How do primordial germ cells (PGCs) migrate across a developing embryo?
#LMBResearch from Katharine Goodwin and Kate McDole (@cellbiol-mrclmb.bsky.social) uncovers the mechanisms PGCs use in mouse embryos to navigate this long and surprisingly risky journey.
Read more: mrclmb.ac.uk/news-events/...
#LMBResearch from Katharine Goodwin and Kate McDole (@cellbiol-mrclmb.bsky.social) uncovers the mechanisms PGCs use in mouse embryos to navigate this long and surprisingly risky journey.
Read more: mrclmb.ac.uk/news-events/...
March 18, 2026 at 6:14 PM
How do primordial germ cells (PGCs) migrate across a developing embryo?
#LMBResearch from Katharine Goodwin and Kate McDole (@cellbiol-mrclmb.bsky.social) uncovers the mechanisms PGCs use in mouse embryos to navigate this long and surprisingly risky journey.
Read more: mrclmb.ac.uk/news-events/...
#LMBResearch from Katharine Goodwin and Kate McDole (@cellbiol-mrclmb.bsky.social) uncovers the mechanisms PGCs use in mouse embryos to navigate this long and surprisingly risky journey.
Read more: mrclmb.ac.uk/news-events/...
To explain briefly, PGCs can be used to give rise to sperm or ova cells
In avian biology, PGCs can be genetically modified, then injected into embryonic chickens, and they mature in the host (usually a male) and produce mature gametes (usually sperm), but there still then needs to be a host hen
In avian biology, PGCs can be genetically modified, then injected into embryonic chickens, and they mature in the host (usually a male) and produce mature gametes (usually sperm), but there still then needs to be a host hen
[sigh] here we go again
Once again, Colossal Biosciences is tech bro grift and journalists don’t need to reprint their press releases uncritically (and they only claim they’ve made Nicobar pigeon germ cells!)
They will not ever produce a live dodo
www.theguardian.com/science/2025...
Once again, Colossal Biosciences is tech bro grift and journalists don’t need to reprint their press releases uncritically (and they only claim they’ve made Nicobar pigeon germ cells!)
They will not ever produce a live dodo
www.theguardian.com/science/2025...
Scientists claim they’ve made ‘pivotal step’ in bringing back the dodo for first time in 300 years
Thousands of dodos could return within a decade according to Colossal Biosciences, a ‘de-extinction’ company – but experts warn of ‘moral hazard’
www.theguardian.com
September 18, 2025 at 3:51 PM
To explain briefly, PGCs can be used to give rise to sperm or ova cells
In avian biology, PGCs can be genetically modified, then injected into embryonic chickens, and they mature in the host (usually a male) and produce mature gametes (usually sperm), but there still then needs to be a host hen
In avian biology, PGCs can be genetically modified, then injected into embryonic chickens, and they mature in the host (usually a male) and produce mature gametes (usually sperm), but there still then needs to be a host hen
NGC 3846A, 83 million light years away.
PGC 36463 to its right.
UGC 6685 top right of center.
Challenge mode: PGCs 2479507 and 2477764 halfway down below 3846A.
The diligent observer can find assorted other stellar PGCs.
#astrophotography #seestar #ngc3846A
PGC 36463 to its right.
UGC 6685 top right of center.
Challenge mode: PGCs 2479507 and 2477764 halfway down below 3846A.
The diligent observer can find assorted other stellar PGCs.
#astrophotography #seestar #ngc3846A
June 11, 2026 at 12:34 PM
NGC 3846A, 83 million light years away.
PGC 36463 to its right.
UGC 6685 top right of center.
Challenge mode: PGCs 2479507 and 2477764 halfway down below 3846A.
The diligent observer can find assorted other stellar PGCs.
#astrophotography #seestar #ngc3846A
PGC 36463 to its right.
UGC 6685 top right of center.
Challenge mode: PGCs 2479507 and 2477764 halfway down below 3846A.
The diligent observer can find assorted other stellar PGCs.
#astrophotography #seestar #ngc3846A
Incredibly excited to share my new preprint! 🪰🧬
Ever wondered how germ cells can specify their fate without having a dedicated transcriptional program?
We found that germ cells keep the uncommitted chromatin state of the early embryo
www.biorxiv.org/content/10.6...
Ever wondered how germ cells can specify their fate without having a dedicated transcriptional program?
We found that germ cells keep the uncommitted chromatin state of the early embryo
www.biorxiv.org/content/10.6...
Decoupling Transcription from Cell Fate Preserves Germ Cell Totipotency
Only germ cells can give rise to a totipotent embryo, yet a conserved transcriptional program for germ cell identity remains elusive. Profiling Drosophila primordial germ cells (PGCs) across embryogen...
www.biorxiv.org
September 19, 2026 at 4:46 PM
Incredibly excited to share my new preprint! 🪰🧬
Ever wondered how germ cells can specify their fate without having a dedicated transcriptional program?
We found that germ cells keep the uncommitted chromatin state of the early embryo
www.biorxiv.org/content/10.6...
Ever wondered how germ cells can specify their fate without having a dedicated transcriptional program?
We found that germ cells keep the uncommitted chromatin state of the early embryo
www.biorxiv.org/content/10.6...
So excited to see the new work out from fellow PhD candidate @mayapahima.bsky.social in the @flomarlow.bsky.social lab where they show that PGCs are not restricted to GSC differentiation and contribute to other cell populations of the early gonad and ovary 🦓🐟❤️!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Clonal analysis reveals differential PGC contributions to the early germline and ovarian reserve
Primordial germ cells (PGCs) are the precursors of the germline and among the first cells to be specified during embryogenesis. Contrary to the common assumption that PGCs directly develop into germli...
www.biorxiv.org
May 7, 2025 at 5:34 PM
So excited to see the new work out from fellow PhD candidate @mayapahima.bsky.social in the @flomarlow.bsky.social lab where they show that PGCs are not restricted to GSC differentiation and contribute to other cell populations of the early gonad and ovary 🦓🐟❤️!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Galaxy with light trails: NGC 3735, 124 million light years away.
CHALLENGE MODE: UGC 6580 at the bottom. UGC 6532 at 4 o'clock.
The diligent observer is invited to locate a handful of nearly stellar PGCs.
#astrophotography #seestar #ngc3735
CHALLENGE MODE: UGC 6580 at the bottom. UGC 6532 at 4 o'clock.
The diligent observer is invited to locate a handful of nearly stellar PGCs.
#astrophotography #seestar #ngc3735
May 29, 2026 at 11:47 PM
Galaxy with light trails: NGC 3735, 124 million light years away.
CHALLENGE MODE: UGC 6580 at the bottom. UGC 6532 at 4 o'clock.
The diligent observer is invited to locate a handful of nearly stellar PGCs.
#astrophotography #seestar #ngc3735
CHALLENGE MODE: UGC 6580 at the bottom. UGC 6532 at 4 o'clock.
The diligent observer is invited to locate a handful of nearly stellar PGCs.
#astrophotography #seestar #ngc3735
Epigenetics Review - Epigenetic reprogramming in mouse and human primordial germ cells bit.ly/4fj3veC
Sun-Min Lee and M. Azim Surani write in EMM on how DNA methylation/histone modifications control the development of PGCs
#Epigenetics #PGCs
---
Get high-res epigenetic insight with epigenome.us
Sun-Min Lee and M. Azim Surani write in EMM on how DNA methylation/histone modifications control the development of PGCs
#Epigenetics #PGCs
---
Get high-res epigenetic insight with epigenome.us
December 16, 2024 at 8:33 AM
Epigenetics Review - Epigenetic reprogramming in mouse and human primordial germ cells bit.ly/4fj3veC
Sun-Min Lee and M. Azim Surani write in EMM on how DNA methylation/histone modifications control the development of PGCs
#Epigenetics #PGCs
---
Get high-res epigenetic insight with epigenome.us
Sun-Min Lee and M. Azim Surani write in EMM on how DNA methylation/histone modifications control the development of PGCs
#Epigenetics #PGCs
---
Get high-res epigenetic insight with epigenome.us
Galaxies like dust.
Galaxy cluster ACO 2151, centered on NGC 6047. Too many NGCs, ICs, and PGCs to list.
#astrophotography #seestar #aco2151
Galaxy cluster ACO 2151, centered on NGC 6047. Too many NGCs, ICs, and PGCs to list.
#astrophotography #seestar #aco2151
June 21, 2026 at 6:04 PM
Galaxies like dust.
Galaxy cluster ACO 2151, centered on NGC 6047. Too many NGCs, ICs, and PGCs to list.
#astrophotography #seestar #aco2151
Galaxy cluster ACO 2151, centered on NGC 6047. Too many NGCs, ICs, and PGCs to list.
#astrophotography #seestar #aco2151
Human #gastruloids as a model for the emergence of #PGCs www.science.org/doi/10.1126/...; early days but it promises as it follows the earlier work of @nmoris.bsky.social on mouse PGCs shorturl.at/FO1p0
The emergence of human primordial germ cell–like cells in stem cell–derived gastruloids
3D human gastruloids mimic gastrulation and postgastrulation development, forming the three germ layer derivatives and hPGCLCs.
www.science.org
March 27, 2025 at 10:51 PM
Human #gastruloids as a model for the emergence of #PGCs www.science.org/doi/10.1126/...; early days but it promises as it follows the earlier work of @nmoris.bsky.social on mouse PGCs shorturl.at/FO1p0
Epigenetics Update - UHRF2 mediates resistance to DNA methylation reprogramming in primordial germ cells go.nature.com/459p0g8
Michael Weber (Université de Strasbourg) in Nat Commun
#Epigenetics #DNAme #DNAm #PGCs
---
Perfect for cancer, immunology, and aging research; epigenometech.com
Michael Weber (Université de Strasbourg) in Nat Commun
#Epigenetics #DNAme #DNAm #PGCs
---
Perfect for cancer, immunology, and aging research; epigenometech.com
August 19, 2025 at 12:49 PM
Epigenetics Update - UHRF2 mediates resistance to DNA methylation reprogramming in primordial germ cells go.nature.com/459p0g8
Michael Weber (Université de Strasbourg) in Nat Commun
#Epigenetics #DNAme #DNAm #PGCs
---
Perfect for cancer, immunology, and aging research; epigenometech.com
Michael Weber (Université de Strasbourg) in Nat Commun
#Epigenetics #DNAme #DNAm #PGCs
---
Perfect for cancer, immunology, and aging research; epigenometech.com
Cool work from the McDole lab just published. Primordial germ cells have to endure some pretty tight spaces on their journey!
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Primordial germ cells experience increasing physical confinement and DNA damage during migration in the mouse embryo
Mammalian PGCs face a challenging journey to the gonads, and experience DNA damage as they navigate through confined spaces.
www.science.org
March 20, 2026 at 12:00 PM
Cool work from the McDole lab just published. Primordial germ cells have to endure some pretty tight spaces on their journey!
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
I believe that over the past ~ two decades, since the breakthrough papers on UHRF1, this is the first reported DNA methylation phenotype of its close paralog, UHRF2 (and not for lack of trying). Congrats to Ambre Bender and Michael Weber on this fantastic study! www.nature.com/articles/s41...
UHRF2 mediates resistance to DNA methylation reprogramming in primordial germ cells - Nature Communications
DNA methylation in mouse primordial germ cells (PGCs) is restricted to transposable elements, but how this unique DNA methylome is established is poorly understood. Here, the authors identify UHRF2 as...
www.nature.com
August 9, 2025 at 6:26 PM
I believe that over the past ~ two decades, since the breakthrough papers on UHRF1, this is the first reported DNA methylation phenotype of its close paralog, UHRF2 (and not for lack of trying). Congrats to Ambre Bender and Michael Weber on this fantastic study! www.nature.com/articles/s41...
Epigenetics Update – A primordial germ cell-like-cell platform enables CRISPRi screen for epigenetic fertility modifiers bit.ly/48iiPI3
John C Schimenti (Cornell University) reporting in EMBO J
#Epigenetics #PGCs #Fertility #CRISPR
---
High-res insights without cell sorting; epigenometech.com
John C Schimenti (Cornell University) reporting in EMBO J
#Epigenetics #PGCs #Fertility #CRISPR
---
High-res insights without cell sorting; epigenometech.com
November 17, 2025 at 12:05 PM
Epigenetics Update – A primordial germ cell-like-cell platform enables CRISPRi screen for epigenetic fertility modifiers bit.ly/48iiPI3
John C Schimenti (Cornell University) reporting in EMBO J
#Epigenetics #PGCs #Fertility #CRISPR
---
High-res insights without cell sorting; epigenometech.com
John C Schimenti (Cornell University) reporting in EMBO J
#Epigenetics #PGCs #Fertility #CRISPR
---
High-res insights without cell sorting; epigenometech.com
Because this is the #UKSR, where Farage and other PGCS types are untouchable.
Rayner's finances were only investigated because a certain British Oligarch (another Untouchable) chose to pursue her.
Rayner's finances were only investigated because a certain British Oligarch (another Untouchable) chose to pursue her.
I'll just point out that if you turned up with £885,000 in cash to buy a house HMRC would audit the hell out of you for criminality/unpaid tax.
Why does Nigel Farage's girlfriend get a free pass?
Why does Nigel Farage's girlfriend get a free pass?
September 8, 2025 at 11:46 AM
Because this is the #UKSR, where Farage and other PGCS types are untouchable.
Rayner's finances were only investigated because a certain British Oligarch (another Untouchable) chose to pursue her.
Rayner's finances were only investigated because a certain British Oligarch (another Untouchable) chose to pursue her.
The peripheral distribution of centromeres in PGCs is apparent in 3D reconstruction of confocal images. The data suggest that centromeres are separated in PGCs.
Surprisingly, despite the de-clustering of centromeres, the signal in the individual CENPA foci seemed more pronounced in PGCs. 4/9
Surprisingly, despite the de-clustering of centromeres, the signal in the individual CENPA foci seemed more pronounced in PGCs. 4/9
November 18, 2025 at 4:57 PM
The peripheral distribution of centromeres in PGCs is apparent in 3D reconstruction of confocal images. The data suggest that centromeres are separated in PGCs.
Surprisingly, despite the de-clustering of centromeres, the signal in the individual CENPA foci seemed more pronounced in PGCs. 4/9
Surprisingly, despite the de-clustering of centromeres, the signal in the individual CENPA foci seemed more pronounced in PGCs. 4/9
#VesselAlert #NEW #FIRST Observation
Name: #TEUNIS_HUIBERTUS
#MMSI: #246849000
Callsign: #PGCS
Type: #Dredging
#Flag: #Netherlands
Seen: 28-Sep-2026 15:49:35 CEST
Status: #under_way_using_engine
Speed: 1.3 kts
Heading: 154 deg
Dest.: DREDGING JADE
Distance: 83.4 nm
Signal #RSSI: 0.0 dBFS
#Ship #AIS VesselAlert ©
Name: #TEUNIS_HUIBERTUS
#MMSI: #246849000
Callsign: #PGCS
Type: #Dredging
#Flag: #Netherlands
Seen: 28-Sep-2026 15:49:35 CEST
Status: #under_way_using_engine
Speed: 1.3 kts
Heading: 154 deg
Dest.: DREDGING JADE
Distance: 83.4 nm
Signal #RSSI: 0.0 dBFS
#Ship #AIS VesselAlert ©
September 28, 2026 at 1:49 PM
#VesselAlert #NEW #FIRST Observation
Name: #TEUNIS_HUIBERTUS
#MMSI: #246849000
Callsign: #PGCS
Type: #Dredging
#Flag: #Netherlands
Seen: 28-Sep-2026 15:49:35 CEST
Status: #under_way_using_engine
Speed: 1.3 kts
Heading: 154 deg
Dest.: DREDGING JADE
Distance: 83.4 nm
Signal #RSSI: 0.0 dBFS
#Ship #AIS VesselAlert ©
Name: #TEUNIS_HUIBERTUS
#MMSI: #246849000
Callsign: #PGCS
Type: #Dredging
#Flag: #Netherlands
Seen: 28-Sep-2026 15:49:35 CEST
Status: #under_way_using_engine
Speed: 1.3 kts
Heading: 154 deg
Dest.: DREDGING JADE
Distance: 83.4 nm
Signal #RSSI: 0.0 dBFS
#Ship #AIS VesselAlert ©
今日の飼育係向け講義は鳥類に関するもの
スライドのシロフクロウは笑顔ですが
胚発生ステージや始原生殖細胞（PGCs）などに関する話
そして小試験もあるという
ちょっと高度な内容でした
#動物園学 #ズーラシア #ZooScience #ZOORASIA
スライドのシロフクロウは笑顔ですが
胚発生ステージや始原生殖細胞（PGCs）などに関する話
そして小試験もあるという
ちょっと高度な内容でした
#動物園学 #ズーラシア #ZooScience #ZOORASIA
May 28, 2025 at 5:40 AM
今日の飼育係向け講義は鳥類に関するもの
スライドのシロフクロウは笑顔ですが
胚発生ステージや始原生殖細胞（PGCs）などに関する話
そして小試験もあるという
ちょっと高度な内容でした
#動物園学 #ズーラシア #ZooScience #ZOORASIA
スライドのシロフクロウは笑顔ですが
胚発生ステージや始原生殖細胞（PGCs）などに関する話
そして小試験もあるという
ちょっと高度な内容でした
#動物園学 #ズーラシア #ZooScience #ZOORASIA
(7/8) There’s more inside: signaling landscapes, PGCs, primary-to-secondary yolk sac transition…
September 16, 2025 at 4:12 PM
(7/8) There’s more inside: signaling landscapes, PGCs, primary-to-secondary yolk sac transition…
Happy to see that our recent work has been discussed in a News & Views @natsmb.nature.com by Christine Disteche and Xinxian Deng 😀
⬇️
rdcu.be/ekTr1
⬇️
rdcu.be/ekTr1
May 6, 2025 at 3:05 PM
Happy to see that our recent work has been discussed in a News & Views @natsmb.nature.com by Christine Disteche and Xinxian Deng 😀
⬇️
rdcu.be/ekTr1
⬇️
rdcu.be/ekTr1
Happy to share our new review on X-chromosome reactivation in the germline, just published in @biochemsoc.bsky.social Transactions!
We highlight the latest discoveries on how this epigenetic mechanism unfolds during mammalian germline reprogramming.
Hope you enjoy the read 😊
We highlight the latest discoveries on how this epigenetic mechanism unfolds during mammalian germline reprogramming.
Hope you enjoy the read 😊
Reprogramming the inactive X chromosome: dynamics and insights from the germline
Abstract. Germline reprogramming is an essential process that resets the epigenome prior to gamete formation. Primordial germ cells (PGCs), the progenitors of oocytes and spermatozoa, undergo extensiv...
portlandpress.com
March 26, 2026 at 1:20 PM
Happy to share our new review on X-chromosome reactivation in the germline, just published in @biochemsoc.bsky.social Transactions!
We highlight the latest discoveries on how this epigenetic mechanism unfolds during mammalian germline reprogramming.
Hope you enjoy the read 😊
We highlight the latest discoveries on how this epigenetic mechanism unfolds during mammalian germline reprogramming.
Hope you enjoy the read 😊
Happy Sunday with a new issue of #cebooc!
Today Florence Marlow and team reveal that different PGCs clones contibute differently to the germline in zebrafish: pubmed.ncbi.nlm.nih.gov/42403048/
Full issue: biomed.news/bims-cebooc/...
Subscribe: biomed.news/bims-cebooc
@biomednews.bsky.social
Today Florence Marlow and team reveal that different PGCs clones contibute differently to the germline in zebrafish: pubmed.ncbi.nlm.nih.gov/42403048/
Full issue: biomed.news/bims-cebooc/...
Subscribe: biomed.news/bims-cebooc
@biomednews.bsky.social
July 12, 2026 at 8:39 AM
Happy Sunday with a new issue of #cebooc!
Today Florence Marlow and team reveal that different PGCs clones contibute differently to the germline in zebrafish: pubmed.ncbi.nlm.nih.gov/42403048/
Full issue: biomed.news/bims-cebooc/...
Subscribe: biomed.news/bims-cebooc
@biomednews.bsky.social
Today Florence Marlow and team reveal that different PGCs clones contibute differently to the germline in zebrafish: pubmed.ncbi.nlm.nih.gov/42403048/
Full issue: biomed.news/bims-cebooc/...
Subscribe: biomed.news/bims-cebooc
@biomednews.bsky.social
🕊️ Exciting breakthrough: for the first time, scientists successfully derived and cultured primordial germ cells (PGCs) from the common pigeon (Columba livia)! This advances reproductive tech for avian conservation, enabling germline manipulation and biobanking in pigeons and related species.
1/2
1/2
June 9, 2026 at 1:09 AM
🕊️ Exciting breakthrough: for the first time, scientists successfully derived and cultured primordial germ cells (PGCs) from the common pigeon (Columba livia)! This advances reproductive tech for avian conservation, enabling germline manipulation and biobanking in pigeons and related species.
1/2
1/2
#VesselAlert
Name: #TEUNIS_HUIBERTUS
#MMSI: #246849000
Callsign: #PGCS
Type: #Dredging
#Flag: #Netherlands
Seen: 25-Sep-2026 13:30:07 CEST
Status: #under_way_using_engine
Speed: 1.2 kts
Heading: 241 deg
Dest.: DREDGING JADE
Distance: 83.0 nm
Signal #RSSI: 0.0 dBFS
#Ship #AIS VesselAlert © #kx1t - link
Name: #TEUNIS_HUIBERTUS
#MMSI: #246849000
Callsign: #PGCS
Type: #Dredging
#Flag: #Netherlands
Seen: 25-Sep-2026 13:30:07 CEST
Status: #under_way_using_engine
Speed: 1.2 kts
Heading: 241 deg
Dest.: DREDGING JADE
Distance: 83.0 nm
Signal #RSSI: 0.0 dBFS
#Ship #AIS VesselAlert © #kx1t - link
September 25, 2026 at 11:30 AM
#VesselAlert
Name: #TEUNIS_HUIBERTUS
#MMSI: #246849000
Callsign: #PGCS
Type: #Dredging
#Flag: #Netherlands
Seen: 25-Sep-2026 13:30:07 CEST
Status: #under_way_using_engine
Speed: 1.2 kts
Heading: 241 deg
Dest.: DREDGING JADE
Distance: 83.0 nm
Signal #RSSI: 0.0 dBFS
#Ship #AIS VesselAlert © #kx1t - link
Name: #TEUNIS_HUIBERTUS
#MMSI: #246849000
Callsign: #PGCS
Type: #Dredging
#Flag: #Netherlands
Seen: 25-Sep-2026 13:30:07 CEST
Status: #under_way_using_engine
Speed: 1.2 kts
Heading: 241 deg
Dest.: DREDGING JADE
Distance: 83.0 nm
Signal #RSSI: 0.0 dBFS
#Ship #AIS VesselAlert © #kx1t - link
Per Kagan recently, Donald Trump losing the Iran War has effectively ended the AAs. Donald has made Iran the dominant regional influence.
PG countries will have to make peace with Iran. PGCs will have to reject or exit AAs for economic survival.
End of AAs damages Donald's legacy & grifting.
PG countries will have to make peace with Iran. PGCs will have to reject or exit AAs for economic survival.
End of AAs damages Donald's legacy & grifting.
May 25, 2026 at 2:59 PM
Per Kagan recently, Donald Trump losing the Iran War has effectively ended the AAs. Donald has made Iran the dominant regional influence.
PG countries will have to make peace with Iran. PGCs will have to reject or exit AAs for economic survival.
End of AAs damages Donald's legacy & grifting.
PG countries will have to make peace with Iran. PGCs will have to reject or exit AAs for economic survival.
End of AAs damages Donald's legacy & grifting.