☕ @majarad.bsky.social et al. show that phosphatidylinositol 3-phosphate (PI3P), produced by the phosphatidylinositol 3-kinase PIK3C3, is formed on ER domains after lysosome damage. ER domain PI3P helps to recruit the ATPase DFCP1, which promotes lysosome repair.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
DFCP1-containing ER microdomains mediate lysosomal membrane repair - Nature Cell Biology
Radulovic et al. show that phosphatidylinositol 3-phosphate (PI3P), produced by the phosphatidylinositol 3-kinase PIK3C3, is formed on ER domains after lysosome damage. ER domain PI3P helps to recruit...
www.nature.com
September 21, 2026 at 12:55 PM
☕ @majarad.bsky.social et al. show that phosphatidylinositol 3-phosphate (PI3P), produced by the phosphatidylinositol 3-kinase PIK3C3, is formed on ER domains after lysosome damage. ER domain PI3P helps to recruit the ATPase DFCP1, which promotes lysosome repair.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Our new publication in Nature Cell Biology 🔬
How cells reseal damaged lysosomes: Ca²⁺ leak → VPS34 makes PI3P on the ER → recruits DFCP1 → clusters VPS13C lipid-transfer bridges at ER–lysosome contacts to patch the membrane. No DFCP1 = failed repair.
www.nature.com/articles/s41...
How cells reseal damaged lysosomes: Ca²⁺ leak → VPS34 makes PI3P on the ER → recruits DFCP1 → clusters VPS13C lipid-transfer bridges at ER–lysosome contacts to patch the membrane. No DFCP1 = failed repair.
www.nature.com/articles/s41...
DFCP1-containing ER microdomains mediate lysosomal membrane repair - Nature Cell Biology
Radulovic et al. show that phosphatidylinositol 3-phosphate (PI3P), produced by the phosphatidylinositol 3-kinase PIK3C3, is formed on ER domains after lysosome damage. ER domain PI3P helps to recruit...
www.nature.com
September 15, 2026 at 4:08 PM
Our new publication in Nature Cell Biology 🔬
How cells reseal damaged lysosomes: Ca²⁺ leak → VPS34 makes PI3P on the ER → recruits DFCP1 → clusters VPS13C lipid-transfer bridges at ER–lysosome contacts to patch the membrane. No DFCP1 = failed repair.
www.nature.com/articles/s41...
How cells reseal damaged lysosomes: Ca²⁺ leak → VPS34 makes PI3P on the ER → recruits DFCP1 → clusters VPS13C lipid-transfer bridges at ER–lysosome contacts to patch the membrane. No DFCP1 = failed repair.
www.nature.com/articles/s41...
Our study on DFCP1 and lysosome membrane repair is live! We uncover a previously unrecognized role for omegasomes in the cellular response to lysosomal membrane damage, revealing another layer of regulation in how damaged lysosomes are repaired.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
DFCP1-containing ER microdomains mediate lysosomal membrane repair - Nature Cell Biology
Radulovic et al. show that phosphatidylinositol 3-phosphate (PI3P), produced by the phosphatidylinositol 3-kinase PIK3C3, is formed on ER domains after lysosome damage. ER domain PI3P helps to recruit...
www.nature.com
September 15, 2026 at 9:33 AM
Our study on DFCP1 and lysosome membrane repair is live! We uncover a previously unrecognized role for omegasomes in the cellular response to lysosomal membrane damage, revealing another layer of regulation in how damaged lysosomes are repaired.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
SARS-CoV-2 Causes Downregulation OF Autophagy Genes PIK3C3 And RAB7A
www.thailandmedical.news/news/sars-co...
www.thailandmedical.news/news/sars-co...
SARS-CoV-2 Causes Downregulation OF Autophagy Genes PIK3C3 And RAB7A - Thailand Medical News
www.thailandmedical.news
April 17, 2024 at 1:09 AM
SARS-CoV-2 Causes Downregulation OF Autophagy Genes PIK3C3 And RAB7A
www.thailandmedical.news/news/sars-co...
www.thailandmedical.news/news/sars-co...
Potassium molybdate blocks APN-dependent coronavirus entry by degrading receptor via PIK3C3-mediated autophagy journals.asm.org/doi/10.1128/...
Potassium molybdate blocks APN-dependent coronavirus entry by degrading receptor via PIK3C3-mediated autophagy | Journal of Virology
Aminopeptidase N (APN) is one of the most important host receptors of coronavirus.
Modulating APN expression can represent a novel approach for controlling APN-dependent
coronaviruses and their varian...
journals.asm.org
December 6, 2024 at 4:06 PM
Potassium molybdate blocks APN-dependent coronavirus entry by degrading receptor via PIK3C3-mediated autophagy journals.asm.org/doi/10.1128/...
ERJ Open Research: Four gene modules were linked to ICS treatment responsiveness. Key pathways represented by them included cilium function, metabolism and inflammation, with genes like LRRC6, IFT46, AKT2 and PIK3C3 playing central roles. https://bit.ly/4o577Gp
March 22, 2026 at 3:52 PM
ERJ Open Research: Four gene modules were linked to ICS treatment responsiveness. Key pathways represented by them included cilium function, metabolism and inflammation, with genes like LRRC6, IFT46, AKT2 and PIK3C3 playing central roles. https://bit.ly/4o577Gp
Hope for stopping the spread of cancer: a study by Drs. Côté and Elkholi published in "Cancer Research"
New hope for understanding and limiting the metastatic recurrence of breast cancer.
Bravo to research!
🔎Learn more: bit.ly/4mzQK44
New hope for understanding and limiting the metastatic recurrence of breast cancer.
Bravo to research!
🔎Learn more: bit.ly/4mzQK44
May 28, 2025 at 12:22 PM
Hope for stopping the spread of cancer: a study by Drs. Côté and Elkholi published in "Cancer Research"
New hope for understanding and limiting the metastatic recurrence of breast cancer.
Bravo to research!
🔎Learn more: bit.ly/4mzQK44
New hope for understanding and limiting the metastatic recurrence of breast cancer.
Bravo to research!
🔎Learn more: bit.ly/4mzQK44
Une avancée prometteuse contre la propagation du cancer du sein: une étude des Drs Côté et Elkholi parue dans «Cancer Research»
Il s’agit d’un nouvel espoir de comprendre et de limiter la récurrence métastatique du cancer du sein.
Bravo à la recherche!
bit.ly/4murFYh
Il s’agit d’un nouvel espoir de comprendre et de limiter la récurrence métastatique du cancer du sein.
Bravo à la recherche!
bit.ly/4murFYh
May 28, 2025 at 12:21 PM
Une avancée prometteuse contre la propagation du cancer du sein: une étude des Drs Côté et Elkholi parue dans «Cancer Research»
Il s’agit d’un nouvel espoir de comprendre et de limiter la récurrence métastatique du cancer du sein.
Bravo à la recherche!
bit.ly/4murFYh
Il s’agit d’un nouvel espoir de comprendre et de limiter la récurrence métastatique du cancer du sein.
Bravo à la recherche!
bit.ly/4murFYh
In a study by Zhang et al., 2024, potassium molybdate (PM) reduced APN-dependent coronavirus infection in piglets by degrading the receptor aminopeptidase N (APN) via PIK3C3-mediated autophagy.
journals.asm.org/doi/10.1128/...
journals.asm.org/doi/10.1128/...
Potassium molybdate blocks APN-dependent coronavirus entry by degrading receptor via PIK3C3-mediated autophagy | Journal of Virology
Aminopeptidase N (APN) is one of the most important host receptors of coronavirus.
Modulating APN expression can represent a novel approach for controlling APN-dependent
coronaviruses and their varian...
journals.asm.org
December 7, 2024 at 4:17 PM
In a study by Zhang et al., 2024, potassium molybdate (PM) reduced APN-dependent coronavirus infection in piglets by degrading the receptor aminopeptidase N (APN) via PIK3C3-mediated autophagy.
journals.asm.org/doi/10.1128/...
journals.asm.org/doi/10.1128/...
A paper using RRID:AB_2923704 from @proteintech.bsky.social was just published in iScience. Thanks for making your methods matter! #reproducibility #ReproducibleResearch #BetterScience
ZBED6–IGF2–PIK3C3 autophagy axis drives ccRCC progression: A multi-omics integration study
Read the full paper: ZBED6–IGF2–PIK3C3 autophagy axis drives ccRCC progression: A multi-omics integration study
doi.org
March 22, 2026 at 7:00 AM
A paper using RRID:AB_2923704 from @proteintech.bsky.social was just published in iScience. Thanks for making your methods matter! #reproducibility #ReproducibleResearch #BetterScience
RRIDs were included in this paper. Thanks for making your methods matter! #accelerateopenscience #ReproducibleResearch #ReproducibleResearch
BRSK2 plays a role in autophagy and cancer cell growth and survival under nutrient deprivation stress via the PIK3C3 pathway
doi.org
November 26, 2025 at 8:00 AM
RRIDs were included in this paper. Thanks for making your methods matter! #accelerateopenscience #ReproducibleResearch #ReproducibleResearch
RRIDs were included in this None paper. Thanks for making your methods matter! #methodsmatter #accelerateopenscience #reproducibility
Targeting the Dependence on PIK3C3-mTORC1 Signaling in Dormancy-Prone Breast Cancer Cells Blunts Metastasis Initiation
doi.org
July 23, 2025 at 7:04 AM
RRIDs were included in this None paper. Thanks for making your methods matter! #methodsmatter #accelerateopenscience #reproducibility
Host PIK3C3 promotes Shigella flexneri spread from cell to cell through vacuole formation https://www.biorxiv.org/content/10.1101/2024.10.31.621244v1
Host PIK3C3 promotes Shigella flexneri spread from cell to cell through vacuole formation https://www.biorxiv.org/content/10.1101/2024.10.31.621244v1
Shigella flexneri is a human intracellular pathogen responsible for bacillary dysentery (bloody diar
www.biorxiv.org
November 1, 2024 at 3:18 AM
Host PIK3C3 promotes Shigella flexneri spread from cell to cell through vacuole formation https://www.biorxiv.org/content/10.1101/2024.10.31.621244v1
New vulnerability of dormant breast cancer cells dependent on a specific isoform of PI3K revealed by Islam Elkholi, JF Cote and team @ircm.bsky.social. Really happy to see this paper out and to have been of service!
aacrjournals.org/cancerres/ar...
aacrjournals.org/cancerres/ar...
Targeting the Dependence on PIK3C3-mTORC1 Signaling in Dormancy-Prone Breast Cancer Cells Blunts Metastasis Initiation
Abstract. Halting breast cancer metastatic relapse following primary tumor removal remains challenging due to a lack of specific vulnerabilities to target during the clinical dormancy phase. To identi...
aacrjournals.org
May 20, 2025 at 2:09 AM
New vulnerability of dormant breast cancer cells dependent on a specific isoform of PI3K revealed by Islam Elkholi, JF Cote and team @ircm.bsky.social. Really happy to see this paper out and to have been of service!
aacrjournals.org/cancerres/ar...
aacrjournals.org/cancerres/ar...
⭐ Our data suggest that targeting PIK3C3 activity relocalize the lysosomes from the cell periphery to the perinuclear region leading to lower mTORC1 activity in BC cells.
May 27, 2025 at 1:39 PM
⭐ Our data suggest that targeting PIK3C3 activity relocalize the lysosomes from the cell periphery to the perinuclear region leading to lower mTORC1 activity in BC cells.
Excited to share our latest discovery just published in Cancer Research.
lnkd.in/e_vNXXJC
⭐ We revealed that dormancy-prone or dormant breast cancer (BC) cells might be eliminated by targeting PIK3C3 (the 3rd class PI3K), hence less #metastasis burden in #breastcancer.
@jf-cotelab.bsky.social
lnkd.in/e_vNXXJC
⭐ We revealed that dormancy-prone or dormant breast cancer (BC) cells might be eliminated by targeting PIK3C3 (the 3rd class PI3K), hence less #metastasis burden in #breastcancer.
@jf-cotelab.bsky.social
May 27, 2025 at 1:39 PM
Excited to share our latest discovery just published in Cancer Research.
lnkd.in/e_vNXXJC
⭐ We revealed that dormancy-prone or dormant breast cancer (BC) cells might be eliminated by targeting PIK3C3 (the 3rd class PI3K), hence less #metastasis burden in #breastcancer.
@jf-cotelab.bsky.social
lnkd.in/e_vNXXJC
⭐ We revealed that dormancy-prone or dormant breast cancer (BC) cells might be eliminated by targeting PIK3C3 (the 3rd class PI3K), hence less #metastasis burden in #breastcancer.
@jf-cotelab.bsky.social
#RNF213, an IFN-inducible #E3Ligase, regulates B-cell development by degrading #SPIB; its loss disrupts AKT-mTOR signaling and antibody responses, while SPIB deletion or #PIK3C3 inhibition restores function. #HumoralImmunity
#OpenAccess in #STTT: doi.org/10.1038/s413...
#OpenAccess in #STTT: doi.org/10.1038/s413...
February 22, 2026 at 1:26 AM
#RNF213, an IFN-inducible #E3Ligase, regulates B-cell development by degrading #SPIB; its loss disrupts AKT-mTOR signaling and antibody responses, while SPIB deletion or #PIK3C3 inhibition restores function. #HumoralImmunity
#OpenAccess in #STTT: doi.org/10.1038/s413...
#OpenAccess in #STTT: doi.org/10.1038/s413...
Host PIK3C3 promotes Shigella flexneri spread from cell to cell through vacuole formation https://www.biorxiv.org/content/10.1101/2024.10.31.621244v1
Host PIK3C3 promotes Shigella flexneri spread from cell to cell through vacuole formation https://www.biorxiv.org/content/10.1101/2024.10.31.621244v1
Shigella flexneri is a human intracellular pathogen responsible for bacillary dysentery (bloody diar
www.biorxiv.org
November 1, 2024 at 3:18 AM
Host PIK3C3 promotes Shigella flexneri spread from cell to cell through vacuole formation https://www.biorxiv.org/content/10.1101/2024.10.31.621244v1