development - preLights
They said flies could develop without centrosomes. The embryos may beg to differ.
prelights.biologists.com
October 21, 2026 at 12:13 PM
They said flies could develop without centrosomes. The embryos may beg to differ.
Jeny Jose highlights a recent #preprint from Beatriz González & colleagues @araujolabub.bsky.social – post includes an insightful authors’ response
#preLight ⬇️
prelights.biologists.com/highlights/c...
Jeny Jose highlights a recent #preprint from Beatriz González & colleagues @araujolabub.bsky.social – post includes an insightful authors’ response
#preLight ⬇️
prelights.biologists.com/highlights/c...
Control of Golgi Architecture Through Three Centrosome Cohesion Pathways www.biorxiv.org/content/10.6...
Control of Golgi Architecture Through Three Centrosome Cohesion Pathways
Centrosome cohesion mechanisms link the two interphase centrosomes into a single microtubule-organizing center that is closely associated with the Golgi apparatus. The contribution of cohesion mechani...
www.biorxiv.org
October 18, 2026 at 12:19 AM
Control of Golgi Architecture Through Three Centrosome Cohesion Pathways www.biorxiv.org/content/10.6...
1/4 Following our 2023 ELI-TriScope work (@NatMethods), we’ve focused on the in situ architectures of native centrosomes & basal bodies (BBs).
October 9, 2026 at 3:20 PM
1/4 Following our 2023 ELI-TriScope work (@NatMethods), we’ve focused on the in situ architectures of native centrosomes & basal bodies (BBs).
owo, what's this?
*notices ur centrosomes*
*notices ur centrosomes*
October 8, 2026 at 11:10 PM
owo, what's this?
*notices ur centrosomes*
*notices ur centrosomes*
Had a great time volunteering at #OpenPRBB and sharing our research on centrosomes with the public in Barcelona! 🔬 Thanks to the MBD lab members @monicabettencourt.bsky.social and @seanamontgomery.bsky.social for making the day memorable. Looking forward to next year! @crg.eu #CellBio
October 3, 2026 at 3:44 PM
Had a great time volunteering at #OpenPRBB and sharing our research on centrosomes with the public in Barcelona! 🔬 Thanks to the MBD lab members @monicabettencourt.bsky.social and @seanamontgomery.bsky.social for making the day memorable. Looking forward to next year! @crg.eu #CellBio
From MBoC: What changes inside a cell as a fertilized egg prepares for its first division?
A new Perspective explores the rapid remodeling of spindles, centrosomes, and chromosomes that helps set the stage for embryogenesis.
https://www.molbiolcell.org/doi/10.1091/mbc.E25-10-0484
A new Perspective explores the rapid remodeling of spindles, centrosomes, and chromosomes that helps set the stage for embryogenesis.
https://www.molbiolcell.org/doi/10.1091/mbc.E25-10-0484
October 2, 2026 at 7:50 PM
From MBoC: What changes inside a cell as a fertilized egg prepares for its first division?
A new Perspective explores the rapid remodeling of spindles, centrosomes, and chromosomes that helps set the stage for embryogenesis.
https://www.molbiolcell.org/doi/10.1091/mbc.E25-10-0484
A new Perspective explores the rapid remodeling of spindles, centrosomes, and chromosomes that helps set the stage for embryogenesis.
https://www.molbiolcell.org/doi/10.1091/mbc.E25-10-0484
Blue light activated Aurora A in engineered human cells without centrosomes, restoring spindle assembly and rescuing cell-division defects. doi.org/hckxvz
LISA to the rescue: Using light to fix cell division
Cell division is a complex process. At the heart of this complexity is a membraneless organelle called the centrosome, which is made up of more than 200 components.
phys.org
September 29, 2026 at 9:00 PM
Blue light activated Aurora A in engineered human cells without centrosomes, restoring spindle assembly and rescuing cell-division defects. doi.org/hckxvz
Lack of centrosomes limits the epithelial-to-mesenchymal transition in human mammary cells https://www.biorxiv.org/content/10.64898/2026.09.18.752689v1
September 24, 2026 at 12:30 AM
Lack of centrosomes limits the epithelial-to-mesenchymal transition in human mammary cells https://www.biorxiv.org/content/10.64898/2026.09.18.752689v1
Lack of centrosomes limits the epithelial-to-mesenchymal transition in human mammary cells https://www.biorxiv.org/content/10.64898/2026.09.18.752689v1
September 24, 2026 at 12:30 AM
Lack of centrosomes limits the epithelial-to-mesenchymal transition in human mammary cells https://www.biorxiv.org/content/10.64898/2026.09.18.752689v1
Great start of the 14th meeting on cilia, flagella and centrosomes (CFC2026) in Aussois with exciting talks of Maya Sarieddine, Jérémy Vincent, Amandine Hecquet, Sarah de Freitas and Vincent Gache, with plenty of questions and debates! Looking forward to two more exciting days!
September 21, 2026 at 9:57 PM
Great start of the 14th meeting on cilia, flagella and centrosomes (CFC2026) in Aussois with exciting talks of Maya Sarieddine, Jérémy Vincent, Amandine Hecquet, Sarah de Freitas and Vincent Gache, with plenty of questions and debates! Looking forward to two more exciting days!
Wong, S. S., Monteiro, J. M., Chang, C. C., ...., Saurya, S., Wainman, A., Raff, J. W. (2025). Centrioles generate two scaffolds with distinct biophysical properties to build mitotic centrosomes. Science advances, 11(6):eadq9549 www.science.org/doi/10.1126/...
Centrioles generate two scaffolds with distinct biophysical properties to build mitotic centrosomes
Spd-2 organizes the assembly of two distinct centriole-scaffolds to build mitotic centrosomes in Drosophila.
www.science.org
September 11, 2026 at 1:36 AM
Wong, S. S., Monteiro, J. M., Chang, C. C., ...., Saurya, S., Wainman, A., Raff, J. W. (2025). Centrioles generate two scaffolds with distinct biophysical properties to build mitotic centrosomes. Science advances, 11(6):eadq9549 www.science.org/doi/10.1126/...
Articles in this collection provide insights into the assembly of centriolar satellites as well as centriole and centrosome structures, while exploring mechanisms underlying centrosome maturation, ciliary transport, and organization or ciliogenesis 👉 rupress.org/jcb/collecti...
#cilia #centrosomes
#cilia #centrosomes
August 31, 2026 at 1:15 PM
Articles in this collection provide insights into the assembly of centriolar satellites as well as centriole and centrosome structures, while exploring mechanisms underlying centrosome maturation, ciliary transport, and organization or ciliogenesis 👉 rupress.org/jcb/collecti...
#cilia #centrosomes
#cilia #centrosomes
Breaking: Study finds 6 pathways enabling cell proliferation despite centrosome amplification, may inform cancer research. Key players: Wnt, Hippo, Tpr53, PIDDosome. PMID:42324259, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-74702-9 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪
Sensing centrosome amplification: the interface between centriole duplication and autophagy | Nature Communications
Multipolar mitotic spindles with extra centrosomes, first observed in cancer cells in the late nineteenth century, remain poorly understood. Here, to address how cells overcome proliferation arrest imposed by centrosome amplification, we describe a genome-wide screen revealing that downregulation of the Wnt, Hippo, Tpr53, PIDDosome, ciliary biogenesis, or autophagy pathways enables proliferation of mouse embryonic stem cells having PLK4-mediated centrosome amplification. We select the tumor suppressor, Guanine-nucleotide Activating Protein ARHGAP15, for further study as its depletion activates autophagy, overcomes centrosome amplification, and enables embryonic fibroblast proliferation. Reduction of centrosomes following ARHGAP15 depletion requires autophagy protein, ATG16L1, which associates with ARHGAP15 when the autophagy pathway is inactive. ARHGAP15 is opposed by Guanine-nucleotide Exchange Factor ARHGEF2, which is activated by the centriolar protein CEP170 to generate RAC1-GTP an
doi.org
August 31, 2026 at 1:00 PM
Happy #FluorescenceFriday 🔬 all!
Looking forward to next week's @embo.org Workshop on "Centrosomes: from fundamentals to diseases" in #Lausanne, Switzerland.
Excited to share our latest work on our favorite cells types - mammalian #multiciliated cells 😍
Looking forward to next week's @embo.org Workshop on "Centrosomes: from fundamentals to diseases" in #Lausanne, Switzerland.
Excited to share our latest work on our favorite cells types - mammalian #multiciliated cells 😍
August 28, 2026 at 5:57 PM
Happy #FluorescenceFriday 🔬 all!
Looking forward to next week's @embo.org Workshop on "Centrosomes: from fundamentals to diseases" in #Lausanne, Switzerland.
Excited to share our latest work on our favorite cells types - mammalian #multiciliated cells 😍
Looking forward to next week's @embo.org Workshop on "Centrosomes: from fundamentals to diseases" in #Lausanne, Switzerland.
Excited to share our latest work on our favorite cells types - mammalian #multiciliated cells 😍
Importin-9 and a TPR domain protein MpH drive periodic patterning of ciliary arrays in #Tetrahymena. From Anushi Suwaneththiya Deraniyagala, Wolfgang Maier, Jacek Gaertig and colleagues: rupress.org/jcb/article/...
📕 Part of #Centrosomes and #Cilia 2026: rupress.org/jcb/collecti...
📕 Part of #Centrosomes and #Cilia 2026: rupress.org/jcb/collecti...
August 27, 2026 at 3:15 PM
Importin-9 and a TPR domain protein MpH drive periodic patterning of ciliary arrays in #Tetrahymena. From Anushi Suwaneththiya Deraniyagala, Wolfgang Maier, Jacek Gaertig and colleagues: rupress.org/jcb/article/...
📕 Part of #Centrosomes and #Cilia 2026: rupress.org/jcb/collecti...
📕 Part of #Centrosomes and #Cilia 2026: rupress.org/jcb/collecti...
Centriolar satellites assemble via a hierarchical pathway driven by PCM1 multimerization. From Efe Begar, Elif Nur Firat-Karalar and colleagues @cytolabkoc.bsky.social: rupress.org/jcb/article/...
📕 Part of #Centrosomes and #Cilia 2026: rupress.org/jcb/collecti...
📕 Part of #Centrosomes and #Cilia 2026: rupress.org/jcb/collecti...
August 26, 2026 at 3:15 PM
Centriolar satellites assemble via a hierarchical pathway driven by PCM1 multimerization. From Efe Begar, Elif Nur Firat-Karalar and colleagues @cytolabkoc.bsky.social: rupress.org/jcb/article/...
📕 Part of #Centrosomes and #Cilia 2026: rupress.org/jcb/collecti...
📕 Part of #Centrosomes and #Cilia 2026: rupress.org/jcb/collecti...
An amazing 56th UK Cilia and Centrosome Network e-symposium yesterday! 6 superb talks spanning spanning all things cilia and centrosomes.
Huge thanks to our speakers! 🙌
We break it all down for you here....
#Cilia #CellBiology #Centrosomes #Ciliopathies
www.linkedin.com/pulse/breakd...
Huge thanks to our speakers! 🙌
We break it all down for you here....
#Cilia #CellBiology #Centrosomes #Ciliopathies
www.linkedin.com/pulse/breakd...
Breakdown of our 56th UK Cilia and Centrosome Network e-symposium (25/08/2026)
🧬 What a sensational 56th e-symposium! Yesterday, we spanned the shrinking divide between motile and sensory ciliopathies, and highlighted the extreme diversity of cilia function, structure and scales...
www.linkedin.com
August 26, 2026 at 11:54 AM
An amazing 56th UK Cilia and Centrosome Network e-symposium yesterday! 6 superb talks spanning spanning all things cilia and centrosomes.
Huge thanks to our speakers! 🙌
We break it all down for you here....
#Cilia #CellBiology #Centrosomes #Ciliopathies
www.linkedin.com/pulse/breakd...
Huge thanks to our speakers! 🙌
We break it all down for you here....
#Cilia #CellBiology #Centrosomes #Ciliopathies
www.linkedin.com/pulse/breakd...
In this review, Saishree S. Iyer and Anna Akhmanova discuss the mechanisms controlling plus-end elongation of centriolar and ciliary #microtubules, revealing shared principles. rupress.org/jcb/article/...
📕 Part of #Centrosomes and #Cilia 2026: rupress.org/jcb/collecti...
📕 Part of #Centrosomes and #Cilia 2026: rupress.org/jcb/collecti...
August 25, 2026 at 3:15 PM
In this review, Saishree S. Iyer and Anna Akhmanova discuss the mechanisms controlling plus-end elongation of centriolar and ciliary #microtubules, revealing shared principles. rupress.org/jcb/article/...
📕 Part of #Centrosomes and #Cilia 2026: rupress.org/jcb/collecti...
📕 Part of #Centrosomes and #Cilia 2026: rupress.org/jcb/collecti...
An inducible multiciliated cell line resolves proteome dynamics and identifies CDK7 as a conserved regulator. From Camille Boutin @camboutin.bsky.social, Laurent Kodjabachian and colleagues: rupress.org/jcb/article/...
📕 Part of #Centrosomes and #Cilia 2026: rupress.org/jcb/collecti...
📕 Part of #Centrosomes and #Cilia 2026: rupress.org/jcb/collecti...
August 24, 2026 at 3:16 PM
An inducible multiciliated cell line resolves proteome dynamics and identifies CDK7 as a conserved regulator. From Camille Boutin @camboutin.bsky.social, Laurent Kodjabachian and colleagues: rupress.org/jcb/article/...
📕 Part of #Centrosomes and #Cilia 2026: rupress.org/jcb/collecti...
📕 Part of #Centrosomes and #Cilia 2026: rupress.org/jcb/collecti...
An example of interesting possibilities in Health opening up with AI...
"Centrosomes act as the cell's organising hubs. They help cells divide correctly and maintain their structure..."
#SDG3 #Health & #Wellbeing #AI
research.uhs.nhs.uk/news/ai-reve...
"Centrosomes act as the cell's organising hubs. They help cells divide correctly and maintain their structure..."
#SDG3 #Health & #Wellbeing #AI
research.uhs.nhs.uk/news/ai-reve...
CenSegNet is an open-source AI platform created by researchers at the University of Southampton. It can analyse hundreds of thousands of cells in tumour samples with unprecedented speed and precision.
research.uhs.nhs.uk
August 24, 2026 at 11:34 AM
An example of interesting possibilities in Health opening up with AI...
"Centrosomes act as the cell's organising hubs. They help cells divide correctly and maintain their structure..."
#SDG3 #Health & #Wellbeing #AI
research.uhs.nhs.uk/news/ai-reve...
"Centrosomes act as the cell's organising hubs. They help cells divide correctly and maintain their structure..."
#SDG3 #Health & #Wellbeing #AI
research.uhs.nhs.uk/news/ai-reve...
🎉 Our open-access Autophagy Punctum is out!
We discuss how centrosome amplification engages a CEP170–ARHGEF2–RAC1–ATG16L1 pathway to promote autophagy, with ARHGAP15 as a negative regulator.
www.tandfonline.com/action/showA...
#Autophagy #Centrosomes
We discuss how centrosome amplification engages a CEP170–ARHGEF2–RAC1–ATG16L1 pathway to promote autophagy, with ARHGAP15 as a negative regulator.
www.tandfonline.com/action/showA...
#Autophagy #Centrosomes
August 24, 2026 at 12:49 AM
🎉 Our open-access Autophagy Punctum is out!
We discuss how centrosome amplification engages a CEP170–ARHGEF2–RAC1–ATG16L1 pathway to promote autophagy, with ARHGAP15 as a negative regulator.
www.tandfonline.com/action/showA...
#Autophagy #Centrosomes
We discuss how centrosome amplification engages a CEP170–ARHGEF2–RAC1–ATG16L1 pathway to promote autophagy, with ARHGAP15 as a negative regulator.
www.tandfonline.com/action/showA...
#Autophagy #Centrosomes